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The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases
The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity
Issue Archive
October 8 2009
Table of Contents
INSIDE BLOOD
PERSPECTIVE
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases
Clinical Trials & Observations
Marc Michel,Valérie Chanet,Agnès Dechartres,Anne-Sophie Morin,Jean-Charles Piette,Lorenzo Cirasino,Giovanni Emilia,Francesco Zaja,Marco Ruggeri,Emmanuel Andrès,Philippe Bierling,Bertrand Godeau,Francesco Rodeghiero
GENE THERAPY
Efficient and stable transduction of resting B lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors
Cecilia Frecha,Caroline Costa,Camille Lévy,Didier Nègre,Stephen J. Russell,Andrea Maisner,Gilles Salles,Kah-Whye Peng,Francois-Loïc Cosset,Els Verhoeyen
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response
Gennadiy Zelinskyy,Kirsten K. Dietze,Yvonne P. Hüsecken,Simone Schimmer,Savita Nair,Tanja Werner,Kathrin Gibbert,Olivia Kershaw,Achim D. Gruber,Tim Sparwasser,Ulf Dittmer
Severe loss of invariant NKT cells exhibiting anti–HTLV-1 activity in patients with HTLV-1–associated disorders
Kazuko Azakami,Tomoo Sato,Natsumi Araya,Atae Utsunomiya,Ryuji Kubota,Kenshi Suzuki,Daisuke Hasegawa,Toshihiko Izumi,Hidetoshi Fujita,Satoko Aratani,Ryoji Fujii,Naoko Yagishita,Hajime Kamijuku,Takuro Kanekura,Ken-ichiro Seino,Kusuki Nishioka,Toshihiro Nakajima,Yoshihisa Yamano
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency
Aisha V. Sauer,Emanuela Mrak,Raisa Jofra Hernandez,Elena Zacchi,Francesco Cavani,Miriam Casiraghi,Eyal Grunebaum,Chaim M. Roifman,Maria C. Cervi,Alessandro Ambrosi,Filippo Carlucci,Maria Grazia Roncarolo,Anna Villa,Alessandro Rubinacci,Alessandro Aiuti
LYMPHOID NEOPLASIA
miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia
Christian Philipp Pallasch,Michaela Patz,Yoon Jung Park,Susanne Hagist,Daniela Eggle,Rainer Claus,Svenja Debey-Pascher,Alexandra Schulz,Lukas P. Frenzel,Julia Claasen,Nadine Kutsch,Günter Krause,Christine Mayr,Andreas Rosenwald,Christoph Plass,Joachim L. Schultze,Michael Hallek,Clemens-Martin Wendtner
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia
Yasuo Yamanaka,Hiroyuki Tagawa,Naoto Takahashi,Atsushi Watanabe,Yong-Mei Guo,Keiko Iwamoto,Junsuke Yamashita,Hirobumi Saitoh,Yoshihiro Kameoka,Norio Shimizu,Ryo Ichinohasama,Ken-ichi Sawada
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance
Simona Blotta,Pierfrancesco Tassone,Rao H. Prabhala,Piersandro Tagliaferri,David Cervi,Samir Amin,Jana Jakubikova,Yu-Tzu Tai,Klaus Podar,Constantine S. Mitsiades,Alessandro Zullo,Brunella Franco,Kenneth C. Anderson,Nikhil C. Munshi
MYELOID NEOPLASIA
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
Olivier Kosmider,Véronique Gelsi-Boyer,Meyling Cheok,Sophie Grabar,Véronique Della-Valle,Françoise Picard,Franck Viguié,Bruno Quesnel,Odile Beyne-Rauzy,Eric Solary,Norbert Vey,Mathilde Hunault-Berger,Pierre Fenaux,Véronique Mansat-De Mas,Eric Delabesse,Philippe Guardiola,Catherine Lacombe,William Vainchenker,Claude Preudhomme,François Dreyfus,Olivier A. Bernard,Daniel Birnbaum,Michaëla Fontenay,on behalf of the Groupe Francophone des Myélodysplasies
The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells
Vivian G. Oehler,Katherine A. Guthrie,Carrie L. Cummings,Kathleen Sabo,Brent L. Wood,Ted Gooley,Taimei Yang,Mirjam T. Epping,Yaping Shou,Era Pogosova-Agadjanyan,Paula Ladne,Derek L. Stirewalt,Janis L. Abkowitz,Jerald P. Radich
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity
Juan D. Matute,Andres A. Arias,Nicola A. M. Wright,Iwona Wrobel,Christopher C. M. Waterhouse,Xing Jun Li,Christophe C. Marchal,Natalie D. Stull,David B. Lewis,MacGregor Steele,James D. Kellner,Weiming Yu,Samy O. Meroueh,William M. Nauseef,Mary C. Dinauer
PLATELETS AND THROMBOPOIESIS
The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity
Brief Report
Jianmin Ding,Hirokazu Komatsu,Shinsuke Iida,Hiroki Yano,Shigeru Kusumoto,Atsushi Inagaki,Fumiko Mori,Masaki Ri,Asahi Ito,Atsushi Wakita,Takashi Ishida,Masakazu Nitta,Ryuzo Ueda
THROMBOSIS AND HEMOSTASIS
VASCULAR BIOLOGY
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Cover Image
Cover Image
![issue cover]()
Angiopoietin-1 stimulation of bovine aortic endothelial cells (BAEC) induces phosphorylation of endothelial nitric oxide synthase (eNOS) on Thr497, which inhibits NO release from endothelial cells, contributing to the inhibition of endothelial permeability by angiopoietin-1. The cover shows a confocal image of BAEC treated with angiopoietin-1 for 15 minutes and stained with anti\Nphospho-Thr497-eNOS (green) and anti-eNOS (red) antibodies. See the article by Oubaha and Gratton on page 3343.
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