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Aino-Maija Leppä
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Journal Articles

A Venetoclax/Azacytidine Single-Cell RNA-Seq Resistance Signature (VARS) Predicts Response and Relapse in AML Patients

Anne Kathrin Merbach, Christian Rohde, Sergi Beneyto-Calabuig, Patrick Stelmach, Aino-Maija Leppä, Alexander Waclawiczek, Simon Renders, Michelle Lotze, Lars Velten, Andreas Trumpp, Tim Sauer, Rabia Shahswar, Michael Heuser, Carsten Müller-Tidow, Maike Janssen
Journal: Blood
Blood (2024) 144 (Supplement 1): 5744.
https://doi.org/10.1182/blood-2024-209706
Published: 2024
Journal Articles

Mapping Genotype to Phenotype in Clonal Hematopoiesis Uncovers Downregulated MHC-II Molecules in DNMT3A R882 - Mutant Hematopoietic Stem Cells

Patrick Stelmach, Dominik Vonficht, Anne Kathrin Merbach, Dawn S Lin, Sergi Beneyto-Calabuig, Marina Scheller, Aino-Maija Leppä, Florian Grünschläger, George S Vassiliou, Simon Haas, Lars Velten, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2024) 144 (Supplement 1): 1292.
https://doi.org/10.1182/blood-2024-203041
Published: 2024
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Macs - a Leukemic Stem Cell- Based Predictor of Clinical Response to Venetoclax and Other BH3 Mimetics for Acute Myeloid Leukemia

Simon Renders, Alexander Waclawiczek, Aino-Maija Leppä, Cecilia Reyneri, Barbara Betz, Karolin Stumpf, Maike Janssen, Julia M. Unglaub, Elisa Donato, Rabia Shahswar, Simon Raffel, Michael Heuser, Richard F. Schlenk, Michael Hundemer, Tim Sauer, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2023–2024.
https://doi.org/10.1182/blood-2022-164831
Published: 2022
Journal Articles

Frequent Whole Blood Donations Select for DNMT3A variants Mediating Enhanced Response to Erythropoietin

Darja Karpova, Hector Huerga Encabo, Elisa Donato, Iuliia Kotova, Silvia Calderazzo, Aino-Maija Leppä, Panten Jasper, Adriana Przybylla, Erhard Seifried, Annette Kopp-Schneider, Terrence N Wong, Dominique Bonnet, Halvard Bonig, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 8605–8606.
https://doi.org/10.1182/blood-2022-167821
Published: 2022
Journal Articles

Exploring Genetic and Non-Genetic Changes Driving Tumor Evolution in CK-AML at Single-Cell Resolution

Aino-Maija Leppä, Karen Grimes, Hyobin Jeong, Tobias Boch, Darja Karpova, Florian Grünschläger, Anna Jauch, Anna Dolnik, Bernardo Rodriguez-Martin, Lars Bullinger, Alwin Krämer, Ashley D Sanders, Jan O Korbel, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 9170–9172.
https://doi.org/10.1182/blood-2022-166007
Published: 2022
Journal Articles

Leukemic Stem Cells of Monocytic AMLs Are Not-Resistant to BCL-2 Inhibition

Simon Renders, Aino-Maija Leppä, Alexander Waclawiczek, Maike Janssen, Elisa Donato, Cecilia Reyneri, Julia M. Unglaub, Michael Hundemer, Richard F. Schlenk, Simon Raffel, Carsten Müller-Tidow, Tim Sauer, Andreas Trumpp
Journal: Blood
Blood (2021) 138 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2021-149781
Published: 2021
Journal Articles

A High-Throughput Biology Approach to Identify Novel Therapies Specifically Targeting AML Blasts and Leukemic Stem Cells

Heikki Kuusanmäki, MSc, Aino Maija Leppä, BSc, Debashish Deb, BSc, Caroline A Heckman, PhD
Journal: Blood
Blood (2016) 128 (22): 2755.
https://doi.org/10.1182/blood.V128.22.2755.2755
Published: 2016
Journal Articles

Simultaneous Monitoring of Drug Responses on Distinct Hematopoietic Cell Populations Allow Assessment of Direct and Indirect Cytotoxic Effects of Targeted Therapies

Muntasir M Majumder, MSc, MPharm, Aino Maija Leppä, BSc, Caroline A Heckman, PhD
Journal: Blood
Blood (2016) 128 (22): 3515.
https://doi.org/10.1182/blood.V128.22.3515.3515
Published: 2016