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Michael Lübbert
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Journal Articles

Phase 3 study of intensive chemotherapy with or without dasatinib in core-binding factor acute myeloid leukemia

Open Access
Hartmut Döhner, Daniela Späth, Maral Saadati, Walter Fiedler, Katharina S Götze, Elisabeth Koller, Jörg Westermann, Wichard Vogel, Michael Heuser, Michael Lübbert, Hans-Joachim Tischler, Ulrich Germing, Lino Lars Teichmann, Lars Fransecky, Albert Wölfler, David Nachbaur, Bernd Hertenstein, Roland Schroers, Uwe M Martens, Stephanie von Harsdorf, Markus P Radsak, Gregor Aschauer, Stefanie Weißhaar, Andrea Corbacioglu, Anika Schrade, Verena I. Gaidzik, Felicitas R Thol, Peter Paschka, Lars Bullinger, Axel Benner, Konstanze Döhner, Arnold Ganser
Journal: Blood
Blood blood.2025030722.
https://doi.org/10.1182/blood.2025030722
Published: 2026
Includes: Supplemental data
Journal Articles

Does stringent cytoreduction improve survival in myeloproliferative chronic myelomonocytic leukemia? a correlative study on the dacota trial.

Free
Dorothée Selimoglu-Buet, Sylvie Chevret, Valeria Santini, Sylvain Thépot, Margot Morabito, Lionel Ades, Lucie Laplane, Aristoteles Giagounidis, Nathalie Droin, Michael Lübbert, Rosa Sapena, Stanislas Nimubona, Jose Miguel Torregrosa Diaz, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, Franciane Paul, Andrea Patriarca, Aspasia Stamatoulas Bastard, Katharina S. Götze, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux, Eric Solary, Raphael Itzykson
Journal: Blood
Blood (2025) 146 (Supplement 1): 791.
https://doi.org/10.1182/blood-2025-791
Published: 2025
Journal Articles

Low-dose oral decitabine and cedazuridine among patients with low-risk myelodysplastic syndromes

Free
Guillermo Garcia-Manero, Lalit Saini, Amer Zeidan, Abdulraheem Yacoub, Lori Maness, Elie Traer, James Foran, Sanjay Mohan, Michael Lübbert, Tom Lodewyck, Blanca Xicoy, Harshad Amin, Kimo Bachiashvili, Habte Yimer, Nancy Zhu, Haifa Kathrin Al-Ali, Patricia Font Lopez, Guillermo Sanz, Valeria Santini, Jesús Berdeja, Victor Priego, Olatoyosi Odenike, Bert Heyrman, David Valcarcel, Yubing Wan, Winny Chan, Aram Oganesian, Yuri Sano, Harold Keer, Elizabeth Griffiths
Journal: Blood
Blood (2025) 146 (Supplement 1): 790.
https://doi.org/10.1182/blood-2025-790
Published: 2025
Journal Articles

Elevation of fetal hemoglobin is a biomarker for response to decitabine in AML: Results of the AML21 randomized phase III trial of the EORTC leukemia group, gimema and german MDS study group

Free
Julia Stomper, Michal Kicinski, Tobias Ma, Thomas Meyer, Sylvain Chantepie, Richard Noppeney, Mario Luppi, Ernesta Audisio, Laimonas Griškevičius, Andreas Neubauer, Robin Foà, Walter Van der Velden, Anna Candoni, Radovan Vrhovac, Gianluca Gaidano, Marjolein Van Der Poel, Mels Hoogendoorn, Stéphanie Antunes, Frederic Baron, Adriano Venditti, Joop Jansen, Pierre Wijermans, Gerwin A. Huls, Michael Lübbert
Journal: Blood
Blood (2025) 146 (Supplement 1): 1709.
https://doi.org/10.1182/blood-2025-1709
Published: 2025
Journal Articles

Post allo-HCT menin-inhibition enhances graft-versus-leukemia effects by endogenous retrovirus induction in AML and T-cell activation

Free
Viktor Fetsch, Lennard Schwöbel, Ezgi Göknar, Anna-Verena Stell, Marco Punta, Thomas Plenge, Tabea Klaus, Manoj Gupta, Geoffroy Andrieux, Khalid Shoumariyeh, Sophie Pfeiffer, Eyleen Corrales, Lina Schlenke, Hosna Baniadam, Simon Brandl, Massimo Andreis, Michal Remen, Alina Hartmann, Kathleen Grueter, Melissa Zwick, Natalie Koehler, Monika Kuban, Eric Metzger, Christoph Rummelt, Justus Duyster, Melanie Boerries, Maike Hofmann, Julian Faerber, Lukas Braun, Alexander Zähringer, Michael Lübbert, Cristina Toffalori, Luca Vago, Florian Heidel, Susana Minguet, Petya Apostolova, Tobias Feuchtinger, Kristina Maas-Bauer, Franziska Blaeschke, Michael Kühn, H.Th. Marc Timmers, Tobias Wertheimer, Florian Perner, Robert Zeiser
Journal: Blood
Blood (2025) 146 (Supplement 1): 5862.
https://doi.org/10.1182/blood-2025-5862
Published: 2025
Journal Articles

10-day decitabine versus conventional chemotherapy (“3+7”) followed by allografting in AML patients ≥ 60 years: Long-term follow-up results of the randomized phase III trial AML21 of the EORTC leukemia group, GIMEMA and german MDS Study group

Free
Michael Lübbert, Pierre Wijermans, Michal Kicinski, Sylvain Chantepie, Walter Van der Velden, Richard Noppeney, Laimonas Griškevičius, Andreas Neubauer, Martina Crysandt, Radovan Vrhovac, Mario Luppi, Stephan Fuhrmann, Ernesta Audisio, Anna Candoni, Ollivier Legrand, Robin Foà, Gianluca Gaidano, Danielle van Lammeren-Venema, Eduardus Posthuma, Mels Hoogendoorn, Anne Giraut, Stéphanie Antunes, Marian Stevens-Kroef, Joop Jansen, Aniek De Graaf, Fabio Efficace, Emanuele Ammatuna, Jean Pierre Vilque, Ralph Wäsch, Heiko Becker, Nicole Blijlevens, Ulrich Dührsen, Frederic Baron, Stefan Suciu, Sergio Amadori, Adriano Venditti, Gerwin A. Huls
Journal: Blood
Blood (2025) 146 (Supplement 1): 1676.
https://doi.org/10.1182/blood-2025-1676
Published: 2025
Journal Articles

Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML

Available to Purchase
Viktor Fetsch, Lennard Frederik Schwöbel, Ezgi Ozyerli-Goknar, PhD, Anna-Verena Stell, Marco Punta, Thomas Plenge, Tabea Klaus, Manoj K. Gupta, Geoffroy Andrieux, Khalid Shoumariyeh, Sophie Pfeiffer, Eyleen Corrales, Lina Schlenke, Hosna Baniadam, Simon M. Brandl, Massimo Andreis, Michal Remen, Alina Hartmann, Kathleen Grueter, Melissa Zwick, Natalie Köhler, Monika Kuban, Eric Metzger, Christoph Rummelt, Justus Duyster, Melanie Börries, Maike Hofmann, Julian Färber, Lukas M Braun, Alexander Zähringer, Michael Lübbert, Cristina Toffalori, Luca Vago, Florian H Heidel, Susana Minguet, Petya Apostolova, Tobias Feuchtinger, Kristina Maas-Bauer, Franziska Blaeschke, Michael W.M. Kühn, Marc Timmers, Tobias Wertheimer, Florian Perner, Robert Zeiser
Journal: Blood
Blood blood.2025029712.
https://doi.org/10.1182/blood.2025029712
Published: 2025
Includes: Supplemental data
Journal Articles

All- Trans Retinoic Acid (ATRA) Enhances the Antileukemic Activity of Decitabine By Increasing Proteasomal Degradation of MYC in a p53-Independent Manner

Free
Usama-Ur Rehman, Steffen Boettcher, Michael Lübbert
Journal: Blood
Blood (2024) 144 (Supplement 1): 5747.
https://doi.org/10.1182/blood-2024-210676
Published: 2024
Journal Articles

Elevating AML Treatment: Enhancing DNMT1 Inhibition Boosts HMA Therapy

Free
Uta Sabine Martens, Desiree Melanie Redhaber, Geoffroy Andrieux, Usama-Ur Rehman, Michael Lübbert, Justus Duyster, Cornelius Miething
Journal: Blood
Blood (2024) 144 (Supplement 1): 5746.
https://doi.org/10.1182/blood-2024-210326
Published: 2024
Journal Articles

Genocopy of EVI1 -AML with Paraneoplastic Diabetes Insipidus: PRDM16 Overexpression By t(1;2) and Enhancer Hijacking

Free
Julian List, Etienne Sollier, Fiona Brown-Burke, Katherine Kelly, Dietmar Pfeifer, Valeria Shlyakhto, Kristina Maas-Bauer, Christoph Plass, Michael Lübbert
Journal: Blood
Blood (2024) 144 (Supplement 1): 6136.
https://doi.org/10.1182/blood-2024-203866
Published: 2024
Journal Articles

A Prospective, Multicenter Study Assessing Functional and Psychosocial Parameters in AML Patients ≥ 60 Years Receiving Induction Chemotherapy

Free
Sophie-Luise Mersiowsky, Gabriele Ihorst, Valerie Arnold, Michael J. Müller, Olga Grishina, Claudia Schmoor, Hartmut Bertz, Barbara Deschler-Baier, Ulrich Germing, Björn Hackanson, Michael Lübbert
Journal: Blood
Blood (2024) 144 (Supplement 1): 2864.
https://doi.org/10.1182/blood-2024-203583
Published: 2024
Journal Articles

SPARC Stabilizes Integrin α4-VCAM-1 Interactions and Is Regulated By Intracellular Rac in NPM1 -Mutated AML

Free
Driti Ashok, Dennis Raith, Martin Helmstädter, Geoffroy Andrieux, Séverine Kayser, Sangya Chatterjee, Judith Treiber, Khalid Shoumariyeh, Tim Struessmann, Valentin Wenger, Julian Rapp, Jesus Duque Afonso, Michael Lübbert, Robert Zeiser, Melanie Boerries, Justus Duyster, Tanja Nicole Hartmann
Journal: Blood
Blood (2024) 144 (Supplement 1): 1298.
https://doi.org/10.1182/blood-2024-205323
Published: 2024
Journal Articles

Decitabine in older patients with AML: quality of life results of the EORTC-GIMEMA-GMDS-SG randomized phase 3 trial

Free
Clinical Trials & Observations
Fabio Efficace, Michal Kicinski, Corneel Coens, Stefan Suciu, Walter J. F. M. van der Velden, Richard Noppeney, Sylvain Chantepie, Laimonas Griskevicius, Andreas Neubauer, Ernesta Audisio, Mario Luppi, Stephan Fuhrmann, Robin Foà, Martina Crysandt, Gianluca Gaidano, Radovan Vrhovac, Adriano Venditti, Eduardus F. M. Posthuma, Anna Candoni, Frédéric Baron, Olivier Legrand, Andrea Mengarelli, Paola Fazi, Marco Vignetti, Anne Giraut, Pierre W. Wijermans, Gerwin Huls, Michael Lübbert
Journal: Blood
Blood (2024) 144 (5): 541–551.
https://doi.org/10.1182/blood.2023023625
Published: 2024
Includes: Supplemental data
Journal Articles

Treatment of a TP53 isogenic AML Cell Line Model with Decitabine and All Trans -Retinoic Acid (ATRA) Targets MYC for Antileukemic Activity in a p53-Independent Fashion

Free
Usama-Ur Rehman, Steffen Boettcher, Michael Lübbert
Journal: Blood
Blood (2023) 142 (Supplement 1): 5745.
https://doi.org/10.1182/blood-2023-189202
Published: 2023
Journal Articles

Single-Center Experience of Decitabine/Venetoclax in Newly Diagnosed Older AML Patients with Non-Favorable Genetics: Bridging to Allo-HCT or Treatment Continuation

Free
David Alber, Christoph Rummelt, Tim Strüßmann, Andrés Rettig, Valeria Shlyakhto, Paul La Rosée, Martin Henkes, Elizaveta Bubnova, Tobias Ma, Johanna Thomas, Gabriele Ihorst, Claudia Wehr, Reinhard Marks, Heiko Becker, Justus Duyster, Ralph Wäsch, Jürgen Finke, Michael Lübbert
Journal: Blood
Blood (2023) 142 (Supplement 1): 7091.
https://doi.org/10.1182/blood-2023-187581
Published: 2023
Journal Articles

The Genomic Landscape and Its Clinical Implication in NPM1 -Mutated AML Patients: A Study within the AMLSG 09-09 Clinical Trial

Free
Sibylle Cocciardi, Nina Weiß, Maral Saadati, Sabrina Skambraks, Daniela Weber, Isabelle Schneider, Annika Meid, Sophia Aicher, Kathrin Bengesser-Kuhn, Andrea Corbacioglu, Verena I. Gaidzik, Frauke Theis, Walter Fiedler, Michael Kühn, Ulrich Germing, Karin T. Mayer, Michael Lübbert, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Axel Benner, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2023) 142 (Supplement 1): 4311.
https://doi.org/10.1182/blood-2023-185566
Published: 2023
Journal Articles

Decider-2: Prospective Randomized Multicenter Phase III Trial of Decitabine and Venetoclax Administered in Combination with All- Trans Retinoic Acid (ATRA) or Placebo in Patients with Acute Myeloid Leukemia Who Are Ineligible for Induction Chemotherapy

Free
Michael Lübbert, Claudia Schmoor, Olga Grishina, Christoph Rummelt, Johanna Thomas, Michael Heuser, Konstanze Döhner, Hartmut Döhner, Heiko Becker, Ralph Wäsch
Journal: Blood
Blood (2023) 142 (Supplement 1): 1495.
https://doi.org/10.1182/blood-2023-181871
Published: 2023
Journal Articles

Identification of Epigenetic Modifiers Essential for Growth and Survival of AML1/ETO-Positive Leukemia

Free
Jesus Duque Afonso, Veratti Pia, Usama-Ur Rehman, Heike Herzog, Jan Mitschke, Gabriele Greve, Julian Eble, Bettina Berberich, Johanna Thomas, Milena Pantic, Miguel Waterhouse, Gaia Gentile, Olaf Heidenreich, Cornelius Miething, Michael Lübbert
Journal: Blood
Blood (2023) 142 (Supplement 1): 5687.
https://doi.org/10.1182/blood-2023-187372
Published: 2023
Journal Articles

Measurable Residual Disease Assessment in Patients with Acute Myeloid Leukemia Aged ≥60 Years Treated with a 10-Day Decitabine Schedule Versus Intensive Chemotherapy in the AML21 Study (NCT02172872)

Free
Adriano Venditti, Michal Kicinski, Ernesta Audisio, Mario Luppi, Gianluca Gaidano, Robin Foà, Anna Candoni, Andrea Mengarelli, Attilio Olivieri, Annalisa Imovilli, Maurizio Musso, Paolo De Fabritiis, Eliana Zuffa, Nicola Cascavilla, Agostino Tafuri, Maria Ilaria Del Principe, Stefan Suciu, Anne Giraut, Stéphanie Antunes, Pierre W. Wijermans, Michael Lübbert, Geert A. Huls, Marco Vignetti, Francesco Buccisano
Journal: Blood
Blood (2023) 142 (Supplement 1): 2948.
https://doi.org/10.1182/blood-2023-184851
Published: 2023
Journal Articles

Oral Decitabine/Cedazuridine Vs Intravenous Decitabine for Acute Myeloid Leukemia: Final Results of a Randomized, Crossover, Registration-Enabling, Pharmacokinetics Study

Free
Klaus Geissler, Zdenek Koristek, Teresa Bernal Del Castillo, Jan Novak, Gabriela Rodriguez Macias, Stephan Metzelder, Arpad Illes, Agnes Nagy, Jiří Mayer, Montserrat Arnan Sangerman, Mary-Margaret Keating, Jürgen Krauter, Monia Lunghi, Nicola Fracchiolla, Uwe Platzbecker, Valeria Santini, Danna Chan, Beloo Mirakhur, Yuri Sano, Aram Oganesian, Harold N. Keer, Michael Lübbert
Journal: Blood
Blood (2023) 142 (Supplement 1): 1538.
https://doi.org/10.1182/blood-2023-173092
Published: 2023