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Volume 127, Issue 26
June 30 2016
Issue Cover

Table of Contents

EDITORIAL

Introduction to a review series on advances in cell-based immune therapeutics in hematology
Clinical Trials & Observations
Catherine M. Bollard,Freda K. Stevenson
View Articletitled, Introduction to a review series on advances in cell-based immune therapeutics in hematology

BLOOD FLASHBACK

Whang J, Frei E III, Tjio JH, Carbone PP, Brecher G. The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. Blood. 1963;22(6):664-673.
View Articletitled, Whang J, Frei E III, Tjio JH, Carbone PP, Brecher G. The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. <em>Blood</em>. 1963;22(6):<span class="related-article">664-673</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
EZH2: a molecular switch of the MPN phenotype
William Vainchenker,Isabelle Plo
View Articletitled, <em>EZH2</em>: a molecular switch of the MPN phenotype
INSIDE BLOOD COMMENTARY
One giant leap for pediatric AMKL
Jessica C. Shand
View Articletitled, One giant leap for pediatric AMKL
INSIDE BLOOD COMMENTARY
Tracers for tracing neutrophils
David C. Dale
View Articletitled, Tracers for tracing neutrophils
INSIDE BLOOD COMMENTARY
The power of cord blood cells
Jaap Jan Boelens
View Articletitled, The power of cord blood cells

REVIEW SERIES

Optimizing T-cell receptor gene therapy for hematologic malignancies
Clinical Trials & Observations
Emma C. Morris,Hans J. Stauss
View Articletitled, Optimizing T-cell receptor gene therapy for hematologic malignancies
CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date
Clinical Trials & Observations
Jae H. Park,Mark B. Geyer,Renier J. Brentjens
View Articletitled, CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date
Toxicities of chimeric antigen receptor T cells: recognition and management
Clinical Trials & Observations
Jennifer N. Brudno,James N. Kochenderfer
View Articletitled, Toxicities of chimeric antigen receptor T cells: recognition and management
T cells for viral infections after allogeneic hematopoietic stem cell transplant
Clinical Trials & Observations
Catherine M. Bollard,Helen E. Heslop
View Articletitled, T cells for viral infections after allogeneic hematopoietic stem cell transplant
Exploitation of natural killer cells for the treatment of acute leukemia
Clinical Trials & Observations
Rupert Handgretinger,Peter Lang,Maya C. André
View Articletitled, Exploitation of natural killer cells for the treatment of acute leukemia
Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies
Clinical Trials & Observations
Chuang Sun,Gianpietro Dotti,Barbara Savoldo
View Articletitled, Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies

CLINICAL TRIALS AND OBSERVATIONS

CHAMPION-1: a phase 1/2 study of once-weekly carfilzomib and dexamethasone for relapsed or refractory multiple myeloma
Clinical Trials & Observations
James R. Berenson,Alan Cartmell,Alberto Bessudo,Roger M. Lyons,Wael Harb,Dimitrios Tzachanis,Richy Agajanian,Ralph Boccia,Morton Coleman,Robert A. Moss,Robert M. Rifkin,Priti Patel,Sandra Dixon,Ying Ou,Janet Anderl,Sanjay Aggarwal,Jesus G. Berdeja
View Articletitled, CHAMPION-1: a phase 1/2 study of once-weekly carfilzomib and dexamethasone for relapsed or refractory multiple myeloma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
Kira Behrens,Ioanna Triviai,Maike Schwieger,Nilgün Tekin,Malik Alawi,Michael Spohn,Daniela Indenbirken,Marion Ziegler,Ursula Müller,Warren S. Alexander,Carol Stocking
View Articletitled, Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
Supplemental data

IMMUNOBIOLOGY

Impairment of dendritic cell functions in patients with adaptor protein-3 complex deficiency
Brief Report
Alberto Prandini,Valentina Salvi,Francesca Colombo,Daniele Moratto,Luisa Lorenzi,William Vermi,Maria Antonia De Francesco,Lucia Dora Notarangelo,Fulvio Porta,Alessandro Plebani,Fabio Facchetti,Silvano Sozzani,Raffaele Badolato
View Articletitled, Impairment of dendritic cell functions in patients with adaptor protein-3 complex deficiency
Supplemental data

LYMPHOID NEOPLASIA

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome
Wesley J. Woollard,Venu Pullabhatla,Anna Lorenc,Varsha M. Patel,Rosie M. Butler,Anthony Bayega,Nelema Begum,Farrah Bakr,Kiran Dedhia,Joshua Fisher,Silvia Aguilar-Duran,Charlotte Flanagan,Aria A. Ghasemi,Ricarda M. Hoffmann,Nubia Castillo-Mosquera,Elisabeth A. Nuttall,Arisa Paul,Ceri A. Roberts,Emmanouil G. Solomonidis,Rebecca Tarrant,Antoinette Yoxall,Carl Z. Beyers,Silvia Ferreira,Isabella Tosi,Michael A. Simpson,Emanuele de Rinaldis,Tracey J. Mitchell,Sean J. Whittaker
View Articletitled, Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome
Supplemental data

MYELOID NEOPLASIA

A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells
Xiaoli Wang,David Haylock,Cing Siang Hu,Wioleta Kowalczyk,Tianbo Jiang,Jiajing Qiu,Goar Mosoyan,Wu He,Netonia Marshall,John Mascarenhas,Anna Tarasova,Joshua Brody,David Winkler,Ronald Hoffman
View Articletitled, A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells
Supplemental data
Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm
Yue Yang,Hajime Akada,Dipmoy Nath,Robert E. Hutchison,Golam Mohi
View Articletitled, Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm
Supplemental data
Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study
Clinical Trials & Observations
Jasmijn D. E. de Rooij,Riccardo Masetti,Marry M. van den Heuvel-Eibrink,Jean-Michel Cayuela,Jan Trka,Dirk Reinhardt,Mareike Rasche,Edwin Sonneveld,Todd A. Alonzo,Maarten Fornerod,Martin Zimmermann,Martina Pigazzi,Rob Pieters,Soheil Meshinchi,C. Michel Zwaan,Franco Locatelli
View Articletitled, Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives
Julio Lahoz-Beneytez,Marjet Elemans,Yan Zhang,Raya Ahmed,Arafa Salam,Michael Block,Christoph Niederalt,Becca Asquith,Derek Macallan
View Articletitled, Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives
Supplemental data

THROMBOSIS AND HEMOSTASIS

Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
Jesse D. Lai,Paul C. Moorehead,Kate Sponagle,Katharina N. Steinitz,Birgit M. Reipert,Christine Hough,David Lillicrap
View Articletitled, Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
Supplemental data

TRANSPLANTATION

Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome
Clinical Trials & Observations
Gérard Michel,Claire Galambrun,Anne Sirvent,Cecile Pochon,Benedicte Bruno,Charlotte Jubert,Anderson Loundou,Ibrahim Yakoub-Agha,Noel Milpied,Patrick Lutz,Aude Marie-Cardine,Virginie Gandemer,Didier Blaise,Mauricette Michallet,Fanny Rialland,Cecile Renard,Claire Oudin,Sophie Esmiol,Mylene Seux,Karine Baumstarck,Mohamad Mohty,Vanderson Rocha,Jean-Hugues Dalle
View Articletitled, Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome
Supplemental data

BLOOD WORK

Rhabdomyosarcoma presenting with leukemic phase and massive bone marrow infiltration
Francisco J. Ortuño,María José López-Poveda
View Articletitled, Rhabdomyosarcoma presenting with leukemic phase and massive bone marrow infiltration
Gray-zone lymphoma: a complex reality
Bushra Moiz,Ayesha Majeed
View Articletitled, Gray-zone lymphoma: a complex reality

ERRATA

Richardson PG, Hungria VTM, Yoon S-S, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment. Blood. 2016;127(6):713-721.
View Articletitled, Richardson PG, Hungria VTM, Yoon S-S, et al. Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment. <em>Blood</em>. 2016;127(6):713-721.
  • Cover Image

    Cover Image

    issue cover

    Dispersed cells showing abnormal megakaryocyte maturation and a block to erythroid differentiation from colonies obtained from the expanded pool of megakaryocyte/erythroid progenitors isolated from Runx1-deficient mice. The authors demonstrate that in addition to the important role of Runx1 in supporting megakaryocyte maturation, it is also an essential suppressor of lineage commitment toward megakaryopoiesis. See the article by Behrens et al on page 3369.

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