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Issue Archive

Volume 125, Issue 15
April 9 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Haplo graft engineering: sculpting to a T
Ephraim J. Fuchs
View Articletitled, Haplo graft engineering: sculpting to a T
INSIDE BLOOD COMMENTARY
Mutations in complement C3 from aHUS patients
Gregers R. Andersen
View Articletitled, Mutations in complement C3 from aHUS patients
INSIDE BLOOD COMMENTARY
Macro-Quest
S. Vincent Rajkumar
View Articletitled, Macro-Quest
INSIDE BLOOD COMMENTARY
Why “R” HIT patients predisposed to thrombosis?
Anand Padmanabhan
View Articletitled, Why “R” HIT patients predisposed to thrombosis?
INSIDE BLOOD COMMENTARY
The primacy of IL-6 in IPS?
Takanori Teshima
View Articletitled, The primacy of IL-6 in IPS?

REVIEW ARTICLE

The biology and treatment of plasmablastic lymphoma
Clinical Trials & Observations
Jorge J. Castillo,Michele Bibas,Roberto N. Miranda
View Articletitled, The biology and treatment of plasmablastic lymphoma

EVIDENCE-BASED FOCUSED REVIEW

Minimal residual disease–directed therapy in acute myeloid leukemia
Clinical Trials & Observations
Sabine Kayser,Richard F. Schlenk,David Grimwade,Victor E. D. Yosuico,Roland B. Walter
View Articletitled, Minimal residual disease–directed therapy in acute myeloid leukemia
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia
Clinical Trials & Observations
Jeff Sharman,Michael Hawkins,Kathryn Kolibaba,Michael Boxer,Leonard Klein,Meihua Wu,Jing Hu,Steve Abella,Chris Yasenchak
View Articletitled, An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia
Supplemental data

HEMATOPOIESIS AND STEM CELLS

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency
Brief Report
Jad I. Belle,David Langlais,Jessica C. Petrov,Mercedes Pardo,Russell G. Jones,Philippe Gros,Anastasia Nijnik
View Articletitled, p53 mediates loss of hematopoietic stem cell function and lymphopenia in <em>Mysm1</em> deficiency
Supplemental data

IMMUNOBIOLOGY

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes
Irma Airoldi,Alice Bertaina,Ignazia Prigione,Alessia Zorzoli,Daria Pagliara,Claudia Cocco,Raffaella Meazza,Fabrizio Loiacono,Barbarella Lucarelli,Maria Ester Bernardo,Giulia Barbarito,Daniela Pende,Alessandro Moretta,Vito Pistoia,Lorenzo Moretta,Franco Locatelli
View Articletitled, γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ<sup>+</sup>/CD19<sup>+</sup> lymphocytes
Supplemental data
Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome
Elizabeth C. Schramm,Lubka T. Roumenina,Tania Rybkine,Sophie Chauvet,Paula Vieira-Martins,Christophe Hue,Tara Maga,Elisabetta Valoti,Valerie Wilson,Sakari Jokiranta,Richard J. H. Smith,Marina Noris,Tim Goodship,John P. Atkinson,Veronique Fremeaux-Bacchi
View Articletitled, Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome
Supplemental data

LYMPHOID NEOPLASIA

The cellular origin and malignant transformation of Waldenström macroglobulinemia
Bruno Paiva,Luis A. Corchete,Maria-Belen Vidriales,Ramón García-Sanz,Jose J. Perez,Irene Aires-Mejia,Maria-Luz Sanchez,Paloma Barcena,Diego Alignani,Cristina Jimenez,Maria-Eugenia Sarasquete,María-Victoria Mateos,Enrique M. Ocio,Noemi Puig,Fernando Escalante,José Hernández,Rebeca Cuello,Alfonso García de Coca,Magdalena Sierra,Maria-Carmen Montes,Tomás J. González-López,Josefina Galende,Abelardo Bárez,José Alonso,Emilia Pardal,Alberto Orfao,Norma C. Gutierrez,Jesús F. San Miguel
View Articletitled, The cellular origin and malignant transformation of Waldenström macroglobulinemia
Supplemental data
CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells
Brief Report
Patricia Amé-Thomas,Sylvia Hoeller,Catherine Artchounin,Jan Misiak,Mounia Sabrina Braza,Rachel Jean,Jérôme Le Priol,Céline Monvoisin,Nadine Martin,Philippe Gaulard,Karin Tarte
View Articletitled, CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells
Supplemental data

MYELOID NEOPLASIA

Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
Francis Mussai,Sharon Egan,Joseph Higginbotham-Jones,Tracey Perry,Andrew Beggs,Elena Odintsova,Justin Loke,Guy Pratt,Kin Pong U,Anthony Lo,Margaret Ng,Pamela Kearns,Paul Cheng,Carmela De Santo
View Articletitled, Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target
Supplemental data

PLATELETS AND THROMBOPOIESIS

Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2
Clinical Trials & Observations
Jérôme Rollin,Claire Pouplard,Hsueh Cheng Sung,Dorothée Leroux,Armand Saada,Valérie Gouilleux-Gruart,Gilles Thibault,Yves Gruel
View Articletitled, Increased risk of thrombosis in FcγRIIA 131RR patients with HIT due to defective control of platelet activation by plasma IgG2
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome
Graham W. Magor,Michael R. Tallack,Kevin R. Gillinder,Charles C. Bell,Naomi McCallum,Bronwyn Williams,Andrew C. Perkins
View Articletitled, <em>KLF1</em>-null neonates display hydrops fetalis and a deranged erythroid transcriptome
Supplemental data

THROMBOSIS AND HEMOSTASIS

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells
Xiaomei Wang,Jin Su,Alexandra Sherman,Geoffrey L. Rogers,Gongxian Liao,Brad E. Hoffman,Kam W. Leong,Cox Terhorst,Henry Daniell,Roland W. Herzog
View Articletitled, Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP<sup>+</sup>CD4<sup>+</sup> T cells
Supplemental data
Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays
Qiulan Ding,Likui Yang,Peyman Dinarvand,Xuefeng Wang,Alireza R. Rezaie
View Articletitled, Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays
Supplemental data

TRANSPLANTATION

Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation
Antiopi Varelias,Kate H. Gartlan,Ellen Kreijveld,Stuart D. Olver,Mary Lor,Rachel D. Kuns,Katie E. Lineburg,Bianca E. Teal,Neil C. Raffelt,Melody Cheong,Kylie A. Alexander,Motoko Koyama,Kate A. Markey,Elise Sturgeon,Justine Leach,Pavan Reddy,Glen A. Kennedy,Gregory A. Yanik,Bruce R. Blazar,Siok-Keen Tey,Andrew D. Clouston,Kelli P. A. MacDonald,Kenneth R. Cooke,Geoffrey R. Hill
View Articletitled, Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation
Supplemental data

BLOOD WORK

Unusual breast mass: lymphoma with crystal-storing histiocytosis
Sanam Loghavi,Joseph D. Khoury
View Articletitled, Unusual breast mass: lymphoma with crystal-storing histiocytosis

CORRESPONDENCE

Regression of an HCV-associated disseminated marginal zone lymphoma under IFN-free antiviral treatment
Philippe Sultanik,Caroline Klotz,Philippe Brault,Stanislas Pol,Vincent Mallet
View Articletitled, Regression of an HCV-associated disseminated marginal zone lymphoma under IFN-free antiviral treatment
Common cancer-associated PIK3CA activating mutations rarely occur in Langerhans cell histiocytosis
Sébastien Héritier,Raphael Saffroy,Nina Radosevic-Robin,Yolaine Pothin,Héléne Pacquement,Michel Peuchmaur,Antoinette Lemoine,Julien Haroche,Jean Donadieu,Jean-Francois Emile
View Articletitled, Common cancer-associated <em>PIK3CA</em> activating mutations rarely occur in Langerhans cell histiocytosis
Supplemental data

ERRATA

Evens AM, Kostakoglu L. The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. Blood. 2014;124(23):3356-3364.
View Articletitled, Evens AM, Kostakoglu L. The role of FDG-PET in defining prognosis of Hodgkin lymphoma for early-stage disease. <em>Blood</em>. 2014;124(23):3356-3364.
Cohen-Saidon C, Nechushtan H, Kahlon S, Livni N, Nissim A, Razin E. A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival. Blood. 2003;102(7):2506-2512.
View Articletitled, Cohen-Saidon C, Nechushtan H, Kahlon S, Livni N, Nissim A, Razin E. A novel strategy using single-chain antibody to show the importance of Bcl-2 in mast cell survival. <em>Blood</em>. 2003;102(7):2506-2512.
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