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Journal Articles

Misregulation Of The PRC2 Complex In CML Stem Cells Confers Sensitivity To An EZH2 Inhibitor

Mary T Scott, PhD, Koorosh Korfi, PhD, Paolo Gallipoli, PhD, Peter Saffrey, PhD, Heather Jorgensen, PhD, Michelle Cruz, Ashley Hamilton, PhD, Amy Sinclair, Andrew Crossan, PhD, Emmanuel Normant, PhD, Vidya Balasubramanian, Tessa L. Holyoake, PhD, David Vetrie, PhD

Blood (2013) 122 (21): 2710.

https://doi.org/10.1182/blood.V122.21.2710.2710

Published: 2013

Journal Articles

p53 and c-Myc Are Critical Signaling Hubs That Maintain Chronic Myeloid Leukemia

Sheela A Abraham, PhD, Lisa Hopcroft, PhD, Emma Carrick, PhD, Andrew Williamson, PhD, Andrew Pierce, PhD, Jennifer Cassels, Francesca Pellicano, PhD, Anthony Whetton, Tessa L Holyoake, PhD, MB, ChB, FRCP, FRCPath, FRSE

Blood (2013) 122 (21): 1465.

https://doi.org/10.1182/blood.V122.21.1465.1465

Published: 2013

Journal Articles

HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells

Deniz Gezer, Amelie V Guitart, Milica Vukovic, Chithra Subramani, Karen Dunn, Patrick Pollard, Peter J Ratcliffe, Tessa L. Holyoake, PhD, Kamil Kranc

Blood (2013) 122 (21): 3767.

https://doi.org/10.1182/blood.V122.21.3767.3767

Published: 2013

Journal Articles

Axl Represents a Therapeutic Target In T315I-Mutated and WT Chronic Myeloid Leukemia

Blood (2013) 122 (21): 1469.

https://doi.org/10.1182/blood.V122.21.1469.1469

Published: 2013

Journal Articles

Inhibition Of Microenvironmental Interleukin-1 Signaling Enhances TKI-Mediated Targeting Of Chronic Myelogenous Leukemia Stem Cells

Bin Zhang, PhD, Yin Wei Ho, Tessa L. Holyoake, PhD, Ravi Bhatia, MD

Blood (2013) 122 (21): 512.

https://doi.org/10.1182/blood.V122.21.512.512

Published: 2013

Journal Articles

Inhibition of Autophagy in Combination with Ponatinib or Dual PI3K/mTOR Inhibition to Improve Treatment Response for Both Bcr-Abl Dependent and Independent Mechanisms of TKI-Resistance in CML

G.Vignir Helgason, PhD, Elaine K Allan, Samanta Mariani, Arunima Mukhopadhyay, Maria Karvela, Sara Galavotti, Alessandra Audia, Ashley Hamilton, Franck E. Nicolini, MD, PhD, Brian J. Druker, Paolo Salomoni, Bruno Calabretta, Tessa L. Holyoake, PhD, FRCP, FRCPath

Blood (2012) 120 (21): 1664.

https://doi.org/10.1182/blood.V120.21.1664.1664

Published: 2012

Journal Articles

Metastasis Suppressor 1 Is Downregulated in CML Stem Cells and Overexpression Impairs Early Leukemic Cell Propagation.

Mirle Schemionek, PhD, Ulrich Steidl, MD, PhD, Albrecht Schwab, MD, Daniel G Tenen, MD, Copland Mhairi, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Christian Preisinger, PhD, Carsten Mueller-Tidow, MD, Tim H Brümmendorf, Steffen Koschmieder, MD

Blood (2012) 120 (21): 2776.

https://doi.org/10.1182/blood.V120.21.2776.2776

Published: 2012

Journal Articles

Microenvironmental Protection of CML Stem and Progenitor Cells From Tyrosine Kinase Inhibitors Through N-Cadherin and Wnt Signaling

Bin Zhang, Tinisha McDonald, B.S., Tessa L. Holyoake, PhD, FRCP, FRCPath, Randall T Moon, PHD, Dario Campana, MD, PhD, Leonard Shultz, PhD, Ravi Bhatia, MD

Blood (2012) 120 (21): 912.

https://doi.org/10.1182/blood.V120.21.912.912

Published: 2012

Journal Articles

Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML

Bin Zhang, Yin Wei Ho, Tessa L. Holyoake, PhD, FRCP, FRCPath, Claudia S Huettner, PhD, Ravi Bhatia, MD

Blood (2011) 118 (21): 962.

https://doi.org/10.1182/blood.V118.21.962.962

Published: 2011

Journal Articles

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Blood (2011) 118 (21): 2736.

https://doi.org/10.1182/blood.V118.21.2736.2736

Published: 2011

Journal Articles

Pharmacological Inhibition of the Stress-Related Deacetylase SIRT1 Enhances Eradication of CML stem Cells

Ling Li, PhD, Lisheng Wang, PhD, Liang Li, PhD, Tinisha McDonald, Yin Wei Ho, Tessa L. Holyoake, PhD, FRCP, FRCPath, Wenyong Chen, PhD, Ravi Bhatia, MD

Blood (2011) 118 (21): 448.

https://doi.org/10.1182/blood.V118.21.448.448

Published: 2011

Journal Articles

Combined Targeting of BCR-ABL and JAK2 with ABL and JAK2 Inhibitors Is Effective Against CML Patients' Leukemic Stem/Progenitor Cells.

Donna DeGeer, MSc, Paolo Gallipoli, MD, Min Chen, PhD, Ivan Sloma, PhD, Heather Jorgensen, PhD, Donna Forrest, MD, Karen Lambie, Helen Nakamoto, Kyi Min Saw, Matthew Chan, Kathleen Newmarch, Leon Zhou, Ali G. Turhan, MD, PhD, Ralph B. Arlinghaus, PhD, Allen C. Eaves, MD, FRCPC, PhD, Connie J. Eaves, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Xiaoyan Jiang, MD, PhD

Blood (2010) 116 (21): 3404.

https://doi.org/10.1182/blood.V116.21.3404.3404

Published: 2010

Journal Articles

Inhibition of Chronic Myeloid Leukemia Stem Cells by the Combination of the Hedgehog Pathway Inhibitor LDE225 with Nilotinib

Bin Zhang, David Irvine, Yin Wei Ho, Silvia Buonamici, PhD, Paul Manley, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Mhairi Copland, PhD, BSc, MRCP, FRCPath, Ravi Bhatia, MD

Blood (2010) 116 (21): 514.

https://doi.org/10.1182/blood.V116.21.514.514

Published: 2010

Journal Articles

BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment

Blood (2010) 116 (21): 515.

https://doi.org/10.1182/blood.V116.21.515.515

Published: 2010

Journal Articles

Alterations In Wnt Signalling In the Megakaryocytic Lineage Leads to Bone Marrow Failure and Myelofibrosis

Simon D Calaminus, PhD, Gareth Inman, PhD, Cedric Ghaevert, PhD, Owen Sansom, PhD, Steve P Watson, Tessa L. Holyoake, PhD, FRCP, FRCPath, Laura Machesky

Blood (2010) 116 (21): 628.

https://doi.org/10.1182/blood.V116.21.628.628

Published: 2010

Journal Articles

BMS-214662 Eliminates Quiescent and Proliferating Acute Myeloid Leukemia Cells through Activation of Protein Kinase Cβ and Enhances the Efficacy of Cytosine Arabinoside

Francesca Pellicano, PhD, Amy Sinclair, BSc, MSc, Alan Hair, BSc, PhD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Mhairi Copland, PhD, BSc, MRCP, FRCPath

Blood (2010) 116 (21): 2167.

https://doi.org/10.1182/blood.V116.21.2167.2167

Published: 2010

Journal Articles

SIRT1 Inhibition Induces Apoptosis In Human CML Progenitors by Enhancing p53 Acetylation and Activation

Ling Li, PhD, Lisheng Wang, PhD, Tinisha McDonald, BS, Aswani Bolla, MS, Tessa L. Holyoake, PhD, FRCP, FRCPath, Wenyong Chen, PhD, Ravi Bhatia, MD

Blood (2010) 116 (21): 200.

https://doi.org/10.1182/blood.V116.21.200.200

Published: 2010

Journal Articles

Effective Targeting of Quiescent CML Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate.

Bin Zhang, MD, PhD, Adam Campbell Strauss, Su Chu, MD, Yin Wei Ho, David S. Snyder, MD, Claudia Huettner, PhD, Lenny Shultz, Tessa L Holyoake, PhD, Ravi Bhatia, MD

Blood (2009) 114 (22): 190.

https://doi.org/10.1182/blood.V114.22.190.190

Published: 2009

Journal Articles

Combination of the Hedgehog Pathway Inhibitor LDE225 and Nilotinib Eliminates Chronic Myeloid Leukemia Stem and Progenitor Cells.

David A Irvine, roMB, ChB, Bin Zhang, MD, PhD, Elaine K Allan, BSc, Tessa L Holyoake, PhD, MB, ChB, FRCP, FRCPath, FRSE, Marion Dorsch, PhD, Paul W Manley, PhD, Ravi Bhatia, MD, PhD, Mhairi Copland, PhD, BSc, MB, ChB, MRCP, FRCPath

Blood (2009) 114 (22): 1428.

https://doi.org/10.1182/blood.V114.22.1428.1428

Published: 2009

NARROW

Misregulation Of The PRC2 Complex In CML Stem Cells Confers Sensitivity To An EZH2 Inhibitor

p53 and c-Myc Are Critical Signaling Hubs That Maintain Chronic Myeloid Leukemia

HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells

Axl Represents a Therapeutic Target In T315I-Mutated and WT Chronic Myeloid Leukemia

Inhibition Of Microenvironmental Interleukin-1 Signaling Enhances TKI-Mediated Targeting Of Chronic Myelogenous Leukemia Stem Cells

Inhibition of Autophagy in Combination with Ponatinib or Dual PI3K/mTOR Inhibition to Improve Treatment Response for Both Bcr-Abl Dependent and Independent Mechanisms of TKI-Resistance in CML

Metastasis Suppressor 1 Is Downregulated in CML Stem Cells and Overexpression Impairs Early Leukemic Cell Propagation.

Microenvironmental Protection of CML Stem and Progenitor Cells From Tyrosine Kinase Inhibitors Through N-Cadherin and Wnt Signaling

Leukemia-Induced Alterations in Bone Marrow Cytokine and Chemokine Levels Contribute to Altered Stem Cell Lodgment and Impairment of Normal Stem Cell Growth in CML

Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells

Pharmacological Inhibition of the Stress-Related Deacetylase SIRT1 Enhances Eradication of CML stem Cells

Combined Targeting of BCR-ABL and JAK2 with ABL and JAK2 Inhibitors Is Effective Against CML Patients' Leukemic Stem/Progenitor Cells.

Inhibition of Chronic Myeloid Leukemia Stem Cells by the Combination of the Hedgehog Pathway Inhibitor LDE225 with Nilotinib

BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment

Alterations In Wnt Signalling In the Megakaryocytic Lineage Leads to Bone Marrow Failure and Myelofibrosis

BMS-214662 Eliminates Quiescent and Proliferating Acute Myeloid Leukemia Cells through Activation of Protein Kinase Cβ and Enhances the Efficacy of Cytosine Arabinoside

SIRT1 Inhibition Induces Apoptosis In Human CML Progenitors by Enhancing p53 Acetylation and Activation

Effective Targeting of Quiescent CML Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate.

Combination of the Hedgehog Pathway Inhibitor LDE225 and Nilotinib Eliminates Chronic Myeloid Leukemia Stem and Progenitor Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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