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Journal Articles

A Two-Part Study Evaluating the Combination of Tazemetostat and CPX-351 (Part 1) and Palbociclib with CPX-351 (Part 2) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Gina Keiffer, Bruno Calabretta, Alexander Mazo, Ubaldo Martinez Outschoorn, Onder Alpdogan, Adam F. Binder, Pierluigi Porcu, Lindsay Wilde, Margaret Kasner

Blood (2023) 142 (Supplement 1): 1550.

https://doi.org/10.1182/blood-2023-186671

Published: 2023

Journal Articles

Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs

Marco De Dominici, Patrizia Porazzi, Youcai Xiao, Allen Chao, Hsin-Yao Tang, Gaurav Kumar, Paolo Fortina, Orietta Spinelli, Alessandro Rambaldi, Luke F. Peterson, Svetlana Petruk, Camilla Barletta, Alexander Mazo, Gino Cingolani, Joseph M. Salvino, Bruno Calabretta

Blood (2020) 135 (18): 1560–1573.

https://doi.org/10.1182/blood.2019003604

Published: 2020

Includes: Supplemental data

Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Blood (2019) 134 (Supplement_1): 4141.

https://doi.org/10.1182/blood-2019-131113

Published: 2019

Journal Articles

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Blood (2017) 130 (Supplement 1): 45.

https://doi.org/10.1182/blood.V130.Suppl_1.45.45

Published: 2017

Journal Articles

Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia

Marco De Dominici, MS, Angela Rachele Soliera, PhD, Patrizia Porazzi, PhD, Samanta A. Mariani, PhD, Sankar Addya, PhD, Luke F. Peterson, PhD, Orietta Spinelli, PhD, Alessandro Rambaldi, MD Prof, Giovanni Martinelli, MD, Ilaria Iacobucci, PhD, Anna Ferrari, PhD, Bruno Calabretta, MD PhD

Blood (2017) 130 (Supplement 1): 2490.

https://doi.org/10.1182/blood.V130.Suppl_1.2490.2490

Published: 2017

Journal Articles

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Justine Yu, B.S., Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Masashi Sanada, MD PhD, Tomoyuki Yamaguchi, PhD, Yang Du, PhD, Jukka Westermarck, MD PhD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, Dragana Milojkovic, MD, Jane F. Apperley, MD, Denis-Claude Roy, MD, Guido Marcucci, MD, Bruno Calabretta, MD PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD

Blood (2016) 128 (22): 2909.

https://doi.org/10.1182/blood.V128.22.2909.2909

Published: 2016

Journal Articles

Inhibition of Autophagy in Combination with Ponatinib or Dual PI3K/mTOR Inhibition to Improve Treatment Response for Both Bcr-Abl Dependent and Independent Mechanisms of TKI-Resistance in CML

G.Vignir Helgason, PhD, Elaine K Allan, Samanta Mariani, Arunima Mukhopadhyay, Maria Karvela, Sara Galavotti, Alessandra Audia, Ashley Hamilton, Franck E. Nicolini, MD, PhD, Brian J. Druker, Paolo Salomoni, Bruno Calabretta, Tessa L. Holyoake, PhD, FRCP, FRCPath

Blood (2012) 120 (21): 1664.

https://doi.org/10.1182/blood.V120.21.1664.1664

Published: 2012

Journal Articles

Targeting Autophagy Potentiates Imatinib-Induced Cell Death in Philadelphia Positive Cells Including Primary CML Stem Cells.

Blood (2008) 112 (11): 1070.

https://doi.org/10.1182/blood.V112.11.1070.1070

Published: 2008

Journal Articles

Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPα in p210 BCR/ABL -expressing cells

Angela Rachele Soliera, Maria Rosa Lidonnici, Giovanna Ferrari-Amorotti, Marco Prisco, Ying Zhang, Robert V. Martinez, Nick J. Donato, Bruno Calabretta

Blood (2008) 112 (5): 1942–1950.

https://doi.org/10.1182/blood-2007-09-114975

Published: 2008

Includes: Supplemental data

Journal Articles

Requirement of c-Myb for p210 BCR/ABL -dependent transformation of hematopoietic progenitors and leukemogenesis

Maria Rosa Lidonnici, Francesca Corradini, Todd Waldron, Timothy P. Bender, Bruno Calabretta

Blood (2008) 111 (9): 4771–4779.

https://doi.org/10.1182/blood-2007-08-105072

Published: 2008

Includes: Supplemental data

Journal Articles

High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2–dependent suppression of C/EBPα-driven myeloid differentiation

Ji Suk Chang, Ramasamy Santhanam, Rossana Trotta, Paolo Neviani, Anna M. Eiring, Edward Briercheck, Mattia Ronchetti, Denis C. Roy, Bruno Calabretta, Michael A. Caligiuri, Danilo Perrotti

Blood (2007) 110 (3): 994–1003.

https://doi.org/10.1182/blood-2007-03-078303

Published: 2007

Journal Articles

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Giovanna Ferrari-Amorotti, Karen Keeshan, Michela Zattoni, Clara Guerzoni, Giorgio Iotti, Sara Cattelani, Nick J. Donato, Bruno Calabretta

Blood (2006) 108 (4): 1353–1362.

https://doi.org/10.1182/blood-2006-01-011833

Published: 2006

Journal Articles

Inducible activation of CEBPB , a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

Clara Guerzoni, Michela Bardini, Samanta A. Mariani, Giovanna Ferrari-Amorotti, Paolo Neviani, Maria Luisa Panno, Ying Zhang, Robert Martinez, Danilo Perrotti, Bruno Calabretta

Blood (2006) 107 (10): 4080–4089.

https://doi.org/10.1182/blood-2005-08-3181

Published: 2006

Journal Articles

The biology of CML blast crisis

Bruno Calabretta, Danilo Perrotti

Blood (2004) 103 (11): 4010–4022.

https://doi.org/10.1182/blood-2003-12-4111

Published: 2004

Journal Articles

Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

Karen Keeshan, Giorgia Santilli, Francesca Corradini, Danilo Perrotti, Bruno Calabretta

Blood (2003) 102 (4): 1267–1275.

https://doi.org/10.1182/blood-2003-02-0477

Published: 2003

Journal Articles

Defective DNA repair in CML

Bruno Calabretta

Blood (2001) 97 (7): 1905.

https://doi.org/10.1182/blood.V97.7.1905b

Published: 2001

Journal Articles

Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation

Maria Cirinnà, Rossana Trotta, Paolo Salomoni, Plamen Kossev, Mariusz Wasik, Danilo Perrotti, Bruno Calabretta

Blood (2000) 96 (12): 3915–3921.

https://doi.org/10.1182/blood.V96.12.3915

Published: 2000

Journal Articles

Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects

Paolo Salomoni, Fabrizio Condorelli, Shawn M. Sweeney, Bruno Calabretta

Blood (2000) 96 (2): 676–684.

https://doi.org/10.1182/blood.V96.2.676

Published: 2000

Journal Articles

BCR-ABL Antisense Oligodeoxynucleotide In Vitro Purging and Autologous Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in Advanced Phase

Paolo de Fabritiis, Maria Concetta Petti, Enrico Montefusco, Maria Stefania De Propris, Roberta Sala, Roberto Bellucci, Marco Mancini, Alessandro Lisci, Francesco Bonetto, Tim Geiser, Bruno Calabretta, Franco Mandelli

Blood (1998) 91 (9): 3156–3162.

https://doi.org/10.1182/blood.V91.9.3156

Published: 1998

Journal Articles

Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment

Pawel Wlodarski, Mariusz Wasik, Mariusz Z. Ratajczak, Cinzia Sevignani, Grazyna Hoser, Jerzy Kawiak, Alan M. Gewirtz, Bruno Calabretta, Thomas Skorski

Blood (1998) 91 (8): 2998–3006.

https://doi.org/10.1182/blood.V91.8.2998.2998_2998_3006

Published: 1998

NARROW

A Two-Part Study Evaluating the Combination of Tazemetostat and CPX-351 (Part 1) and Palbociclib with CPX-351 (Part 2) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Inhibition of Autophagy in Combination with Ponatinib or Dual PI3K/mTOR Inhibition to Improve Treatment Response for Both Bcr-Abl Dependent and Independent Mechanisms of TKI-Resistance in CML

Targeting Autophagy Potentiates Imatinib-Induced Cell Death in Philadelphia Positive Cells Including Primary CML Stem Cells.

Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPα in p210 BCR/ABL -expressing cells

Requirement of c-Myb for p210 BCR/ABL -dependent transformation of hematopoietic progenitors and leukemogenesis

High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2–dependent suppression of C/EBPα-driven myeloid differentiation

Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Inducible activation of CEBPB , a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

The biology of CML blast crisis

Transcription activation function of C/EBPα is required for induction of granulocytic differentiation

Defective DNA repair in CML

Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation

Versatility of BCR/ABL-expressing leukemic cells in circumventing proapoptotic BAD effects

BCR-ABL Antisense Oligodeoxynucleotide In Vitro Purging and Autologous Bone Marrow Transplantation for Patients With Chronic Myelogenous Leukemia in Advanced Phase

Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment

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American Society of Hematology

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American Society of Hematology

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