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Volume 3, Issue 19

October 8 2019

In this Issue

DRUG ADVANCES
STIMULUS REPORTS
CLINICAL TRIALS AND OBSERVATIONS
GENE THERAPY
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION

DRUG ADVANCES

Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval

Adam Yuh Lin,Shira Naomi Dinner

View Articletitled, Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval

STIMULUS REPORTS

CXCR4^S338X clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia

Joshua N. Gustine,Lian Xu,Nicholas Tsakmaklis,Maria G. Demos,Amanda Kofides,Jiaji G. Chen,Xia Liu,Manit Munshi,Maria Luisa Guerrera,Gloria G. Chan,Christopher J. Patterson,Andrew Keezer,Kirsten Meid,Toni Dubeau,Guang Yang,Zachary R. Hunter,Steven P. Treon,Jorge J. Castillo

View Articletitled, <em>CXCR4</em><sup>S338X</sup> clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia

Supplemental data

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

Alfred L. Garfall,Ehren K. Dancy,Adam D. Cohen,Wei-Ting Hwang,Joseph A. Fraietta,Megan M. Davis,Bruce L. Levine,Don L. Siegel,Edward A. Stadtmauer,Dan T. Vogl,Adam Waxman,Aaron P. Rapoport,Michael C. Milone,Carl H. June,J. Joseph Melenhorst

View Articletitled, T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

Supplemental data

Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD

Jonathan L. Golob,Martha M. DeMeules,Tillie Loeffelholz,Z. Z. Quinn,Michael K. Dame,Sabrina S. Silvestri,Michael C. Wu,Thomas M. Schmidt,Tina L. Fiedler,Matthew J. Hoostal,Marco Mielcarek,Jason Spence,Steven A. Pergam,David N. Fredricks

View Articletitled, Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD

Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

The impact of response kinetics for multiple myeloma in the era of novel agents
Clinical Trials & Observations

Yuting Yan,Xuehan Mao,Jiahui Liu,Huishou Fan,Chenxing Du,Zengjun Li,Shuhua Yi,Yan Xu,Rui Lv,Wei Liu,Shuhui Deng,Weiwei Sui,Qi Wang,Dehui Zou,Jianxiang Wang,Tao Cheng,Fenghuang Zhan,Yu-Tzu Tai,Chenglu Yuan,Xin Du,Lugui Qiu,Kenneth C. Anderson,Gang An

View Articletitled, The impact of response kinetics for multiple myeloma in the era of novel agents

Supplemental data

GENE THERAPY

High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells

Hongjie Wang,Zhinan Liu,Chang Li,Sucheol Gil,Thalia Papayannopoulou,Christopher B. Doering,André Lieber

View Articletitled, High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Identification of a tumor-specific allo-HLA–restricted γδTCR

G. J. J. Kierkels,W. Scheper,A. D. Meringa,I. Johanna,D. X. Beringer,A. Janssen,M. Schiffler,T. Aarts-Riemens,L. Kramer,T. Straetemans,S. Heijhuurs,J. H. W. Leusen,E. San José,K. Fuchs,M. Griffioen,J. H. Falkenburg,L. Bongiovanni,A. de Bruin,D. Vargas-Diaz,M. Altelaar,A. J. R. Heck,L. D. Shultz,F. Ishikawa,M. I. Nishimura,Z. Sebestyén,J. Kuball

View Articletitled, Identification of a tumor-specific allo-HLA–restricted γδTCR

Supplemental data

LYMPHOID NEOPLASIA

Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma

Brian C.-H. Chiu,Zhou Zhang,Qiancheng You,Chang Zeng,Elizabeth Stepniak,Paige M. Bracci,Kangkang Yu,Girish Venkataraman,Sonali M. Smith,Chuan He,Wei Zhang

View Articletitled, Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma

Supplemental data

Outcomes of stage I/II follicular lymphoma in the PET era: an international study from the Australian Lymphoma Alliance

Joshua W. D. Tobin,Gabrielle Rule,Katherine Colvin,Lourdes Calvente,David Hodgson,Stephen Bell,Chengetai Dunduru,James Gallo,Erica S. Tsang,Xuan Tan,Jonathan Wong,Jessica Pearce,Robert Campbell,Shao Tneh,Sophie Shorten,Melissa Ng,Tara Cochrane,Constantine S. Tam,Emad Abro,Eliza Hawkes,Georgina Hodges,Roopesh Kansara,Dipti Talaulikar,Michael Gilbertson,Anna M. Johnston,Kerry J. Savage,Diego Villa,Kirk Morris,Sumi Ratnasingam,Wojt Janowski,Robert Kridel,Chan Y. Cheah,Michael MacManus,Nicholas Matigian,Peter Mollee,Maher K. Gandhi,Greg Hapgood

View Articletitled, Outcomes of stage I/II follicular lymphoma in the PET era: an international study from the Australian Lymphoma Alliance

Supplemental data

High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

Johan Jeong,Astraea Jager,Pablo Domizi,Mara Pavel-Dinu,Linda Gojenola,Masayuki Iwasaki,Michael C. Wei,Feng Pan,James L. Zehnder,Matthew H. Porteus,Kara L. Davis,Michael L. Cleary

View Articletitled, High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

Supplemental data

MYELOID NEOPLASIA

DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes

Brian Reilly,Tiffany N. Tanaka,Dinh Diep,Huwate Yeerna,Pablo Tamayo,Kun Zhang,Rafael Bejar

View Articletitled, DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes

Supplemental data

THROMBOSIS AND HEMOSTASIS

Heterogeneity in neutrophil responses to immune complexes

Madelaine Duarte,Maragatha Kuchibhatla,Sanjay Khandelwal,Gowthami M. Arepally,Grace M. Lee

View Articletitled, Heterogeneity in neutrophil responses to immune complexes

Supplemental data

TRANSPLANTATION

Reversal of a rheologic cardiomyopathy following hematopoietic stem cell transplantation for sickle cell disease

Vandana Sachdev,Matthew Hsieh,Neal Jeffries,Anna Noreuil,Wen Li,Stanislav Sidenko,Hwaida Hannoush,Emily Limerick,Delon Wilson,John Tisdale,Courtney Fitzhugh

View Articletitled, Reversal of a rheologic cardiomyopathy following hematopoietic stem cell transplantation for sickle cell disease

Supplemental data

Myeloablative vs reduced intensity T-cell–replete haploidentical transplantation for hematologic malignancy

Scott R. Solomon,Andrew St. Martin,Nirav N. Shah,Giancarlo Fatobene,Monzr M. Al Malki,Karen K. Ballen,Asad Bashey,Nelli Bejanyan,Javier Bolaños Meade,Claudio G. Brunstein,Zachariah DeFilipp,Richard E. Champlin,Ephraim J. Fuchs,Mehdi Hamadani,Peiman Hematti,Christopher G. Kanakry,Joseph P. McGuirk,Ian K. McNiece,Stefan O. Ciurea,Marcelo C. Pasquini,Vanderson Rocha,Rizwan Romee,Sagar S. Patel,Sumithira Vasu,Edmund K. Waller,John R. Wingard,Mei-Jie Zhang,Mary Eapen

View Articletitled, Myeloablative vs reduced intensity T-cell–replete haploidentical transplantation for hematologic malignancy

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Kate H. Gartlan,Motoko Koyama,Katie E. Lineburg,Karshing Chang,Kathleen S. Ensbey,Rachel D. Kuns,Andrea S. Henden,Luke D. Samson,Andrew D. Clouston,Angel F. Lopez,Kelli P. A. MacDonald,Geoffrey R. Hill

View Articletitled, Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Supplemental data

Cover Image

Cover Image

COVER FIGURE
High-dimensional phenotype analysis of leukemias induced by gene-edited hematopoietic stem and progenitor cells. This uniform manifold approximation and projection (UMAP) plot shows the distribution of individual leukemia cells from patients (purple) and gene-edited leukemias (orange), highlighting diverse and shared phenotypes dependent on sample origin and lineage. See the article by Jeong et al.
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Retreatment of multiple myeloma with previously refractory drugs

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DRUG ADVANCES

Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval

STIMULUS REPORTS

CXCR4^S338X clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD

CLINICAL TRIALS AND OBSERVATIONS

The impact of response kinetics for multiple myeloma in the era of novel agents
Clinical Trials & Observations

GENE THERAPY

High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Identification of a tumor-specific allo-HLA–restricted γδTCR

LYMPHOID NEOPLASIA

Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma

Outcomes of stage I/II follicular lymphoma in the PET era: an international study from the Australian Lymphoma Alliance

High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells

MYELOID NEOPLASIA

DNA methylation identifies genetically and prognostically distinct subtypes of myelodysplastic syndromes

THROMBOSIS AND HEMOSTASIS

Heterogeneity in neutrophil responses to immune complexes

TRANSPLANTATION

Reversal of a rheologic cardiomyopathy following hematopoietic stem cell transplantation for sickle cell disease

Myeloablative vs reduced intensity T-cell–replete haploidentical transplantation for hematologic malignancy

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

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DRUG ADVANCES

STIMULUS REPORTS

CLINICAL TRIALS AND OBSERVATIONS

The impact of response kinetics for multiple myeloma in the era of novel agents Clinical Trials & Observations

GENE THERAPY

IMMUNOBIOLOGY AND IMMUNOTHERAPY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

THROMBOSIS AND HEMOSTASIS

TRANSPLANTATION

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The impact of response kinetics for multiple myeloma in the era of novel agents
Clinical Trials & Observations