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Journal Articles

Pirtobrutinib in Relapsed/Refractory (R/R) Waldenström macroglobulinemia (WM): Up to 5 years of follow-up from the Phase 1/2 BRUIN study

Free
Chan Cheah, Manish Patel, Toby Eyre, Wojciech Jurczak, David Lewis, Thomas Gastinne, Shuo Ma, Jonathon Cohen, Krish Patel, Jennifer Brown, Lydia Scarfo, Talha Munir, Ewa Lech-Maranda, Marc Hoffmann, Chaitra Ujjani, Bita Fakhri, Michael Wang, Koji Izutsu, Hirokazu Nagai, Constantine Tam, Joanna Rhodes, Julie Vose, Matthew McKinney, James Gerson, Minal Barve, Bryone Kuss, Youngil Koh, Aisling Barrett, Steven Treon, Jorge Castillo, John Seymour, Amy Ruppert Stark, Samuel McNeely, Richard Walgren, Donald Tsai, Katherine Bao, Binoj Chandrasekharan Nair, Jennifer Woyach, Lia Palomba
Journal: Blood
Blood (2025) 146 (Supplement 1): 226.
https://doi.org/10.1182/blood-2025-226
Published: 2025
Journal Articles

Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up

Free
William Wierda, Jennifer Brown, Paolo Ghia, Lindsey Roeker, Krish Patel, Toby Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine Tam, John Seymour, Benoit Tessoulin, Nirav Shah, Chaitra Ujjani, Bita Fakhri, Catherine Coombs, Ian Flinn, Manish Patel, Sunita Dwivedy Nasta, Jonathon Cohen, Alvaro Alencar, Chan Cheah, Shuo Ma, Joanna Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Österborg, Koji Izutsu, Noriko Fukuhara, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Wojciech Jurczak, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 2115.
https://doi.org/10.1182/blood-2025-2115
Published: 2025
Journal Articles

A compelling case for central pathology review of multiparameter flow cytometry measurable residual disease results in Acute Myeloid Leukemia (AML) clinical trials: Data from the PALG-AML1/2016 multicenter randomized study

Free
Agnieszka Wierzbowska, Anna Czyz, Agnieszka Pluta, Marta Libura, Magdalena Czemerska, Zuzanna Nowicka, Agata Majchrzak, Michał Soin, Anna Kopinska, Krzysztof Wozniczka, Martyna Wlodarczyk, Joanna Dziaczkowska, Krystyna Jagoda, Grzegorz Helbig, Karol Wojcik, Małgorzata Razny, Marta Sobas, Donata Szymczak, Tomasz Wrobel, Andrzej Szczepaniak, Jolanta Parulska, Lidia Gil, Magdalena Dutka, Krzysztof Lewandowski, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elżbieta Patkowska, Jolanta Wozniak, Ewa Lech-Marańda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Sebastian Giebel, Jerzy Holowiecki, Krzysztof Gawronski, Grzegorz Charlinski, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin Kaner, Michal Bar-Natan, Jonathan Canaani, Ellen Ritchie, Monica Guzman, Sylvie Freeman, Gail Roboz
Journal: Blood
Blood (2025) 146 (Supplement 1): 1737.
https://doi.org/10.1182/blood-2025-1737
Published: 2025
Journal Articles

Minimal residual disease-guided venetoclax plus rituximab for patients with previously untreated chronic lymphocytic leukemia (VERITA PALG-CLL5): primary endpoint analysis of the prospective, multicenter, Phase 2 trial

Free
Krzysztof Jamroziak, Elzbieta Iskierka-Jazdzewska, Tadeusz Robak, Klaudia Zielonka, Sebastian Giebel, Kamil Wisniewski, Joanna Drozd-Sokolowska, Justyna Rybka, Weronika Piszczek, Monika Joks, Anna Dabrowska-Iwanicka, Andrzej Mital, Pawel Steckiewicz, Ewa Lech-Marańda, Marcin Jasinski, Marcin Rymko, Dawid Marciniak, Tomasz Wrobel, Lidia Gil, Joanna Romejko-Jarosinska, Dorota Kruk-Kwapisz, Agnieszka Chudy, Marcin Machnicki, Krzysztof Giannopoulos, Tomasz Stoklosa, Tomasz Górecki, Bartosz Pula
Journal: Blood
Blood (2025) 146 (Supplement 1): 5675.
https://doi.org/10.1182/blood-2025-5675
Published: 2025
Journal Articles

Tyrosine kinase inhibitors, low intensity chemotherapy and allohct for adults with Philadelphia-positive acute lymphoblastic leukemia. Results of the polish adult leukemia group (PALG) ALL7 protocol

Free
Sebastian Giebel, Elżbieta Patkowska, Anna Kopinska, Anna Szmigielska-Kaplon, Marta Baranska, Jacek Kwiatkowski, Agnieszka Piekarska, Krzysztof Gawronski, Marzena Watek, Jaroslaw Piszcz, Katarzyna Brzezniakiewicz-Janus, Janusz Hałka, Tomasz Gromek, Edyta Cichocka, Agnieszka Kopacz, Monika Paluszewska, Elzbieta Wiater, Aleksandra Butrym, Grzegorz Helbig, Ewa Lech-Maranda, Anna Czyz
Journal: Blood
Blood (2025) 146 (Supplement 1): 5134.
https://doi.org/10.1182/blood-2025-5134
Published: 2025
Journal Articles

Prospective assessment of measurable residual disease kinetics in intensively treated patients with Acute Myeloid Leukemia (AML) - results of the PALG-AML1/2016 study

Free
Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Libura, Magdalena Czemerska, Zuzanna Nowicka, Agata Majchrzak, Michał Soin, Anna Kopinska, Krzysztof Wozniczka, Martyna Wlodarczyk, Grzegorz Helbig, Karol Wojcik, Małgorzata Razny, Marta Sobas, Donata Szymczak, Tomasz Wrobel, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elzbieta Patkowska, Ewa Lech-Marańda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Sebastian Giebel, Jerzy Holowiecki, Krzysztof Gawronski, Grzegorz Charlinski, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin Kaner, Michal Bar-Natan, Ellen Ritchie, Jonathan Canaani, Monica Guzman, Sylvie Freeman, Gail Roboz
Journal: Blood
Blood (2025) 146 (Supplement 1): 344.
https://doi.org/10.1182/blood-2025-344
Published: 2025
Journal Articles

MRD-Driven Venetoclax and Rituximab Combination in Previously Untreated Chronic Lymphocytic Leukemia: First Results of the Prospective, Multicenter, Phase II Trial of the Polish Adult Leukemia Group (VERITA PALG-CLL5)

Free
Krzysztof Jamroziak, Elzbieta Iskierka-Jazdzewska, Sebastian Giebel, Kamil Wisniewski, Joanna Drozd-Sokolowska, Tadeusz Robak, Justyna Rybka, Weronika Piszczek, Monika Joks, Anna Paulina Dabrowska-Iwanicka, Andrzej Mital, Paweł Steckiewicz, Ewa Lech-Maranda, Marcin Jasinski, Marcin Rymko, Dawid Marciniak, Tomasz Wrobel, Lidia Gil, Joanna Romejko-Jarosinska, Dorota Kruk-Kwapisz, Agnieszka Chudy, Krzysztof Giannopoulos, Tomasz Stoklosa, Bartosz Michal Pula
Journal: Blood
Blood (2024) 144 (Supplement 1): 3242.
https://doi.org/10.1182/blood-2024-201076
Published: 2024
Journal Articles

Standard Non-Intensive Chemotherapy Vs Venetoclax-Azacytidine (Ven-AZA) for Unfit AML Patients with Therapy-Related Acute Myeloid Leukaemia (t-AML) - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Free
Lukasz Bolkun, Judyta Strzala, Magdalena Czemerska, Bozena Katarzyna Budziszewska, Aleksandra Golos, Anna Holownia, Wanda Knopinska-Posluszny, Ewa Lech Marańda, Jaroslaw Piszcz, Janusz Halka, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 6056.
https://doi.org/10.1182/blood-2024-207883
Published: 2024
Journal Articles

A Polish Adult Leukemia Group (PALG) Prospective International Randomized Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) in Acute Myeloid Leukemia (AML) Patients ≤ 60 Years Old (PALG-AML1/2016) - Topline Results

Free
Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Libura, Sebastian Giebel, Michał Soin, Damian Mikulski, Kacper Kościelny, Wojciech Fendler, Magdalena Czemerska, Agata Majchrzak, Anna Kopinska, Krzysztof Woźniczka, Martyna Włodarczyk, Karol Wójcik, Grzegorz Helbig, Małgorzata Raźny, Marta Sobas, Tomasz Wróbel, Donata Szymczak, Andrzej Szczepaniak, Lidia Gil, Magdalena Dutka, Maria Bieniaszewska, Tomasz Gromek, Marek Hus, Edyta Cichocka, Janusz Hałka, Elzbieta Patkowska, Marzena Wątek, Jolanta Wozniak, Ewa Lech-Maranda, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Grzegorz Charlinski, Jerzy Holowiecki, Andi Rustani, Ameenah Sukkur, Nuria Mencia-Trinchant, Pinkal Desai, Michael Samuel, Justin D. Kaner, Michal Bar-Natan, Jonathan Canaani, Ellen K. Ritchie, Monica L Guzman, Sylvie D Freeman, Gail J. Roboz
Journal: Blood
Blood (2024) 144 (Supplement 1): 970.
https://doi.org/10.1182/blood-2024-202365
Published: 2024
Journal Articles

The Premature Reduction of Venetoclax in an Initial Cycle of Ven-AZA Regimen for Unfit AML Patients Leads to Shortened Overall Survival - a Retrospective Study of Polish Adult Leukemia Group (PALG)

Free
Lukasz Bolkun, Bozena Katarzyna Budziszewska, Bartosz Michal Pula, Joanna Drozd-Sokolowska, Krzysztof Mądry, Paweł Główka, Marta Sobas, Kinga Krawiec, Piotr Strzalka, Sylwia Kościołek-Zgódka, Jaroslaw Piszcz, Janusz Halka, Edyta Cichocka, Kamila Kruczkowska-Tarantowicz, Judyta Strzala, Agnieszka Mosler, Ewa Lech Marańda, Aleksandra Butrym, Sebastian Giebel, Agnieszka Wierzbowska
Journal: Blood
Blood (2024) 144 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2024-208144
Published: 2024
Journal Articles

The Outcome of the First-Line Therapy of Patients with Follicular Lymphoma during COVID-19 Pandemic. a Real-World Data from the Polish Lymphoma Research Group (PLRG)

Free
Ewa Paszkiewicz-Kozik, Monika Palka, Malgorzata Debowska, Marcin Szymanski, Agnieszka Konska, Elzbieta Kalicinska, Agata Tyczynska, Joanna Drozd-Sokolowska, Agnieszka Giza, Ryszard Swoboda, Anna Paulina Dabrowska-Iwanicka, Marta Morawska, Justyna Owczarek-Kaczmarek, Lukasz Bolkun, Anna Kopinska, Ewa Wasik-Szczepanek, Dominika Maksylewicz, Anna Wisniewska, Lukasz Targonski, Edyta Subocz, Pawel Steckiewicz, Katarzyna Domanska-Czyz, Beata Ostrowska, Monika Swierkowska, Jacek Krzanowski, Agnieszka Druzd-Sitek, Ewa Mroz-Zycinska, Joanna Romejko-Jarosinska, Iwona Hus, Monika Dlugosz-Danecka, Ewa Lech-Maranda, Tomasz Wrobel, Jan M. Zaucha, Jan Walewski
Journal: Blood
Blood (2023) 142 (Supplement 1): 1679.
https://doi.org/10.1182/blood-2023-186945
Published: 2023
Journal Articles

Targeting CDK8/CDK19 to Disrupt Leukemic Stem Cell-like Population in Acute Myeloid Leukemia: Exploring RVU120 As a Promising Frontline Therapy

Free
Milena Mazan, Urszula Pakulska, Adrianna Moszyńska, Agnieszka Sroka-Porada, Krzysztof Tomasz Szade, Michał Mikula, Magdalena Kozakowska, Przemysław Juszczyński, Katarzyna Wiklik, Kristina Göller, Marta Obacz, Camille N. Abboud, Jan Maciej Zaucha, Ewa Lech Marańda, Noemi Angelosanto, Hendrik Nogai, Tomasz Rzymski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4175.
https://doi.org/10.1182/blood-2023-188866
Published: 2023
Journal Articles

Pirtobrutinib in Post-cBTKi CLL/SLL: ~30 Months Follow-up and Subgroup Analysis With/Without Prior BCL2i from the Phase 1/2 BRUIN Study

Free
Jennifer A. Woyach, Jennifer R. Brown, Paolo Ghia, Lindsey E. Roeker, Krish Patel, Toby A. Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine S. Tam, John F. Seymour, Benoit Tessoulin, Nirav N. Shah, Chaitra S Ujjani, Bita Fakhri, Catherine C. Coombs, Ian W. Flinn, Manish Patel, Sunita D. Nasta, Jonathon B. Cohen, Alvaro J. Alencar, Chan Y. Cheah, Shuo Ma, Joanna M. Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Osterborg, Koji Izutsu, Donald E. Tsai, Paolo Abada, Minna Balbas, Jian Li, Amy S. Ruppert, Wojciech Jurczak, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 325.
https://doi.org/10.1182/blood-2023-185852
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed/Refractory Follicular Lymphoma: Results from the Phase 1/2 BRUIN Study

Free
Nirav N. Shah, Pier Luigi Zinzani, Michael L. Wang, Sunita D. Nasta, Ewa Lech-Maranda, Yoshiaki Ogawa, Bita Fakhri, Bryone Kuss, Kaname Miyashita, Krish Patel, Catherine C. Coombs, Shuo Ma, Manish Patel, Minal A. Barve, Benoit Tessoulin, Anastasios Stathis, Won Seog Kim, Daisuke Ennishi, Daigo Hashimoto, Kensuke Kojima, Andrew D. Zelenetz, Jonathon B. Cohen, Julie M. Vose, Kami J. Maddocks, Talha Munir, Fangfang Sun, Faith Bian, Donald E. Tsai, Paolo Abada, Chan Y. Cheah
Journal: Blood
Blood (2023) 142 (Supplement 1): 3026.
https://doi.org/10.1182/blood-2023-181309
Published: 2023
Journal Articles

Safety and Efficacy Results from CLI120-001 a Phase 1 Study in RR-AML and HR-MDS: Update from Higher Dose Levels

Free
Ewa Lech Marańda, Elżbieta Patkowska, Natalia Jakacka, Camille N. Abboud, Howard A. Burris, Scott R. Solomon, Noemi Angelosanto, Tomasz Rzymski, Peter Littlewood, Kamil Kuś, Agnieszka Sroka-Porada, Renata Dudziak, Hendrik Nogai, Axel Glasmacher, Terrence Bradley, Gautam Borthakur, Elie Mouhayar, Paweł Steckiewicz, Sylwia Kościółek- Zgódka, Agata Szymańska, Jan Maciej Zaucha
Journal: Blood
Blood (2023) 142 (Supplement 1): 2913.
https://doi.org/10.1182/blood-2023-186620
Published: 2023
Journal Articles

Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Relapsed / Refractory Marginal Zone Lymphoma: Results from Phase 1/2 BRUIN Study

Free
Krish Patel, Julie M. Vose, Sunita D. Nasta, Jennifer R. Brown, Kami J. Maddocks, Jennifer A. Woyach, Nirav N. Shah, Bita Fakhri, Benoit Tessoulin, Shuo Ma, Deepa Jagadeesh, Ewa Lech-Maranda, Catherine C. Coombs, Manish Patel, Joanna M. Rhodes, Chaitra S Ujjani, Marc S. Hoffmann, Chan Y Cheah, Talha Munir, David Lewis, Lydia Scarfo, Toby A. Eyre, Alvaro J. Alencar, Jonathon B. Cohen, Andrew D. Zelenetz, Donald E. Tsai, Mei Li, Faith Bian, Paolo Abada, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1660.
https://doi.org/10.1182/blood-2023-180048
Published: 2023
Journal Articles

Stratification Using ECOG, ADL and HCT-CI Scales, but Not CGA Enables Identifying Elderly AML Patients Fit for Intensive Chemotherapy - a Multicenter Study from Polish Adult Leukemia Group

Free
Bozena Katarzyna Budziszewska, Michał Łomiak, Joanna Barankiewicz, Elzbieta Patkowska, Grzegorz Helbig, Lukasz Bolkun, Anna Irga-Staniukiewicz, Anna Kiżewska, Agnieszka Piekarska, Anna Koclęga, Agnieszka Pluta, Marta Kuydowicz, Sylwia Kościółek- Zgódka, Edyta Cichocka, Agata Malenda, Karol Wójcik, Tomasz Gromek, Piotr Małecki, Sebastian Grosicki, Agnieszka Wierzbowska, Ewa Lech-Maranda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4218.
https://doi.org/10.1182/blood-2023-189713
Published: 2023
Journal Articles

Pirtobrutinib in Richter Transformation: Updated Efficacy and Safety Results with 18-Month Median Survival Follow-up from the Phase 1/2 BRUIN Study

Free
William G. Wierda, Nirav N. Shah, Chan Yoon Cheah, David Lewis, Marc S. Hoffmann, Catherine C. Coombs, Nicole Lamanna, Shuo Ma, Deepa Jagadeesh, Talha Munir, Yucai Wang, Toby A. Eyre, Joanna M. Rhodes, Matthew McKinney, Ewa Lech-Maranda, Constantine S. Tam, Wojciech Jurczak, Koji Izutsu, Alvaro J. Alencar, Manish Patel, John F. Seymour, Jennifer A. Woyach, Lindsey E. Roeker, Philip A. Thompson, Paolo Abada, Caleb Ho, Narasimha Marella, Chunxiao Wang, Amy S. Ruppert, Binoj Chandrasekharan Nair, Hui Liu, Donald E. Tsai, Paolo Ghia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1737.
https://doi.org/10.1182/blood-2023-181108
Published: 2023
Journal Articles

Preclinical and Clinical Evidence for Erythroid-Stimulating Activity of RVU120 CDK8/19 Inhibitor in AML and MDS

Free
Noemi Angelosanto, Ewa Lech Marańda, Jan Maciej Zaucha, Camille N. Abboud, Agnieszka Sroka-Porada, Wiktoria Ogrodzińska, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Tomasz Rzymski, Milena Mazan, Urszula Pakulska, Kristina Göller, Ewa Zarzycka, Hendrik Nogai
Journal: Blood
Blood (2023) 142 (Supplement 1): 2800.
https://doi.org/10.1182/blood-2023-189064
Published: 2023
Journal Articles

CDK 8/19 Kinase Inhibitor RVU120 in Patients with AML or Higher-Risk MDS: Safety and Efficacy Results from New Dose Escalation Cohorts

Free
Camille Abboud, Sr., Jan Maciej Zaucha, Scott R. Solomon, Terrence Bradley, Elie Mouhayar, Noemi Angelosanto, Hendrik Nogai, Renata Dudziak, Tomasz Rzymski, Peter Littlewood, Krzysztof Brzózka, Axel Glasmacher, Gautam Borthakur, Howard A. Burris, Sr., Ewa Lech Marańda
Journal: Blood
Blood (2022) 140 (Supplement 1): 6228–6229.
https://doi.org/10.1182/blood-2022-163150
Published: 2022