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Volume 133, Issue 12
March 21 2019
Issue Cover

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS
A new medical therapy for anemia in thalassemia
Clinical Trials & Observations
Emanuele Angelucci
View Articletitled, A new medical therapy for anemia in thalassemia
Lymphoid Neoplasia
A unique genome in EBV-positive BL
Jonathan C. Strefford,David G. Oscier
View Articletitled, A unique genome in EBV-positive BL
MYELOID NEOPLASIA
Clonal monocytosis of clinical significance
Mario Cazzola
View Articletitled, Clonal monocytosis of clinical significance
PLATELETS AND THROMBOPOIESIS
PTPRJ: a novel inherited thrombocytopenia gene
Renren Wen,Demin Wang
View Articletitled, PTPRJ: a novel inherited thrombocytopenia gene
THROMBOSIS AND HEMOSTASIS
ABO on platelets goes beyond transfusion
Jing-fei Dong
View Articletitled, ABO on platelets goes beyond transfusion
TRANSPLANTATION
In ALD, I feel the need for speed
Sandhya Kharbanda,Christopher C. Dvorak
View Articletitled, In ALD, I feel the need for speed

PLENARY PAPER

CLINICAL TRIALS AND OBSERVATIONS
Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia
Clinical Trials & Observations
Antonio Piga,Silverio Perrotta,Maria Rita Gamberini,Ersi Voskaridou,Angela Melpignano,Aldo Filosa,Vincenzo Caruso,Antonello Pietrangelo,Filomena Longo,Immacolata Tartaglione,Caterina Borgna-Pignatti,Xiaosha Zhang,Abderrahmane Laadem,Matthew L. Sherman,Kenneth M. Attie

There is a Blood Commentary on this article in this issue.

View Articletitled, Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia
Supplemental data

PERSPECTIVE

Mechanisms of immune escape after allogeneic hematopoietic cell transplantation
CME
Robert Zeiser,Luca Vago
View Articletitled, Mechanisms of immune escape after allogeneic hematopoietic cell transplantation

HOW I TREAT

How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia
Clinical Trials & Observations
Deborah M. Stephens,John C. Byrd
View Articletitled, How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia

HEMATOPOIESIS AND STEM CELLS

Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita
Brief Report
Wilson Chun Fok,Siddharth Shukla,Alexandre Teixeira Vessoni,Kirsten Ann Brenner,Roy Parker,Christopher M. Sturgeon,Luis Francisco Zirnberger Batista
View Articletitled, Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita
Supplemental data

LYMPHOID NEOPLASIA

Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Bruno M. Grande,Daniela S. Gerhard,Aixiang Jiang,Nicholas B. Griner,Jeremy S. Abramson,Thomas B. Alexander,Hilary Allen,Leona W. Ayers,Jeffrey M. Bethony,Kishor Bhatia,Jay Bowen,Corey Casper,John Kim Choi,Luka Culibrk,Tanja M. Davidsen,Maureen A. Dyer,Julie M. Gastier-Foster,Patee Gesuwan,Timothy C. Greiner,Thomas G. Gross,Benjamin Hanf,Nancy Lee Harris,Yiwen He,John D. Irvin,Elaine S. Jaffe,Steven J. M. Jones,Patrick Kerchan,Nicole Knoetze,Fabio E. Leal,Tara M. Lichtenberg,Yussanne Ma,Jean Paul Martin,Marie-Reine Martin,Sam M. Mbulaiteye,Charles G. Mullighan,Andrew J. Mungall,Constance Namirembe,Karen Novik,Ariela Noy,Martin D. Ogwang,Abraham Omoding,Jackson Orem,Steven J. Reynolds,Christopher K. Rushton,John T. Sandlund,Roland Schmitz,Cynthia Taylor,Wyndham H. Wilson,George W. Wright,Eric Y. Zhao,Marco A. Marra,Ryan D. Morin,Louis M. Staudt
View Articletitled, Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Supplemental data

MYELOID NEOPLASIA

The use of targeted sequencing and flow cytometry to identify patients with a clinically significant monocytosis
Catherine Cargo,Matthew Cullen,Jan Taylor,Mike Short,Paul Glover,Suzan Van Hoppe,Alex Smith,Paul Evans,Simon Crouch
View Articletitled, The use of targeted sequencing and flow cytometry to identify patients with a clinically significant monocytosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by Streptococcus pneumoniae serotype 3
Sagar Paudel,Pankaj Baral,Laxman Ghimire,Scott Bergeron,Liliang Jin,Joseph A. DeCorte,John T. Le,Shanshan Cai,Samithamby Jeyaseelan
View Articletitled, CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by <em>Streptococcus pneumoniae</em> serotype 3
Supplemental data

PLATELETS AND THROMBOPOIESIS

Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia
Caterina Marconi,Christian A. Di Buduo,Kellie LeVine,Serena Barozzi,Michela Faleschini,Valeria Bozzi,Flavia Palombo,Spencer McKinstry,Giuseppe Lassandro,Paola Giordano,Patrizia Noris,Carlo L. Balduini,Anna Savoia,Alessandra Balduini,Tommaso Pippucci,Marco Seri,Nicholas Katsanis,Alessandro Pecci
View Articletitled, Loss-of-function mutations in <em>PTPRJ</em> cause a new form of inherited thrombocytopenia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1
Sarah Rio,Marc Gastou,Narjesse Karboul,Raphaёl Derman,Thunwarat Suriyun,Hana Manceau,Thierry Leblanc,Jamel El Benna,Caroline Schmitt,Slim Azouzi,Jérome Larghéro,Zoubida Karim,Alejandra Macias-Garcia,Jane-Jane Chen,Olivier Hermine,Geneviève Courtois,Hervé Puy,Laurent Gouya,Narla Mohandas,Lydie Da Costa
View Articletitled, Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1
Supplemental data

THROMBOSIS AND HEMOSTASIS

Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function
Eimear Dunne,Qin M. Qi,Eric S. Shaqfeh,Jamie M. O’Sullivan,Ingmar Schoen,Antonio J. Ricco,James S. O’Donnell,Dermot Kenny
View Articletitled, Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function
Supplemental data

TRANSPLANTATION

Successful donor engraftment and repair of the blood-brain barrier in cerebral adrenoleukodystrophy
Brief Report
Paul J. Orchard,David R. Nascene,Weston P. Miller,Ashish Gupta,Dan Kenney-Jung,Troy C. Lund
View Articletitled, Successful donor engraftment and repair of the blood-brain barrier in cerebral adrenoleukodystrophy
Supplemental data

BLOOD WORK

γ Heavy chain disease
Vidya Nagrale,Lois Richard
View Articletitled, γ Heavy chain disease
Unexpected bone marrow findings in a patient with pancytopenia and coagulopathy
Omar Shakeel,Shiu-Ki Rocky Hui
View Articletitled, Unexpected bone marrow findings in a patient with pancytopenia and coagulopathy

ERRATUM

Dabaja BS, Hoppe BS, Plastaras JP, et al. Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines. Blood. 2018;132(16):1635-1646.
View Articletitled, Dabaja BS, Hoppe BS, Plastaras JP, et al. Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines. <em>Blood.</em> 2018;132(16):1635-1646.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Mechanisms of immune escape after allo-HCT
CME
View Articletitled, Mechanisms of immune escape after allo-HCT
  • Cover Image

    Cover Image

    issue cover

    Megakaryocyte of a patient with thrombocytopenia due to mutations in PTPRJ extending proplatelets on a fibrinogen-coated surface. The megakaryocyte is stained with anti–β1-tubulin (red). The nucleus is counterstained with Hoechst (blue). Proplatelets exhibit an altered morphology that is characterized by reduced length and ramification of their shafts, resulting in a small number of proplatelet tips. See the article by Marconi et al on page 1346.

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