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Issue Archive

Volume 4, Issue 12
June 23 2020
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

COVID-19 coagulopathy vs disseminated intravascular coagulation
Marcel Levi
View Articletitled, COVID-19 coagulopathy vs disseminated intravascular coagulation
Supplemental data

CLINICAL GUIDELINES

American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain
Amanda M. Brandow,C. Patrick Carroll,Susan Creary,Ronisha Edwards-Elliott,Jeffrey Glassberg,Robert W. Hurley,Abdullah Kutlar,Mohamed Seisa,Jennifer Stinson,John J. Strouse,Fouza Yusuf,William Zempsky,Eddy Lang
View Articletitled, American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain
Supplemental data

STIMULUS REPORTS

Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency
Panojot Bifsha,Jennifer W. Leiding,Sung-Yun Pai,Aurelien B. L. Colamartino,Nicholas Hartog,Joseph A. Church,Benjamin R. Oshrine,Jennifer M. Puck,M. Louise Markert,Elie Haddad
View Articletitled, Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency
Supplemental data
Vancomycin use and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Shijia Zhang,Ryan Shanley,Daniel J. Weisdorf,Armin Rashidi
View Articletitled, Vancomycin use and cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation
Supplemental data

REVIEW ARTICLE

Hurdles in treating Hurler disease: potential routes to achieve a “real” cure
Brigitte T. A. van den Broek,Jaap van Doorn,Charlotte V. Hegeman,Stefan Nierkens,Caroline A. Lindemans,Nanda Verhoeven-Duif,Jaap Jan Boelens,Peter M. van Hasselt
View Articletitled, Hurdles in treating Hurler disease: potential routes to achieve a “real” cure

SYSTEMATIC REVIEWS

First-line imatinib vs second- and third-generation TKIs for chronic-phase CML: a systematic review and meta-analysis
Clinical Trials & Observations
Claudia Vener,Rita Banzi,Federico Ambrogi,Annalisa Ferrero,Giuseppe Saglio,Gabriella Pravettoni,Milena Sant
View Articletitled, First-line imatinib vs second- and third-generation TKIs for chronic-phase CML: a systematic review and meta-analysis
Supplemental data
Systematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis
Payal Patel,Parth Patel,Meha Bhatt,Cody Braun,Housne Begum,Robby Nieuwlaat,Rasha Khatib,Carolina C. Martins,Yuan Zhang,Itziar Etxeandia-Ikobaltzeta,Jamie Varghese,Hani Alturkmani,Waled Bahaj,Mariam Baig,Rohan Kehar,Ahmad Mustafa,Rakesh Ponnapureddy,Anchal Sethi,Merrill Thomas,David Wooldridge,Wendy Lim,Shannon M. Bates,Eddy Lang,Grégoire Le Gal,Marc Righini,Wojtek Wiercioch,Holger J. Schünemann,Reem A. Mustafa
View Articletitled, Systematic review and meta-analysis of outcomes in patients with suspected deep vein thrombosis
Supplemental data
Pharmacologic thromboprophylaxis in adult patients undergoing neurosurgical interventions for preventing venous thromboembolism
Juan José Yepes-Nuñez,Anita Rajasekhar,Maryam Rahman,Philipp Dahm,David R. Anderson,Luis Enrique Colunga-Lozano,Stephanie Ross,Meha Bhatt,Kelly Estrada Orozco,Federico Popoff,Matthew Ventresca,Angela M. Barbara,Sara Balduzzi,Housne Begum,Arnav Agarwal,Wojtek Wiercioch,Robby Nieuwlaat,Gian Paolo Morgano,Holger J. Schünemann
View Articletitled, Pharmacologic thromboprophylaxis in adult patients undergoing neurosurgical interventions for preventing venous thromboembolism
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

KEYNOTE-013 4-year follow-up of pembrolizumab in classical Hodgkin lymphoma after brentuximab vedotin failure
Clinical Trials & Observations
Philippe Armand,John Kuruvilla,Jean-Marie Michot,Vincent Ribrag,Pier Luigi Zinzani,Ying Zhu,Patricia Marinello,Akash Nahar,Craig H. Moskowitz
View Articletitled, KEYNOTE-013 4-year follow-up of pembrolizumab in classical Hodgkin lymphoma after brentuximab vedotin failure
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia
Marita Bosticardo,Francesca Pala,Enrica Calzoni,Ottavia M. Delmonte,Kerry Dobbs,Cameron L. Gardner,Nicolo’ Sacchetti,Tomoki Kawai,Elizabeth K. Garabedian,Debbie Draper,Jenna R. E. Bergerson,Suk See DeRavin,Alexandra F. Freeman,Tayfun Güngör,Nicholas Hartog,Steven M. Holland,Donald B. Kohn,Harry L. Malech,Mary Louise Markert,Katja G. Weinacht,Anna Villa,Christopher S. Seet,Amelie Montel-Hagen,Gay M. Crooks,Luigi D. Notarangelo
View Articletitled, Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia
Supplemental data
Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency
Zhijie Wu,Shouguo Gao,Carrie Diamond,Sachiko Kajigaya,Jinguo Chen,Rongye Shi,Cindy Palmer,Amy P. Hsu,Katherine R. Calvo,Dennis D. Hickstein,Steven M. Holland,Neal S. Young
View Articletitled, Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency
Supplemental data
Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita
Siddharth Shukla,Ho-Chang Jeong,Christopher M. Sturgeon,Roy Parker,Luis Francisco Zirnberger Batista
View Articletitled, Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Frequency and spectrum of disease-causing variants in 1892 patients with suspected genetic HLH disorders
Clinical Trials & Observations
Vanessa Gadoury-Levesque,Lei Dong,Rui Su,Jianjun Chen,Kejian Zhang,Kimberly A. Risma,Rebecca A. Marsh,Miao Sun
View Articletitled, Frequency and spectrum of disease-causing variants in 1892 patients with suspected genetic HLH disorders
Supplemental data
CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages
Ole Audun W. Haabeth,Kjartan Hennig,Marte Fauskanger,Geir Åge Løset,Bjarne Bogen,Anders Tveita
View Articletitled, CD4<sup>+</sup> T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages
Supplemental data

LYMPHOID NEOPLASIA

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL
Donia M. Moujalled,Diane T. Hanna,Soroor Hediyeh-zadeh,Giovanna Pomilio,Lauren Brown,Veronique Litalien,Ray Bartolo,Shaun Fleming,Maïa Chanrion,Sébastien Banquet,Ana-Leticia Maragno,Laurence Kraus-Berthier,Marie Schoumacher,Charles G. Mullighan,Angela Georgiou,Christine A. White,Guillaume Lessene,David C. S. Huang,Andrew W. Roberts,Olivier Geneste,Lorna Rasmussen,Melissa J. Davis,Paul G. Ekert,Andrew Wei,Ashley P. Ng,Seong L. Khaw
View Articletitled, Cotargeting BCL-2 and MCL-1 in high-risk B-ALL
Supplemental data
Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance
Alyssa I. Clay-Gilmour,Michelle A. T. Hildebrandt,Elizabeth E. Brown,Jonathan N. Hofmann,John J. Spinelli,Graham G. Giles,Wendy Cozen,Parveen Bhatti,Xifeng Wu,Rosalie G. Waller,Alem A. Belachew,Dennis P. Robinson,Aaron D. Norman,Jason P. Sinnwell,Sonja I. Berndt,S. Vincent Rajkumar,Shaji K. Kumar,Stephen J. Chanock,Mitchell J. Machiela,Roger L. Milne,Susan L. Slager,Nicola J. Camp,Elad Ziv,Celine M. Vachon
View Articletitled, Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance
Supplemental data
TLR-mediated activation of Waldenström macroglobulinemia B cells reveals an uncoupling from plasma cell differentiation
Jennifer Shrimpton,Matthew A. Care,Jonathan Carmichael,Kieran Walker,Paul Evans,Charlotte Evans,Ruth de Tute,Roger Owen,Reuben M. Tooze,Gina M. Doody
View Articletitled, TLR-mediated activation of Waldenström macroglobulinemia B cells reveals an uncoupling from plasma cell differentiation
Supplemental data

MYELOID NEOPLASIA

Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden
Clinical Trials & Observations
Theodoros Karantanos,Shruti Chaturvedi,Evan M. Braunstein,Jerry Spivak,Linda Resar,Styliani Karanika,Donna M. Williams,Ophelia Rogers,Christopher D. Gocke,Alison R. Moliterno
View Articletitled, Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden
Supplemental data
Ex vivo drug screening defines novel drug sensitivity patterns for informing personalized therapy in myeloid neoplasms
Clinical Trials & Observations
Michael A. Spinner,Alexey Aleshin,Marianne T. Santaguida,Steven A. Schaffert,James L. Zehnder,A. Scott Patterson,Christos Gekas,Diane Heiser,Peter L. Greenberg
View Articletitled, Ex vivo drug screening defines novel drug sensitivity patterns for informing personalized therapy in myeloid neoplasms
Supplemental data

PLATELETS AND THROMBOPOIESIS

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients
Paul Vulliamy,Samantha J. Montague,Scarlett Gillespie,Melissa V. Chan,Lucy A. Coupland,Robert K. Andrews,Timothy D. Warner,Elizabeth E. Gardiner,Karim Brohi,Paul C. Armstrong
View Articletitled, Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice
Giada Ingoglia,Ayla Yalamanoglu,Marc Pfefferlé,Irina L. Dubach,Christian A. Schaer,Kristyna Valkova,Kerstin Hansen,Nadja Schulthess,Rok Humar,Dominik J. Schaer,Florence Vallelian
View Articletitled, Line-selective macrophage activation with an anti-CD40 antibody drives a hemophagocytic syndrome in mice
Supplemental data

THROMBOSIS AND HEMOSTASIS

Risk models for VTE and bleeding in medical inpatients: systematic identification and expert assessment
Andrea J. Darzi,Samer G. Karam,Frederick A. Spencer,Alex C. Spyropoulos,Lawrence Mbuagbaw,Scott C. Woller,Neil A. Zakai,Michael B. Streiff,Michael K. Gould,Mary Cushman,Rana Charide,Itziar Etxeandia-Ikobaltzeta,Federico Germini,Marta Rigoni,Arnav Agarwal,Rami Z. Morsi,Elie A. Akl,Alfonso Iorio,Holger J. Schünemann
View Articletitled, Risk models for VTE and bleeding in medical inpatients: systematic identification and expert assessment
Supplemental data
A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation
Clinical Trials & Observations
Masahiko Okada,Norio Tominaga,Goichi Honda,Junji Nishioka,Nobuyuki Akita,Tatsuya Hayashi,Koji Suzuki,Hiroyuki Moriuchi
View Articletitled, A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation
Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A
Julie Tarrant,Matthew Cormier,Kate Nesbitt,Courtney Dwyer,Christine Hough,David Lillicrap
View Articletitled, Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A
Supplemental data

TRANSFUSION MEDICINE

Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin
Donald A. Belcher,Carlos Munoz,Ivan S. Pires,Alexander T. Williams,Pedro Cabrales,Andre F. Palmer
View Articletitled, Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin

TRANSPLANTATION

Geriatric assessment in older alloHCT recipients: association of functional and cognitive impairment with outcomes
Clinical Trials & Observations
Rebecca L. Olin,Caitrin Fretham,Marcelo C. Pasquini,Mukta Arora,Vijaya R. Bhatt,Benjamin Derman,Sergio A. Giralt,Li-Wen Huang,Thuy Koll,Sang Mee Lee,Richard J. Lin,Linda Pang,Uday R. Popat,Daniel J. Weisdorf,Andrew Artz
View Articletitled, Geriatric assessment in older alloHCT recipients: association of functional and cognitive impairment with outcomes
Supplemental data

COMMENTARY

A report of clustered COVID-19 in a hematology ward
Clinical Trials & Observations
Yaohui Wu,Fang Liu,Yun Fang,Xuan Lu,Yingying Wu,Linghui Xia,Mei Hong
View Articletitled, A report of clustered COVID-19 in a hematology ward

ERRATUM

Papaioannou D, Volinia S, Nicolet D, et al. Clinical and functional significance of circular RNAs in cytogenetically normal AML. Blood Adv. 2020;4(2):239-251.
View Articletitled, Papaioannou D, Volinia S, Nicolet D, et al. Clinical and functional significance of circular RNAs in cytogenetically normal AML. <em>Blood Adv.</em> 2020;4(2):239-251.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Three-dimensional ribbon models of the complex between α-thrombin (blue) and the epidermal growth factor (EGF)–like domains of human thrombomodulin (TME4-6) (pink, EGF4 domain; green, EGF5 domain; yellow, EGF6 domain). The surface representation of the EGF6 domain is overlaid with G412 in the EGF5 domain, which is shown as spheres (blue, red, and green spheres are nitrogen, oxygen, and carbon atoms, respectively). See the article by Okada et al.

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