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Volume 131, Issue 10
March 8 2018
Issue Cover

Table of Contents

EDITORIAL

Introduction to a review series on strategies to improve GVL effects
Robert Zeiser
View Articletitled, Introduction to a review series on strategies to improve GVL effects

BLOOD COMMENTARIES

PLATELETS AND THROMBOPOIESIS
An exit strategy for new platelets
J. Rivera,E. E. Gardiner
View Articletitled, An exit strategy for new platelets
THROMBOSIS AND HEMOSTASIS
Csk/CD148 and platelet SFK activation: a balancing act!
Jieqing Zhu
View Articletitled, Csk/CD148 and platelet SFK activation: a balancing act!

REVIEW SERIES

Posttransplant chimeric antigen receptor therapy
Melody Smith,Johannes Zakrzewski,Scott James,Michel Sadelain
View Articletitled, Posttransplant chimeric antigen receptor therapy
Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation
Sarah Cooley,Peter Parham,Jeffrey S. Miller
View Articletitled, Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation
The potential role of γδ T cells after allogeneic HCT for leukemia
Rupert Handgretinger,Karin Schilbach
View Articletitled, The potential role of γδ T cells after allogeneic HCT for leukemia
Tyrosine kinase inhibitors and immune checkpoint blockade in allogeneic hematopoietic cell transplantation
Robert J. Soiffer,Matthew S. Davids,Yi-Bin Chen
View Articletitled, Tyrosine kinase inhibitors and immune checkpoint blockade in allogeneic hematopoietic cell transplantation

HEMATOPOIESIS AND STEM CELLS

NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling
Pablo R. Freire,Orla M. Conneely
View Articletitled, NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling
Supplemental data

LYMPHOID NEOPLASIA

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies
Francesca Zammarchi,Simon Corbett,Lauren Adams,Peter C. Tyrer,Konstantinos Kiakos,Narinder Janghra,Teresa Marafioti,Charles E. Britten,Carin E. G. Havenith,Simon Chivers,Francois D’Hooge,David G. Williams,Arnaud Tiberghien,Philip W. Howard,John A. Hartley,Patrick H. van Berkel
View Articletitled, ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies
Supplemental data

PLATELETS AND THROMBOPOIESIS

GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice
Brief Report
Shuchi Gupta,Deya Cherpokova,Markus Spindler,Martina Morowski,Markus Bender,Bernhard Nieswandt
View Articletitled, GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum
Meng-Yao Zhang,Yang Zhang,Xiao-Dong Wu,Kun Zhang,Peng Lin,Hui-Jie Bian,Min-Min Qin,Wan Huang,Ding Wei,Zhao Zhang,Jiao Wu,Ruo Chen,Fei Feng,Bin Wang,Gang Nan,Ping Zhu,Zhi-Nan Chen
View Articletitled, Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by <em>Plasmodium falciparum</em>
Supplemental data

THROMBOSIS AND HEMOSTASIS

Professional illustration by Patrick Lane, ScEYEnce Studios.

Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148
Jun Mori,Zoltan Nagy,Giada Di Nunzio,Christopher W. Smith,Mitchell J. Geer,Rashid Al Ghaithi,Johanna P. van Geffen,Silke Heising,Luke Boothman,Bibian M. E. Tullemans,Joao N. Correia,Louise Tee,Marijke J. E. Kuijpers,Paul Harrison,Johan W. M. Heemskerk,Gavin E. Jarvis,Alexander Tarakhovsky,Arthur Weiss,Alexandra Mazharian,Yotis A. Senis
View Articletitled, Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148
Supplemental data

LETTERS TO BLOOD

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium
Clinical Trials & Observations
Weili Sun,Timothy Triche, Jr,Jemily Malvar,Paul Gaynon,Richard Sposto,Xiaojing Yang,Henrique Bittencourt,Andrew E. Place,Yoav Messinger,Chris Fraser,Luciano Dalla-Pozza,Bodour Salhia,Peter Jones,Alan S. Wayne,Lia Gore,Todd M. Cooper,Gangning Liang
View Articletitled, A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium
Supplemental data
The impact of age, NPM1mut, and FLT3ITD allelic ratio in patients with acute myeloid leukemia
Clinical Trials & Observations
Jasmin Straube,Victoria Y. Ling,Geoffrey R. Hill,Steven W. Lane
View Articletitled, The impact of age, NPM1<sup>mut</sup>, and FLT3<sup>ITD</sup> allelic ratio in patients with acute myeloid leukemia
Supplemental data

BLOOD WORK

Unusual cause of infant pancytopenia: granulomatous bone marrow lesion with disseminated histoplasmosis
Weijie Li,Mukta Sharma
View Articletitled, Unusual cause of infant pancytopenia: granulomatous bone marrow lesion with disseminated histoplasmosis
  • Cover Image

    Cover Image

    issue cover

    Checkpoint blockade can harness donor immunity to treat hematologic malignancies that relapse after allogeneic hematopoietic stem cell transplantation. The image shows the histopathological response of relapsed leukemia cutis, characterized by sparse chronic inflammation and fibrosis with no evidence of cancer (low magnification, hematoxylin and eosin stain) before and after treatment with the anti–CTLA-4 antibody ipilimumab. See the article by Soiffer et al on page 1073.

  • PDF Icon PDF LinkFront Matter
  • PDF Icon PDF LinkTable of Contents
  • PDF Icon PDF LinkBack Matter
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