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Willem H. Ouwehand
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Journal Articles

The common, VTE-protective, G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding

Matthew Christopher Sims, Magdalena Gierula, Jonathan C. Stephens, Alex Tokolyi, Luca Stefanucci, Elodie Persyn, Luanluan Sun, Janine H Collins, Emma Davenport, Emanuele Di Angelantonio, Kate Downes, Michael Inouye, Dirk S Paul, William Thomas, Alexander Tolios, NIHR BioResource, Willem H Ouwehand, Nicholas S Gleadall, James T.B. Crawley, Adam S Butterworth, Mattia Frontini, Josefin Ahnstrom
Journal: Blood Advances
Blood Adv bloodadvances.2024014020.
https://doi.org/10.1182/bloodadvances.2024014020
Published: 2024
Includes: Supplemental data
Journal Articles

G protein–coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1

Kate Downes, Xuefei Zhao, Nicholas S. Gleadall, Harriet McKinney, Carly Kempster, Joana Batista, Patrick L. Thomas, Matthew Cooper, James V. Michael, Roman Kreuzhuber, Katherine Wedderburn, Kathryn Waller, Bianca Varney, Hippolyte Verdier, Neline Kriek, Sofie E. Ashford, Kathleen E. Stirrups, Joanne L. Dunster, Steven E. McKenzie, Willem H. Ouwehand, Jonathan M. Gibbins, Jing Yang, William J. Astle, Peisong Ma
Journal: Blood Advances
Blood Adv (2022) 6 (7): 2319–2330.
https://doi.org/10.1182/bloodadvances.2021005453
Published: 2022
Includes: Supplemental data
Journal Articles

Neutrophil specific granule and NETosis defects in gray platelet syndrome

Cathelijn E. M. Aarts, Kate Downes, Arie J. Hoogendijk, Evelien G. G. Sprenkeler, Roel P. Gazendam, Rémi Favier, Marie Favier, Anton T. J. Tool, John L. van Hamme, Myrto A. Kostadima, Kate Waller, Barbara Zieger, Maaike G. J. M. van Bergen, Saskia M. C. Langemeijer, Bert A. van der Reijden, Hans Janssen, Timo K. van den Berg, Robin van Bruggen, Alexander B. Meijer, Willem H. Ouwehand, Taco W. Kuijpers
Journal: Blood Advances
Blood Adv (2021) 5 (2): 549–564.
https://doi.org/10.1182/bloodadvances.2020002442
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Elevated levels of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency

Clinical Trials & Observations
Dino Mehic, Alexander Tolios, Stefanie Hofer, Cihan Ay, Helmuth Haslacher, Judit Rejtö, Willem H. Ouwehand, Kate Downes, Matthias Haimel, Ingrid Pabinger, Johanna Gebhart
Journal: Blood Advances
Blood Adv (2021) 5 (2): 391–398.
https://doi.org/10.1182/bloodadvances.2020003464
Published: 2021
Includes: Supplemental data
Journal Articles

Development and validation of a universal blood donor genotyping platform: a multinational prospective study

Nicholas S. Gleadall, Barbera Veldhuisen, Jeremy Gollub, Adam S. Butterworth, John Ord, Christopher J. Penkett, Tiffany C. Timmer, Carolin M. Sauer, Nieke van der Bolt, Colin Brown, Kim Brugger, Alexander T. Dilthey, Daniel Duarte, Shane Grimsley, Katja van den Hurk, John M. Jongerius, Jessie Luken, Karyn Megy, Gail Miflin, Christopher S. Nelson, Femmeke J. Prinsze, Jennifer Sambrook, Ilenia Simeoni, Michael Sweeting, Nicole Thornton, Sara Trompeter, Salih Tuna, Ram Varma, Matthew R. Walker, NIHR BioResource, John Danesh, David J. Roberts, Willem H. Ouwehand, Kathleen E. Stirrups, Augusto Rendon, Connie M. Westhoff, Emanuele Di Angelantonio, C. Ellen van der Schoot, William J. Astle, Nicholas A. Watkins, William J. Lane
Journal: Blood Advances
Blood Adv (2020) 4 (15): 3495–3506.
https://doi.org/10.1182/bloodadvances.2020001894
Published: 2020
Includes: Supplemental data
Journal Articles

Phenotype description and response to thrombopoietin receptor agonist in DIAPH1 -related disorder

Clinical Trials & Observations
Sarah K. Westbury, Kate Downes, Claire Burney, Maria L. Lozano, Samya G. Obaji, Cheng Hock Toh, Teresa Sevivas, Neil V. Morgan, Wendy N. Erber, Carly Kempster, Samantha F. Moore, Chantal Thys, Sofia Papadia, Willem H. Ouwehand, NIHR BioResource–Rare Diseases, Michael A. Laffan, Keith Gomez, Kathleen Freson, Jose Rivera, Andrew D. Mumford
Journal: Blood Advances
Blood Adv (2018) 2 (18): 2341–2346.
https://doi.org/10.1182/bloodadvances.2018020370
Published: 2018
Includes: Supplemental data