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Mark W. Lowdell
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Journal Articles

Safety, Efficiency and Long-Term Follow-up of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, Juliana Dias Alves Pinto, Maeve A O'Reilly, Marina Mitsikakou, Eftychia Charalambous, Louisa Green, Mhairi Vaughan, Giulia Agliardi, John Garcia, Evie Lewin, Mark W. Lowdell, Maria A V Marzolini, Leigh Wood, Helen Holmes, Yenting Ngai, Bilyana Popova, William Wilson, Sangeetha Kunaseelan, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Simon Morley, David C. Linch, Adrian Bloor, David A. Irvine, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2022) 140 (Supplement 1): 7452–7453.
https://doi.org/10.1182/blood-2022-167053
Published: 2022
Journal Articles

In Vivo Generation of Memory-like NK Cells for the Treatment of AML and Myelodysplastic Syndrome; Early Clinical Applications of INKmune TM

Kim H. Orchard, Helena Ballestero, Aga Zubiak, Chris Dalley, Deborah Susan Richardson, Rob Torrance, Trinity Eales, Dimitra Peppa, May Sabry, Mark W. Lowdell
Journal: Blood
Blood (2022) 140 (Supplement 1): 4590–4591.
https://doi.org/10.1182/blood-2022-166175
Published: 2022
Journal Articles

Safety and Efficacy of AUTO1, a Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)

Claire Roddie, Juliana Dias, Maeve A O'Reilly, Amaia Cadinanos Garai, Louisa Green, Mahnaz Abbasian, Marina Mitsikakou, Mhairi Vaughan, Vitoria Meyer Cantinho Pereira, Maria A V Marzolini, Leigh Wood, Joanna Olejnik, Yenting Ngai, Bilyana Popova, William Wilson, Victoria Spanswick, Helen Lowe, Leah Ensell, John A. Hartley, Farzin Farzaneh, Mark W. Lowdell, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2021) 138 (Supplement 1): 3823.
https://doi.org/10.1182/blood-2021-146316
Published: 2021
Journal Articles

ALLCAR19: Updated Data Using AUTO1, a Novel Fast-Off Rate CD19 CAR in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukaemia and Other B-Cell Malignancies

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias, Amaia Cadinanos Garai, BSc MSc, Leticia Bosshard, Mahnaz Abbasian, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, MSc, Laura Clifton-Hadley, PhDBSc, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farhatullah Syed, Waseem Qasim, MBBS, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, MDPhD, Karl S Peggs, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-137768
Published: 2020
Journal Articles

AUTO1, a Novel Fast Off CD19CAR Delivers Durable Remissions and Prolonged CAR T Cell Persistence with Low CRS or Neurotoxicity in Adult ALL

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Joanna Olejnik, Bilyana Popova, Kim Champion, Alexia Gali, Yashma Pathak, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 226.
https://doi.org/10.1182/blood-2019-131086
Published: 2019
Journal Articles

Automated Manufacture of Matched Donor-Derived Allogeneic CD19 CAR T-Cells for Relapsed/Refractory B-ALL Following Allogeneic Stem Cell Transplantation: Toxicity, Efficacy and the Important Role of Lymphodepletion

Claire Roddie, PhD MD, Maeve A O'Reilly, MBBCHBAO, Maria A V Marzolini, Leigh Wood, BA, Juliana Dias Alves Pinto, PhD, Mahnaz Abbasian, Ketki Vispute, Leticia Bosshard, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Graham Wheeler, Alex Day, Bilyana Popova, Kim Champion, Yashma Pathak, Alexia Gali, Nasir Mahmoud, Victoria Spanswick, Helen Lowe, John A. Hartley, PhD, Farzin Farzaneh, PhD, Lauren Nickolay, PhD, Fahetullah Syed, Waseem Qasim, MBBS, PhD, David C. Linch, Martin Pule, Karl S Peggs
Journal: Blood
Blood (2019) 134 (Supplement_1): 776.
https://doi.org/10.1182/blood-2019-129640
Published: 2019
Journal Articles

Predictors of Response in Patients Receiving CD34-Selected Stem Cell Infusions without Conditioning to Correct Graft Failure Following Allogeneic Stem Cell Transplantation

Maria del Mar Cuadrado, MBBS, Mark W. Lowdell, BSc, MSc, PhD FRCPath, Stuart Ings, Michael J. Watts, PhD, Richard Szydlo, PhD, Chloe Anthias, MD, J. Alejandro Madrigal, MDPhDDSc,FRCP,FRCPath, Panagiotis Kottaridis, FRCPath,PhDMSc, Ben Carpenter, PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Karl Peggs, MBBChir, Kirsty Thomson, PhD, Emma Morris, FRCPath, MA, MBBChir, PhD MRCP, Ronjon Chakraverty, BMBS, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 204.
https://doi.org/10.1182/blood-2018-99-115054
Published: 2018
Journal Articles

Preliminary Results of a Phase 1/2 Clinical Trial of Cndo-109-Activated Allogeneic Natural Killer Cells in High Risk Acute Myelogenous Leukemia Patients in First Complete Remission

Todd A. Fehniger, MD PhD, Robert K Stuart, MD, Sarah A. Cooley, MD MS, Jeffrey S. Miller, MD, Julie Curtsinger, PhD, Timothy Mark Hillman, MSc, Nova Silver, RN, Michael Szarek, PhD, Mark W Lowdell, BSc, MSc, PhD FRCPath, Leonid Gorelik, PhD, Eric Rowinsky, MD
Journal: Blood
Blood (2014) 124 (21): 2320.
https://doi.org/10.1182/blood.V124.21.2320.2320
Published: 2014
Journal Articles

Results of a Phase 1 Clinical Trial of Allogeneic Tumor-Primed Natural Killer Cells in AML

Panagiotis Kottaridis, MD, PhD, Maria Tsirogianni, MD, Janet North, BSc, MSc, Chloe Marden, PhD, Stephen Mackinnon, MD, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2011) 118 (21): 946.
https://doi.org/10.1182/blood.V118.21.946.946
Published: 2011
Journal Articles

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment

Andrew J. Steele, Archibald G. Prentice, Kate Cwynarski, A. Victor Hoffbrand, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, R. Gitendra Wickremasinghe
Journal: Blood
Blood (2010) 116 (22): 4569–4577.
https://doi.org/10.1182/blood-2009-09-245811
Published: 2010
Includes: Supplemental data
Journal Articles

Detection of Immunophenotypic Residual Disease After Induction Therapy Is An Independent Prognostic Factor for Duration of Remission In Older AML Patients Treated Intensively

Sylvie Freeman, Robert Hills, MA, MSc, DPhil, Paul Virgo, Steve Couzens, Mark W Lowdell, BSc, MSc, PhD, FRCPath, Christopher J McNamara, Paul White, Alan Burnett
Journal: Blood
Blood (2010) 116 (21): 2714.
https://doi.org/10.1182/blood.V116.21.2714.2714
Published: 2010
Journal Articles

CMV-Reactive T Cells Can Be Isolated From G-CSF Mobilised Peripheral Blood Apheresates.

Edward R Samuel, MSc, Katy Newton, PhD, Stephen Mackinnon, MD, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2010) 116 (21): 1276.
https://doi.org/10.1182/blood.V116.21.1276.1276
Published: 2010
Journal Articles

CMV-Reactive γ/δ T Cells Are Equivalent to Their α/β Counterparts In the Lysis of CMV-Infected Targets – Potential for Post Transplant Adoptive Immunotherapy.

Andrea Knight, PhD, Stephen Mackinnon, MD, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2010) 116 (21): 1277.
https://doi.org/10.1182/blood.V116.21.1277.1277
Published: 2010
Journal Articles

The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation

Clinical Trials & Observations
Andrea Knight, Alejandro J. Madrigal, Sarah Grace, Janani Sivakumaran, Panagiotis Kottaridis, Stephen Mackinnon, Paul J. Travers, Mark W. Lowdell
Journal: Blood
Blood (2010) 116 (12): 2164–2172.
https://doi.org/10.1182/blood-2010-01-255166
Published: 2010
Journal Articles

Adoptive Transfer of CMV-Specific Donor T Cells Following Allogeneic Transplantation Leads to Rapid and Safe Systemic Reconstitution.

Karl S Peggs, MD, Kirsty Thomson, MD, Edward Samuel, BSc, MSc, Gemma Dyer, Julie Armoogum, Kwok Pang, BSc, MSc, Ronjon Chakraverty, MD, PhD, Stephen Mackinnon, MD, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2009) 114 (22): 44.
https://doi.org/10.1182/blood.V114.22.44.44
Published: 2009
Journal Articles

CMV-Reactive Gamma/Delta T Cells Expanded From CMV Seronegative Normal Healthy Individuals Lyse CMV-Infected Targets – Potential Adoptive Immunotherapy for Recipients of Stem Cell Transplants From CMV Seronegative Donors.

Andrea Knight, PhD, Stephen Mackinnon, MD, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2009) 114 (22): 2233.
https://doi.org/10.1182/blood.V114.22.2233.2233
Published: 2009
Journal Articles

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, Janet M. North, Elisabeth P. Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, R. Gitendra Wickremasinghe
Journal: Blood
Blood (2009) 114 (6): 1217–1225.
https://doi.org/10.1182/blood-2008-11-190587
Published: 2009
Includes: Supplemental data
Journal Articles

A Phase I/II Clinical Trial of Tumour-Activated Allogeneic Natural Killer Cells in AML

Panos Kottaridis, Janet North, Ismail Bakhsh, Edward Samuel, Stephen Mackinnon, Mark W Lowdell, PhD, FRCPath
Journal: Blood
Blood (2008) 112 (11): 2901.
https://doi.org/10.1182/blood.V112.11.2901.2901
Published: 2008
Journal Articles

Tumor-Activated Human NK Cells Specificall Ylyse Autologous and Allogeneic NK-Resistant Tumor Targets.

Mark W. Lowdell, PhD, Ismail Bakhsh, MSc, Janet North, MSc, Chloe Marden, PhD, Elena Addison, MSc, Stephen Mackinnon, MD
Journal: Blood
Blood (2006) 108 (11): 3707.
https://doi.org/10.1182/blood.V108.11.3707.3707
Published: 2006
Journal Articles

Direct Isolation of Donor-Derived Antigen - Specific T Cells and Their Adoptive Transfer for Treatment or Prophylaxis of CMV Infection Following Allogeneic Transplantation.

Kirsty Thomson, MD, Moran Julie, BSc, Kwok Pang, MSc, Ed Samuel, BSc, Michael Desborough, BSc, Mark W. Lowdell, PhD, Stephen Mackinnon, MD
Journal: Blood
Blood (2006) 108 (11): 589.
https://doi.org/10.1182/blood.V108.11.589.589
Published: 2006