Skip to Main Content

Advertisement intended for health care professionals

Umbrella Alt Text
Cart
header search
Search
Skip Nav Destination

Issue Archive

Volume 4, Issue 15
August 11 2020
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

Gene therapy for hemophilia: anticipating the unexpected
Clinical Trials & Observations
Glenn F. Pierce
View Articletitled, Gene therapy for hemophilia: anticipating the unexpected
Supplemental data

CLINICAL GUIDELINES

American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults
Mikkael A. Sekeres,Gordon Guyatt,Gregory Abel,Shabbir Alibhai,Jessica K. Altman,Rena Buckstein,Hannah Choe,Pinkal Desai,Harry Erba,Christopher S. Hourigan,Thomas W. LeBlanc,Mark Litzow,Janet MacEachern,Laura C. Michaelis,Sudipto Mukherjee,Kristen O’Dwyer,Ashley Rosko,Richard Stone,Arnav Agarwal,L. E. Colunga-Lozano,Yaping Chang,QiuKui Hao,Romina Brignardello-Petersen
View Articletitled, American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults
Supplemental data

DRUG ADVANCES

The development of ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease
Clinical Trials & Observations
Robert Zeiser,Gérard Socié
View Articletitled, The development of ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease

REVIEW ARTICLE

Cell interactions in the bone marrow microenvironment affecting myeloid malignancies
Konstantinos D. Kokkaliaris,David T. Scadden
View Articletitled, Cell interactions in the bone marrow microenvironment affecting myeloid malignancies

CLINICAL TRIALS AND OBSERVATIONS

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities
Clinical Trials & Observations
Nadine Abdallah,Patricia Greipp,Prashant Kapoor,Morie A. Gertz,Angela Dispenzieri,Linda B. Baughn,Martha Q. Lacy,Suzanne R. Hayman,Francis K. Buadi,David Dingli,Ronald S. Go,Yi L. Hwa,Amie Fonder,Miriam Hobbs,Yi Lin,Nelson Leung,Taxiarchis Kourelis,Rahma Warsame,Mustaqeem Siddiqui,John Lust,Robert A. Kyle,Leif Bergsagel,Rhett Ketterling,S. Vincent Rajkumar,Shaji K. Kumar
View Articletitled, Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities
Supplemental data
High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers
Clinical Trials & Observations
Hélène Guermouche,Noémie Ravalet,Nathalie Gallay,Caroline Deswarte,Amelie Foucault,Jenny Beaud,Emmanuelle Rault,Emeline Saindoy,Sébastien Lachot,Jean-Alain Martignoles,Valérie Gissot,Ludovic Suner,Emmanuel Gyan,François Delhommeau,Olivier Herault,Pierre Hirsch
View Articletitled, High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers
Supplemental data
Eculizumab impairs Neisseria meningitidis serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients
Clinical Trials & Observations
Jeroen D. Langereis,Bryan van den Broek,Sjoerd Franssen,Irma Joosten,Nicole M. A. Blijlevens,Marien I. de Jonge,Saskia Langemeijer
View Articletitled, Eculizumab impairs <em>Neisseria meningitidis</em> serogroup B killing in whole blood despite 4CMenB vaccination of PNH patients
Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial
Clinical Trials & Observations
Andrés J. M. Ferreri,Teresa Calimeri,Maurilio Ponzoni,Flavio Curnis,Gian Marco Conte,Eloise Scarano,Eltjona Rrapaj,Daniela De Lorenzo,Dario Cattaneo,Federico Fallanca,Alessandro Nonis,Marco Foppoli,Paolo Lopedote,Giovanni Citterio,Letterio S. Politi,Marianna Sassone,Piera Angelillo,Elena Guggiari,Sara Steffanoni,Vittoria Tarantino,Fabio Ciceri,Claudio Bordignon,Nicoletta Anzalone,Angelo Corti
View Articletitled, Improving the antitumor activity of R-CHOP with NGR-hTNF in primary CNS lymphoma: final results of a phase 2 trial
Supplemental data
Prospective phase 2 trial of ixazomib after nonmyeloablative haploidentical peripheral blood stem cell transplant
Clinical Trials & Observations
Scott R. Solomon,Melhem Solh,Xu Zhang,Stacey Brown,Katelin C. Jackson,H. Kent Holland,Lawrence E. Morris,Asad Bashey
View Articletitled, Prospective phase 2 trial of ixazomib after nonmyeloablative haploidentical peripheral blood stem cell transplant
Supplemental data
Prospective long-term follow-up after first-line subcutaneous cladribine in hairy cell leukemia: a SAKK trial
Clinical Trials & Observations
Rudolf Benz,Kornelius Arn,Martin Andres,Thomas Pabst,Michael Baumann,Urban Novak,Felicitas Hitz,Urs Hess,Reinhard Zenhaeusern,Yves Chalandon,Ulrich Mey,Sabine Blum,Daniel Rauch,Alix O'Meara Stern,Nathan Cantoni,Mario Bargetzi,Elena Bianchi-Papina,Davide Rossi,Jakob Passweg,Andreas Lohri,Simona Berardi,Qiyu Li,Anita Feller,Georg Stussi
View Articletitled, Prospective long-term follow-up after first-line subcutaneous cladribine in hairy cell leukemia: a SAKK trial
Supplemental data
Molecular profiling and risk classification of patients with myeloproliferative neoplasms and splanchnic vein thromboses
Clinical Trials & Observations
Pierre-Edouard Debureaux,Bruno Cassinat,Juliette Soret-Dulphy,Barbara Mora,Emmanuelle Verger,Nabih Maslah,Aurelie Plessier,Pierre-Emmanuel Rautou,Isabelle Ollivier-Hourman,Victor De Ledinghen,Odile Goria,Christophe Bureau,Claudia Siracusa,Dominique Valla,Stephane Giraudier,Francesco Passamonti,Jean-Jacques Kiladjian
View Articletitled, Molecular profiling and risk classification of patients with myeloproliferative neoplasms and splanchnic vein thromboses
Supplemental data
Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study
Clinical Trials & Observations
Elisabet Bergsten,AnnaCarin Horne,Ida Hed Myrberg,Maurizio Aricó,Itziar Astigarraga,Eiichi Ishii,Gritta Janka,Stephan Ladisch,Kai Lehmberg,Kenneth L. McClain,Milen Minkov,Vasanta Nanduri,Diego A. Rosso,Elena Sieni,Jacek Winiarski,Jan-Inge Henter
View Articletitled, Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study
Supplemental data
Physical activity in children at risk of postthrombotic sequelae: a pilot randomized controlled trial
Clinical Trials & Observations
Rida Hasan,Maria Hanna,Song Zhang,Kendra Malone,Elizabeth Tong,Niavana Salas,Ravi Sarode,Janna Journeycake,Ayesha Zia
View Articletitled, Physical activity in children at risk of postthrombotic sequelae: a pilot randomized controlled trial
Supplemental data

HEALTH SERVICES AND OUTCOMES

End-of-life care quality outcomes among Medicare beneficiaries with hematologic malignancies
Clinical Trials & Observations
Pamela C. Egan,Thomas W. LeBlanc,Adam J. Olszewski
View Articletitled, End-of-life care quality outcomes among Medicare beneficiaries with hematologic malignancies
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Immunomodulatory drugs suppress Th1-inducing ability of dendritic cells but enhance Th2-mediated allergic responses
Vien Phan,Tomoki Ito,Muneo Inaba,Yoshiko Azuma,Kayoko Kibata,Noriko Inagaki-Katashiba,Akihiro Tanaka,Atsushi Satake,Shosaku Nomura
View Articletitled, Immunomodulatory drugs suppress Th1-inducing ability of dendritic cells but enhance Th2-mediated allergic responses
Supplemental data
Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood
Xiaoming Zhan,Xue Zhong,Jin Huk Choi,Lijing Su,Jianhui Wang,Evan Nair-Gill,Priscilla Anderton,Xiaohong Li,Miao Tang,Jamie Russell,Sara Ludwig,Thomas Gallagher,Bruce Beutler
View Articletitled, Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood
Supplemental data
Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies
Clinical Trials & Observations
Tania Jain,Andrea Knezevic,Martina Pennisi,Yunxin Chen,Josel D. Ruiz,Terence J. Purdon,Sean M. Devlin,Melody Smith,Gunjan L. Shah,Elizabeth Halton,Claudia Diamonte,Michael Scordo,Craig S. Sauter,Elena Mead,Bianca D. Santomasso,M. Lia Palomba,Connie W. Batlevi,Molly A. Maloy,Sergio Giralt,Eric Smith,Renier Brentjens,Jae H. Park,Miguel-Angel Perales,Sham Mailankody
View Articletitled, Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies
Supplemental data

LYMPHOID NEOPLASIA

Bendamustine and rituximab as induction therapy in both transplant-eligible and -ineligible patients with mantle cell lymphoma
Clinical Trials & Observations
Diego Villa,Laurie H. Sehn,Kerry J. Savage,Cynthia L. Toze,Kevin Song,Wendie D. den Brok,Ciara L. Freeman,David W. Scott,Alina S. Gerrie
View Articletitled, Bendamustine and rituximab as induction therapy in both transplant-eligible and -ineligible patients with mantle cell lymphoma
Supplemental data
Timing of high-dose methotrexate CNS prophylaxis in DLBCL: an analysis of toxicity and impact on R-CHOP delivery
Clinical Trials & Observations
Matthew R. Wilson,Toby A. Eyre,Nicolas Martinez-Calle,Matthew Ahearne,Katrina E. Parsons,Gavin Preston,Jahanzaib Khwaja,Jeremy Schofield,Johnathon Elliot,Almurtadha Mula Kh,Nimish Shah,Cheuk-Kie Cheung,Matthew A. Timmins,Thomas Creasey,Kim Linton,Jeffery Smith,Christopher P. Fox,Fiona Miall,Kate Cwynarski,Pamela McKay
View Articletitled, Timing of high-dose methotrexate CNS prophylaxis in DLBCL: an analysis of toxicity and impact on R-CHOP delivery
Supplemental data
In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure
Clinical Trials & Observations
Mathieu Simonin,Anne Auperin,Yves Bertrand,Nathalie Aladjidi,André Baruchel,Audrey Contet,Carole Coze,Virginie Gandemer,Stephanie Haouy,Thierry Leblanc,Guy Leverger,Jean Michon,Catherine Patte,Veronique Minard-Colin
View Articletitled, In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure
Molecular background delineates outcome of double protein expressor diffuse large B-cell lymphoma
Clinical Trials & Observations
Leo Meriranta,Annika Pasanen,Amjad Alkodsi,Jari Haukka,Marja-Liisa Karjalainen-Lindsberg,Sirpa Leppä
View Articletitled, Molecular background delineates outcome of double protein expressor diffuse large B-cell lymphoma
Supplemental data

MYELOID NEOPLASIA

Exploitable metabolic dependencies in MLL-ENL–induced leukemia
Maria-Paz Garcia-Cuellar,Jennifer Lawlor,Martin Böttcher,Dimitrios Mougiakakos,Markus Metzler,Robert K. Slany
View Articletitled, Exploitable metabolic dependencies in MLL-ENL–induced leukemia
Supplemental data
RAS/CBL mutations predict resistance to JAK inhibitors in myelofibrosis and are associated with poor prognostic features
Clinical Trials & Observations
Giacomo Coltro,Giada Rotunno,Lara Mannelli,Carmela Mannarelli,Sara Fiaccabrino,Simone Romagnoli,Niccolò Bartalucci,Enrica Ravenda,Eleonora Gelli,Emanuela Sant’Antonio,Mrinal M. Patnaik,Ayalew Tefferi,Alessandro M. Vannucchi,Paola Guglielmelli
View Articletitled, <em>RAS</em>/<em>CBL</em> mutations predict resistance to JAK inhibitors in myelofibrosis and are associated with poor prognostic features
Supplemental data
Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age–specific mouse model
Nitza Vara,Yuqing Liu,Yan Yan,Shelly Y. Lensing,Natalia Colorado,Delli Robinson,Jingliao Zhang,Xin Zhang,Erich A. Peterson,Nicholas J. Baltz,Daohong Zhou,Alice Bertaina,Donald J. Johann, Jr,Peter D. Emanuel,Y. Lucy Liu
View Articletitled, Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age–specific mouse model
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength
Sumith R. Panicker,Tadayuki Yago,Bojing Shao,Rodger P. McEver
View Articletitled, Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Iron deficiency following bariatric surgery: a retrospective cohort study
Clinical Trials & Observations
Zachary Gowanlock,Anastasiya Lezhanska,Maeve Conroy,Mark Crowther,Maria Tiboni,Lawrence Mbuagbaw,Deborah M. Siegal
View Articletitled, Iron deficiency following bariatric surgery: a retrospective cohort study
Supplemental data
Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease
Erdem Kucukal,Yuncheng Man,Erina Quinn,Neil Tewari,Ran An,Anton Ilich,Nigel S. Key,Jane A. Little,Umut A. Gurkan
View Articletitled, Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

Predictors of preprocedural direct oral anticoagulant levels in patients having an elective surgery or procedure
Clinical Trials & Observations
Joseph R. Shaw,Na Li,Thomas Vanassche,Michiel Coppens,Alex C. Spyropoulos,Summer Syed,Mansoor Radwi,Joanne Duncan,Sam Schulman,James D. Douketis
View Articletitled, Predictors of preprocedural direct oral anticoagulant levels in patients having an elective surgery or procedure
Supplemental data
Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay
Wenwen Gao,Yaqi Xu,Hongli Liu,Meng Gao,Qing Cao,Yiyi Wang,Longteng Cui,Rong Huang,Yan Shen,Sanqiang Li,Haiping Yang,Yixiang Chen,Chaokun Li,Haichuan Yu,Weikai Li,Guomin Shen
View Articletitled, Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay
Supplemental data
An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms
Annette von Drygalski,Vikas Bhat,Andrew J. Gale,Patricia M. Averell,Thomas J. Cramer,Darlene J. Elias,John H. Griffin,Laurent O. Mosnier
View Articletitled, An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms
Supplemental data

TRANSFUSION MEDICINE

Development and validation of a universal blood donor genotyping platform: a multinational prospective study
Nicholas S. Gleadall,on behalf of the Blood Transfusion Genomics Consortium,Barbera Veldhuisen,on behalf of the Blood Transfusion Genomics Consortium,Jeremy Gollub,on behalf of the Blood Transfusion Genomics Consortium,Adam S. Butterworth,on behalf of the Blood Transfusion Genomics Consortium,John Ord,on behalf of the Blood Transfusion Genomics Consortium,Christopher J. Penkett,on behalf of the Blood Transfusion Genomics Consortium,Tiffany C. Timmer,on behalf of the Blood Transfusion Genomics Consortium,Carolin M. Sauer,on behalf of the Blood Transfusion Genomics Consortium,Nieke van der Bolt,on behalf of the Blood Transfusion Genomics Consortium,Colin Brown,on behalf of the Blood Transfusion Genomics Consortium,Kim Brugger,on behalf of the Blood Transfusion Genomics Consortium,Alexander T. Dilthey,on behalf of the Blood Transfusion Genomics Consortium,Daniel Duarte,on behalf of the Blood Transfusion Genomics Consortium,Shane Grimsley,on behalf of the Blood Transfusion Genomics Consortium,Katja van den Hurk,on behalf of the Blood Transfusion Genomics Consortium,John M. Jongerius,on behalf of the Blood Transfusion Genomics Consortium,Jessie Luken,on behalf of the Blood Transfusion Genomics Consortium,Karyn Megy,on behalf of the Blood Transfusion Genomics Consortium,Gail Miflin,on behalf of the Blood Transfusion Genomics Consortium,Christopher S. Nelson,on behalf of the Blood Transfusion Genomics Consortium,Femmeke J. Prinsze,on behalf of the Blood Transfusion Genomics Consortium,Jennifer Sambrook,on behalf of the Blood Transfusion Genomics Consortium,Ilenia Simeoni,on behalf of the Blood Transfusion Genomics Consortium,Michael Sweeting,on behalf of the Blood Transfusion Genomics Consortium,Nicole Thornton,on behalf of the Blood Transfusion Genomics Consortium,Sara Trompeter,on behalf of the Blood Transfusion Genomics Consortium,Salih Tuna,on behalf of the Blood Transfusion Genomics Consortium,Ram Varma,on behalf of the Blood Transfusion Genomics Consortium,Matthew R. Walker,on behalf of the Blood Transfusion Genomics Consortium,NIHR BioResource,John Danesh,on behalf of the Blood Transfusion Genomics Consortium,David J. Roberts,on behalf of the Blood Transfusion Genomics Consortium,Willem H. Ouwehand,on behalf of the Blood Transfusion Genomics Consortium,Kathleen E. Stirrups,on behalf of the Blood Transfusion Genomics Consortium,Augusto Rendon,on behalf of the Blood Transfusion Genomics Consortium,Connie M. Westhoff,on behalf of the Blood Transfusion Genomics Consortium,Emanuele Di Angelantonio,on behalf of the Blood Transfusion Genomics Consortium,C. Ellen van der Schoot,on behalf of the Blood Transfusion Genomics Consortium,William J. Astle,on behalf of the Blood Transfusion Genomics Consortium,Nicholas A. Watkins,on behalf of the Blood Transfusion Genomics Consortium,William J. Lane,on behalf of the Blood Transfusion Genomics Consortium
View Articletitled, Development and validation of a universal blood donor genotyping platform: a multinational prospective study
Supplemental data

TRANSPLANTATION

Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantation
Clinical Trials & Observations
Jun Zou,Stefan O. Ciurea,Piyanuch Kongtim,Min Yi,Yudith Carmazzi,Gabriela Rondon,Samer Srour,David Partlow,Richard E. Champlin,Kai Cao
View Articletitled, Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantation
Supplemental data

ERRATA

Bosticardo M, Pala F, Calzoni E, et al. Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. Blood Adv. 2020;4(12):2611-2616.
View Articletitled, Bosticardo M, Pala F, Calzoni E, et al. Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. <em>Blood Adv.</em> 2020;4(12):2611-2616.
Vander Lugt MT, Chen X, Escolar ML, et al. Reduced-intensity single-unit unrelated cord blood transplant with optional immune boost for nonmalignant disorders. Blood Adv. 2020;4(13):3041-3052.
View Articletitled, Vander Lugt MT, Chen X, Escolar ML, et al. Reduced-intensity single-unit unrelated cord blood transplant with optional immune boost for nonmalignant disorders. <em>Blood Adv</em>. 2020;4(13):3041-3052.
Nakajima R, Moskowitz AJ, Michaud L, et al. Baseline FDG-PET/CT detects bone marrow involvement in follicular lymphoma and provides relevant prognostic information. Blood Adv. 2020;4(8):1812-1823.
View Articletitled, Nakajima R, Moskowitz AJ, Michaud L, et al. Baseline FDG-PET/CT detects bone marrow involvement in follicular lymphoma and provides relevant prognostic information. <em>Blood Adv.</em> 2020;4(8):1812-1823.
Von Drygalski A, Giermasz A, Castaman G, et al. Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B. Blood Adv. 2019;3(21):3241-3247.
View Articletitled, Von Drygalski A, Giermasz A, Castaman G, et al. Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B. <em>Blood Adv.</em> 2019;3(21):3241-3247.
Silasi R, Keshari RS, Lupu C, et al. Inhibition of contact-mediated activation of factor XI protects baboons against S aureus–induced organ damage and death. Blood Adv. 2019;3(4):658-669.
View Articletitled, Silasi R, Keshari RS, Lupu C, et al. Inhibition of contact-mediated activation of factor XI protects baboons against <em>S aureus</em>–induced organ damage and death. <em>Blood Adv.</em> 2019;3(4):658-669.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Three-dimensional immunofluorescence imaging of different bone marrow vessels in a leukemic Kmt2atm2(MLLT3)Thr/KsyJ knockin mouse genetically engineered to express the MLL-AF9 fusion protein mimicking the t(9;11)(p22;q23) translocation found in patients with acute myeloid leukemia. Bone marrow sections were stained with anti-Sca1, anti-CD105, and antilaminin antibodies using a 20× objective magnification. Source: Konstantinos D. Kokkaliaris, Ninib Baryawno, and David T. Scadden. See the article by Kokkaliaris and Scadden.

  • PDF Icon PDF LinkFront Matter
  • PDF Icon PDF LinkEditorial Board
All Issues

Advertisement intended for health care professionals

IDCH: is it now determined?
PETAL: a global view on R/R T-/NK-lymphoma treatment reality
A telemedicine triage model for infusion center–based management of adult sickle cell pain episodes
Loss of protein C vs protein S results in discrepant thrombotic phenotypes
Evolving racial/ethnic disparities in AML survival in the novel therapy era

Advertisement intended for health care professionals

Advertisement intended for health care professionals

  • American Society of Hematology
  • 2021 L Street NW, Suite 900
  • Washington, DC 20036
  • TEL +1 202-776-0544
  • FAX +1 202-776-0545

ASH Publications

American Society of Hematology

Copyright 2024 by American Society of Hematology
 
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Advertisement intended for health care professionals