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A new medical therapy for anemia in thalassemia
Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia
Issue Archive
March 21 2019
In this Issue
Table of Contents
BLOOD COMMENTARIES
CLINICAL TRIALS AND OBSERVATIONS
A new medical therapy for anemia in thalassemia
Clinical Trials & Observations
PLENARY PAPER
CLINICAL TRIALS AND OBSERVATIONS
Luspatercept improves hemoglobin levels and blood transfusion requirements in a study of patients with β-thalassemia
Clinical Trials & Observations
Antonio Piga,Silverio Perrotta,Maria Rita Gamberini,Ersi Voskaridou,Angela Melpignano,Aldo Filosa,Vincenzo Caruso,Antonello Pietrangelo,Filomena Longo,Immacolata Tartaglione,Caterina Borgna-Pignatti,Xiaosha Zhang,Abderrahmane Laadem,Matthew L. Sherman,Kenneth M. Attie
There is a Blood Commentary on this article in this issue.
PERSPECTIVE
HOW I TREAT
HEMATOPOIESIS AND STEM CELLS
LYMPHOID NEOPLASIA
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Bruno M. Grande,Daniela S. Gerhard,Aixiang Jiang,Nicholas B. Griner,Jeremy S. Abramson,Thomas B. Alexander,Hilary Allen,Leona W. Ayers,Jeffrey M. Bethony,Kishor Bhatia,Jay Bowen,Corey Casper,John Kim Choi,Luka Culibrk,Tanja M. Davidsen,Maureen A. Dyer,Julie M. Gastier-Foster,Patee Gesuwan,Timothy C. Greiner,Thomas G. Gross,Benjamin Hanf,Nancy Lee Harris,Yiwen He,John D. Irvin,Elaine S. Jaffe,Steven J. M. Jones,Patrick Kerchan,Nicole Knoetze,Fabio E. Leal,Tara M. Lichtenberg,Yussanne Ma,Jean Paul Martin,Marie-Reine Martin,Sam M. Mbulaiteye,Charles G. Mullighan,Andrew J. Mungall,Constance Namirembe,Karen Novik,Ariela Noy,Martin D. Ogwang,Abraham Omoding,Jackson Orem,Steven J. Reynolds,Christopher K. Rushton,John T. Sandlund,Roland Schmitz,Cynthia Taylor,Wyndham H. Wilson,George W. Wright,Eric Y. Zhao,Marco A. Marra,Ryan D. Morin,Louis M. Staudt
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopenia
Caterina Marconi,Christian A. Di Buduo,Kellie LeVine,Serena Barozzi,Michela Faleschini,Valeria Bozzi,Flavia Palombo,Spencer McKinstry,Giuseppe Lassandro,Paola Giordano,Patrizia Noris,Carlo L. Balduini,Anna Savoia,Alessandra Balduini,Tommaso Pippucci,Marco Seri,Nicholas Katsanis,Alessandro Pecci
RED CELLS, IRON, AND ERYTHROPOIESIS
Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1
Sarah Rio,Marc Gastou,Narjesse Karboul,Raphaёl Derman,Thunwarat Suriyun,Hana Manceau,Thierry Leblanc,Jamel El Benna,Caroline Schmitt,Slim Azouzi,Jérome Larghéro,Zoubida Karim,Alejandra Macias-Garcia,Jane-Jane Chen,Olivier Hermine,Geneviève Courtois,Hervé Puy,Laurent Gouya,Narla Mohandas,Lydie Da Costa
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
BLOOD WORK
ERRATUM
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS
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Cover Image
Cover Image
Megakaryocyte of a patient with thrombocytopenia due to mutations in PTPRJ extending proplatelets on a fibrinogen-coated surface. The megakaryocyte is stained with anti–β1-tubulin (red). The nucleus is counterstained with Hoechst (blue). Proplatelets exhibit an altered morphology that is characterized by reduced length and ramification of their shafts, resulting in a small number of proplatelet tips. See the article by Marconi et al on page 1346.
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