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Issue Archive

Volume 130, Issue 3
July 20 2017
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Ironing out the role of hepcidin in infection
Josef T. Prchal
View Articletitled, Ironing out the role of hepcidin in infection
INSIDE BLOOD COMMENTARY
Check this checkpoint inhibitor in lymphoma
Clinical Trials & Observations
Fernando Cabanillas,Noridza Rivera
View Articletitled, Check this checkpoint inhibitor in lymphoma
INSIDE BLOOD COMMENTARY
Choosing wisely: RUNX1 alternate promoter use
Alan B. Cantor
View Articletitled, Choosing wisely: <em>RUNX1</em> alternate promoter use
INSIDE BLOOD COMMENTARY
CD70 turns on NK cells to attack lymphoma
Todd A. Fehniger
View Articletitled, CD70 turns on NK cells to attack lymphoma
INSIDE BLOOD COMMENTARY
Might broader be better?
Amy J. Johnson
View Articletitled, Might broader be better?
INSIDE BLOOD COMMENTARY
Prenatal diagnosis by droplet digital PCR
Margaret V. Ragni
View Articletitled, Prenatal diagnosis by droplet digital PCR
INSIDE BLOOD COMMENTARY
Raising the bar for chronic GVHD trials
Nicolaus Kröger
View Articletitled, Raising the bar for chronic GVHD trials
INSIDE BLOOD COMMENTARY
A new therapeutic strategy for atypical HUS
Clinical Trials & Observations
Joel L. Moake
View Articletitled, A new therapeutic strategy for atypical HUS

PLENARY PAPER

Red Cells, Iron, and Erythropoiesis
Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron
Deborah Stefanova,Antoan Raychev,Joao Arezes,Piotr Ruchala,Victoria Gabayan,Mikael Skurnik,Barbara J. Dillon,Marcus A. Horwitz,Tomas Ganz,Yonca Bulut,Elizabeta Nemeth
View Articletitled, Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron
Supplemental data

REVIEW ARTICLE

Can histologic transformation of follicular lymphoma be predicted and prevented?
CME
Robert Kridel,Laurie H. Sehn,Randy D. Gascoyne
View Articletitled, Can histologic transformation of follicular lymphoma be predicted and prevented?

CLINICAL TRIALS AND OBSERVATIONS

Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma
Clinical Trials & Observations Brief Report
Pier Luigi Zinzani,Vincent Ribrag,Craig H. Moskowitz,Jean-Marie Michot,John Kuruvilla,Arun Balakumaran,Yayan Zhang,Sabine Chlosta,Margaret A. Shipp,Philippe Armand
View Articletitled, Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors
Julia E. Draper,Patrycja Sroczynska,Hui Sun Leong,Muhammad Z. H. Fadlullah,Crispin Miller,Valerie Kouskoff,Georges Lacaud
View Articletitled, Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors
Supplemental data

IMMUNOBIOLOGY

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies
Diogo Gomes-Silva,Madhuwanti Srinivasan,Sandhya Sharma,Ciaran M. Lee,Dimitrios L. Wagner,Timothy H. Davis,Rayne H. Rouce,Gang Bao,Malcolm K. Brenner,Maksim Mamonkin
View Articletitled, CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies
Supplemental data

LYMPHOID NEOPLASIA

CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies
Mohamad F. Al Sayed,Carla A. Ruckstuhl,Tamara Hilmenyuk,Christina Claus,Jean-Pierre Bourquin,Beat C. Bornhauser,Ramin Radpour,Carsten Riether,Adrian F. Ochsenbein
View Articletitled, CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies
Supplemental data
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL
Tabea Erdmann,Pavel Klener,James T. Lynch,Michael Grau,Petra Vočková,Jan Molinsky,Diana Tuskova,Kevin Hudson,Urszula M. Polanska,Michael Grondine,Michele Mayo,Beiying Dai,Matthias Pfeifer,Kristian Erdmann,Daniela Schwammbach,Myroslav Zapukhlyak,Annette M. Staiger,German Ott,Wolfgang E. Berdel,Barry R. Davies,Francisco Cruzalegui,Marek Trneny,Peter Lenz,Simon T. Barry,Georg Lenz
View Articletitled, Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL
Supplemental data
Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation
Brief Report
Janine Schmidt,Joan Enric Ramis-Zaldivar,Ferran Nadeu,Blanca Gonzalez-Farre,Alba Navarro,Caoimhe Egan,Ivonne Aidee Montes-Mojarro,Teresa Marafioti,Jose Cabeçadas,Jon van der Walt,Stefan Dojcinov,Andreas Rosenwald,German Ott,Irina Bonzheim,Falko Fend,Elias Campo,Elaine S. Jaffe,Itziar Salaverria,Leticia Quintanilla-Martinez
View Articletitled, Mutations of <em>MAP2K1</em> are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils
Zakir Khan,Xiao Z. Shen,Ellen A. Bernstein,Jorge F. Giani,Masahiro Eriguchi,Tuantuan V. Zhao,Romer A. Gonzalez-Villalobos,Sebastien Fuchs,George Y. Liu,Kenneth E. Bernstein
View Articletitled, Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils
Supplemental data

THROMBOSIS AND HEMOSTASIS

Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers
Irena Hudecova,Peiyong Jiang,Joanna Davies,Y. M. Dennis Lo,Rezan A. Kadir,Rossa W. K. Chiu
View Articletitled, Noninvasive detection of <em>F8 int22h</em>-related inversions and sequence variants in maternal plasma of hemophilia carriers
Supplemental data

TRANSPLANTATION

T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD
Trisha A. Dant,Kaifeng L. Lin,Danny W. Bruce,Stephanie A. Montgomery,Oleg V. Kolupaev,Hemamalini Bommiasamy,Lisa M. Bixby,John T. Woosley,Karen P. McKinnon,Frank J. Gonzalez,Bruce R. Blazar,Benjamin G. Vincent,James M. Coghill,Jonathan S. Serody
View Articletitled, T-cell expression of AhR inhibits the maintenance of pT<sub>reg</sub> cells in the gastrointestinal tract in acute GVHD
Supplemental data
An endpoint associated with clinical benefit after initial treatment of chronic graft-versus-host disease
Paul J. Martin,Barry E. Storer,Yoshihiro Inamoto,Mary E. D. Flowers,Paul A. Carpenter,Joseph Pidala,Jeanne Palmer,Mukta Arora,Madan Jagasia,Sally Arai,Corey S. Cutler,Stephanie J. Lee
View Articletitled, An endpoint associated with clinical benefit after initial treatment of chronic graft-versus-host disease
Supplemental data

LETTERS TO BLOOD

Eculizumab cessation in atypical hemolytic uremic syndrome
Clinical Trials & Observations
Samuel A. Merrill,Zachary D. Brittingham,Xuan Yuan,Alison R. Moliterno,C. John Sperati,Robert A. Brodsky
View Articletitled, Eculizumab cessation in atypical hemolytic uremic syndrome
Supplemental data
CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells
Yan Li,Long Gao,Brandon Hadland,Kai Tan,Nancy A. Speck
View Articletitled, CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells
Supplemental data
NF-κB p50 (nfkb1) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia
Timothy L. Chen,Minh Tran,Aparna Lakshmanan,Bonnie K. Harrington,Nikhil Gupta,Virginia M. Goettl,Amy M. Lehman,Stephen Trudeau,David M. Lucas,Amy J. Johnson,John C. Byrd,Erin Hertlein
View Articletitled, NF-κB p50 (<em>nfkb1</em>) contributes to pathogenesis in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia
Supplemental data

BLOOD WORK

Peripheral eosinophilia as the first manifestation of B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32)
Dolores Gómez Toboso,Carmen Benet Campos
View Articletitled, Peripheral eosinophilia as the first manifestation of B-cell acute lymphoblastic leukemia with t(5;14)(q31;q32)
Classical Hodgkin lymphoma and Castleman disease: a rare morphologic combination
Shunyou Gong,Nobuko Hijiya
View Articletitled, Classical Hodgkin lymphoma and Castleman disease: a rare morphologic combination

ERRATUM

Curtis C, Mineyko A, Massicotte P, et al. Thrombophilia risk is not increased in children after perinatal stroke. Blood. 2017;129(20):2793-2800.
View Articletitled, Curtis C, Mineyko A, Massicotte P, et al. Thrombophilia risk is not increased in children after perinatal stroke. <em>Blood.</em> 2017;129(20):2793-2800.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Predicting transformation of follicular lymphoma
CME
View Articletitled, Predicting transformation of follicular lymphoma
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