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Journal Articles

Efficacy and Safety of Lenalidomide, PD-1 Monoclonal Antibodies Combined with Orelabrutinib in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Multicenter, Open-Label, Single-Arm, Phase II Study

Lingling Wang, Yongfen Huang, Hui Chen, Hao Xu, Yuexin Cheng, Yuqing Miao
Journal: Blood
Blood (2024) 144 (Supplement 1): 6488.
https://doi.org/10.1182/blood-2024-198309
Published: 2024
Journal Articles

Interferon-Activated Gene Signatures Associate with Chemotherapy Resistance and Sensitivity to JAK-Inhibition in Refractory ETP-ALL

Jason Xu, Jonathan Sussman, Austin Yang, Satoshi Yoshimura, Changya Chen, Omar Elghawy, Tiffaney Vincent, Caroline Diorio, Shovik Bandyopadyay, Jianzhong Hu, Alexander Lai Li, Gregory M. Chen, Chia-Hui Chen, Rawan Shraim, Haley Newman, Yang Ding, Elizabeth Li, Wenbao Yu, Anusha Thadi, Kyung Jin Ahn, Petri Pölönen, Abdelrahman Elsayed, David Frank, Elizabeth A. Raetz, Mignon L. Loh, Brent L. Wood, Stuart S. Winter, Kimberly P. Dunsmore, Meenakshi Devidas, Chunxu Qu, Stanley Pounds, Stephen P. Hunger, Charles G. Mullighan, Jun J. Yang, Kai Tan, David T. Teachey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1464.
https://doi.org/10.1182/blood-2024-211090
Published: 2024
Journal Articles

A Multicenter Clinical Study of Cccg - APL-2017 in the Treatment of Children with Acute Promyelocytic Leukemia

Lixian Chang, Ju GAO, Xiaoying Lei, Yingyi He, Shuquan Zhuang, Chunhuai Li, Kaizhi Weng, Lingzhen Wang, Xia Guo, Qihui Liu, Pengfei Wang, Yong Zhuang, Mei Yan, Wei Liu, Hui Chen, Min Zhang, Shuhong Shen, Xiaofan Zhu, Xiuli Ju, Li Zhang, Zhuo Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2899.
https://doi.org/10.1182/blood-2024-203264
Published: 2024
Journal Articles

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Jihan Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia Hui Chen, Anusha Thadi, Changya Chen, Jason Xu, Melissa Reichart, Vinodh Pillai, Oraine Snaith, Derek Oldridge, Siddharth Bhattacharyya, Ivan Maillard, Martin Carroll, Charles Nelson, Ling Qin, Kai Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4072.
https://doi.org/10.1182/blood-2023-179280
Published: 2023
Journal Articles

Progenitor Sub-Populations in Treatment Resistant T-ALL

Jason Xu, Changya Chen, Tiffaney L. Vincent, Petri Pölönen, Abdelrahman Elsayed, Jianzhong Hu, Satoshi Yoshimura, Wenbao Yu, Chia-hui Chen, Elizabeth Li, Rawan Shraim, Marieke Lavaert, Haley Newman, Yang-yang Ding, Anusha Thadi, Kyung Jin Ahn, Jacqueline Peng, Chujie Gong, Yusha Sun, Shovik Bandyopadhyay, David Frank, Mignon L. Loh, Elizabeth A. Raetz, Zhiguo Chen, Brent L. Wood, Meenakshi Devidas, Kimberly P. Dunsmore, Stuart S. Winter, Gang Wu, Avinash Bhandoola, Stanley B. Pounds, Stephen P. Hunger, Jun J. Yang, Charles G. Mullighan, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1724–1726.
https://doi.org/10.1182/blood-2022-166521
Published: 2022
Journal Articles

Single-Cell Pan-Cancer Analysis Reveals Treatment Resistance Stem/Progenitor-like Subpopulation in the High-Risk Pediatric Leukemia

Changya Chen, Jason Xu, Tiffaney L. Vincent, Wenbao Yu, Yang Y Ding, Chia-hui Chen, Samuel Kim, Elizabeth Li, Shovik Bandyopadhyay, Petri Pölönen, Abdelrahman Elsayed, Haley Newman, Brent L. Wood, Jianzhong Hu, Rawan Shraim, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Stanley B. Pounds, Jun J. Yang, Charles G. Mullighan, David Frank, Kathrin M. Bernt, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1273–1274.
https://doi.org/10.1182/blood-2022-167057
Published: 2022
Journal Articles

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2022) 139 (14): 2198–2211.
https://doi.org/10.1182/blood.2021013442
Published: 2022
Includes: Supplemental data
Journal Articles

Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis

Hui Chen, Min Zhou, Huiying Shu, Weiqing Su, Liuming Yang, Liang Li, Beng H Chong, Mo Yang
Journal: Blood
Blood (2021) 138 (Supplement 1): 4288.
https://doi.org/10.1182/blood-2021-152162
Published: 2021
Journal Articles

Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Hao Wu, Patrick A. Brown, Erin Guest, David M Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2021-146102
Published: 2021
Journal Articles

Reference Mapping Pediatric Leukemia Using Single Cell Multiomic Atlas of Pediatric Hematopoiesis

Jason Xu, Changya Chen, Tiffaney Vincent, Elizabeth Li, Yusha Sun, Chia-hui Chen, David Frank, David T. Teachey, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3265.
https://doi.org/10.1182/blood-2021-153428
Published: 2021
Journal Articles

Treatment Resistance in ETP-ALL Is Associated with Progenitor-like Arrest State

Changya Chen, Jason Xu, Tiffaney Vincent, Chia-hui Chen, Elizabeth Li, Yusha Sun, Jackie Peng, Rawan Shraim, Anusha Thadi, Sydney D'Amaddio, David Teachey, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 618.
https://doi.org/10.1182/blood-2021-153291
Published: 2021
Journal Articles

GPS2 promotes erythroid differentiation by control of the stability of EKLF protein

Wen-Bing Ma, Xiao-Han Wang, Chang-Yan Li, Huan-Huan Tian, Jie Zhang, Jun-Jie Bi, Guang-Ming Ren, Shou-Song Tao, Xian Liu, Wen Zhang, Dong-Xu Li, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Xiao-Ming Yang, Rong-Hua Yin
Journal: Blood
Blood (2020) 135 (25): 2302–2315.
https://doi.org/10.1182/blood.2019003867
Published: 2020
Includes: Supplemental data
Journal Articles

Novel V1551L Mutation in SAMD9L Inhibits Cell Cycle Progression and Results in Pancytopenia That Progresses to MDS with Monosomy 7

Rebecca Ortolano, MD, Dina S. Parekh, MD, Benjamin J Rosen, MD, Victoria Bryant, PhD MSc, Dong-Hui Chen, PhD, Jeffery M. Klco, MD PhD, Wendy Herlihy Raskind, MD PhD, Kenneth Lieuw, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3863.
https://doi.org/10.1182/blood-2018-99-120250
Published: 2018
Journal Articles

Quantification of IGF-1 Receptor May be Useful in the Differential Diagnosis of Essential Thrombocytosis from Reactive Thrombocytosis- Suggested to Add IGF-1Receptor Quantification As the Minor Criteria for the Diagnosis of ET

Guanfang Shi, PhD, Hui Chen, MD, Andrei Bandarchuk, MD, Ching Wong, MD, Vladimir K. Gotlieb, MD, Madhumati Kalavar, MD, Jen-Chin Wang, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5291.
https://doi.org/10.1182/blood.V130.Suppl_1.5291.5291
Published: 2017
Journal Articles

Derangements of Toll-like Receptors, Inflammatory Cytokines, and Reactive Oxygen Species in Philadelphia Chromosome-Negative Myeloproliferative Neoplasm: Implicate Roles of Inflammation in the Pathogenesis

Guanfang Shi, MD, Hui Chen, MD PhD, Cherif Abdelmalek, MD, Andrei Bandarchuk, MD, Abdullah Khawer Mahmood, MD MBBS, Wong Ching, Madhumati Kalavar, MD, Vladimir Gotlieb, MD, Tony W. Cheung, MD, Jen-Chin Wang, MD
Journal: Blood
Blood (2016) 128 (22): 1945.
https://doi.org/10.1182/blood.V128.22.1945.1945
Published: 2016
Journal Articles

TLR-2 Signal Pathway Is Enhanced in Myeloproliferative Neoplasm - Related to the Increased Infammatory Cytokine and Pathogenesis?

Guanfang Shi, Maryna Yarotska, MD, Hui Chen, MD PhD, Abdelmalek Cherif, MD, Ching Wong, MD, Madhumati Kalavar, MD, Vladimir Gottlib, MD, Jen-Chin Wang, MD
Journal: Blood
Blood (2015) 126 (23): 5202.
https://doi.org/10.1182/blood.V126.23.5202.5202
Published: 2015
Journal Articles

SIRPαFc, a CD47-Blocking Cancer Immunotherapeutic, Sensitizes Malignant B Cells to Macrophage-Mediated Destruction

Natasja Nielsen Viller, Saman Maleki Vareki, Karen Dodge, Hui Chen, Vivian Lee, Vien Chai, Xinli Pang, Mark Wong, Suzanne Trudel, MD, Rene Figueredo, Macarena Pampillo, James Koropatnick, Penka S. Petrova, Robert A. Uger
Journal: Blood
Blood (2015) 126 (23): 2191.
https://doi.org/10.1182/blood.V126.23.2191.2191
Published: 2015
Journal Articles

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner

Weiwei Yi, Xuelian Hu, Zhiyang Chen, Leiming Liu, Yuan Tian, Hui Chen, Yu-sheng Cong, Fan Yang, Lianfeng Zhang, Karl Lenhard Rudolph, Zhixin Zhang, Yong Zhao, Zhenyu Ju
Journal: Blood
Blood (2015) 126 (5): 620–628.
https://doi.org/10.1182/blood-2015-02-624114
Published: 2015
Includes: Supplemental data
Journal Articles

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang, Edimara S. Reis, Hui Chen, Patrizia Ricci, Zhuoer Lin, Caterina Pascariello, Maddalena Raia, Michela Sica, Luigi Del Vecchio, Fabrizio Pane, Florea Lupu, Rosario Notaro, Ranillo R. G. Resuello, Robert A. DeAngelis, John D. Lambris
Journal: Blood
Blood (2014) 123 (13): 2094–2101.
https://doi.org/10.1182/blood-2013-11-536573
Published: 2014
Includes: Supplemental data
Journal Articles

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Daniel Ricklin, Ph.D., Antonio M. Risitano, MD, PhD, Edimara S. Reis, Ph.D., Patrizia Ricci, Yijun Huang, Ph.D., Zhuoer Lin, Ph.D., Hui Chen, Ph.D., Caterina Pascariello, Maddalena Raia, Luigi Del Vecchio, MD, Fabrizio Pane, MD, Ranillo R. G. Resuello, D.V.M., Robert A. DeAngelis, Ph.D., John D. Lambris, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1239.
https://doi.org/10.1182/blood.V122.21.1239.1239
Published: 2013