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Journal Articles

DARTs point the way forward in AML

Clinical Trials & Observations
Saar Gill
Journal: Blood
Blood (2021) 137 (6): 720–721.
https://doi.org/10.1182/blood.2020009020
Published: 2021
Journal Articles

BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice

Ekta Seth Chhabra, Tongyao Liu, John Kulman, Susannah Patarroyo-White, Buyue Yang, Qi Lu, Douglas Drager, Nancy Moore, Jiayun Liu, Amy M. Holthaus, Jurg M. Sommer, Ayman Ismail, Deana Rabinovich, Zhan Liu, Arjan van der Flier, Allison Goodman, Chris Furcht, Mark Tie, Tyler Carlage, Randy Mauldin, Terrence M. Dobrowsky, Zhiqian Liu, Oblaise Mercury, Lily Zhu, Baisong Mei, Volker Schellenberger, Haiyan Jiang, Glenn F. Pierce, Joe Salas, Robert Peters
Journal: Blood
Blood (2020) 135 (17): 1484–1496.
https://doi.org/10.1182/blood.2019001292
Published: 2020
Includes: Supplemental data
Journal Articles

Pharmacokinetics of Extended Half-Life Factor VIII Products By myPKFiT R Is Useful for Personalized Treatment in Children with Severe Hemophilia a

Risa Matsumura, Keita Tomioka, MD, Shiho Nishimura, MD, Yoko Mizoguchi, MD PhD, Hiroshi Kawaguchi, MD PhD, Masao Kobayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1127.
https://doi.org/10.1182/blood-2019-128149
Published: 2019
Journal Articles

Can Monosomy 7 be Targeted By Next Generation Cereblon-Modulating Agents?

Vera Adema, PhD, Cassandra M Kerr, MS, Wencke Walter, PhD, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, MD, Sunisa Kongkiatkamon, Christina A. Snider, BA, Milo Co, Rainey Magdalena, Arda Durmaz, Manja Meggendorfer, PhD, Aziz Nazha, MD, Jacob Scott, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Torsten Haferlach, MD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1270.
https://doi.org/10.1182/blood-2019-128967
Published: 2019
Journal Articles

Identification of Novel Combination Therapies Active in BCL2 Inhibitor-Resistant Patient-Derived AML Models

Courtney L Andersen, PhD, Amanda L Christie, MS, Alan Rosen, MS, Kim Maratea, DVM, PhD, Maureen Hattersley, Jon Travers, PhD, Justin Cidado, PhD, Sai Pulukuri, PhD, Jamal Saeh, PhD, Edwin Clark, PhD, Corinne Reimer, PhD, Jerome Mettetal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1273.
https://doi.org/10.1182/blood-2019-129475
Published: 2019
Journal Articles

Pharmacokinetics of Ticagrelor in Infants and Toddlers Aged <24 Months with Sickle Cell Disease

Baba PD Inusa, MD, Adlette Inati, MD, Philip Maes, MD, Jessie Githanga, MBChB, MMed, Miguel R. Abboud, MD, Maurizio Miano, Elena Cela, Videlis Nduba, Mohammad Niazi, Magnus Åstrand, Kevin Persson, Anders Rikard Berggren, MD PhD, Glenn Carlson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1005.
https://doi.org/10.1182/blood-2019-129855
Published: 2019
Journal Articles

Hyper-Sialylated IgG M254, an Innovative Therapeutic Candidate, Evaluated in Healthy Volunteers and in Patients with Immune Thrombocytopenia Purpura: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics

Santiago Arroyo, MD PhD, Renger G Tiessen, MD, William S Denney, PhD, Jim Jin, MS, Mattheus Paulus (Thijs) van Iersel, MD, Heidi Zeitz, MD CCRA, Anthony M Manning, PhD, Martin R. Schipperus, MD PhD, James B. Bussel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1090.
https://doi.org/10.1182/blood-2019-125993
Published: 2019
Journal Articles

Safety, Clinical Activity, Pharmacokinetics, and Pharmacodynamics from a Phase I Study of PF-06863135, a B-Cell Maturation Antigen (BCMA)-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Noopur S. Raje, MD, Andrzej Jakubowiak, MD PhD, Cristina Gasparetto, MD, Robert F. Cornell, MD MS, Heike I. Krupka, PhD PMP, Daniel Navarro, MD MSc, Alison J. Forgie, DPhil, Chandrasekhar Udata, PhD, Cynthia Basu, PhD, Jeffrey Chou, MD PhD, Abraham Leung, MD, Alexander M. Lesokhin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1869.
https://doi.org/10.1182/blood-2019-121805
Published: 2019
Journal Articles

Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT

Aswin Anand PAI, MSc, John C Panetta, PhD, Ezhil Pavai Mohanan, PhD, Raveen Stephen Stallon Illangeswaran, MSc, Balaji Balakrishnan, PhD, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Uday Prakash Kulkarni, MD DM, Anup Joseph Devasia, MD DM, Fouzia N., Anu Korula, MD DM, Aby Abraham, MD DM, Biju George, MDDM, Vikram Mathews, MD DM, Alok Srivastava, MD,FRACP,FRCPA, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1977.
https://doi.org/10.1182/blood-2019-125604
Published: 2019
Journal Articles

Anticancer Activity of a Highly Potent Small Molecule Tubulin Polymerization Inhibitor, AB8939

Martine Humbert, PhD, Armelle Goubard, PhD, Colin Mansfield, PhD, Olivier Hermine, MD PhD, Patrice Dubreuil, PhD, The AB8939 Study Group
Journal: Blood
Blood (2019) 134 (Supplement_1): 2075.
https://doi.org/10.1182/blood-2019-122540
Published: 2019
Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2073.
https://doi.org/10.1182/blood-2019-130666
Published: 2019
Journal Articles

Correlations between von Willebrand Factor Antigen Levels and Factor VIII Pharmacokinetics Are Similar across Different FVIII Products in Patients with Severe Hemophilia A

Alfonso Iorio, Monika Maas Enriquez, Heinz Delesen, Alexander Solms, Stacy E. Croteau, Erik Berntorp
Journal: Blood
Blood (2019) 134 (Supplement_1): 3637.
https://doi.org/10.1182/blood-2019-127046
Published: 2019
Journal Articles

A Phase I Study to Investigate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Tripegfilgrastim (Dulastin®) after Single Administration in Pediatric Patients

Kyung Taek Hong, MD, Soyoung Lee, Jaeseong Oh, Jung Yoon Choi, MD, Hee Young Shin, MD PhD, Kyung-Sang Yu, MD PhD, Hyoung Jin Kang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3594.
https://doi.org/10.1182/blood-2019-125266
Published: 2019
Journal Articles

Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety Comparison of Deferasirox Formulations for Treatment Tailoring

Andrea Piolatto, MS, Carmen Gaglioti, MD, Filomena Longo, MD, Silvia De Francia, PhD, Sarah Allegra, PhD, Paola Berchialla, PhD, Antonio Piga
Journal: Blood
Blood (2019) 134 (Supplement_1): 3547.
https://doi.org/10.1182/blood-2019-122030
Published: 2019
Journal Articles

Relationship between Pharmacokinetics and Antidrug Antibody Status of ABP 959, a Biosimilar Candidate to Eculizumab: Results from a Pharmacokinetic Similarity Study

Vladimir Hanes, MD, Jean Pan, Daniel T. Mytych, PhD, David Chien, MD, Vincent Chow
Journal: Blood
Blood (2019) 134 (Supplement_1): 3520.
https://doi.org/10.1182/blood-2019-128621
Published: 2019
Journal Articles

Modulation of the IL-6/STAT3 Signaling Axis in CD4 + T Cells As a Potential Immune Mechanism of Action of Azacytidine in High-Risk Myelodysplastic Syndromes

Eleftheria Lamprianidou, Chrysoula Kordella, Anastasiya Kazachenka, Emmanouela Zoulia, Elsa Bernard, PhD, Anastasia Filia, Stamatia Laidou, Theodoros P. Vassilakopoulos, MD PhD, Sotirios Papageorgiou, MD PhD, Vassiliki Pappa, MD, Athanasios Galanopoulos, MD PhD, Nora-Athina Viniou, MD PhD, Evangelia Nakou, Anastasia Hadzidimitriou, PhD, George Kassiotis, Elli Papaemmanuil, PhD, Ioannis Mitroulis, Ioannis Kotsianidis
Journal: Blood
Blood (2019) 134 (Supplement_1): 2988.
https://doi.org/10.1182/blood-2019-126504
Published: 2019
Journal Articles

First China Approved Rituximab Biosimilar HLX01: Pharmacokinetics, Safety and Efficacy Comparison to Reference Rituximab in the Phase 3 Diffuse Large B-Cell Lymphoma Study

Yuankai Shi, MD PhD, Yongping Song, MD PhD, Yan Qin, MD PhD, Qingyuan Zhang, MD, Xiaohong Han, MD, Xiaonan Hong, MD, Dong Wang, MD, Xiaofeng Zeng, MD PhD, Pei Hu, MD PhD, Shuiyu Zhao, Kaka Y. Hong, MSSB, Chaoming Ma, Jiancheng Cheng, Peng Ting, PhD, Kevin Li, MD, Weidong Jiang, PhD, Scott Liu, PhD, Eugene Liu, MD PhD, Xin Zhang, MD, Katherine Chai, PhD MsLaw, Dan Yao, PhD, Alvin Y. Luk, PhDMBA
Journal: Blood
Blood (2019) 134 (Supplement_1): 2878.
https://doi.org/10.1182/blood-2019-130603
Published: 2019
Journal Articles

The Binding of CD38 Therapeutics to Red Blood Cells and Platelets Subverts Depletion of Target Cells

Eric Robert Fedyk, BSc, MSc, PhD, Neeraja Idamakanti, BVSc MSc DVM, Jia Chen, BSc, MSc, PhD, Jose Estevam, BSc MSc, Vivian Hernandez, BSc PhD, Matthew Wagoner, BSc PhD, Mary Carsillo, BSc DVM PhD, Deborah Berg, RN, MSN, Kristina Allikmets, MD PhD, Gezim Lahu, BSc MSc PhD, Antonio Palumbo, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3136.
https://doi.org/10.1182/blood-2019-128238
Published: 2019
Journal Articles

The Real-World Experience of rFVIII-Fc Used in Hemophilia a Patients in Taiwan: Prophylaxis Rates, Pharmacokinetics and Clinical Correlates, and the Effects on Joint Health

Chia-Yau Chang, MD, Yeu-Chin Chen, MD, Chen-Hua Tsai, MD, Jia-Ruey Tsai, MD, Yen-Lin Liu, MD, Shu-Hsia Hu
Journal: Blood
Blood (2019) 134 (Supplement_1): 2406.
https://doi.org/10.1182/blood-2019-132137
Published: 2019
Journal Articles

Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia

Gretchen Johnston, Haley E. Ramsey, PhDMSc, Kristy Stengel, PhD, Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Maria Arrate, MSc, Matthew C. Stubbs, PhD, Timothy Burn, PhD, Scott Hiebert, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2509.
https://doi.org/10.1182/blood-2019-130458
Published: 2019