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Journal Articles

Real World Efficacy and Safety of Momelotinib for Myelofibrosis: Evaluation of a UK-Wide Study Confirms 40% Anaemia Response Rate in a Non-Clinical Trial Cohort

Alexandros Rampotas, Elena Torre, Luke Carter-Brzezinski, Andrea Duminuco, Llywelyn Cadman-Davies, Ashlyn Chee, Fotios Panitsas, Samah Alimam, Dragana Milojkovic, Richard Kaczmarski, Louise Fraser, Rebecca Frewin, Kate Foley, Catherine Hockings, Alesia Khan, Rhys Williams, Jennifer Ryan, Kawai Yip, Kyaw Htin Thaw, Amna Sheikh, Frances Wadelin, Anna L Godfrey, Chun Huat Teh, Andrew J. Wilson, Jonathan Lambert, Adam J Mead, Donal P McLornan, Andrew J Innes, Andrew McGregor, Tim Somervaille, Claire Harrison, Patrick Harrington, Bethan Psaila
Journal: Blood
Blood (2024) 144 (Supplement 1): 1804.
https://doi.org/10.1182/blood-2024-207251
Published: 2024
Journal Articles

Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib

Clinical Trials & Observations
Alex Rampotas, Luke Carter-Brzezinski, Tim C. P. Somervaille, James Forryan, Fotios Panitsas, Claire Harrison, Ruth Witherall, Andrew J. Innes, Louise Wallis, Naumann M. Butt, Bethan Psaila, Adam J. Mead, Matthew Carter, Anna L. Godfrey, Heather Laing, Mamta Garg, Sebastian Francis, Joanne Ewing, Chun Huat Teh, Hannah Bibi Cowen, Peter Dyer, Conall McConville, Frances Wadelin, Ali Sahra, Andrew McGregor, Elizabeth Kulakov, Donal P. McLornan, Jonathan Lambert
Journal: Blood
Blood (2024) 143 (2): 178–182.
https://doi.org/10.1182/blood.2023022345
Published: 2024
Includes: Supplemental data
Journal Articles

Polygenic Germline Risk of Common Haematological Traits Drives Clonal Selection on JAK2 V617F and Development of Myeloproliferative Neoplasms

Jyoti Nangalia, Jing Guo, Klaudia Walter, Pedro Quiros, Muxin Gu, E Joanna Baxter, John Danesh, Emanuele Di Angelantonio, David Roberts, Paola Guglielmelli, Claire N Harrison, Anna L Godfrey, Anthony R Green, George Vassiliou, Dragana Vuckovic, Nicole Soranzo
Journal: Blood
Blood (2023) 142 (Supplement 1): 863.
https://doi.org/10.1182/blood-2023-189551
Published: 2023
Journal Articles

Essential thrombocythemia: challenges in clinical practice and future prospects

Anna L. Godfrey, Anna C. Green, Claire N. Harrison
Journal: Blood
Blood (2023) 141 (16): 1943–1953.
https://doi.org/10.1182/blood.2022017625
Published: 2023
Journal Articles

Ruxolitinib Versus Best Available Therapy for PV Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial

Claire Harrison, Jyoti Nangalia, Rebecca H. Boucher, Aimee Jackson, Christina Yap, Jennifer O'Sullivan, Sonia Fox, Isaak Ailts, Amylou C Dueck, Holly L. Geyer, Ruben Mesa, William Dunn, Eugene Nadezhdin, Natalia Curto-Garcia, Anna Green, Bridget Wilkins, Jason Coppell, John Laurie, Mamta Garg, Joanne Ewing, Steve Knapper, Josephine Crowe, Ioannis Koutsavlis, Anna L Godfrey, Siamak Arami, Mark W. Drummond, Jennifer Byrne, Fiona J Clark, Carolyn Mead-Harvey, Joanna E Baxter, Mary Frances McMullin, Adam J Mead
Journal: Blood
Blood (2022) 140 (Supplement 1): 1781–1783.
https://doi.org/10.1182/blood-2022-157273
Published: 2022
Journal Articles

Disease Characteristics and Outcomes of Non-Melanoma Skin Cancers in Myeloproliferative Neoplasm (MPN) Patients Treated with Ruxolitinib

Alexandros Rampotas, Luke Carter-Brzezinski, Tim C.P Somervaille, James Forryan, Bethan Psaila, Adam J Mead, Mamta Garg, Heather Laing, Louise Wallis, Nauman M Butt, Conal McConville, Ali Sahra, Andrew McGregor, Hannah Cowan, Andrew J. Innes, Joanne Ewing, Matthew Carter, Peter Dyer, Chun Huat Teh, Sebastian Francis, Frances Wadelin, Claire Harrison, Anna L Godfrey, Elizabeth Kulakov, Donal P. McLornan, Jonathan Lambert
Journal: Blood
Blood (2022) 140 (Supplement 1): 9721–9723.
https://doi.org/10.1182/blood-2022-162417
Published: 2022
Journal Articles

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Clinical Trials & Observations
Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J. M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou
Journal: Blood
Blood (2022) 140 (14): 1650–1655.
https://doi.org/10.1182/blood.2022015721
Published: 2022
Includes: Supplemental data
Journal Articles

Exploring Genotype:Phenotype Correlations at Baseline and at One Year for ET and PV Patients in the Majic Study

Chandan Saha, Carolyn Mead-Harvey, Adam J. Mead, Rebecca H. Boucher, Sonia Fox, Isaak Ailts, Christina Yap, Aimee E Jackson, Joanne Ewing, Jason Coppell, Steve Knapper, Mark W. Drummond, Anna L Godfrey, Amylou C. Dueck, Ruben A. Mesa, Robyn Scherber, Mary Frances McMullin, Holly L. Geyer, Claire N. Harrison
Journal: Blood
Blood (2021) 138 (Supplement 1): 1507.
https://doi.org/10.1182/blood-2021-151568
Published: 2021
Journal Articles

Changes in Clonal Architecture Inform MPN Disease Course in Advance of Phenotypic Manifestations

Joe S Lee, Nicholas Williams, Joanna E Baxter, Anna L Godfrey, Kate Milne, Karim Mane, David C Wedge, Peter J. Campbell, Anthony R Green, Jyoti Nangalia
Journal: Blood
Blood (2021) 138 (Supplement 1): 3590.
https://doi.org/10.1182/blood-2021-152436
Published: 2021
Journal Articles

Correlation of Quality of Life between Treatment Outcomes in the Majic Study Which Compared Ruxolitinib to Best Available Therapy in Polycythemia Vera

Isaak Ailts, Carolyn Mead-Harvey, Adam J. Mead, Sonia Fox, Rebecca H. Boucher, Christina Yap, Chandan Saha, Robyn Scherber, Aimee Jackson, Joanne Ewing, Jason Coppell, Steve Knapper, Mark W. Drummond, Anna L Godfrey, Amylou C. Dueck, Mary Frances McMullin, Ruben A. Mesa, Claire N. Harrison, Holly L. Geyer
Journal: Blood
Blood (2021) 138 (Supplement 1): 3644.
https://doi.org/10.1182/blood-2021-147637
Published: 2021
Journal Articles

Clonal hematopoiesis and therapy-related myeloid neoplasms following neuroblastoma treatment

Clinical Trials & Observations
Tim H. H. Coorens, Grace Collord, Wanhua Lu, Emily Mitchell, Jannat Ijaz, Thomas Roberts, Thomas R. W. Oliver, G. A. Amos Burke, Michael Gattens, Emmy Dickens, Jyoti Nangalia, Marc Tischkowitz, John Anderson, Adam Shlien, Anna L. Godfrey, Matthew J. Murray, Sam Behjati
Journal: Blood
Blood (2021) 137 (21): 2992–2997.
https://doi.org/10.1182/blood.2020010150
Published: 2021
Includes: Supplemental data
Journal Articles

Driver Mutation Acquisition in Utero and Childhood Followed By Lifelong Clonal Evolution Underlie Myeloproliferative Neoplasms

Nicholas Williams, PhD, Joe Lee, MBBS, Luiza Moore, PhD, Joanna E Baxter, PhD, James Hewinson, PhD, Kevin J Dawson, PhD, Andrew Menzies, MSc, Anna L Godfrey, PhD, Anthony R Green, PhDFRCPath FMedSci, Peter J Campbell, PhD, Jyoti Nangalia, MBBChir
Journal: Blood
Blood (2020) 136 (Supplement_2): LBA-1.
https://doi.org/10.1182/blood-2020-143813
Published: 2020
Journal Articles

Effects of Tamoxifen on the Mutant Allele Burden and Disease Course in Patients with Myeloproliferative Neoplasms - Results of the Tamarin Study

Claire Harrison, DM, FRCP, FRCPath, Joanna Baxter, PhD, Rebecca H. Boucher, BSc, MSc, PhD, Thomas McKerrell, MD PhD, Aimee Jackson, BSc, MSc, Rachel S Fletcher, PhD, Adam J. Mead, MD PhD, Steve Knapper, BMBCh, MRCP, FRCPath, DM, Joanne Ewing, MD PhD, Nauman M Butt, MD, Manish Jain, MBBS, MRCP, FRCpath, Sebastian Francis, MBChB, FRCPath, MD, Fiona J Clark, FRCP, FRCPath, Jason Coppell, MBBS, Mary Frances McMullin, MDFRCP, FRCPath, Frances Wadelin, MB ChB, PhD FRCPath, Srinivasan Narayanan, FRCP, FRCPath, Dragana Milojkovic, Mark W. Drummond, PhD FRCPath, Mallika Sekhar, MBBS, MD, Maike Paramor, James Roberts, BSc, Rachel Glover, BSc, Erica Harris, MSc, Luigi Grassi, PhD, Alba Rodriguez-Meira, PhD, Jason Carroll, PhD FMedSci, José-Ezequiel Martín, PhD, Giuditta Corbizi Fattori, PhD, Zijian Fang, BSc, Anna L Godfrey, BMBCh, PhD, Simón Méndez-Ferrer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–35.
https://doi.org/10.1182/blood-2020-134764
Published: 2020
Journal Articles

Niche Heterogeneity Impacts Evolution of Myeloproliferative Neoplasms Driven By the Same Oncogenic Pathway

Claudia Korn, PhD, Justyna Rak, PhD, Andrés García-García, PhD, Claire Fielding, Reema Khorshed, PhD, Sara González-Antón, Juan Li, PhD, Ruggiero Norfo, PhD, E Joanna Baxter, PhD, Thomas McKerrell, MD PhD, Thomas Roberts, Hesham Eldaly, MD, Anna L Godfrey, PhD, Aracely Castillo-Venzor, Anjali Kusumbe, PhD, Adam J. Mead, MD PhD, Anthony R Green, David Kent, PhD, Cristina Lo Celso, PhD, Simon Mendez-Ferrer, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 98.
https://doi.org/10.1182/blood-2018-99-113495
Published: 2018
Journal Articles

Hydroxycarbamide Plus Aspirin Vs Aspirin Alone in Intermediate Risk Essential Thrombocythemia: Results of the PT-1 International, Prospective, Randomized Clinical Trial

Anna L. Godfrey, BMBCh, PhD MRCP, FRCPath, Peter J Campbell, MD PhD, Cathy MacLean, BSc, MSc, MBA, Georgina Buck, BSc, MSc, Clare L. East, BSc, Julia Cook, BSc, Julie Temple, BSc, Bridget S. Wilkins, MD FRCPath, Keith Wheatley, DPhil, Jyoti Nangalia, MBBChir, MA, MRCP, FRCPath, PhD, Jacob Grinfeld, MBChB, BSc, MRCP, FRCPath, Mary Frances Frances McMullin, MB,Bch BAO, MD FRCPath, Cecily Forsyth, MB BS, Jean-Jacques Kiladjian, MD PhD, Anthony R. Green, FRCP, FRCPath, FMed Sci, Claire N. Harrison, BMBCh, DM, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 319.
https://doi.org/10.1182/blood.V130.Suppl_1.319.319
Published: 2017
Journal Articles

Personalized Prognostic Predictions for Patients with Myeloproliferative Neoplasms through Integration of Comprehensive Genomic and Clinical Information

Jacob Grinfeld, MBChB, BSc, MRCP, FRCPath, Jyoti Nangalia, MBBChir, MA, MRCP, FRCPath, PhD, E Joanna Baxter, PhD, Anna L. Godfrey, BMBCh, PhD MRCP, FRCPath, Paola Guglielmelli, MD PhD, Rob Cantrill, PhD, David Wedge, PhD, Nicos Angelopoulos, PhD, Gunes Gundem, PhD, Charlie Massie, PhD, Elli Papaemmanuil, PhD, Cathy MacLean, BSc, MSc, MBA, Julia Cook, BSc, Francesca Lauren Nice, PhD MSc, Christen Lykkegaard Andersen, PhD, Hans Carl Hasselbalch, MD Professor, DMSc, Mary Frances McMullin, MB,Bch BAO, MD FRCPath, Alessandro M. Vannucchi, Claire N. Harrison, BMBCh, DM, FRCP, FRCPath, Moritz Gerstung, PhD, Peter J Campbell, MD PhD, Anthony R Green, PhD FRCP, FRCPath, FMedSci
Journal: Blood
Blood (2017) 130 (Supplement 1): 491.
https://doi.org/10.1182/blood.V130.Suppl_1.491.491
Published: 2017
Journal Articles

Nongenetic stochastic expansion of JAK2V617F -homozygous subclones in polycythemia vera?

Anna L. Godfrey, Jyoti Nangalia, E. Joanna Baxter, Charles E. Massie, David G. Kent, Elli Papaemmanuil, Peter J. Campbell, Anthony R. Green
Journal: Blood
Blood (2014) 124 (22): 3332–3334.
https://doi.org/10.1182/blood-2014-09-603043
Published: 2014
Includes: Supplemental data
Journal Articles

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Juan Li, David G. Kent, Anna L. Godfrey, Harriet Manning, Jyoti Nangalia, Athar Aziz, Edwin Chen, Kourosh Saeb-Parsy, Juergen Fink, Rachel Sneade, Tina L. Hamilton, Dean C. Pask, Yvonne Silber, Xiaodong Zhao, Cedric Ghevaert, Pentao Liu, Anthony R. Green
Journal: Blood
Blood (2014) 123 (20): 3139–3151.
https://doi.org/10.1182/blood-2013-06-510222
Published: 2014
Includes: Supplemental data
Journal Articles

The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients

Jyoti Nangalia, MBBChir FRCPath, Charles Massie, PhD, E Joanna Baxter, PhD, Francesca L Nice, MRes, Gunes Gundem, PhD, David Wedge, PhD, Edward Avezov, PhD, Juan Li, PhD, Karoline Kollmann, PhD, David G. Kent, PhD, Athar Aziz, PhD, Anna L Godfrey, BMBCh FRCPath, Jonathan Hinton, MSc, Inigo Martincorena, PhD, Peter Van Loo, PhD, Amy V Jones, PhD, Paola Guglielmelli, PhD MD, Patrick Tarpey, PhD, Heather P Harding, PhD, John D Fitzpatrick, BA, Calum T Goudie, BA, Christina A Ortmann, MD, Stephen J Loughran, PhD, Keiran Raine, MSc, David Jones, MSc, Adam Butler, MSc, Jon W Teague, MSc, Sarah O'Meara, Stuart McLaren, Michele Bianchi, Yvonne Silber, MSc, Danai Dimitropolou, BSc, David Bloxham, MSc FRCPath, Laura J Mudie, BSc, Mark Maddison, BSc, Ben Robinson, BSc, Clodagh Keohane, MD, Cathy MacLean, MSc, Kate Hill, BM BS, Kim H. Orchard, MBBS, PhD, FRCP, FRCPath, Sudhir Tauro, PhD, Ming-Qing Du, MB, PhD, Mel Greaves, PhD, FRS, David Bowen, MD, PhD, Brian Huntly, MBChB FRCPath PhD, Claire N Harrison, DM, FRCP, FRCPath, Nicholas C.P. Cross, PhD, FRCPath, David Ron, MD, Alessandro M Vannucchi, MD, Elli Papaemmanuil, PhD, Peter J. Campbell, PhD, Anthony R Green, FRCPath FMedSci
Journal: Blood
Blood (2013) 122 (21): LBA-2.
https://doi.org/10.1182/blood.V122.21.LBA-2.LBA-2
Published: 2013
Journal Articles

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

Brief Report
Anna L. Godfrey, Edwin Chen, Francesca Pagano, Christina A. Ortmann, Yvonne Silber, Beatriz Bellosillo, Paola Guglielmelli, Claire N. Harrison, John T. Reilly, Frank Stegelmann, Fontanet Bijou, Eric Lippert, Mary F. McMullin, Jean-Michel Boiron, Konstanze Döhner, Alessandro M. Vannucchi, Carlos Besses, Peter J. Campbell, Anthony R. Green
Journal: Blood
Blood (2012) 120 (13): 2704–2707.
https://doi.org/10.1182/blood-2012-05-431791
Published: 2012
Includes: Supplemental data