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Journal Articles

Phase 1b Study of IDH Inhibition with Enasidenib and MEK Inhibition with Cobimetinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-Occurring IDH2 and RAS Signaling Gene Mutations

Brian J. Ball, Jianying Zhang, Michelle Afkhami, Marjorie Robbins, Lauren Chang, Samantha Humpal, Vania Porras, Yilun Liu, Tim W Synold, Sarah Farzinkhou, Azra Borogovac, Paul B. Koller, Hoda Pourhassan, Vaibhav Agrawal, Anthony S. Stein, Mary-Elizabeth M. Percival, Alexey V. Danilov, Guido Marcucci
Journal: Blood
Blood (2024) 144 (Supplement 1): 6043.
https://doi.org/10.1182/blood-2024-211652
Published: 2024
Journal Articles

Final Analysis of Phase 2a Study of Adding Itacitinib to Tacrolimus/Sirolimus Gvhd Prophylaxis after Fludarabine/Melphalan-Based Conditioning Hematopoietic Cell Transplantation for Acute Leukemias, Myelodysplastic Syndrome (MDS), or Myelofibrosis (MF)

Haris Ali, Dongyun Yang, NI-Chun Tsai, Sally Mokhtari, Tim W Synold, Idoroenyi Amanam, Andrew Artz, Peter T. Curtin, Karamjeet S Sandhu, Anthony S. Stein, Shukaib Arslan, Salman Otoukesh, Firoozeh Sahebi, Joshua Mansour, Paul B. Koller, Amandeep Salhotra, Ibrahim Aldoss, Vinod Pullarkat, Brian J. Ball, Stephen J. Forman, Guido Marcucci, MHD Monzr M. Al Malki, Ryotaro Nakamura
Journal: Blood
Blood (2024) 144 (Supplement 1): 1043.
https://doi.org/10.1182/blood-2024-206169
Published: 2024
Journal Articles

TP53 Mutations Increased the Risk of CD19 Negative Relapse Following Blinatumomab in Adults with B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Ibrahim Aldoss, Jeffrey Li, Jianying Zhang, Mary C Clark, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Ahmed Aribi, Haris Ali, Amanda Blackmon, Salman Otoukesh, Karamjeet S Sandhu, Brian J. Ball, Andrew Artz, Idoroenyi Amanam, MHD Monzr M. Al Malki, Amandeep Salhotra, Lindsey A. Murphy, Dat Ngo, Jose Tinajero, Zhaohui Gu, Pamela S. Becker, Ryotaro Nakamura, Anthony S. Stein, Guido Marcucci, Stephen J. Forman, Vinod Pullarkat
Journal: Blood
Blood (2024) 144 (Supplement 1): 729.
https://doi.org/10.1182/blood-2024-208674
Published: 2024
Journal Articles

Olverembatinib (HQP1351) Overcomes Resistance/Intolerance to Asciminib and Ponatinib in Patients (pts) with Heavily Pretreated Chronic-Phase Chronic Myeloid Leukemia (CP-CML): A 1.5-Year Follow-up Update with Comprehensive Exposure-Response (E-R) Analyses

Elias Jabbour, Omer Jamy, Paul B. Koller, Vivian G. Oehler, Maria R. Baer, Elza Lomaia, Anthony M. Hunter, Olga Uspenskaya, Svetlana Samarina, Jorge E. Cortes, Sudipto Mukherjee, Dennis Dong Hwan Kim, Vera Zherebtsova, Vasily Shuvaev, Anna Turkina, Igor Davydkin, Huanshan Guo, Zi Chen, Hengbang Wang, Tommy Fu, Lixin Jiang, Zhihong Yang, Cunlin Wang, Dajun Yang, Yifan Zhai, Hagop Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3151.
https://doi.org/10.1182/blood-2024-207139
Published: 2024
Journal Articles

Efficacy and Safety of Asciminib in Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Interim Results from the Phase 2 ASC2ESCALATE Trial in the Cohort of Patients (Pts) after 1 Prior Tyrosine Kinase Inhibitor (TKI)

Ehab L. Atallah, Moshe Y. Levy, Paul B. Koller, Koji Sasaki, Srinivas K Tantravahi, David Andorsky, Celesteann T Bremer, Joshua F Zeidner, Marlise R. Luskin, Reinhold Munker, Daisy Yang, Dramane Laine, John Sabo, Ennan Gu, Michael J. Mauro, Jorge E. Cortes
Journal: Blood
Blood (2024) 144 (Supplement 1): 479.
https://doi.org/10.1182/blood-2024-200717
Published: 2024
Journal Articles

Phase 1 Safety and Efficacy of Tuspetinib Plus Venetoclax Combination Therapy in Study Participants with Relapsed or Refractory Acute Myeloid Leukemia (AML) Support Exploration of Triplet Combination Therapy of Tuspetinib Plus Venetoclax and Azacitidine for Newly Diagnosed AML

Naval Daver, Kyoo Hyung Lee, Yunsuk Choi, Pau Montesinos, Brian A. Jonas, Martha L. Arellano, Uma Borate, Justin M. Watts, Paul B. Koller, Chul Won Jung, Sang Kyun Sohn, Amir T. Fathi, Pankit Vachhani, Nikolai A. Podoltsev, Olga Salamero, Sung-Soo Yoon, Jeong-Ok Lee, Gabriel N Mannis, Shuhying Tan, Sudipto Mukherjee, Harry Erba, Ho-Jin Shin, Uwe Platzbecker, Mar Tormo, Eric Tam, Leanne Berkahn, Teresa Bernal, Donna Nguyen Haney, Jia Hu, Ranjeet Kumar Sinha, Nawazish Khan, Vivian Costa Victory, William G. Rice, Rafael Bejar
Journal: Blood
Blood (2024) 144 (Supplement 1): 4255.
https://doi.org/10.1182/blood-2024-200397
Published: 2024
Journal Articles

ICT01, an Investigational γ9δ2 T Cell Activator, Added to Azacitidine-Venetoclax Achieves Frequent and Early Complete Remissions in Adults with AML Unfit for Intensive Induction Chemotherapy: Interim Results from the Ongoing Open-Label, Randomized Phase 1 Study Eviction

Abhishek Maiti, Pierre Yves Dumas, Pierre Peterlin, Daniel Morillo, Jose Torregrosa, Paul B. Koller, Maelle Mairesse, Patrick Brune, Emmanuel Valenitn, Aude De Gassart, Katrien Lemmens, Daniel Olive, Naval Daver, Stephan Braun, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2876.
https://doi.org/10.1182/blood-2024-193493
Published: 2024
Journal Articles

Outpatient Administration of Brexucabtagene Autoleucel (brexu-cel) for Acute Lymphoblastic Leukemia (ALL) and Mantle Cell Lymphoma (MCL) Is Safe and Feasible

Tamer Othman, John H. Baird, Yan Wang, Stacy Pak, Ibrahim Aldoss, Ji-Lian Cai, Alexey Danilov, Tycel J. Phillips, Vaibhav Agrawal, Karamjeet S Sandhu, Matthew Mei, Paul B. Koller, Joycelynne Michelle Palmer, Stephen J. Forman, Lihua E. Budde, Ahmed Aribi
Journal: Blood
Blood (2024) 144 (Supplement 1): 2278.
https://doi.org/10.1182/blood-2024-207085
Published: 2024
Journal Articles

Outcomes of Hypomethylating Agents/Venetoclax (HMA/VEN) Treatment for Relapse of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) after Allogeneic Hematopoietic Cell Transplant (alloHCT)

Diana T Samuels, Brian J. Ball, NI-Chun Tsai, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Idoroenyi Amanam, Paul B. Koller, Shukaib Arslan, Salman Otoukesh, Karamjeet S Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, MHD Monzr M. Al Malki, Andrew Artz, Pamela S. Becker, Ahmed Aribi, Eileen Patricia Smith, Stephen J. Forman, Anthony S. Stein, Guido Marcucci, Ryotaro Nakamura, Vinod Pullarkat
Journal: Blood
Blood (2024) 144 (Supplement 1): 4935.
https://doi.org/10.1182/blood-2024-210956
Published: 2024
Journal Articles

Favorable Survival Outcomes in AML Patients Undergoing Allogeneic Hematopoietic Cell Transplant with Fludarabine/Melphalan-Conditioning with Tacrolimus/Sirolimus-Based Gvhd Prophylaxis

Amandeep Salhotra, Monzr M. Al Malki, Dongyun Yang, Sally Mokhtari, Ibrahim Aldoss, Ahmed Aribi, Idoroenyi Amanam, Haris Ali, Karamjeet S. Sandhu, Vaibhav Agrawal, Paul B. Koller, Brian J. Ball, Shukaib Arslan, Salman Otoukesh, Amanda Blackmon, Hoda Pourhassan, Yazeed Samara, Tamer Othman, Pamela S. Becker, Vinod Pullarkat, Ricardo Spielberger, Forest Marc Stewart, Eileen Patricia Smith, Andrew Artz, Stephen J. Forman, Guido Marcucci, Anthony Stein, Ryotaro Nakamura
Journal: Blood
Blood (2023) 142 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2023-187156
Published: 2023
Journal Articles

A Phase 1a/b Trial of Luxeptinib (CG-806) in Patients with Relapsed/Refractory B-Cell Malignancies or Acute Myeloid Leukemia and Evaluation of New G3 Formulation

Aaron D. Goldberg, Felipe Samaniego, Maro Ohanian, Paul B. Koller, Namrata Sonia Chandhok, Ahad A. Sadiq, Daruka Mahadevan, Mohamad A. Cherry, Jessica K. Altman, John M. Burke, Michael Z. Koontz, J. C. C Villasboas, Ben K. Tomlinson, Laura E. Finn, Erin G Reid, Jason Melear, Victor Priego, Patrick Cobb, Elizabeth Heritage Cull, Paul Conkling, David Cosgrove, Lindsey E. Roeker, Eric Tam, Donna Nguyen Haney, Jia Hu, Ranjeet Sinha, Nawazish Khan, William G. Rice, Rafael Bejar
Journal: Blood
Blood (2023) 142 (Supplement 1): 5953.
https://doi.org/10.1182/blood-2023-181151
Published: 2023
Journal Articles

A Multicenter Analysis of Allogeneic Transplant Outcomes in Patients with Philadelphia-like (Ph-like) Acute Lymphoblastic Leukemia (ALL)

Zaid Abdel Rahman, Paul B. Koller, Tamer Othman, Rima M. Saliba, Yenny Alejandra Moreno Vanegas, Razan Mohty, Celina Ledesma, Gabriela Rondon, Nitin Jain, Elias Jabbour, Vinod Pullarkat, Hassan Alkhateeb, Hagop M. Kantarjian, Patricia Greipp, Ryotaro Nakamura, Mohamed A. Kharfan-Dabaja, Richard E. Champlin, Stephen J. Forman, Elizabeth J. Shpall, Mark R. Litzow, James M. Foran, Ibrahim Aldoss, Partow Kebriaei
Journal: Blood
Blood (2023) 142 (Supplement 1): 656.
https://doi.org/10.1182/blood-2023-178150
Published: 2023
Journal Articles

Fractionated Total Body Irradiation and Fludarabine Based Conditioning Regimen with Post-Transplant Cyclophosphamide (PTCy) for Mismatched Related and Unrelated Donors HCT for Acute Leukemia and MDS

Shukaib Arslan, Amrita Desai, Dongyun Yang, Sally Mokhtari, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Brian J. Ball, Idoroenyi Amanam, Salman Otoukesh, Paul B. Koller, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Tamer Othman, Ahmed Aribi, Andrew Artz, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 3537.
https://doi.org/10.1182/blood-2023-187728
Published: 2023
Journal Articles

Toxicities Associated with Tyrosine Kinase Inhibitor Maintenance Following Allogeneic Hematopoietic Cell Transplantation in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Tamer Othman, Paul B. Koller, NI-Chun Tsai, Dat Ngo, Jason Chen, Amanda Blackmon, Hoda Pourhassan, Vaibhav Agrawal, Idoroenyi Amanam, Brian J. Ball, Salman Otoukesh, Amandeep Salhotra, Shukaib Arslan, Monzr M. Al Malki, Haris Ali, Karamjeet S. Sandhu, Ahmed Aribi, Andrew Artz, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Ryotaro Nakamura, Vinod Pullarkat, Ibrahim Aldoss, Matthew Genyeh Mei
Journal: Blood
Blood (2023) 142 (Supplement 1): 2873.
https://doi.org/10.1182/blood-2023-187460
Published: 2023
Journal Articles

Single Center Retrospective Study of Midostaurin Plus Intensive Chemotherapy for Older Patients with Newly Diagnosed FLT-3 Mutated Acute Myelogenous Leukemia

Jose Tinajero, Dat Ngo, Jianying Zhang, NI-Chun Tsai, Joycelynne Michelle Palmer, Ahmed Aribi, Ibrahim Aldoss, Vaibhav Agrawal, Shukaib Arslan, Idoroenyi Amanam, Hoda Pourhassan, Karamjeet S. Sandhu, Monzr M. Al Malki, Vinod Pullarkat, Pamela S. Becker, Ryotaro Nakamura, Anthony Stein, Guido Marcucci, Andrew Artz, Paul B. Koller, Amandeep Salhotra
Journal: Blood
Blood (2023) 142 (Supplement 1): 5937.
https://doi.org/10.1182/blood-2023-173978
Published: 2023
Journal Articles

Concurrent Versus Sequential or No Triazole Anti-Fungal Therapy in Patients Undergoing 7+3 Plus Midostaurin Induction for FLT-3 Acute Myelogenous Leukemia

Dat Ngo, Jose Tinajero, Jianying Zhang, Anthony Stein, Guido Marcucci, Amandeep Salhotra, Vinod Pullarkat, Karamjeet S. Sandhu, Brian J. Ball, Paul B. Koller
Journal: Blood
Blood (2023) 142 (Supplement 1): 5932.
https://doi.org/10.1182/blood-2023-173973
Published: 2023
Journal Articles

Total Marrow and Lymphoid Irradiation (TMLI) -Based Conditioning Regimen in Patients with Acute Leukemia Undergoing Allogeneic Hematopoietic Cell Transplant with Measurable Residual Disease

Amandeep Salhotra, Monzr M. Al Malki, Dongyun Yang, Sally Mokhtari, Ahmed Aribi, Ibrahim Aldoss, Vinod Pullarkat, Ricardo Spielberger, Pamela S. Becker, Karamjeet S. Sandhu, Haris Ali, Amanda Blackmon, Brian J. Ball, Paul B. Koller, Salman Otoukesh, Shukaib Arslan, Vaibhav Agrawal, Firoozeh Sahebi, Susanta Hui, Guido Marcucci, Ryotaro Nakamura, Jeffrey Wong, Anthony Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2162.
https://doi.org/10.1182/blood-2023-185034
Published: 2023
Journal Articles

Consolidation with First and Second Allogeneic Transplants in Adults with Relapsed/Refractory B-ALL Following Response to CD19CAR T Cell Therapy

Ibrahim Aldoss, Haoyue Shan, Dongyun Yang, Mary C Clark, Monzr M. Al Malki, Ahmed Aribi, Karamjeet S. Sandhu, Amandeep Salhotra, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Haris Ali, Andrew Artz, Idoroenyi Amanam, Nicole Karras, Anna Pawlowska, Lindsey Murphy, Joycelynne Michelle Palmer, Guido Marcucci, Anthony Stein, Vinod Pullarkat, Ryotaro Nakamura, Stephen J. Forman
Journal: Blood
Blood (2023) 142 (Supplement 1): 4981.
https://doi.org/10.1182/blood-2023-182058
Published: 2023
Journal Articles

Outcomes of Patients Undergoing Fludarabine and Melphalan-Based Conditioning with Post-Transplant Cyclophosphamide for Peripheral Blood Stem Cell Allogeneic Hematopoietic Cell Transplant: Donor Type Effect

Tamer Othman, Paul B. Koller, Dongyun Yang, Sally Mokhtari, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Brian J. Ball, Idoroenyi Amanam, Shukaib Arslan, Salman Otoukesh, Karamjeet S. Sandhu, Ibrahim Aldoss, Haris Ali, Amandeep Salhotra, Ahmed Aribi, Andrew Artz, Yazeed Samara, Pamela S. Becker, Vinod Pullarkat, Forest Marc Stewart, Eileen Patricia Smith, Anthony Stein, Guido Marcucci, Stephen J. Forman, Ryotaro Nakamura, Monzr M. Al Malki
Journal: Blood
Blood (2023) 142 (Supplement 1): 2151.
https://doi.org/10.1182/blood-2023-187687
Published: 2023
Journal Articles

Covalent-103: A Phase 1, Open-Label, Dose-Escalation, and Dose-Expansion Study of Bmf-500, an Oral Covalent FLT3 Inhibitor, in Adults with Acute Leukemia (AL)

Marcello Rotta, Farhad Ravandi, Mitul Gandhi, Paul B. Koller, Gary J. Schiller, Courtney Follit, Mona Vimal, Stephan W. Morris, Sanchita Mourya, Thomas Butler, Eunice S. Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1546.
https://doi.org/10.1182/blood-2023-182361
Published: 2023