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Issue Archive

Volume 4, Issue 1
January 14 2020
Issue Cover

Table of Contents

BLOOD ADVANCES TALK

TA-TMA: state of the art for diagnosis and treatment
Clinical Trials & Observations
Christopher C. Dvorak
View Articletitled, TA-TMA: state of the art for diagnosis and treatment
Supplemental data

TESTING ADVANCES

Clinical diagnostics and treatment strategies for Philadelphia chromosome–like acute lymphoblastic leukemia
Clinical Trials & Observations
Richard C. Harvey,Sarah K. Tasian
View Articletitled, Clinical diagnostics and treatment strategies for Philadelphia chromosome–like acute lymphoblastic leukemia

EXCEPTIONAL CASE REPORT

Clinical response to larotrectinib in adult Philadelphia chromosome–like ALL with cryptic ETV6-NTRK3 rearrangement
Clinical Trials & Observations
Valentina Nardi,Nora Ku,Matthew J. Frigault,Adrian M. Dubuc,Harrison Kwei Tsai,Philip C. Amrein,Gabriela S. Hobbs,Andrew M. Brunner,Rupa Narayan,Meghan E. Burke,Julia Foster,Paola Dal Cin,Marcela V. Maus,Amir T. Fathi,Hanno Hock
View Articletitled, Clinical response to larotrectinib in adult Philadelphia chromosome–like ALL with cryptic <em>ETV6-NTRK3</em> rearrangement
Supplemental data

STIMULUS REPORTS

Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria
Thayer K. Darling,Michael P. Schenk,Chengjing C. Zhou,Franklin M. Maloba,Patrice N. Mimche,Jonathan M. Gibbins,Shawn M. Jobe,Tracey J. Lamb
View Articletitled, Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria
Supplemental data
Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma
Clinical Trials & Observations
Tim M. Illidge,Elizabeth H. Phillips,Nicholas Counsell,Ruth Pettengell,Peter W. M. Johnson,Dominic J. Culligan,Bilyana Popova,Laura Clifton-Hadley,Andrew McMillan,Peter Hoskin,Sally F. Barrington,John Radford
View Articletitled, Maximum tumor diameter is associated with event-free survival in PET-negative patients with stage I/IIA Hodgkin lymphoma
Supplemental data

REVIEW ARTICLE

An update on the molecular pathogenesis and potential therapeutic targeting of AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
Sayer Al-Harbi,Mahmoud Aljurf,Mohamad Mohty,Fahad Almohareb,Syed Osman Ali Ahmed
View Articletitled, An update on the molecular pathogenesis and potential therapeutic targeting of AML with t(8;21)(q22;q22.1);<em>RUNX1-RUNX1T1</em>

CLINICAL TRIALS AND OBSERVATIONS

Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma
Clinical Trials & Observations
Armando Santoro,Rita Mazza,Alessandro Pulsoni,Alessandro Re,Maurizio Bonfichi,Vittorio Ruggero Zilioli,Manuela Zanni,Francesco Merli,Antonella Anastasia,Stefano Luminari,Giorgia Annechini,Manuel Gotti,Annalisa Peli,Anna Marina Liberati,Nicola Di Renzo,Luca Castagna,Laura Giordano,Francesca Ricci,Carmelo Carlo-Stella
View Articletitled, Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma
Supplemental data
A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry
Clinical Trials & Observations
Zhaohui Du,Niels Weinhold,Gregory Chi Song,Kristin A. Rand,David J. Van Den Berg,Amie E. Hwang,Xin Sheng,Victor Hom,Sikander Ailawadhi,Ajay K. Nooka,Seema Singhal,Karen Pawlish,Edward S. Peters,Cathryn Bock,Ann Mohrbacher,Alexander Stram,Sonja I. Berndt,William J. Blot,Graham Casey,Victoria L. Stevens,Rick Kittles,Phyllis J. Goodman,W. Ryan Diver,Anselm Hennis,Barbara Nemesure,Eric A. Klein,Benjamin A. Rybicki,Janet L. Stanford,John S. Witte,Lisa Signorello,Esther M. John,Leslie Bernstein,Antoinette M. Stroup,Owen W. Stephens,Maurizio Zangari,Frits Van Rhee,Andrew Olshan,Wei Zheng,Jennifer J. Hu,Regina Ziegler,Sarah J. Nyante,Sue Ann Ingles,Michael F. Press,John David Carpten,Stephen J. Chanock,Jayesh Mehta,Graham A. Colditz,Jeffrey Wolf,Thomas G. Martin,Michael Tomasson,Mark A. Fiala,Howard Terebelo,Nalini Janakiraman,Laurence Kolonel,Kenneth C. Anderson,Loic Le Marchand,Daniel Auclair,Brian C.-H. Chiu,Elad Ziv,Daniel Stram,Ravi Vij,Leon Bernal-Mizrachi,Gareth J. Morgan,Jeffrey A. Zonder,Carol Ann Huff,Sagar Lonial,Robert Z. Orlowski,David V. Conti,Christopher A. Haiman,Wendy Cozen
View Articletitled, A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry
Supplemental data

GENE THERAPY

The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression
Qizhen Shi,Jeremy G. Mattson,Scot A. Fahs,Aron M. Geurts,Hartmut Weiler,Robert R. Montgomery
View Articletitled, The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression

HEALTH SERVICES AND OUTCOMES

Assessment of health-related quality of life among adults hospitalized with sickle cell disease vaso-occlusive crisis
Clinical Trials & Observations
Kimberly S. Esham,Angie Mae Rodday,Hedy P. Smith,Farzad Noubary,Ruth Ann Weidner,Rachel J. Buchsbaum,Susan K. Parsons
View Articletitled, Assessment of health-related quality of life among adults hospitalized with sickle cell disease vaso-occlusive crisis

LYMPHOID NEOPLASIA

Eμ and 3′RR transcriptional enhancers of the IgH locus cooperate to promote c-myc–induced mature B-cell lymphomas
Nour Ghazzaui,Hussein Issaoui,Mélissa Ferrad,Claire Carrion,Jeanne Cook-Moreau,Yves Denizot,François Boyer
View Articletitled, E<sub>μ</sub> and 3′RR transcriptional enhancers of the IgH locus cooperate to promote c-myc–induced mature B-cell lymphomas
Supplemental data
Trends in postrelapse survival in classic Hodgkin lymphoma patients after experiencing therapy failure following auto-HCT
Clinical Trials & Observations
Talha Badar,Narendranath Epperla,Aniko Szabo,Steven Borson,John Vaughn,Gemlyn George,Neeraj Saini,Abdul Rashid Shah,Romil D. Patel,Sairah Ahmed,Nirav N. Shah,Amanda F. Cashen,Mehdi Hamadani,Timothy S. Fenske
View Articletitled, Trends in postrelapse survival in classic Hodgkin lymphoma patients after experiencing therapy failure following auto-HCT
PD-1 blockade for diffuse large B-cell lymphoma after autologous stem cell transplantation
Matthew J. Frigault,Philippe Armand,Robert A. Redd,Erin Jeter,Reid W. Merryman,Kimberly C. Coleman,Alex F. Herrera,Parastoo Dahi,Yago Nieto,Ann S. LaCasce,David C. Fisher,Samuel Y. Ng,Oreife O. Odejide,Arnold S. Freedman,Austin I. Kim,Jennifer L. Crombie,Caron A. Jacobson,Eric D. Jacobsen,Jeffrey L. Wong,Jad Bsat,Sanjay S. Patel,Jerome Ritz,Scott J. Rodig,Margaret A. Shipp,Yi-Bin Chen,Robin M. Joyce
View Articletitled, PD-1 blockade for diffuse large B-cell lymphoma after autologous stem cell transplantation
Supplemental data
Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas
Xia Liu,Jiaji G. Chen,Manit Munshi,Zachary R. Hunter,Lian Xu,Amanda Kofides,Nickolas Tsakmaklis,Maria G. Demos,Maria Luisa Guerrera,Gloria G. Chan,Cristina Jimenez,Christopher J. Patterson,Kirsten Meid,Andrew Keezer,Jorge J. Castillo,Steven P. Treon,Guang Yang
View Articletitled, Expression of the prosurvival kinase HCK requires PAX5 and mutated MYD88 signaling in MYD88-driven B-cell lymphomas
Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months
Clinical Trials & Observations
Thomas E. Lew,Mary Ann Anderson,Victor S. Lin,Sasanka M. Handunnetti,Neil A. Came,Piers Blombery,David A. Westerman,Meaghan Wall,Constantine S. Tam,Andrew W. Roberts,John F. Seymour
View Articletitled, Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months
Supplemental data

MYELOID NEOPLASIA

Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11
Clinical Trials & Observations
Yuichi Ishikawa,for the Japan Adult Leukemia Study Group,Naomi Kawashima,for the Japan Adult Leukemia Study Group,Yoshiko Atsuta,for the Japan Adult Leukemia Study Group,Isamu Sugiura,for the Japan Adult Leukemia Study Group,Masashi Sawa,for the Japan Adult Leukemia Study Group,Nobuaki Dobashi,for the Japan Adult Leukemia Study Group,Hisayuki Yokoyama,for the Japan Adult Leukemia Study Group,Noriko Doki,for the Japan Adult Leukemia Study Group,Akihiro Tomita,for the Japan Adult Leukemia Study Group,Toru Kiguchi,for the Japan Adult Leukemia Study Group,Shiro Koh,for the Japan Adult Leukemia Study Group,Heiwa Kanamori,for the Japan Adult Leukemia Study Group,Noriyoshi Iriyama,for the Japan Adult Leukemia Study Group,Akio Kohno,for the Japan Adult Leukemia Study Group,Yukiyoshi Moriuchi,for the Japan Adult Leukemia Study Group,Noboru Asada,for the Japan Adult Leukemia Study Group,Daiki Hirano,for the Japan Adult Leukemia Study Group,Kazuto Togitani,for the Japan Adult Leukemia Study Group,Toru Sakura,for the Japan Adult Leukemia Study Group,Maki Hagihara,for the Japan Adult Leukemia Study Group,Tatsuki Tomikawa,for the Japan Adult Leukemia Study Group,Yasuhisa Yokoyama,for the Japan Adult Leukemia Study Group,Norio Asou,for the Japan Adult Leukemia Study Group,Shigeki Ohtake,for the Japan Adult Leukemia Study Group,Itaru Matsumura,for the Japan Adult Leukemia Study Group,Yasushi Miyazaki,for the Japan Adult Leukemia Study Group,Tomoki Naoe,for the Japan Adult Leukemia Study Group,Hitoshi Kiyoi,for the Japan Adult Leukemia Study Group
View Articletitled, Prospective evaluation of prognostic impact of <em>KIT</em> mutations on acute myeloid leukemia with <em>RUNX1-RUNX1T1</em> and <em>CBFB-MYH11</em>
Supplemental data
Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells
Karen Phaik Har Lim,Paul Milne,Michael Poidinger,Kaibo Duan,Howard Lin,Naomi McGovern,Harshal Abhyankar,Daniel Zinn,Thomas M. Burke,Olive S. Eckstein,Rikhia Chakraborty,Amel Sengal,Brooks Scull,Evan Newell,Miriam Merad,Kenneth L. McClain,Tsz-Kwong Man,Florent Ginhoux,Matthew Collin,Carl E. Allen
View Articletitled, Circulating CD1c<sup>+</sup> myeloid dendritic cells are potential precursors to LCH lesion CD1a<sup>+</sup>CD207<sup>+</sup> cells
Supplemental data

PLATELETS AND THROMBOPOIESIS

A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia
Hanny Al-Samkari,Rachel P. Rosovsky,Rebecca S. Karp Leaf,David B. Smith,Katayoon Goodarzi,Annemarie E. Fogerty,David B. Sykes,David J. Kuter
View Articletitled, A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia
Supplemental data
Supramaximal calcium signaling triggers procoagulant platelet formation
Nima Abbasian,Sarah L. Millington-Burgess,Shirom Chabra,Jean-Daniel Malcor,Matthew T. Harper
View Articletitled, Supramaximal calcium signaling triggers procoagulant platelet formation
Supplemental data

THROMBOSIS AND HEMOSTASIS

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets
Xi Chen,Shuchi Gupta,Matthew Cooper,Daniel DeHelian,Xuefei Zhao,Meghna U. Naik,Jeremy G. T. Wurtzel,Timothy J. Stalker,Lawrence E. Goldfinger,Jeffrey Benovic,Lawrence F. Brass,Steven E. McKenzie,Ulhas P. Naik,Peisong Ma
View Articletitled, GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets
Supplemental data
Low VWF levels in children and lack of association with bleeding in children undergoing tonsillectomy
Clinical Trials & Observations
Joan Cox Gill,Stephen F. Conley,Victoria P. Johnson,Pamela A. Christopherson,Sandra L. Haberichter,Christina D. Diaz,Tatyana C. Strong,Jian Zhang,Pippa Simpson,Thomas C. Abshire,Robert R. Montgomery,Veronica H. Flood
View Articletitled, Low VWF levels in children and lack of association with bleeding in children undergoing tonsillectomy
Supplemental data
MRI predicts 5-year joint bleeding and development of arthropathy on radiographs in hemophilia
Clinical Trials & Observations
Wouter Foppen,Irene C. van der Schaaf,Frederik J. A. Beek,Willem P. T. M. Mali,Kathelijn Fischer
View Articletitled, MRI predicts 5-year joint bleeding and development of arthropathy on radiographs in hemophilia
Metabolic syndrome increases risk of venous thromboembolism recurrence after acute deep vein thrombosis
Clinical Trials & Observations
Lauren K. Stewart,Jeffrey A. Kline
View Articletitled, Metabolic syndrome increases risk of venous thromboembolism recurrence after acute deep vein thrombosis
von Willebrand factor binding to myosin assists in coagulation
Veronica H. Flood,Tricia L. Slobodianuk,Daniel Keesler,Hannah K. Lohmeier,Scot Fahs,Liyun Zhang,Pippa Simpson,Robert R. Montgomery
View Articletitled, von Willebrand factor binding to myosin assists in coagulation
Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor
Steven P. Grover,Clare M. Schmedes,Alyson C. Auriemma,Emily Butler,Molly L. Parrish,Adam Miszta,Audrey C. Cleuren,Mayken Visser,Stefan Heitmeier,Jens J. Posma,Henri M. Spronk,Silvio Antoniak,Alisa S. Wolberg,Rafal Pawlinski,David Gailani,Nigel Mackman
View Articletitled, Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor
Supplemental data

TRANSPLANTATION

Refined National Institutes of Health response algorithm for chronic graft-versus-host disease in joints and fascia
Clinical Trials & Observations
Yoshihiro Inamoto,Stephanie J. Lee,Lynn E. Onstad,Mary E. D. Flowers,Betty K. Hamilton,Madan H. Jagasia,Paul J. Martin,Steven Z. Pavletic,Joseph A. Pidala,Iskra Pusic,Georgia B. Vogelsang,Daniel Wolff,Paul A. Carpenter
View Articletitled, Refined National Institutes of Health response algorithm for chronic graft-versus-host disease in joints and fascia
Robust CD4+ T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin
Ioannis Politikos,Jessica A. Lavery,Patrick Hilden,Christina Cho,Taylor Borrill,Molly A. Maloy,Sergio A. Giralt,Marcel R. M. van den Brink,Miguel-Angel Perales,Juliet N. Barker
View Articletitled, Robust CD4<sup>+</sup> T-cell recovery in adults transplanted with cord blood and no antithymocyte globulin
Supplemental data

ERRATUM

Goldmann L, Duan R, Kragh T, et al. Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT? Blood Adv. 2019;3(23):4021-4033.
View Articletitled, Goldmann L, Duan R, Kragh T, et al. Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT? <em>Blood Adv</em>. 2019;3(23):4021-4033.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Circos plot illustrating the association of mutated genes in acute myeloid leukemia (AML) with RUNX1-RUNX1T1 or CBFB-MYH11. KIT mutation is the most frequently identified in AML with RUNX1-RUNX1T1, while NRAS mutation is the most frequent in AML with CBFB-MYH11. See the article by Ishikawa et al.

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