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Emma Gudgin
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Journal Articles

RUX-AZA Response in AP/BP-MPN Is Driven By Release of the Differentiation Block in Mutant HSPCs: A Single-Cell Multi-Omic Analysis of Responders on the Phase Ib Phazar Study

Charlotte K Brierley, Charlotte Gaskell, Claire Harrison, Christina Yap, Aimee Jackson, Jennifer Byrne, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Alba Rodriguez-Meira, Lauren Murphy, Fiona Jane Clarke, Srinivasan Narayanan, David T. Bowen, Emma Gudgin, Dragana Milojkovic, Rebecca Collings, Bethan Psaila, Steve Knapper, Mark W. Drummond, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 3146.
https://doi.org/10.1182/blood-2024-204818
Published: 2024
Journal Articles

Phazar: A Phase Ib Study to Assess the Safety and Tolerability of Ruxolitinib in Combination with Azacitidine in Advanced Phase Myeloproliferative Neoplasms (MPN), Including Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukaemia (AML) Arising from MPN [ISRCTN16783472]

Mark W. Drummond, PhD FRCPath, Charlotte Gaskell, BSc, MSc, Claire Harrison, DM, FRCP, FRCPath, Adam J. Mead, MD PhD, Christina Yap, PhD CStat, Aimee E Jackson, BSc, MSc, Jennifer Byrne, FRCP, FRCPath, PhD, Fiona J Clark, FRCP, FRCPath, Srinivasan Narayanan, FRCP, FRCPath, David Bowen, MD, Tim C.P Somervaille, PhD FRCP, FRCPath, Emma Gudgin, MBBS, MRCP, FRCPath, PhD, Dragana Milojkovic, Rachel S Fletcher, PhD, Charlotte K Brierley, MRCP, MD, Steve Knapper, BMBCh, MRCP, FRCPath, DM
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-138437
Published: 2020
Journal Articles

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

Eva Diffner, Dominik Beck, Emma Gudgin, Julie A. I. Thoms, Kathy Knezevic, Clare Pridans, Sam Foster, Debbie Goode, Weng Khong Lim, Lies Boelen, Klaus H. Metzeler, Gos Micklem, Stefan K. Bohlander, Christian Buske, Alan Burnett, Katrin Ottersbach, George S. Vassiliou, Jake Olivier, Jason W. H. Wong, Berthold Göttgens, Brian J. Huntly, John E. Pimanda
Journal: Blood
Blood (2013) 121 (12): 2289–2300.
https://doi.org/10.1182/blood-2012-07-446120
Published: 2013
Includes: Supplemental data
Journal Articles

Activity of a Heptad of Transcription Factors Is Associated with Stem Cell Programs and Clinical Outcome in Acute Myeloid Leukaemia

Eva Diffner, PhD, Dominik Beck, PhD, Emma Gudgin, MBBS, MRCP, Julie Thoms, PhD, Kathy Knezevic, BSc (Hons), Clare Pridans, PhD, Sam Foster, PhD, Debbie Goode, PhD, Wheng Khong Lim, PhD, Lies Boelen, PhD, Klaus H. Metzeler, MD, Gos Micklem, PhD, Stefan K Bohlander, MD, Christian Buske, MD, Alan K Burnett, MD, Katrin Ottersbach, PhD, George Vassiliou, MD, PhD, Jake Olivier, PhD, Jason WH Wong, PhD, Berthold Gottgens, Ph.D., Brian Huntly, MD, PHD, John E Pimanda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3525.
https://doi.org/10.1182/blood.V120.21.3525.3525
Published: 2012
Journal Articles

Inhibition of BET Recruitment to Chromatin As An Effective Treatment for MLL-Fusion Leukaemia

Mark A Dawson, MBBS, BMedSc, FRACP, FRCPA, PhD, Rab Prinjha, Antje Dittman, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel Robson, Chun-wa Chung, Carsten Hopf, Mikhail Savitski, Konstanze Döhner, M.D., Alan K Burnett, MD, Ruud Delwel, Ph.D., Huthmacher Carola, Emma Gudgin, MBBS, MRCP, Dave Lugo, Soren Beinke, Peter Soden, Kurt R. Auger, Olivier Mirguet, Phillip Jeffrey, Gerard Drewes, Kevin Lee, Tony Kouzarides, Brian J.P. Huntly
Journal: Blood
Blood (2011) 118 (21): 55.
https://doi.org/10.1182/blood.V118.21.55.55
Published: 2011
Journal Articles

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms

Shubha Anand, Frances Stedham, Emma Gudgin, Peter Campbell, Philip Beer, Anthony R. Green, Brian J. P. Huntly
Journal: Blood
Blood (2011) 118 (6): 1610–1621.
https://doi.org/10.1182/blood-2011-02-335042
Published: 2011
Includes: Supplemental data
Journal Articles

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms

Brief Report
Shubha Anand, Frances Stedham, Philip Beer, Emma Gudgin, Christina A. Ortmann, Anthony Bench, Wendy Erber, Anthony R. Green, Brian J. P. Huntly
Journal: Blood
Blood (2011) 118 (1): 177–181.
https://doi.org/10.1182/blood-2010-12-327593
Published: 2011
Includes: Supplemental data