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Journal Articles

Alberta Cellular and Immunotherapy (ACIT) 001, Updated Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)

Michael P. Chu, Zack Breckenridge, Deanna Hockley, Mona Shafey, Sunil J. Desai, Victor A. Lewis, Peng Wang, Vladimir Sapon-Cousineau, Charles Yin, Carina Debes-Marun, Irwindeep Sandhu
Journal: Blood
Blood (2024) 144 (Supplement 1): 3464.
https://doi.org/10.1182/blood-2024-209646
Published: 2024
Journal Articles

Ktx-1029, a Potent, Selective MMSET/NSD2 Inhibitor Is Effective in t(4;14) Multiple Myeloma Preclinical Models

Erin Flynt, Chad A. Lewis, Benjamin Winograd, Terry Connolly, Lan Xu, Anil Menon
Journal: Blood
Blood (2024) 144 (Supplement 1): 1878.
https://doi.org/10.1182/blood-2024-198468
Published: 2024
Journal Articles

Characterization of the Biochemical Activity of Ktx-1001, a Selective Small Molecule NSD2 Inhibitor, in Surface Plasmon Resonance (SPR)

Chad A. Lewis, Charles Schmidt, Lisa Beebe, Terry Connolly
Journal: Blood
Blood (2024) 144 (Supplement 1): 2205.
https://doi.org/10.1182/blood-2024-201515
Published: 2024
Journal Articles

First Results from the Dose Escalation Part of the Phase 1 Study of KTX1001, an Oral, First-in-Class, Potent Inhibitor of MMSET/NSD2 for Relapsed/Refractory Multiple Myeloma (RRMM)

Pierre Bories, Cristina Gasparetto, David Dingli, Sagar Lonial, Saad Z. Usmani, Jesus G Berdeja, Alfred Chung, Aimaz Afrough, Laura Rosiñol, Andrew J. Yee, Suzanne Trudel, David S. Siegel, Paula Rodríguez-Otero, Soo Bang, Terry Connolly, Chad A. Lewis, Erin Flynt, Julie Vazquez, Sanjana U. Miskin, Benjamin Winograd, Maria-Victoria Mateos, Cyrille Touzeau, Vivek Roy
Journal: Blood
Blood (2024) 144 (Supplement 1): 3370.
https://doi.org/10.1182/blood-2024-199174
Published: 2024
Journal Articles

Trial in Progress: A Phase 1 Study of KTX-1001, an Oral, First-in-Class, Selective MMSET Inhibitor in Patients with Relapsed and Refractory Multiple Myeloma

Jesus G. Berdeja, David Dingli, Sagar Lonial, Andrew J. Yee, Alfred Chung, Cristina Gasparetto, P. Leif Bergsagel, Vivek Roy, Al-Ola Abdallah, Sharmilan Thanendrarajan, Aimaz Afrough, Laura Rosiñol, Suzanne Trudel, Paula Rodriguez Otero, Cyrille Touzeau, Pierre Bories, Soo Bang, Terry Connolly, Michelle Kim, Chad A. Lewis, Bao-Van Tran Linberg, M. Travis Quigley, Ola Landgren, Saad Z Usmani, Maria-Victoria Mateos, David S. Siegel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3391.
https://doi.org/10.1182/blood-2023-174550
Published: 2023
Journal Articles

Outcome of Infants Treated on Total Therapy for Infants with Acute Lymphoblastic Leukemia I: Results from a Non-Randomized Multi-Center Study

Tanja A. Gruber, Minxuan Huang, Sima Jeha, Rebecca J. Deyell, Victor A. Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Nathan Gossai, Erin H. Breese, Thai Hoa Tran, Norman J. Lacayo, Christine Bolen, Sunil J. Desai, Jennifer L. Pauley, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Krysta Schils, Linda C. Stork, Van Thu Huynh, Michael Richards, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah E. Schiff, Paul S. Gaynon
Journal: Blood
Blood (2023) 142 (Supplement 1): 823.
https://doi.org/10.1182/blood-2023-177798
Published: 2023
Journal Articles

Barriers to the Use of Disease-Modifying Treatments in Sickle Cell Disease: A Survey of Patients and Caregivers

Christina Kazarov, Enrico M. Novelli, Sandra Kane-Gill, Charles L Jonassaint, Maggie Jalowsky, Cory A. Lewis, Terri Newman
Journal: Blood
Blood (2022) 140 (Supplement 1): 5152–5153.
https://doi.org/10.1182/blood-2022-170881
Published: 2022
Journal Articles

Alberta Cellular and Immunotherapy (ACIT) 001, Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)

Michael P. Chu, Zack M. Breckenridge, Andrew Daly, Mona Shafey, Victor A. Lewis, Sunil J. Desai, Peng Wang, Joseph Brandwein, Peter Duggan, Beverly Wilson, Bindu Thapa, Carina Debes-Marun, Irwindeep Sandhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 7466–7467.
https://doi.org/10.1182/blood-2022-165887
Published: 2022
Journal Articles

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

Anne C. Wilke, Carmen Doebele, Alena Zindel, Kwang Seok Lee, Sara A. Rieke, Michele Ceribelli, Federico Comoglio, James D. Phelan, James Q. Wang, Yana Pikman, Dominique Jahn, Björn Häupl, Constanze Schneider, Sebastian Scheich, Frances A. Tosto, Hanibal Bohnenberger, Philipp Stauder, Frank Schnütgen, Mikolaj Slabicki, Zana A. Coulibaly, Sebastian Wolf, Kamil Bojarczuk, Björn Chapuy, Christian H. Brandts, Philipp Stroebel, Caroline A. Lewis, Michael Engelke, Xincheng Xu, Hahn Kim, Thanh Hung Dang, Roland Schmitz, Daniel J. Hodson, Kimberly Stegmaier, Henning Urlaub, Hubert Serve, Clemens A. Schmitt, Fernando Kreuz, Gero Knittel, Joshua D. Rabinowitz, Hans Christian Reinhardt, Matthew G. Vander Heiden, Craig Thomas, Louis M. Staudt, Thorsten Zenz, Thomas Oellerich
Journal: Blood
Blood (2022) 139 (4): 538–553.
https://doi.org/10.1182/blood.2021012081
Published: 2022
Includes: Supplemental data
Journal Articles

Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease

Clinical Trials & Observations
Divya Subburaj, Bernard Ng, Amina Kariminia, Sayeh Abdossamadi, Madeline Lauener, Eneida R. Nemecek, Jacob Rozmus, Sandhya Kharbanda, Carrie L. Kitko, Victor A. Lewis, Tal Schechter-Finklestein, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Donald Coulter, Joseph H. Chewning, Michael Joyce, Anna B. Pawlowska, Gail C. Megason, Anita Lawitschka, Elena Ostroumov, Ramon Klein Geltink, Geoffrey D. E. Cuvelier, Kirk R. Schultz
Journal: Blood
Blood (2022) 139 (2): 287–299.
https://doi.org/10.1182/blood.2021013244
Published: 2022
Includes: Supplemental data
Journal Articles

Naïve Helper T-Cell and Regulatory T- and NK-Cell Subsets Are Associated with Pediatric Chronic Graft-Versus-Host Disease: Results of the ABLE / PBMTC 1202 Study

Geoff D.E. Cuvelier, MD, Amina Kariminia, PhD, Eneida R. Nemecek, MDMBA,MSc, Carrie Kitko, MD, Justin T. Wahlstrom, MD, Andrew C Harris, MD, Henrique Bittencourt, MD PhD, Victor A. Lewis, MD, Michael A Pulsipher, MD, Tal Schechter-Finkelstein, MD, Sung W. Choi, MD, Emi Caywood, MD, Monica Bhatia, MD, Kimberly A. Kasow, DO, David Jacobsohn, MD, Benjamin Oshrine, MD, Sonali Chaudhury, MD, Joseph H. Chewning, MD, Flower Allyson, MD, Don W. Coulter, MD, Michael J. Joyce, MD, Sureyya Savasan, MD, Anna Pawlowska, MD, Gail Megason, MD, David Mitchell, MD, Alexandra Cheerva, MD, Anita Lawitschka, MD, Bernard Ng, PhD, Kirk R. Schultz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-139031
Published: 2020
Journal Articles

A Novel Anti-Cancer Vaccine Approach for the Treatment of High-Risk Leukemia in Children

Thakur Satbir, PhD, Son Tran, Mohit Jain, PhD, Austin Lewis, Luis Murguia-Favela, MD, Faisal M Khan, PhD D (ABHI), Kevin J. Bielamowicz, MD, Olena Vaske, PhD, Victor A. Lewis, MD, Norman J. Lacayo, MD, Aru Narendran, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25.
https://doi.org/10.1182/blood-2020-143381
Published: 2020
Journal Articles

Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies

Clinical Trials & Observations
Kirk R. Schultz, Amina Kariminia, Bernard Ng, Sayeh Abdossamadi, Madeline Lauener, Eneida R. Nemecek, Justin T. Wahlstrom, Carrie L. Kitko, Victor A. Lewis, Tal Schechter, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Allyson Flower, Sonali Chaudhury, Donald Coulter, Joseph H. Chewning, Michael Joyce, Sureyya Savasan, Anna B. Pawlowska, Gail C. Megason, David Mitchell, Alexandra C. Cheerva, Anita Lawitschka, Shima Azadpour, Elena Ostroumov, Peter Subrt, Anat Halevy, Sara Mostafavi, Geoffrey D. E. Cuvelier
Journal: Blood
Blood (2020) 135 (15): 1287–1298.
https://doi.org/10.1182/blood.2019003186
Published: 2020
Includes: Supplemental data
Journal Articles

Establishing a Novel in Vitro Informed Precision Clinical Trial Pathway for Refractory Pediatric Leukemia

Chunfen Zhang, MD, Ritul Sharma, MSc., Thakur Satbir, PhD, Allison Cheney, Olena Vaske, PhD, Lauren Sanders, Jessica Boklan, MD, Victor A. Lewis, MD, Ronald Anderson, MDFRCPC, Olga Kovalchuk, MD, PhD, Norman J. Lacayo, MD, Aru Narendran, MD PhD, Kevin J. Bielamowicz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2633.
https://doi.org/10.1182/blood-2019-131444
Published: 2019
Journal Articles

Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

CME
Geoffrey D. E. Cuvelier, Eneida R. Nemecek, Justin T. Wahlstrom, Carrie L. Kitko, Victor A. Lewis, Tal Schechter, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Allyson Flower, Sonali Chaudhury, Donald Coulter, Joseph H. Chewning, Michael Joyce, Süreyya Savaşan, Anna B. Pawlowska, Gail C. Megason, David Mitchell, Alexandra C. Cheerva, Anita Lawitschka, Lori J. West, Bo Pan, Yazid N. Al Hamarneh, Anat Halevy, Kirk R. Schultz
Journal: Blood
Blood (2019) 134 (3): 304–316.
https://doi.org/10.1182/blood.2019000216
Published: 2019
Includes: Supplemental data
Journal Articles

Early Prediction of Moderate-Severe Chronic GvHD By Immunity Related Transcriptome

Amit Kalra, MBBS, MSc, Poonam Dharmani-Khan, PhD, Stuti Patel, BHSc, Rehan Mujeeb Faridi, PhD, Victor A. Lewis, MD, Andrew Daly, MD, Adnan Mansoor, MDPhD, Meer-Taher Shabani-Rad, MD, Jan Storek, MD PhD, Faisal M Khan, PhD D (ABHI)
Journal: Blood
Blood (2018) 132 (Supplement 1): 70.
https://doi.org/10.1182/blood-2018-99-119926
Published: 2018
Journal Articles

Syndromic congenital myelofibrosis associated with a loss-of-function variant in RBSN

Clinical Trials & Observations
Pilar L. Magoulas, Oleg A. Shchelochkov, Matthew N. Bainbridge, Shay Ben-Shachar, Svetlana Yatsenko, Lorraine Potocki, Richard A. Lewis, Charles Searby, Andrea N. Marcogliese, M. Tarek Elghetany, Gladys Zapata, Paula P. Hernández, Manasi Gadkari, Derek Einhaus, Donna M. Muzny, Richard A. Gibbs, Alison A. Bertuch, Daryl A. Scott, Silvia Corvera, Luis M. Franco
Journal: Blood
Blood (2018) 132 (6): 658–662.
https://doi.org/10.1182/blood-2017-12-824433
Published: 2018
Includes: Supplemental data
Journal Articles

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis

Nai-Jia Huang, Ying-Cing Lin, Chung-Yueh Lin, Novalia Pishesha, Caroline A. Lewis, Elizaveta Freinkman, Colin Farquharson, José Luis Millán, Harvey Lodish
Journal: Blood
Blood (2018) 131 (26): 2955–2966.
https://doi.org/10.1182/blood-2018-03-838516
Published: 2018
Includes: Supplemental data
Journal Articles

Alemtuzumab/Low Dose TBI Conditioning Facilitates Stable Long-Term Donor Hematopoietic Cell Engraftment from Sibling Donors in Children with Sickle Cell Disease

Gregory M Guilcher, MDBSc,FRCPC, Dania Monagel, MDFRCPC,FAAP, Michael Leaker, MDFRCPC, Tony H Truong, MDFRCPC, Alberto Nettel-Aguirre, PhD PStat, Aisha Bruce, MD, Catherine Corriveau-Bourque, MD, Sunil Desai, MD, Victor A. Lewis, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4592.
https://doi.org/10.1182/blood.V130.Suppl_1.4592.4592
Published: 2017
Journal Articles

Functional GSTA1 Haplotypes Affect Clearance and Toxicity of Busulfan When Administered in 16 Doses to Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Multicenter Prospective Study on Behalf of the Pediatric Disease Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Marc Ansari, MD, Patricia Huezo-Diaz, PhD, Chakradhara Rao Satyanarayana Uppugunduri, PhD, Tiago Nava, MD, Mohammed Aziz Rezgui, MSc, Vid Mlakar, PhD, Laurence Lesne, MSc, Yves Theoret, PhD, Yves Chalandon, MD, L Lee Dupuis, PhD, Tal Schechter, MD, Imke H Bartelink, PhD, Jaap Jan Boelens, MD PhD, R.G.M. Bredius, MD, Jean-Hugues Dalle, MD PhD Prof., Saba Azarnoush, MD, Petr Sedlacek, MD PhD, Victor A. Lewis, MD, Martin Champagne, MD, Christina Peters, MD, Henrique Bittencourt, MD PhD, Maja Krajinovic, MDPhD
Journal: Blood
Blood (2016) 128 (22): 665.
https://doi.org/10.1182/blood.V128.22.665.665
Published: 2016