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Issue Archive

Volume 117, Issue 7
February 17 2011
Issue Cover

Table of Contents

Inside blood

IMMUNOBIOLOGY
B cells inflamed within and without
Marta Chesi
View Articletitled, B cells inflamed within and without
CLINICAL TRIALS
Self-determinism: alloBMT for AML
Philip L. McCarthy,Theresa Hahn
View Articletitled, Self-determinism: alloBMT for AML
CLINICAL TRIALS
Childhood ALL: ContRoL it or not?
André Baruchel
View Articletitled, Childhood ALL: <em>ContRoL</em> it or not?
IMMUNOBIOLOGY
T lymphocytes to IDO+ cells: check
Cailin Moira Wilke,Weiping Zou
View Articletitled, T lymphocytes to IDO<sup>+</sup> cells: check
THROMBOSIS & HEMOSTASIS
Platelet Syk is a HIT target
Alastair W. Poole
View Articletitled, Platelet Syk is a HIT target
THROMBOSIS & HEMOSTASIS
Two-faced catalytic autoantibodies
Sudhir Paul
View Articletitled, Two-faced catalytic autoantibodies
TRANSPLANTATION
Chronic GVHD: B cells come of age
Gérard Socié
View Articletitled, Chronic GVHD: B cells come of age

Blood Work

Skin nodules in multiple myeloma
View Articletitled, Skin nodules in multiple myeloma

Perspectives

Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model
Clinical Trials & Observations
Neil A. Goldenberg,Alex C. Spyropoulos,Jonathan L. Halperin,Craig M. Kessler,Sam Schulman,Alexander G. G. Turpie,Allan M. Skene,Neal R. Cutler,William R. Hiatt,for the Antithrombotic Trials Leadership and Steering Group
View Articletitled, Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model

Review Articles

Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma
Ivan K. H. Poon,Kruti K. Patel,David S. Davis,Christopher R. Parish,Mark D. Hulett
View Articletitled, Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma

Hematopoiesis and Stem Cells

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex
Kamel El Omari,Sarah J. Hoosdally,Kapil Tuladhar,Dimple Karia,Paresh Vyas,Roger Patient,Catherine Porcher,Erika J. Mancini
View Articletitled, Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
Shuyang Yu,Kairong Cui,Raja Jothi,Dong-Mei Zhao,Xuefang Jing,Keji Zhao,Hai-Hui Xue
View Articletitled, GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells
Supplemental data

Immunobiology

Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors
Jamieson Bretz,Josefina Garcia,Xiangao Huang,Lin Kang,Yang Zhang,Kai-Michael Toellner,Selina Chen-Kiang
View Articletitled, Noxa mediates p18<sup>INK4c</sup> cell-cycle control of homeostasis in B cells and plasma cell precursors
Supplemental data
HIV disease progression correlates with the generation of dysfunctional naive CD8low T cells
David Favre,Cheryl A. Stoddart,Brinda Emu,Rebecca Hoh,Jeffrey N. Martin,Frederick M. Hecht,Steven G. Deeks,Joseph M. McCune
View Articletitled, HIV disease progression correlates with the generation of dysfunctional naive CD8<sup>low</sup> T cells
Supplemental data
Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
Rikke Bæk Sørensen,Sine Reker Hadrup,Inge Marie Svane,Mads Christian Hjortsø,Per thor Straten,Mads Hald Andersen
View Articletitled, Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
Yuanyuan Chu,J. Christoph Vahl,Dilip Kumar,Klaus Heger,Arianna Bertossi,Edyta Wójtowicz,Valeria Soberon,Dominik Schenten,Brigitte Mack,Miriam Reutelshöfer,Rudi Beyaert,Kerstin Amann,Geert van Loo,Marc Schmidt-Supprian
View Articletitled, B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
Supplemental data

Lymphoid Neoplasia

Testing G-CSF responsiveness predicts the individual susceptibility to infection and consecutive treatment in recipients of high-dose chemotherapy
Clinical Trials & Observations
Christian Straka,Michael Sandherr,Hans Salwender,Hannes Wandt,Bernd Metzner,Kai Hübel,Gerda Silling,Marcus Hentrich,Daniel Franke,Rainer Schwerdtfeger,Mathias Freund,Orhan Sezer,Alexander Giagounidis,Gerhard Ehninger,Wolfgang Grimminger,Andreas Engert,Günter Schlimok,Christof Scheid,Peter Hellmann,Harald Heinisch,Hermann Einsele,Axel Hinke,Bertold Emmerich
View Articletitled, Testing G-CSF responsiveness predicts the individual susceptibility to infection and consecutive treatment in recipients of high-dose chemotherapy
Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial
Clinical Trials & Observations
Hannah M. Ensor,Claire Schwab,Lisa J. Russell,Sue M. Richards,Heather Morrison,Dino Masic,Lisa Jones,Sally E. Kinsey,Ajay J. Vora,Christopher D. Mitchell,Christine J. Harrison,Anthony V. Moorman
View Articletitled, Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and <em>CRLF2</em> deregulation: results from the MRC ALL97 clinical trial
Supplemental data

Myeloid Neoplasia

A Markov decision analysis of allogeneic hematopoietic cell transplantation versus chemotherapy in patients with acute myeloid leukemia in first remission
Clinical Trials & Observations
Saiko Kurosawa,Takuhiro Yamaguchi,Shuichi Miyawaki,Naoyuki Uchida,Heiwa Kanamori,Kensuke Usuki,Takuya Yamashita,Masato Watanabe,Kazuaki Yakushiji,Shingo Yano,Yuichiro Nawa,Jun Taguchi,Jin Takeuchi,Junji Tomiyama,Yuko Nakamura,Ikuo Miura,Yoshinobu Kanda,Yoichi Takaue,Takahiro Fukuda
View Articletitled, A Markov decision analysis of allogeneic hematopoietic cell transplantation versus chemotherapy in patients with acute myeloid leukemia in first remission
Supplemental data
The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML
Clinical Trials & Observations
Sabine Kayser,Konstanze Döhner,Jürgen Krauter,Claus-Henning Köhne,Heinz A. Horst,Gerhard Held,Marie von Lilienfeld-Toal,Sibylla Wilhelm,Andrea Kündgen,Katharina Götze,Mathias Rummel,David Nachbaur,Brigitte Schlegelberger,Gudrun Göhring,Daniela Späth,Carina Morlok,Manuela Zucknick,Arnold Ganser,Hartmut Döhner,Richard F. Schlenk,for the German-Austrian AMLSG
View Articletitled, The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML
Supplemental data
N-RasG12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene
Brief Report
Fu-Sheng Chou,Mark Wunderlich,Andrea Griesinger,James C. Mulloy
View Articletitled, N-Ras<sup>G12D</sup> induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells
Shunsuke Kanada,Chiharu Nishiyama,Nobuhiro Nakano,Ryuyo Suzuki,Keiko Maeda,Mutsuko Hara,Nao Kitamura,Hideoki Ogawa,Ko Okumura
View Articletitled, Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells
Supplemental data

Platelets and Thrombopoiesis

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects
Marco Cattaneo
View Articletitled, The platelet P2Y<sub>12</sub> receptor for adenosine diphosphate: congenital and drug-induced defects
PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model
Michael P. Reilly,Uma Sinha,Pierrette André,Scott M. Taylor,Yvonne Pak,Francis R. DeGuzman,Nisha Nanda,Anjali Pandey,Moritz Stolla,Wolfgang Bergmeier,Steven E. McKenzie
View Articletitled, PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model
Supplemental data

Red Cells, Iron, and Erythropoiesis

Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells
Xinqiang Huang,Eric Gschweng,Ben Van Handel,Donghui Cheng,Hanna K. A. Mikkola,Owen N. Witte
View Articletitled, Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells
Supplemental data
Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair
Luca Colnaghi,Mathew J. K. Jones,Xiomaris M. Cotto-Rios,Detlev Schindler,Helmut Hanenberg,Tony T. Huang
View Articletitled, Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair

Thrombosis and Hemostasis

Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A mice
Ai-Hong Zhang,Jonathan Skupsky,David W. Scott
View Articletitled, Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A mice
Supplemental data
Proteolytic antibodies activate factor IX in patients with acquired hemophilia
Bharath Wootla,Olivier D. Christophe,Ankit Mahendra,Jordan D. Dimitrov,Yohann Repessé,Véronique Ollivier,Alain Friboulet,Annie Borel-Derlon,Hervé Levesque,Jeanne-Yvonne Borg,Sebastien Andre,Jagadeesh Bayry,Thierry Calvez,Srinivas V. Kaveri,Sébastien Lacroix-Desmazes
View Articletitled, Proteolytic antibodies activate factor IX in patients with acquired hemophilia
Supplemental data

Transplantation

Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease–associated dysgammaglobulinemia
Zoya Kuzmina,Hildegard T. Greinix,Roman Weigl,Ulrike Körmöczi,Arno Rottal,Sophie Frantal,Sandra Eder,Winfried F. Pickl
View Articletitled, Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease–associated dysgammaglobulinemia
Supplemental data
Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease
Stefanie Sarantopoulos,Kristen E. Stevenson,Haesook T. Kim,Whitney S. Washel,Nazmim S. Bhuiya,Corey S. Cutler,Edwin P. Alyea,Vincent T. Ho,Robert J. Soiffer,Joseph H. Antin,Jerome Ritz
View Articletitled, Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease
Supplemental data

Vascular Biology

Endothelial reticulon-4B (Nogo-B) regulates ICAM-1–mediated leukocyte transmigration and acute inflammation
Annarita Di Lorenzo,Thomas D. Manes,Alberto Davalos,Paulette L. Wright,William C. Sessa
View Articletitled, Endothelial reticulon-4B (Nogo-B) regulates ICAM-1–mediated leukocyte transmigration and acute inflammation
All Issues

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