Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 42

Sort by

Sort Order Select

Journal Articles

Genetic disruption of N-Ras G12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Noemi A. Zambetti, Ari J. Firestone, Jarrett R. Remsberg, Benjamin J. Huang, Jasmine C. Wong, Amanda M. Long, Marina Predovic, Radu M. Suciu, Anagha Inguva, Scott C. Kogan, Kevin M. Haigis, Benjamin F. Cravatt, Kevin Shannon

Blood (2020) 135 (20): 1772–1782.

https://doi.org/10.1182/blood.2019003530

Published: 2020

Includes: Supplemental data

Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD

Blood (2019) 134 (Supplement_1): 731.

https://doi.org/10.1182/blood-2019-125959

Published: 2019

Journal Articles

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

Lu Liu, PhD, Meiling Zhao, MS, Kevin B Yang, Xi Jin, PhD, Gina Ney, MD PhD, Juan Del Valle, BS, PhD, Takao Iwawaki, PhD, Qing Li, MD PhD

Blood (2016) 128 (22): 567.

https://doi.org/10.1182/blood.V128.22.567.567

Published: 2016

Journal Articles

Molecular Characterization of Relapsed Core-Binding Factor (CBF) Acute Myeloid Leukemia (AML)

Blood (2015) 126 (23): 2586.

https://doi.org/10.1182/blood.V126.23.2586.2586

Published: 2015

Journal Articles

Preclinical efficacy of MEK inhibition in Nras -mutant AML

Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Huang, Jin Xu, Johannes Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis, Deepak Sampath, Scott Lowe, Kevin Shannon, Qing Li

Blood (2014) 124 (26): 3947–3955.

https://doi.org/10.1182/blood-2014-05-574582

Published: 2014

Includes: Supplemental data

Journal Articles

Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML

Blood (2014) 124 (21): 481.

https://doi.org/10.1182/blood.V124.21.481.481

Published: 2014

Journal Articles

Analysis of WT1 Mutations and Combined Aberrations in Childhood Acute Myeloid Leukemia using Whole Exome Sequencing

Nils von Neuhoff, PhD, Peter Husemann, PhD, Robert Geffers, PhD, Christiane Walter, M.Sc., Christine von Neuhoff, MD, Martin Zimmermann, PhD, Brigitte Schlegelberger, MD, Dirk Reinhardt, MD PhD

Blood (2014) 124 (21): 2340.

https://doi.org/10.1182/blood.V124.21.2340.2340

Published: 2014

Journal Articles

Identifying Novel Genes and Signaling Pathways That Predispose to Therapy Related MDS (t-MDS)

Shailaja Akunuru, PhD, Kimberly Seymore, Rupali Kumar, Kalpana Nattamai, Hartmut Geiger

Blood (2014) 124 (21): 1905.

https://doi.org/10.1182/blood.V124.21.1905.1905

Published: 2014

Journal Articles

Clonal Leukemic Evolution In Myelodysplastic Syndromes With ASXL1 and EZH2 mutations: A Comparative Analysis Of 58 Paired Samples

Hsuan-Jen Shih, MD, Lee-Yung Shih, MD, Hung Chang, MD, Ming-Chung Kuo, MD, Tung-Huei Lin, MS, Chen-Yu Lai, MS, Yu-Shu Shih, MS, Yu-Hui Huang, MS, Tung-Liang Lin, MD, Po-Nan Wang, MD, Jin-Hou Wu, MD

Blood (2013) 122 (21): 2786.

https://doi.org/10.1182/blood.V122.21.2786.2786

Published: 2013

Journal Articles

Using Small Molecules To Identify Critical Signaling Pathways Of Mutant N-RAS In Acute Leukemia Cells

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Jianming Zhang, PhD, Qingsong Liu, PhD, Matthew Patricell, PhD, Hojong Yoon, Amanda L. Christie, B.S., Amy M. Sauer, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S. Gray, PhD, James D. Griffin, MD

Blood (2013) 122 (21): 169.

https://doi.org/10.1182/blood.V122.21.169.169

Published: 2013

Journal Articles

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Liu Qingsong, PhD, Jianming Zhang, PhD, Guillaume Adelmant, PhD, Jarrod A Marto, PhD, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S Gray, PhD, James D. Griffin, MD

Blood (2012) 120 (21): 2455.

https://doi.org/10.1182/blood.V120.21.2455.2455

Published: 2012

Journal Articles

Molecular Aberrations in 107 Children with Myelodysplastic Syndrome (MDS).

Blood (2012) 120 (21): 2802.

https://doi.org/10.1182/blood.V120.21.2802.2802

Published: 2012

Journal Articles

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Jin Xu, Christian Hedberg, Frank J. Dekker, Qing Li, Kevin M. Haigis, Eugene Hwang, Herbert Waldmann, Kevin Shannon

Blood (2012) 119 (4): 1032–1035.

https://doi.org/10.1182/blood-2011-06-358960

Published: 2012

Includes: Supplemental data

Journal Articles

Mutational Analysis of N-Ras Proto-Oncogene in Acute Myeloid Leukemia: A Study of 70 Adult Korean Patients

Jihun Jeong, Jeong Yeal Ahn, Jae Hoon Lee, MD

Blood (2011) 118 (21): 4883.

https://doi.org/10.1182/blood.V118.21.4883.4883

Published: 2011

Journal Articles

Discovering the Epigenetic Modifications and the Alterations in Cellular DNA Damage Response Pathways That Drive Myelomagenesis; Clinical Implications Into the Biology of Multiple Myeloma

Maria Gkotzamanidou, Evangelos Terpos, Petros P. Sfikakis, Meletios Athanasios Dimopoulos, MD, Vassilis L. Souliotis

Blood (2011) 118 (21): 299.

https://doi.org/10.1182/blood.V118.21.299.299

Published: 2011

Journal Articles

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

Yang Shen, Yong-Mei Zhu, Xing Fan, Jing-Yi Shi, Qin-Rong Wang, Xiao-Jing Yan, Zhao-Hui Gu, Yan-Yan Wang, Bing Chen, Chun-Lei Jiang, Han Yan, Fei-Fei Chen, Hai-Min Chen, Zhu Chen, Jie Jin, Sai-Juan Chen

Blood (2011) 118 (20): 5593–5603.

https://doi.org/10.1182/blood-2011-03-343988

Published: 2011

Includes: Supplemental data

Journal Articles

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Salvador Iborra, Manuel Soto, Luiz Stark-Aroeira, Esther Castellano, Balbino Alarcón, Carlos Alonso, Eugenio Santos, Edgar Fernández-Malavé

Blood (2011) 117 (19): 5102–5111.

https://doi.org/10.1182/blood-2010-10-315770

Published: 2011

Journal Articles

N-Ras G12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

Fu-Sheng Chou, Mark Wunderlich, Andrea Griesinger, James C. Mulloy

Blood (2011) 117 (7): 2237–2240.

https://doi.org/10.1182/blood-2010-01-264119

Published: 2011

Includes: Supplemental data

Journal Articles

Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival

Torsten Steinbrunn, Thorsten Stühmer, Stefan Gattenlöhner, Andreas Rosenwald, Anja Mottok, Christian Unzicker, Hermann Einsele, Manik Chatterjee, Ralf C. Bargou

Blood (2011) 117 (6): 1998–2004.

https://doi.org/10.1182/blood-2010-05-284422

Published: 2011

Includes: Supplemental data

Journal Articles

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Aref Al-Kali, MD, Rajyalakshmi Luthra, PhD, Carlos E. Bueso-Ramos, MD, Sherry Pierce, RN, BS, Tapan Kadia, MD, Gautam Borthakur, MD, Zeev Estrov, MD, Elias Jabbour, MD, Stefan Faderl, MD, Farhad Ravandi, MD, Jorge Cortes, MD, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD

Blood (2010) 116 (21): 2926.

https://doi.org/10.1182/blood.V116.21.2926.2926

Published: 2010

NARROW

Genetic disruption of N-Ras G12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

N-RasG12D-Mediated Dysregulation of IRE1alpha-Xbp1s Signaling Promotes Pre-Leukemic Hematopoietic Stem Cell Expansion

Molecular Characterization of Relapsed Core-Binding Factor (CBF) Acute Myeloid Leukemia (AML)

Preclinical efficacy of MEK inhibition in Nras -mutant AML

Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML

Analysis of WT1 Mutations and Combined Aberrations in Childhood Acute Myeloid Leukemia using Whole Exome Sequencing

Identifying Novel Genes and Signaling Pathways That Predispose to Therapy Related MDS (t-MDS)

Clonal Leukemic Evolution In Myelodysplastic Syndromes With ASXL1 and EZH2 mutations: A Comparative Analysis Of 58 Paired Samples

Using Small Molecules To Identify Critical Signaling Pathways Of Mutant N-RAS In Acute Leukemia Cells

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Molecular Aberrations in 107 Children with Myelodysplastic Syndrome (MDS).

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

Mutational Analysis of N-Ras Proto-Oncogene in Acute Myeloid Leukemia: A Study of 70 Adult Korean Patients

Discovering the Epigenetic Modifications and the Alterations in Cellular DNA Damage Response Pathways That Drive Myelomagenesis; Clinical Implications Into the Biology of Multiple Myeloma

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

N-Ras G12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival

Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only