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Ewa Lech Marańda
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Journal Articles

MRD-Driven Venetoclax and Rituximab Combination in Previously Untreated Chronic Lymphocytic Leukemia: First Results of the Prospective, Multicenter, Phase II Trial of the Polish Adult Leukemia Group (VERITA PALG-CLL5)

Krzysztof Jamroziak, Elzbieta Iskierka-Jazdzewska, Sebastian Giebel, Kamil Wisniewski, Joanna Drozd-Sokolowska, Tadeusz Robak, Justyna Rybka, Weronika Piszczek, Monika Joks, Anna Paulina Dabrowska-Iwanicka, Andrzej Mital, Paweł Steckiewicz, Ewa Lech-Maranda, Marcin Jasinski, Marcin Rymko, Dawid Marciniak, Tomasz Wrobel, Lidia Gil, Joanna Romejko-Jarosinska, Dorota Kruk-Kwapisz, Agnieszka Chudy, Krzysztof Giannopoulos, Tomasz Stoklosa, Bartosz Michal Pula
Journal: Blood
Blood (2024) 144 (Supplement 1): 3242.
https://doi.org/10.1182/blood-2024-201076
Published: 2024
Journal Articles

Standard Non-Intensive Chemotherapy Vs Venetoclax-Azacytidine (Ven-AZA) for Unfit AML Patients with Therapy-Related Acute Myeloid Leukaemia (t-AML) - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Lukasz Bolkun, Judyta Strzala, Magdalena Czemerska, Bozena Katarzyna Budziszewska, Aleksandra Golos, Anna Holownia, Wanda Knopinska-Posluszny, Ewa Lech Marańda, Jaroslaw Piszcz, Janusz Halka, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 6056.
https://doi.org/10.1182/blood-2024-207883
Published: 2024
Journal Articles

A Polish Adult Leukemia Group (PALG) Prospective International Randomized Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) in Acute Myeloid Leukemia (AML) Patients ≤ 60 Years Old (PALG-AML1/2016) - Topline Results

Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Libura, Sebastian Giebel, Michał Soin, Damian Mikulski, Kacper Kościelny, Wojciech Fendler, Magdalena Czemerska, Agata Majchrzak, Anna Kopinska, Krzysztof Woźniczka, Martyna Włodarczyk, Karol Wójcik, Grzegorz Helbig, Małgorzata Raźny, Marta Sobas, Tomasz Wróbel, Donata Szymczak, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elzbieta Patkowska, Marzena Wątek, Jolanta Wozniak, Ewa Lech-Maranda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Grzegorz Charlinski, Jerzy Holowiecki, Andi Rustani, Ameenah Sukkur, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin D. Kaner, Michal Bar-Natan, Jonathan Canaani, Ellen K. Ritchie, Monica L Guzman, Sylvie D Freeman, Gail J. Roboz
Journal: Blood
Blood (2024) 144 (Supplement 1): 970.
https://doi.org/10.1182/blood-2024-202365
Published: 2024
Journal Articles

The Premature Reduction of Venetoclax in an Initial Cycle of Ven-AZA Regimen for Unfit AML Patients Leads to Shortened Overall Survival - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Lukasz Bolkun, Bozena Katarzyna Budziszewska, Bartosz Michal Pula, Joanna Drozd-Sokolowska, Krzysztof Mądry, Paweł Główka, Marta Sobas, Kinga Krawiec, Piotr Strzalka, Sylwia Kościołek-Zgódka, Jaroslaw Piszcz, Janusz Halka, Edyta Cichocka, Kamila Kruczkowska-Tarantowicz, Judyta Strzala, Agnieszka Mosler, Ewa Lech Marańda, Aleksandra Butrym, Sebastian Giebel, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2024-208144
Published: 2024
Journal Articles

Stratification Using ECOG, ADL and HCT-CI Scales, but Not CGA Enables Identifying Elderly AML Patients Fit for Intensive Chemotherapy - a Multicenter Study from Polish Adult Leukemia Group

Bozena Katarzyna Budziszewska, Michał Łomiak, Joanna Barankiewicz, Elzbieta Patkowska, Grzegorz Helbig, Lukasz Bolkun, Anna Irga-Staniukiewicz, Anna Kiżewska, Agnieszka Piekarska, Anna Koclęga, Agnieszka Pluta, Marta Kuydowicz, Sylwia Kościółek- Zgódka, Edyta Cichocka, Agata Malenda, Karol Wójcik, Tomasz Gromek, Piotr Małecki, Sebastian Grosicki, Agnieszka Wierzbowska, Ewa Lech-Maranda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4218.
https://doi.org/10.1182/blood-2023-189713
Published: 2023
Journal Articles

The Outcome of the First-Line Therapy of Patients with Follicular Lymphoma during COVID-19 Pandemic. a Real-World Data from the Polish Lymphoma Research Group (PLRG)

Ewa Paszkiewicz-Kozik, Monika Palka, Malgorzata Debowska, Marcin Szymanski, Agnieszka Konska, Elzbieta Kalicinska, Agata Tyczynska, Joanna Drozd-Sokolowska, Agnieszka Giza, Ryszard Swoboda, Anna Paulina Dabrowska-Iwanicka, Marta Morawska, Justyna Owczarek-Kaczmarek, Lukasz Bolkun, Anna Kopinska, Ewa Wasik-Szczepanek, Dominika Maksylewicz, Anna Wisniewska, Lukasz Targonski, Edyta Subocz, Pawel Steckiewicz, Katarzyna Domanska-Czyz, Beata Ostrowska, Monika Swierkowska, Jacek Krzanowski, Agnieszka Druzd-Sitek, Ewa Mroz-Zycinska, Joanna Romejko-Jarosinska, Iwona Hus, Monika Dlugosz-Danecka, Ewa Lech-Maranda, Tomasz Wrobel, Jan M. Zaucha, Jan Walewski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1679.
https://doi.org/10.1182/blood-2023-186945
Published: 2023
Journal Articles

Pirtobrutinib in Richter Transformation: Updated Efficacy and Safety Results with 18-Month Median Survival Follow-up from the Phase 1/2 BRUIN Study

William G. Wierda, Nirav N. Shah, Chan Yoon Cheah, David Lewis, Marc S. Hoffmann, Catherine C. Coombs, Nicole Lamanna, Shuo Ma, Deepa Jagadeesh, Talha Munir, Yucai Wang, Toby A. Eyre, Joanna M. Rhodes, Matthew McKinney, Ewa Lech-Maranda, Constantine S. Tam, Wojciech Jurczak, Koji Izutsu, Alvaro J. Alencar, Manish Patel, John F. Seymour, Jennifer A. Woyach, Lindsey E. Roeker, Philip A. Thompson, Paolo Abada, Caleb Ho, Narasimha Marella, Chunxiao Wang, Amy S. Ruppert, Binoj Chandrasekharan Nair, Hui Liu, Donald E. Tsai, Paolo Ghia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1737.
https://doi.org/10.1182/blood-2023-181108
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Marginal Zone Lymphoma: Results from Phase 1/2 BRUIN Study

Krish Patel, Julie M. Vose, Sunita D. Nasta, Jennifer R. Brown, Kami J. Maddocks, Jennifer A. Woyach, Nirav N. Shah, Bita Fakhri, Benoit Tessoulin, Shuo Ma, Deepa Jagadeesh, Ewa Lech-Maranda, Catherine C. Coombs, Manish Patel, Joanna M. Rhodes, Chaitra S Ujjani, Marc S. Hoffmann, Chan Y Cheah, Talha Munir, David Lewis, Lydia Scarfo, Toby A. Eyre, Alvaro J. Alencar, Jonathon B. Cohen, Andrew D. Zelenetz, Donald E. Tsai, Mei Li, Faith Bian, Paolo Abada, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1660.
https://doi.org/10.1182/blood-2023-180048
Published: 2023
Journal Articles

Targeting CDK8/CDK19 to Disrupt Leukemic Stem Cell-like Population in Acute Myeloid Leukemia: Exploring RVU120 As a Promising Frontline Therapy

Milena Mazan, Urszula Pakulska, Adrianna Moszyńska, Agnieszka Sroka-Porada, Krzysztof Tomasz Szade, Michał Mikula, Magdalena Kozakowska, Przemysław Juszczyński, Katarzyna Wiklik, Kristina Göller, Marta Obacz, Camille N. Abboud, Jan Maciej Zaucha, Ewa Lech Marańda, Noemi Angelosanto, Hendrik Nogai, Tomasz Rzymski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4175.
https://doi.org/10.1182/blood-2023-188866
Published: 2023
Journal Articles

Pirtobrutinib in Post-cBTKi CLL/SLL: ~30 Months Follow-up and Subgroup Analysis With/Without Prior BCL2i from the Phase 1/2 BRUIN Study

Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Lindsey E. Roeker, Krish Patel, Toby A. Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine S. Tam, John F. Seymour, Benoit Tessoulin, Nirav N. Shah, Chaitra S Ujjani, Bita Fakhri, Catherine C. Coombs, Ian W. Flinn, Manish Patel, Sunita D. Nasta, Jonathon B. Cohen, Alvaro J. Alencar, Chan Y. Cheah, Shuo Ma, Joanna M. Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Osterborg, Koji Izutsu, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Amy S. Ruppert, Wojciech Jurczak, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 325.
https://doi.org/10.1182/blood-2023-185852
Published: 2023
Journal Articles

Preclinical and Clinical Evidence for Erythroid-Stimulating Activity of RVU120 CDK8/19 Inhibitor in AML and MDS

Noemi Angelosanto, Ewa Lech Marańda, Jan Maciej Zaucha, Camille N. Abboud, Agnieszka Sroka-Porada, Wiktoria Ogrodzińska, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Tomasz Rzymski, Milena Mazan, Urszula Pakulska, Kristina Göller, Ewa Zarzycka, Hendrik Nogai
Journal: Blood
Blood (2023) 142 (Supplement 1): 2800.
https://doi.org/10.1182/blood-2023-189064
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed/Refractory Follicular Lymphoma: Results from the Phase 1/2 BRUIN Study

Nirav N. Shah, Pier Luigi Zinzani, Michael L. Wang, Sunita D. Nasta, Ewa Lech-Maranda, Yoshiaki Ogawa, Bita Fakhri, Bryone Kuss, Kaname Miyashita, Krish Patel, Catherine C. Coombs, Shuo Ma, Manish Patel, Minal A. Barve, Benoit Tessoulin, Anastasios Stathis, Won Seog Kim, Daisuke Ennishi, Daigo Hashimoto, Kensuke Kojima, Andrew D. Zelenetz, Jonathon B. Cohen, Julie M. Vose, Kami J. Maddocks, Talha Munir, Fangfang Sun, Faith Bian, Donald E. Tsai, Paolo Abada, Chan Y. Cheah
Journal: Blood
Blood (2023) 142 (Supplement 1): 3026.
https://doi.org/10.1182/blood-2023-181309
Published: 2023
Journal Articles

Safety and Efficacy Results from CLI120-001 a Phase 1 Study in RR-AML and HR-MDS: Update from Higher Dose Levels

Ewa Lech Marańda, Elżbieta Patkowska, Natalia Jakacka, Camille N. Abboud, Howard A. Burris, Scott R. Solomon, Noemi Angelosanto, Tomasz Rzymski, Peter Littlewood, Kamil Kuś, Agnieszka Sroka-Porada, Renata Dudziak, Hendrik Nogai, Axel Glasmacher, Terrence Bradley, Gautam Borthakur, Elie Mouhayar, Paweł Steckiewicz, Sylwia Kościółek- Zgódka, Agata Szymańska, Jan Maciej Zaucha
Journal: Blood
Blood (2023) 142 (Supplement 1): 2913.
https://doi.org/10.1182/blood-2023-186620
Published: 2023
Journal Articles

Prospective Assessment of Measurable Residual Disease Kinetics in Intensively Treated Patients with Acute Myeloid Leukemia - Results of the Polish Adult Leukemia Group PALG-AML1/2016 Study

Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Antonina Libura, Sebastian Giebel, Piotr Stelmach, Magdalena Czemerska, Piotr Strzałka, Anna Kopinska, Krzysztof Wozniczka, Grzegorz Helbig, Karol Wojcik, Malgorzata Razny, Marta Anna Sobas, Tomasz Wróbel, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Halka, Elzbieta Patkowska, Marzena Watek, Jolanta Wozniak, Ewa Lech-Marańda, Agnieszka Kopacz, Katarzyna Dulik, Jerzy Holowiecki, Michal Soin, Damian Mikulski, Ewelina Perdas, Wojciech Fendler, Ameenah Sukkur, Andi Rustani, Nuria Mencia Trinchant, Pinkal Desai, Sangmin Lee, Michael Samuel, Justin D. Kaner, Ellen Ritchie, Monica L. Guzman, Gail J. Roboz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6241–6243.
https://doi.org/10.1182/blood-2022-156950
Published: 2022
Journal Articles

Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703

Filip Garbicz, Sonia Debek, Anna Szumera-Ciećkiewicz, Joanna Barankiewicz, Dorota Komar, Michał Pawlak, Aleksandra Matrejek, Thorsten Stuehmer, Aleksander Salomon-Perzynski, Agata Malenda, Julia Ostrowska, Julia Dudkiewicz, Krzysztof Brzózka, Tomasz Rzymski, Daniela Bellarosa, Ewa Lech-Marańda, Monika Prochorec-Sobieszek, Zofia Pilch, Dominika Nowis, Jakub Golab, Helen Tanton, Teru Hideshima, David M. Dorfman, Irena Misiewicz-Krzeminska, Tomasz Sewastianik, Ruben D. Carrasco, Maciej Szydlowski, Przemyslaw Juszczynski
Journal: Blood
Blood (2022) 140 (Supplement 1): 4189–4190.
https://doi.org/10.1182/blood-2022-168770
Published: 2022
Journal Articles

Prognostic Impact of Persistent Measurable Residual Disease in Patients with Acute Myeloid Leukemia FLT3+ Treated with Intensive Chemotherapy Plus Midostaurin - a Retrospective Study of the Polish Adult Leukemia Group (PALG)

Elzbieta Patkowska, Alicja Sadowska-Klasa, Jan Zaucha, Andrzej Szczepaniak, Lidia Gil, Lukasz Bolkun, Michal Gorka, Marta Antonina Libura, Renata Guzicka-Kazimierczak, Marta Anna Sobas, Anna Koclega, Jolanta Wozniak, Krzysztof Lewandowski, Iwona Solarska, Magdalena Wojtas, Aleksandra Leszczynska, Zuzanna Kandula, Edyta Subocz, Edyta Cichocka, Katarzyna Krawczyk, Dorota Hawrylecka, Agnieszka Pluta, Agnieszka Wierzbowska, Sebastian Giebel, Ewa Lech-Marańda
Journal: Blood
Blood (2022) 140 (Supplement 1): 11836–11837.
https://doi.org/10.1182/blood-2022-170126
Published: 2022
Journal Articles

Efficacy of Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Richter Transformation: Results from the Phase 1/2 BRUIN Study

William G. Wierda, David John Lewis, Paolo Ghia, Nirav N. Shah, Catherine C. Coombs, Chan Y. Cheah, Nicole Lamanna, Joanna M. Rhodes, Marc Hoffmann, Shuo Ma, Toby A. Eyre, Talha Munir, Manish R. Patel, Alvaro J. Alencar, Constantine S. Tam, John F. Seymour, Wojciech Jurczak, Ewa Lech-Marańda, Lindsey E. Roeker, Philip A. Thompson, Paolo B. Abada, Chunxiao Wang, Binoj Nair, Hui Liu, Donald E. Tsai, Anthony R. Mato
Journal: Blood
Blood (2022) 140 (Supplement 1): 846–849.
https://doi.org/10.1182/blood-2022-157058
Published: 2022
Journal Articles

Safety and Tolerability of Pirtobrutinib Monotherapy in Patients with B-Cell Malignancies Who Were Previously Intolerant to a Covalent BTK Inhibitor: Results from the Phase 1/2 BRUIN Study

Nirav N. Shah, Michael L. Wang, Jennifer R. Brown, Krish Patel, Jennifer A. Woyach, William G. Wierda, Chaitra S. Ujjani, Toby A. Eyre, Pier Luigi Zinzani, Alvaro J. Alencar, Thomas Gastinne, Paolo Ghia, Nicole Lamanna, Marc Hoffmann, Manish R. Patel, Ian W. Flinn, James N. Gerson, Shuo Ma, Catherine C. Coombs, Chan Y. Cheah, Ewa Lech-Marańda, Bita Fakhri, Won-Seog Kim, Minal A. Barve, Jonathon B. Cohen, Wojciech Jurczak, Talha Munir, Meghan C. Thompson, Lindsey E. Roeker, Katherine Bao, Nicholas A. Cangemi, Jennifer F. Kherani, Richard A. Walgren, Hongmei Han, Amy S. Ruppert, Anthony R. Mato
Journal: Blood
Blood (2022) 140 (Supplement 1): 4127–4132.
https://doi.org/10.1182/blood-2022-159035
Published: 2022
Journal Articles

A Comparison of Outcomes in Patients with Secondary Acute Promyelocytic Leukemia (APL) and De Novo APL - a Case-Match Retrospective Analysis of Polish Adult Leukemia Group (PALG)

Agnieszka Pluta, Marta Anna Sobas, Damian Mikulski, Kinga Krawiec, Magdalena Czemerska, Bozena Katarzyna Budziszewska, Tomasz Wróbel, Marzena Watek, Ewa Lech-Marańda, Tomasz Gromek, Dorota Hawrylecka, Marek Hus, Ewa Zarzycka, Jan Zaucha, Anna Armatys, Grzegorz Helbig, Jolanta Oleksiuk, Jaroslaw Piszcz, Andrzej Szczepaniak, Lidia Gil, Rafal Becht, Wojciech Fendler, Sebastian Giebel, Agnieszka Wierzbowska
Journal: Blood
Blood (2022) 140 (Supplement 1): 3206–3207.
https://doi.org/10.1182/blood-2022-166227
Published: 2022
Journal Articles

CDK 8/19 Kinase Inhibitor RVU120 in Patients with AML or Higher-Risk MDS: Safety and Efficacy Results from New Dose Escalation Cohorts

Camille Abboud, Sr., Jan Maciej Zaucha, Scott R. Solomon, Terrence Bradley, Elie Mouhayar, Noemi Angelosanto, Hendrik Nogai, Renata Dudziak, Tomasz Rzymski, Peter Littlewood, Krzysztof Brzózka, Axel Glasmacher, Gautam Borthakur, Howard A. Burris, Sr., Ewa Lech Marańda
Journal: Blood
Blood (2022) 140 (Supplement 1): 6228–6229.
https://doi.org/10.1182/blood-2022-163150
Published: 2022