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Journal Articles

Deuterated water labeling in ibrutinib-treated patients with CLL: leukemia cell kinetics correlate with IGHV , ZAP-70, and MRD

Clinical Trials & Observations
Ekaterina Kim, Shih-Shih Chen, Mariela Sivina, Hyunsoo Hwang, Xuelin Huang, Alessandra Ferrajoli, Nitin Jain, William G. Wierda, Dominik Wodarz, Nicholas Chiorazzi, Jan A. Burger
Journal: Blood
Blood (2024) 144 (25): 2678–2681.
https://doi.org/10.1182/blood.2024025683
Published: 2024
Includes: Supplemental data
Journal Articles

A Phase II Study of Time-Limited Treatment with Acalabrutinib Plus Obinutuzumab in Patients with Treatment-Naïve Chronic Lymphocytic Leukemia

Jan A. Burger, Ekaterina Kim, Gitanjali Jayachandran, Wanda Lopez, Ghayas C. Issa, Musa Yilmaz, Mahesh Swaminathan, Jo Ishizawa, Alexandre Bazinet, Yesid Alvarado Valero, Nitin Jain, William G. Wierda, Alessandra Ferrajoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1868.
https://doi.org/10.1182/blood-2024-200331
Published: 2024
Journal Articles

Atezolizumab Combined with Venetoclax and Obinutuzumab for Frontline CLL

Patrick K. Reville, Sogand Sajedi, Alessandra Ferrajoli, Jan A. Burger, Michael J. Keating, Naveen Garg, Qing Deng, Michael R. Green, Hussein A. Abbas, William G. Wierda, Nitin Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 1014.
https://doi.org/10.1182/blood-2024-206306
Published: 2024
Journal Articles

Deep and Sustained Responses in Patients with CLL Treated with Zanubrutinib or Zanubrutinib + Obinutuzumab in Phase 1/2 AU-003 and Phase 1b GA-101 Studies: A Report from the Zanubrutinib Extension Study

Constantine S. Tam, Stephen S. Opat, Eileen Grace Merriman, Jan A. Burger, Emma Verner, Paula Marlton, David Gottlieb, Ian W. Flinn, Sumit Madan, Matthew Ku, Radha Prathikanti, Heather Allewelt, Tian Tian, Remus Vezan, Gavin Cull
Journal: Blood
Blood (2024) 144 (Supplement 1): 3255.
https://doi.org/10.1182/blood-2024-200363
Published: 2024
Journal Articles

A Phase II Study of Cladribine, Idarubicin, and Cytarabine (CLIA) in Combination with Gilteritinib for Patients with Newly Diagnosed FLT3 -Mutated Acute Myeloid Leukemia

Hannah Goulart, Hagop M. Kantarjian, Naval Daver, Musa Yilmaz, Guillermo Garcia-Manero, Kelly S. Chien, Jan A. Burger, Naveen Pemmaraju, Courtney D. DiNardo, Nicholas J. Short, Guillermo Montalban-Bravo, Abhishek Maiti, Danielle Hammond, Ghayas C. Issa, Elias Jabbour, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2024) 144 (Supplement 1): 2901.
https://doi.org/10.1182/blood-2024-205340
Published: 2024
Journal Articles

Phase II Study of Inotuzumab Ozogamicin for the Treatment of Measurable Residual Disease-Positive B-Cell Acute Lymphoblastic Leukemia: 3-Year Update

Fadi G. Haddad, Hagop M. Kantarjian, Nicholas J. Short, Jayastu Senapati, Nitin Jain, Koji Sasaki, Jeffrey L. Jorgensen, Joseph E. Jabbour, Sa A. Wang, Yesid Alvarado Valero, Xuemei Wang, Alessandra Ferrajoli, Diane Habib, Jan A. Burger, Courtney D. DiNardo, Zena Komrokji, Lucia Masarova, Tapan M. Kadia, Guillermo Garcia-Manero, Farhad Ravandi, Rebecca Garris, Elias Jabbour
Journal: Blood
Blood (2024) 144 (Supplement 1): 4194.
https://doi.org/10.1182/blood-2024-210642
Published: 2024
Journal Articles

Predictors for Time-to-First-Treatment in Patients with Del(17p) and/or TP53 -Mutated Chronic Lymphocytic Leukemia

Anjali Lankford, Mahesh Swaminathan, Amrit S. Gonugunta, Himachandana Atluri, Hannah Goulart, Koji Sasaki, Guilin Tang, Rashmi Kanagal-Shamanna, Jan A. Burger, Alessandra Ferrajoli, Hagop Kantarjian, William G. Wierda, Nitin Jain
Journal: Blood
Blood (2024) 144 (Supplement 1): 3246.
https://doi.org/10.1182/blood-2024-208974
Published: 2024
Journal Articles

Early Obinutuzumab Significantly Increases Bone Marrow Undetectable MRD (10 -4 sensitivity) (uMRD4) Rate When Combined with Acalabrutinib and Venetoclax in a Randomized Phase II Trial for Treatment Naïve CLL

Mahesh Swaminathan, Philip A. Thompson, Jan A. Burger, Musa Yilmaz, Nitin Jain, Tapan M. Kadia, Lucia Masarova, Yesid Alvarado Valero, Prithviraj Bose, Alessandra Ferrajoli, Ghayas C. Issa, Steven M. Kornblau, Farhad Ravandi, Koji Sasaki, Gautam Borthakur, Kelly S. Chien, Courtney D. DiNardo, Danielle Hammond, Elias Jabbour, Guillermo Montalban-Bravo, Naveen Pemmaraju, Nicholas J. Short, Koichi Takahashi, Francesco Paolo Tambaro, Wei Qiao, Naveen Garg, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1855.
https://doi.org/10.1182/blood-2024-211110
Published: 2024
Journal Articles

Combined Pirtobrutinib, Venetoclax, and Obinutuzumab As First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL)

Nitin Jain, Alessandra Ferrajoli, Mahesh Swaminathan, Patrick K. Reville, Jan A. Burger, Vanthana Bharathi, Himachandana Atluri, Hua-Jay J Cherng, Alex Bataller, Elias Jabbour, Tapan M. Kadia, Gautam Borthakur, Koichi Takahashi, Kelly S. Chien, Musa Yilmaz, Naveen Pemmaraju, Naval Daver, Fadi G. Haddad, Yesid Alvarado Valero, Jo Ishizawa, Guillermo Montalban-Bravo, Naveen Garg, Hyunsoo Hwang, Wei Qiao, Cameron Garcia, Anna Evangelio, Ana Ayala, Deepa Sampath, Varsha Gandhi, Michael J. Keating, Hagop M. Kantarjian, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1011.
https://doi.org/10.1182/blood-2024-211454
Published: 2024
Journal Articles

Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTK C481S -Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia

Ramon Massoni-Badosa, Joshua S. Schiffman, Barun Pradhan, Rebecca M. Murray, Andrew H. Lipsky, Debra Van Egeren, Danny Luan, Shirley Chen, Ronan Chaligne, Kai Beattie, Alyssa Indart, Nada Chraiki, Neville Dusaj, Erica B. Bhavsar, Chelston Ang, Anna S. Nam, Federico Gaiti, Paulina Chamely, Nathaniel D. Omans, Preeti Trisal, Anita K. Gandhi, Kyu-Tae Kim, Rafael Schulman, Franco Izzo, Gavriel Mullokandov, Chingiz Underbayev, Jan A. Burger, Adrian Wiestner, Elisa Ten Hacken, John N. Allan, Jennifer A. Woyach, Richard R. Furman, Dan A. Landau
Journal: Blood
Blood (2024) 144 (Supplement 1): 4610.
https://doi.org/10.1182/blood-2024-205727
Published: 2024
Journal Articles

Time-Limited Therapy with Zanubrutinib Plus Rituximab in Patients with Treatment-Naïve Chronic Lymphocytic Leukemia: Early Results of an Ongoing Phase II Trial

Jan A. Burger, Ekaterina Kim, Gitanjali Jayachandran, Thomas Mathew, Koji Sasaki, Yesid Alvarado Valero, Danielle Hammond, Fadi G. Haddad, William G. Wierda, Alessandra Ferrajoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 4631.
https://doi.org/10.1182/blood-2024-198701
Published: 2024
Journal Articles

Treatment with First-Line Ibrutinib Improves Overall Survival in Patients with Chronic Lymphocytic Leukemia (CLL) and High-Risk Genomic Features to Rates Approximating an Age-Matched US Population: Pooled Analysis of Phase 3 Trials with 10 Years of Follow-up

Jan A. Burger, Neil E. Kay, John N. Allan, Paul M Barr, Jacqueline C. Barrientos, Carolyn Owen, Victoria Wang, Hsin-Hui Huang, Lynne Neumayr, Christopher Abbazio, Gabriel S. Krigsfeld, Sneh Mody, Paolo Ghia, Tait D. Shanafelt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4615.
https://doi.org/10.1182/blood-2024-194382
Published: 2024
Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

CLL Cell-Derived Exosomes Impair Immune Function and Normal Hematopoiesis in CLL

Ivo Veletic, David M. Harris, Uri Rozovski, Ping Li, Zhiming Liu, Taghi Manshouri, Maria Teresa S. Bertilaccio, George A. Calin, Rares-Constantin Drula, Koichi Takahashi, Ken Furudate, Muharrem Muftuoglu, Anwar Hossain, Alessandra Ferrajoli, Jan A. Burger, Nitin Jain, William G. Wierda, Srdan Verstovsek, Michael J. Keating, Zeev Estrov
Journal: Blood
Blood (2023) 142 (Supplement 1): 3264.
https://doi.org/10.1182/blood-2023-190712
Published: 2023
Journal Articles

Azacitidine Plus Venetoclax Maintenance in Acute Myeloid Leukemia Produces Sustained Remissions with Low Toxicity: Results of a Phase 2 Study

Alexandre Bazinet, Hagop M. Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias Jabbour, Yesid Alvarado Valero, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas J. Short, Naval Daver, Ghayas C. Issa, Nitin Jain, Danielle E. Hammond, Debra Bull-Linderman, Courtney D. DiNardo, Jan A. Burger, Alessandra Ferrajoli, Guillermo Montalban-Bravo, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 2884.
https://doi.org/10.1182/blood-2023-172882
Published: 2023
Journal Articles

Time-Limited Therapy with Zanubrutinib Plus Rituximab in Treatment-Naïve Chronic Lymphocytic Leukemia: Early Results of an Ongoing Phase 2 Trial

Jan A. Burger, Ekaterina Kim, Mariela Sivina, Thomas Mathew, Danielle E. Hammond, Fadi G. Haddad, Alessandra Ferrajoli, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 6524.
https://doi.org/10.1182/blood-2023-178774
Published: 2023
Journal Articles

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Jayastu Senapati, Hagop M. Kantarjian, Elias Jabbour, Rodrick Babakhanlou, Tapan M. Kadia, Gautam Borthakur, Marina Y. Konopleva, William G. Wierda, Jan A. Burger, Ghayas C. Issa, Abhishek Maiti, Hayley S. Balkin, Mary Kelly, Rebecca Garris, Alessandra Ferrajoli, Guillermo Garcia-Manero, Yesid Alvarado Valero, Partow Kebriaei, Nicholas J. Short, Nitin Jain, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 963.
https://doi.org/10.1182/blood-2023-179562
Published: 2023
Journal Articles

NK Cell Dysfunction in CLL Is Mediated through SHP-1 Signaling and Is Associated with Poor Prognosis

Hila Shaim, Hind Rafei, Mecit Kaplan, Rafet Basar, May Daher, MD, Mayra Shanley, Pinaki Banerjee, Bijender Kumar, Ana K. Nunez Cortes, Sanjida Islam, Xin Ru Jiang, Lucila Nassif Kerbauy, Paul Lin, Elif Gokdemir, Nadima Uprety, Sunil Acharya, Mayela Carolina Mendt, Luciana Melo Garcia, Alexander Biederstädt, Bin Liu, Enli Liu, Sonny Ang, Jan A. Burger, William G. Wierda, Alessandra Ferrajoli, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1895.
https://doi.org/10.1182/blood-2023-189671
Published: 2023
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 5-Year Follow-up Data

Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Mahesh Swaminathan, Koichi Takahashi, Zeev Estrov, Marina Y. Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado Valero, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A. Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop M. Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2023-189711
Published: 2023