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Srinivasan Narayanan
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Journal Articles

ASTX727 delivers superior response rates and associated survival benefit versus hydroxycarbamide/best supportive care in CMML and other MDS/MPN overlap syndromes: First results from the Phase 2 UK multicenter randomized ammo trial

Free
Daniel Wiseman, Jak Laight, Rebecca Boucher, Chhaya Sankhalpara, Rebecca Record, Jennifer Byrne, Onima Chowdhury, Dominic Culligan, Nicholas Cunningham, Srinivasan Narayanan, Rob Sellar, Kiran Batta, Manoj Raghavan, Dr. Emma Searle, Catherine Cargo, Steve Knapper, Austin Kulasekararaj
Journal: Blood
Blood (2025) 146 (Supplement 1): 488.
https://doi.org/10.1182/blood-2025-488
Published: 2025
Journal Articles

Fedora preliminary analysis of a Phase II study evaluating the tolerability, safety and activity of fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis.

Free
Mary Frances McMullin, Fitsum Ghebretinsea, Rebecca Boucher, Sebastian Francis, Gillian Horne, Hayder Hussein, Steve Knapper, Donal McLornan, Srinivasan Narayanan, Jennifer O Sullivan, Tim Somervaille, Chun Teh, Frances Wadelin, Chhaya Sankhalpara, Emily Yafai, Catherine Thomas, Rupen Hargreaves, Nawshad Hayder, Graham Mcllroy, Claire Harrison, Adam Mead
Journal: Blood
Blood (2025) 146 (Supplement 1): 486.
https://doi.org/10.1182/blood-2025-486
Published: 2025
Journal Articles

Patient experience sub-study of a randomised UK multicentre Phase 2 trial of ASTX727 versus hydroxycarbamide/best supportive care in myelodysplastic (MDS)/myeloproliferative (MPN) overlap syndromes (AMMO)

Free
Ashleigh Ward, Sally Taylor, Grant Punnett, Ramsay Devaraj, Chhaya Sankhalpara, Rebecca Record, Kiran Batta, Jennifer Byrne, Catherine Cargo, Onima Chowdhury, Dominic Culligan, Nicholas Cunningham, Steve Knapper, Austin Kulasekararaj, Srinivasan Narayanan, Manoj Raghavan, Rob Sellar, Daniel Wiseman, Janelle Yorke
Journal: Blood
Blood (2025) 146 (Supplement 1): 8164.
https://doi.org/10.1182/blood-2025-8164
Published: 2025
Journal Articles

Interim analysis of promise, a clinical study combining the BET inhibitor OPN-2853 with ruxolitinib in patients with advanced myelofibrosis experiencing an inadequate response to ruxolitinib

Free
Adam Mead, Bethan Psaila, Rebecca Boucher, Jiayi Wang, Rebecca Collings, Rebecca Record, Zsofia Nagy, Aishah Begum, Steve Knapper, Frances Wadelin, Manish Jain, Jenny O'Nions, Mary Frances McMullin, Sebastian Francis, Patrick Harrington, Srinivasan Narayanan, Kerry Inokuchi, Jackie Walling, Brain Huntley, Claire Harrison
Journal: Blood
Blood (2025) 146 (Supplement 1): 3794.
https://doi.org/10.1182/blood-2025-3794
Published: 2025
Journal Articles

RUX-AZA Response in AP/BP-MPN Is Driven By Release of the Differentiation Block in Mutant HSPCs: A Single-Cell Multi-Omic Analysis of Responders on the Phase Ib Phazar Study

Free
Charlotte K Brierley, Charlotte Gaskell, Claire Harrison, Christina Yap, Aimee Jackson, Jennifer Byrne, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Alba Rodriguez-Meira, Lauren Murphy, Fiona Jane Clarke, Srinivasan Narayanan, David T. Bowen, Emma Gudgin, Dragana Milojkovic, Rebecca Collings, Bethan Psaila, Steve Knapper, Mark W. Drummond, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 3146.
https://doi.org/10.1182/blood-2024-204818
Published: 2024
Journal Articles

Effects of Tamoxifen on the Mutant Allele Burden and Disease Course in Patients with Myeloproliferative Neoplasms - Results of the Tamarin Study

Free
Claire Harrison, DM, FRCP, FRCPath, Joanna Baxter, PhD, Rebecca H. Boucher, BSc, MSc, PhD, Thomas McKerrell, MD PhD, Aimee Jackson, BSc, MSc, Rachel S Fletcher, PhD, Adam J. Mead, MD PhD, Steve Knapper, BMBCh, MRCP, FRCPath, DM, Joanne Ewing, MD PhD, Nauman M Butt, MD, Manish Jain, MBBS, MRCP, FRCpath, Sebastian Francis, MBChB, FRCPath, MD, Fiona J Clark, FRCP, FRCPath, Jason Coppell, MBBS, Mary Frances McMullin, MDFRCP, FRCPath, Frances Wadelin, MB ChB, PhD FRCPath, Srinivasan Narayanan, FRCP, FRCPath, Dragana Milojkovic, Mark W. Drummond, PhD FRCPath, Mallika Sekhar, MBBS, MD, Maike Paramor, James Roberts, BSc, Rachel Glover, BSc, Erica Harris, MSc, Luigi Grassi, PhD, Alba Rodriguez-Meira, PhD, Jason Carroll, PhD FMedSci, José-Ezequiel Martín, PhD, Giuditta Corbizi Fattori, PhD, Zijian Fang, BSc, Anna L Godfrey, BMBCh, PhD, Simón Méndez-Ferrer, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–35.
https://doi.org/10.1182/blood-2020-134764
Published: 2020
Journal Articles

Phazar: A Phase Ib Study to Assess the Safety and Tolerability of Ruxolitinib in Combination with Azacitidine in Advanced Phase Myeloproliferative Neoplasms (MPN), Including Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukaemia (AML) Arising from MPN [ISRCTN16783472]

Free
Mark W. Drummond, PhD FRCPath, Charlotte Gaskell, BSc, MSc, Claire Harrison, DM, FRCP, FRCPath, Adam J. Mead, MD PhD, Christina Yap, PhD CStat, Aimee E Jackson, BSc, MSc, Jennifer Byrne, FRCP, FRCPath, PhD, Fiona J Clark, FRCP, FRCPath, Srinivasan Narayanan, FRCP, FRCPath, David Bowen, MD, Tim C.P Somervaille, PhD FRCP, FRCPath, Emma Gudgin, MBBS, MRCP, FRCPath, PhD, Dragana Milojkovic, Rachel S Fletcher, PhD, Charlotte K Brierley, MRCP, MD, Steve Knapper, BMBCh, MRCP, FRCPath, DM
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-138437
Published: 2020
Journal Articles

A Phase Ib Study to Assess the Safety and Tolerability of Ruxolitinib in Combination with Azacitidine in Patients with Advanced Phase Myeloproliferative Neoplasms (MPN), Including Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukaemia (AML) Arising from MPN (The Bloodwise / TAP PHAZAR Study on Behalf of the UK MPN CSG)

Free
Mark W Drummond, MB ChB, PhD FRCPath, Claire N. Harrison, BMBCh, DM, FRCP, FRCPath, Samuel Munoz Vicente, MSc, Adam J Mead, MD PhD, Christina Yap, MSci, PhD CStat, Frederick Chen, FRCP, FRCPath, PhD, Srinivasan Narayanan, MBBS, MRCP, FRCPath, Dragana Milojkovic, MBBS, PhD, Leyre Navarro-Nunez, PhD, Steven Knapper, BMBCh, MRCP, MRCPath, DM
Journal: Blood
Blood (2017) 130 (Supplement 1): 1649.
https://doi.org/10.1182/blood.V130.Suppl_1.1649.1649
Published: 2017