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Volume 131, Issue 2
January 11 2018
Issue Cover

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS
Limited-stage DLBCL: it’s patient selection
Clinical Trials & Observations
Daniel O. Persky
View Articletitled, Limited-stage DLBCL: it’s patient selection
CLINICAL TRIALS AND OBSERVATIONS
Choosing ibrutinib wisely
Clinical Trials & Observations
Farrukh T. Awan
View Articletitled, Choosing ibrutinib wisely
Hematopoiesis and Stem Cells
NOTCHing down a win for megakaryocytes
Samir Taoudi
View Articletitled, NOTCHing down a win for megakaryocytes
Lymphoid Neoplasia
Clinicogenetic risk modeling in ATL
Noriaki Yoshida,David M. Weinstock
View Articletitled, Clinicogenetic risk modeling in ATL
TRANSPLANTATION
NK cell destiny after haploSCT with PT-Cy
Amnon Peled,Arnon Nagler
View Articletitled, NK cell destiny after haploSCT with PT-Cy

HOW I TREAT

How I manage monoclonal gammopathy of undetermined significance
Clinical Trials & Observations
Ronald S. Go,S. Vincent Rajkumar
View Articletitled, How I manage monoclonal gammopathy of undetermined significance

CLINICAL TRIALS AND OBSERVATIONS

R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma
Clinical Trials & Observations
Thierry Lamy,Gandhi Damaj,Pierre Soubeyran,Emmanuel Gyan,Guillaume Cartron,Krimo Bouabdallah,Rémy Gressin,Jérôme Cornillon,Anne Banos,Katell Le Du,Mohamed Benchalal,Marie-Pierre Moles,Steven Le Gouill,Joel Fleury,Pascal Godmer,Hervé Maisonneuve,Eric Deconinck,Roch Houot,Kamel Laribi,Jean Pierre Marolleau,Olivier Tournilhac,Bernard Branger,Anne Devillers,Jean Philippe Vuillez,Thierry Fest,Philippe Colombat,Valérie Costes,Vanessa Szablewski,Marie C. Béné,Vincent Delwail,on behalf of the LYSA Group
View Articletitled, R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma
Supplemental data
Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial
Clinical Trials & Observations
Nancy L. Bartlett,Brian A. Costello,Betsy R. LaPlant,Stephen M. Ansell,John G. Kuruvilla,Craig B. Reeder,Lim S. Thye,Daniel M. Anderson,Kilannin Krysiak,Cody Ramirez,Jing Qi,Barry A. Siegel,Malachi Griffith,Obi L. Griffith,Felicia Gomez,Todd A. Fehniger
View Articletitled, Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
Yueying Li,Chen Jin,Hao Bai,Yongxing Gao,Shu Sun,Lei Chen,Lei Qin,Paul P. Liu,Linzhao Cheng,Qian-Fei Wang
View Articletitled, Human <em>NOTCH4</em> is a key target of RUNX1 in megakaryocytic differentiation
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Decitabine enhances targeting of AML cells by CD34+ progenitor-derived NK cells in NOD/SCID/IL2Rgnull mice
Jeannette Cany,Mieke W. H. Roeven,Janneke S. Hoogstad-van Evert,Willemijn Hobo,Frans Maas,Rosalia Franco Fernandez,Nicole M. A. Blijlevens,Walter J. van der Velden,Gerwin Huls,Joop H. Jansen,Nicolaas P. M. Schaap,Harry Dolstra
View Articletitled, Decitabine enhances targeting of AML cells by CD34<sup>+</sup> progenitor-derived NK cells in NOD/SCID/IL2Rg<sup>null</sup> mice
Supplemental data

LYMPHOID NEOPLASIA

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma
Clinical Trials & Observations
Keisuke Kataoka,Masako Iwanaga,Jun-ichirou Yasunaga,Yasunobu Nagata,Akira Kitanaka,Takuro Kameda,Makoto Yoshimitsu,Yuichi Shiraishi,Aiko Sato-Otsubo,Masashi Sanada,Kenichi Chiba,Hiroko Tanaka,Yotaro Ochi,Kosuke Aoki,Hiromichi Suzuki,Yusuke Shiozawa,Tetsuichi Yoshizato,Yusuke Sato,Kenichi Yoshida,Kisato Nosaka,Masakatsu Hishizawa,Hidehiro Itonaga,Yoshitaka Imaizumi,Wataru Munakata,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Tsuyoshi Nakamaki,Ken Ishiyama,Shuichi Miyawaki,Ryohei Ishii,Osamu Nureki,Kensei Tobinai,Yasushi Miyazaki,Akifumi Takaori-Kondo,Tatsuhiro Shibata,Satoru Miyano,Kenji Ishitsuka,Atae Utsunomiya,Kazuya Shimoda,Masao Matsuoka,Toshiki Watanabe,Seishi Ogawa
View Articletitled, Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma
Supplemental data
FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab and chemotherapy
Anja Mottok,Vindi Jurinovic,Pedro Farinha,Andreas Rosenwald,Ellen Leich,German Ott,Heike Horn,Wolfram Klapper,Michael Boesl,Wolfgang Hiddemann,Christian Steidl,Joseph M. Connors,Laurie H. Sehn,Randy D. Gascoyne,Eva Hoster,Oliver Weigert,Robert Kridel
View Articletitled, FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab and chemotherapy
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model
Daniel Garcia-Santos,Amel Hamdi,Zuzana Saxova,Carine Fillebeen,Kostas Pantopoulos,Monika Horvathova,Prem Ponka
View Articletitled, Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model
Supplemental data

TRANSPLANTATION

NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications
Antonio Russo,Giacomo Oliveira,Sofia Berglund,Raffaella Greco,Valentina Gambacorta,Nicoletta Cieri,Cristina Toffalori,Laura Zito,Francesca Lorentino,Simona Piemontese,Mara Morelli,Fabio Giglio,Andrea Assanelli,Maria Teresa Lupo Stanghellini,Chiara Bonini,Jacopo Peccatori,Fabio Ciceri,Leo Luznik,Luca Vago
View Articletitled, NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications
Supplemental data

LETTERS TO BLOOD

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study
Clinical Trials & Observations
Ali T. Taher,Zeynep Karakas,Elena Cassinerio,Noppadol Siritanaratkul,Antonis Kattamis,Aurelio Maggio,Stefano Rivella,Norbert Hollaender,Bruyère Mahuzier,Brian Gadbaw,Yesim Aydinok
View Articletitled, Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study
Supplemental data
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes
Clinical Trials & Observations
Anuhya Kommalapati,Sri Harsha Tella,Martin Durkin,Ronald S. Go,Gaurav Goyal
View Articletitled, Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes

BLOOD WORK

Talaromyces marneffei and dysplastic neutrophils on blood smear in newly diagnosed HIV
Jad Othman,Christina M. Brown
View Articletitled, <em>Talaromyces marneffei</em> and dysplastic neutrophils on blood smear in newly diagnosed HIV
When a marginal zone–type lymphocytosis mimics large granular lymphocytes
Coralie Derrieux,Emilie Klein
View Articletitled, When a marginal zone–type lymphocytosis mimics large granular lymphocytes
  • Cover Image

    Cover Image

    issue cover

    Color map obtained using the Barnes-Hut stochastic neighbor embedding bioinformatic algorithm for multidimensional single-cell analysis of a complex data set of immunophenotypic data, obtained upon analysis of a large panel of natural killer cell maturation markers in 5 healthy controls, 10 leukaphereses, and 10 patients analyzed at multiple time points after haploidentical hematopoietic stem cell transplantation. The map provides a visual representation of how samples in the data set cluster together. Coloring denotes the expression of the CD62L marker in individual samples, with red indicating high expression and blue indicating low expression. See the article by Russo et al on page 247.

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MRD and EFS in pediatric T-lymphoblastic lymphoma
Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (>24 months): the LATE-POD study
Mutational profile of previously treated chronic lymphocytic leukemia patients progressing on acalabrutinib or ibrutinib

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