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Issue Archive

Volume 114, Issue 11
September 10 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
TERTrific hormones promote hematopoiesis
Laura S. Haneline
View Articletitled, TERTrific hormones promote hematopoiesis
IMMUNOBIOLOGY
Tolerance: pregnancy matters
Franco Locatelli
View Articletitled, Tolerance: pregnancy matters
TRANSFUSION MEDICINE
RBC transfusion and BMT rejection
Allen R. Chen
View Articletitled, RBC transfusion and BMT rejection
TRANSPLANTATION
The osteoblastic niche following TBI
Susie Nilsson
View Articletitled, The osteoblastic niche following TBI

PERSPECTIVE

Do studies in humans better depict Th17 cells?
Francesco Annunziato,Sergio Romagnani
View Articletitled, Do studies in humans better depict Th17 cells?

CLINICAL TRIALS AND OBSERVATIONS

Minimal residual disease levels assessed by NPM1 mutation–specific RQ-PCR provide important prognostic information in AML
Clinical Trials & Observations
Susanne Schnittger,Wolfgang Kern,Claudia Tschulik,Tamara Weiss,Frank Dicker,Brunangelo Falini,Claudia Haferlach,Torsten Haferlach
View Articletitled, Minimal residual disease levels assessed by <em>NPM1</em> mutation–specific RQ-PCR provide important prognostic information in AML
Chronic myeloid leukemia (CML) with P190BCR-ABL: analysis of characteristics, outcomes, and prognostic significance
Brief Report
Dushyant Verma,Hagop M. Kantarjian,Dan Jones,Rajyalakshmi Luthra,Gautam Borthakur,Srdan Verstovsek,Mary Beth Rios,Jorge Cortes
View Articletitled, Chronic myeloid leukemia (CML) with P190<sup>BCR-ABL</sup>: analysis of characteristics, outcomes, and prognostic significance

HEMATOPOIESIS AND STEM CELLS

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
Rodrigo T. Calado,William T. Yewdell,Keisha L. Wilkerson,Joshua A. Regal,Sachiko Kajigaya,Constantine A. Stratakis,Neal S. Young
View Articletitled, Sex hormones, acting on the <em>TERT</em> gene, increase telomerase activity in human primary hematopoietic cells

IMMUNOBIOLOGY

Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognition
Michael Rist,Corey Smith,Melissa J. Bell,Scott R. Burrows,Rajiv Khanna
View Articletitled, Cross-recognition of HLA DR4 alloantigen by virus-specific CD8<sup>+</sup> T cells: a new paradigm for self-/nonself-recognition
The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function
John J. Lee,Ingrid Rauter,Lilit Garibyan,Esra Ozcan,Tatyana Sannikova,Stacey R. Dillon,Anthony C. Cruz,Richard M. Siegel,Richard Bram,Haifa Jabara,Raif S. Geha
View Articletitled, The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function
Supplemental data
Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members
Astrid G. S. van Halteren,Ewa Jankowska-Gan,Antoinette Joosten,Els Blokland,Jos Pool,Anneke Brand,William J. Burlingham,Els Goulmy
View Articletitled, Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members

LYMPHOID NEOPLASIA

Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival
Nathalie A. Johnson,Kerry J. Savage,Olga Ludkovski,Susana Ben-Neriah,Ryan Woods,Christian Steidl,Martin J. S. Dyer,Reiner Siebert,John Kuruvilla,Richard Klasa,Joseph M. Connors,Randy D. Gascoyne,Douglas E. Horsman
View Articletitled, Lymphomas with concurrent <em>BCL2</em> and <em>MYC</em> translocations: the critical factors associated with survival
Supplemental data
Mice deficient for CD137 ligand are predisposed to develop germinal center–derived B-cell lymphoma
Sabine Middendorp,Yanling Xiao,Ji-Ying Song,Victor Peperzak,Peter H. L. Krijger,Heinz Jacobs,Jannie Borst
View Articletitled, Mice deficient for CD137 ligand are predisposed to develop germinal center–derived B-cell lymphoma
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor–related protein 1 (LRP1) on megakaryocytes
Michele P. Lambert,Yuhuan Wang,Khalil H. Bdeir,Yvonne Nguyen,M. Anna Kowalska,Mortimer Poncz
View Articletitled, Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor–related protein 1 (LRP1) on megakaryocytes

RED CELLS, IRON, AND ERYTHROPOIESIS

Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming
Orapan Sripichai,Christine M. Kiefer,Natarajan V. Bhanu,Toshihiko Tanno,Seung-Jae Noh,Sung-Ho Goh,J. Eric Russell,Cheryl L. Rognerud,Ching-Nan Ou,Patricia A. Oneal,Emily R. Meier,Nicole M. Gantt,Colleen Byrnes,Y. Terry Lee,Ann Dean,Jeffery L. Miller
View Articletitled, Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming
Supplemental data

THROMBOSIS AND HEMOSTASIS

Generation and phenotypic analysis of protein S–deficient mice
François Saller,Anne C. Brisset,Svetlana N. Tchaikovski,Monica Azevedo,Roman Chrast,José A. Fernández,Marc Schapira,Tilman M. Hackeng,John H. Griffin,Anne Angelillo-Scherrer
View Articletitled, Generation and phenotypic analysis of protein S–deficient mice
Supplemental data

TRANSFUSION MEDICINE

Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model
Maxime Desmarets,Chantel M. Cadwell,Kenneth R. Peterson,Renee Neades,James C. Zimring
View Articletitled, Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model

TRANSPLANTATION

Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients
Katharina Pfistershammer,Anita Lawitschka,Christoph Klauser,Judith Leitner,Roman Weigl,Mirjam H. M. Heemskerk,Winfried F. Pickl,Otto Majdic,Georg A. Böhmig,Gottfried F. Fischer,Hildegard T. Greinix,Peter Steinberger
View Articletitled, Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients
Supplemental data
Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation
Massimo Dominici,Valeria Rasini,Rita Bussolari,Xiaohua Chen,Ted J. Hofmann,Carlotta Spano,Daniela Bernabei,Elena Veronesi,Filippo Bertoni,Paolo Paolucci,PierFranco Conte,Edwin M. Horwitz
View Articletitled, Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation
Supplemental data

VASCULAR BIOLOGY

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions
Eugenia Manevich-Mendelson,Sara W. Feigelson,Ronit Pasvolsky,Memet Aker,Valentin Grabovsky,Ziv Shulman,Sara Sebnem Kilic,Maria Alessandra Rosenthal-Allieri,Shifra Ben-Dor,Adi Mory,Alain Bernard,Markus Moser,Amos Etzioni,Ronen Alon
View Articletitled, Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions
Supplemental data

CORRESPONDENCE

Degree of immune suppression and risk of HIV-related Hodgkin lymphoma: time points matter
Riccardo Dolcetti,Paolo De Paoli,Diego Serraino
View Articletitled, Degree of immune suppression and risk of HIV-related Hodgkin lymphoma: time points matter
Response: Lymphocyte counts prior to Hodgkin lymphoma development
Gary Clifford,Silvia Franceschi,Martin Rickenbach
View Articletitled, Response: Lymphocyte counts prior to Hodgkin lymphoma development
A monoclonal gammopathy in search of clinical significance: 57 years later
Ronald S. Go,Leah M. Doyle
View Articletitled, A monoclonal gammopathy in search of clinical significance: 57 years later
Response: Multiple myeloma is universally preceded by a prolonged premalignant stage: novel clinical insights and future directions
Ola Landgren,Robert A. Kyle,Vincent Rajkumar
View Articletitled, Response: Multiple myeloma is universally preceded by a prolonged premalignant stage: novel clinical insights and future directions
Does HUMARA assay for assessment of clonal hematopoiesis have shortcomings?
Neeraj Agarwal,Roberto H. Nussenzveig,Sabina I. Swierczek,Charles J. Parker,Josef T. Prchal
View Articletitled, Does HUMARA assay for assessment of clonal hematopoiesis have shortcomings?
Response: To be skewed or not to be? This is no longer the question
Lambert Busque,Yves Paquette,Luigina Mollica,Denis-Claude Roy,Ross L. Levine,D. Gary Gilliland
View Articletitled, Response: To be skewed or not to be? This is no longer the question
Therapeutic use of tea derivatives: all that glitters is not gold
Cesare Mancuso,Eugenio Barone
View Articletitled, Therapeutic use of tea derivatives: all that glitters is not gold
Iron excess treatable by copper supplementation in acquired aceruloplasminemia: a new form of secondary human iron overload?
Dorothée Videt-Gibou,Serge Belliard,Edouard Bardou-Jacquet,Marie-Bérengère Troadec,Caroline Le Lan,Anne-Marie Jouanolle,Olivier Loréal,Joseph Rivalan,Pierre Brissot
View Articletitled, Iron excess treatable by copper supplementation in acquired aceruloplasminemia: a new form of secondary human iron overload?

ERRATUM

Ditadi et al. Human and murine amniotic fluid c-Kit+Lin− cells display hematopoietic activity. Blood. 2009;113(17):3953-3960.
View Articletitled, Ditadi et al. Human and murine amniotic fluid c-Kit<sup>+</sup>Lin<sup>−</sup> cells display hematopoietic activity. <em>Blood</em>. 2009;113(17):3953-3960.
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