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Issue Archive

Volume 7, Issue 6
March 28 2023
Issue Cover

Table of Contents

STIMULUS REPORTS

Transformation of FL into DLBCL with a PMBL gene expression signature
Tristan Loveday,Gerben Duns,Lisa M. Rimsza,Karen L. Rech,James R. Cook,Ryan S. Robetorye,Allison C. Rosenthal,Colleen A. Ramsower,Tameson K. Yip,Catherine L. McKinney,Steven H. Swerdlow,Shweta Bhavsar,Christian Steidl,Sarah E. Gibson
View Articletitled, Transformation of FL into DLBCL with a PMBL gene expression signature
Supplemental data
The interplay between GPIb/IX antibodies, platelet hepatic sequestration, and TPO levels in patients with chronic ITP
Sufia N. Amini,Vivianne S. Nelson,Leendert Porcelijn,Tanja Netelenbos,Jaap Jan Zwaginga,Masja de Haas,Martin R. Schipperus,Rick Kapur
View Articletitled, The interplay between GPIb/IX antibodies, platelet hepatic sequestration, and TPO levels in patients with chronic ITP
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease
Clinical Trials & Observations
Julie Kanter,R. Clark Brown,Cynthia Norris,Santosh M. Nair,Abdullah Kutlar,Deepa Manwani,Nirmish Shah,Chiaki Tanaka,Shankaranand Bodla,Gessami Sanchez-Olle,Urs Albers,Darla Liles
View Articletitled, Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease
Supplemental data
Pembrolizumab for the treatment of disease relapse after allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations
James Godfrey,Hongtao Liu,Jovian Yu,Michael Tallarico,Emily Curran,Andrew Artz,Peter A. Riedell,Wendy Stock,Theodore Karrison,Carrie Fitzpatrick,Girish Venkataraman,Alan Cooper,Sonali M. Smith,Michael R. Bishop,Justin Kline
View Articletitled, Pembrolizumab for the treatment of disease relapse after allogeneic hematopoietic stem cell transplantation
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Efficacy of combined immunosuppression with or without eltrombopag in children with newly diagnosed aplastic anemia
Clinical Trials & Observations
Olga Goronkova,Galina Novichkova,Tatiana Salimova,Irina Kalinina,Dina Baidildina,Ulyana Petrova,Kristina Antonova,Maria Sadovskaya,Elena Suntsova,Dmitry Evseev,Victor Matveev,Dmitry Venyov,Lili Khachatryan,Dmitry Litvinov,Alexey Pshonkin,Galina Ovsyannikova,Natalia Kotskaya,Darina Gobadze,Yulia Olshanskaya,Alexander Popov,Elena Raykina,Olga Mironenko,Kirill Voronin,Bazarma Purbueva,Elmira Boichenko,Yulia Dinikina,Evgeniya Guseynova,Dmitry Sherstnev,Elena Kalinina,Sergey Mezentsev,Olga Streneva,Natalia Yudina,Olga Plaksina,Elena Erega,Michael Maschan,Alexey Maschan
View Articletitled, Efficacy of combined immunosuppression with or without eltrombopag in children with newly diagnosed aplastic anemia
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

GFAP and NfL increase during neurotoxicity from high baseline levels in pediatric CD19-CAR T-cell patients
Clinical Trials & Observations
Juliane Gust,Stephanie D. Rawlings-Rhea,Ashley L. Wilson,Niklas M. Tulberg,Amber L. Sherman,Kristy D. Seidel,Qian “Vicky” Wu,Julie R. Park,Rebecca A. Gardner,Colleen E. Annesley
View Articletitled, GFAP and NfL increase during neurotoxicity from high baseline levels in pediatric CD19-CAR T-cell patients
Supplemental data
Sequencing T-cell redirection therapies leads to deep and durable responses in patients with relapsed/refractory myeloma
Tarek H. Mouhieddine,Oliver Van Oekelen,David T. Melnekoff,Jeanne Li,Yogita Ghodke-Puranik,Guido Lancman,Santiago Thibaud,Darren Pan,Sridevi Rajeeve,Sarita Agte,Adolfo Aleman,Larysa Sanchez,Shambavi Richard,Adriana Rossi,Joshua Richter,Hearn Jay Cho,Cesar Rodriguez,Alessandro Lagana,Erin Moshier,Ajai Chari,Sundar Jagannath,Samir Parekh
View Articletitled, Sequencing T-cell redirection therapies leads to deep and durable responses in patients with relapsed/refractory myeloma
Supplemental data

LYMPHOID NEOPLASIA

Outcomes after biochemical or clinical progression in patients with multiple myeloma
Clinical Trials & Observations
Sarah Goldman-Mazur,Alissa Visram,Prashant Kapoor,Angela Dispenzieri,Martha Q. Lacy,Morie A. Gertz,Francis K. Buadi,Suzanne R. Hayman,David Dingli,Taxiarchis Kourelis,Wilson Gonsalves,Rahma Warsame,Eli Muchtar,Nelson Leung,Moritz Binder,Amie Fonder,Miriam Hobbs,Yi Lisa Hwa,Robert A. Kyle,S. Vincent Rajkumar,Shaji K. Kumar
View Articletitled, Outcomes after biochemical or clinical progression in patients with multiple myeloma
Supplemental data
Generation of a humanized afucosylated BAFF-R antibody with broad activity against human B-cell malignancies
Zhenyuan Dong,Joo Y. Song,Elana Thieme,Aaron Anderson,Elizabeth Oh,Wesley A. Cheng,Benjamin Z. Kuang,Vincent Lee,Tiantian Zhang,Zhe Wang,Szymon Szymura,D. Lynne Smith,Jianbing Zhang,Weihong Nian,Xintong Zheng,Feng He,Qing Zhou,Soung-chul Cha,Alexey V. Danilov,Hong Qin,Larry W. Kwak
View Articletitled, Generation of a humanized afucosylated BAFF-R antibody with broad activity against human B-cell malignancies
Supplemental data
Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations
Kylee H. Maclachlan,Tina Bagratuni,Efstathios Kastritis,Bachisio Ziccheddu,Sydney Lu,Venkata Yellapantula,Chris Famulare,Kimon Argyropoulos,Andriy Derkach,Elli Papaemmanuil,Ahmet Dogan,Alexander Lesokhin,Saad Z. Usmani,C. Ola Landgren,Lia M. Palomba,Francesco Maura,Meletios A. Dimopoulos
View Articletitled, Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations
Supplemental data
Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase
Takeshi Harada,Hiroto Ohguchi,Asuka Oda,Michiyasu Nakao,Jumpei Teramachi,Masahiro Hiasa,Ryohei Sumitani,Masahiro Oura,Kimiko Sogabe,Tomoko Maruhashi,Mamiko Takahashi,Shiro Fujii,Shingen Nakamura,Hirokazu Miki,Kumiko Kagawa,Shuji Ozaki,Shigeki Sano,Teru Hideshima,Masahiro Abe
View Articletitled, Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase
Supplemental data

MYELOID NEOPLASIA

Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML
Ghayas C. Issa,Aram Bidikian,Sangeetha Venugopal,Marina Konopleva,Courtney D. DiNardo,Tapan M. Kadia,Gautam Borthakur,Elias Jabbour,Naveen Pemmaraju,Musa Yilmaz,Nicholas J. Short,Abhishek Maiti,Koji Sasaki,Lucia Masarova,Sherry Pierce,Koichi Takahashi,Guilin Tang,Sanam Loghavi,Keyur Patel,Michael Andreeff,Kapil Bhalla,Guillermo Garcia-Manero,Farhad Ravandi,Hagop Kantarjian,Naval Daver
View Articletitled, Clinical outcomes associated with <em>NPM1</em> mutations in patients with relapsed or refractory AML
Supplemental data
Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs
Elisa Donato,Nadia Correia,Carolin Andresen,Darja Karpova,Roberto Würth,Corinna Klein,Markus Sohn,Adriana Przybylla,Petra Zeisberger,Kathrin Rothfelder,Helmut Salih,Halvard Bonig,Sebastian Stasik,Christoph Röllig,Anna Dolnik,Lars Bullinger,Frank Buchholz,Christian Thiede,Daniel Hübschmann,Andreas Trumpp
View Articletitled, Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in <em>DNMT3A</em><sup>mut</sup><em>NPM1</em><sup>mut</sup> AMLs
Supplemental data
Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia: an I-BFM Study Group collaboration
Anne Sofie Borg Hammer,Kristian Løvvik Juul-Dam,Julie Damgaard Sandahl,Jonas Abrahamsson,Malgorzata Czogala,Emmanuelle Delabesse,Iren Haltrich,Kirsi Jahnukainen,E. Anders Kolb,Gábor Kovács,Guy Leverger,Franco Locatelli,Riccardo Masetti,Ulrika Noren-Nyström,Susana C. Raimondi,Mareike Rasche,Dirk Reinhardt,Tomohiko Taki,Daisuke Tomizawa,Bernward Zeller,Henrik Hasle,Eigil Kjeldsen,on behalf of the I-BFM-AML Study Group
View Articletitled, Hypodiploidy has unfavorable impact on survival in pediatric acute myeloid leukemia: an I-BFM Study Group collaboration
Supplemental data

PLATELETS AND THROMBOPOIESIS

Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia
Catherine M. Broome,Alexander Röth,David J. Kuter,Marie Scully,Roy Smith,Jennifer Wang,Caroline Reuter,William Hobbs,Ahmed Daak
View Articletitled, Safety and efficacy of classical complement pathway inhibition with sutimlimab in chronic immune thrombocytopenia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept
Laura Hertz,Daniel Flormann,Lutz Birnbaumer,Christian Wagner,Matthias W. Laschke,Lars Kaestner
View Articletitled, Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept
Supplemental data

THROMBOSIS AND HEMOSTASIS

Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia
Clinical Trials & Observations
Anton Ilich,Terry B. Gernsheimer,Darrell J. Triulzi,Heather Herren,Siobhan P. Brown,Lori A. Holle,Andrew T. Lucas,Bas de Laat,Nahed El Kassar,Alisa S. Wolberg,Susanne May,Nigel S. Key
View Articletitled, Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia
Supplemental data

TRANSFUSION MEDICINE

Haplotype sequence collection of ABO blood group alleles by long-read sequencing reveals putative A1-diagnostic variants
Morgan Gueuning,Gian Andri Thun,Michael Wittig,Anna-Lena Galati,Stefan Meyer,Nadine Trost,Elise Gourri,Janina Fuss,Sonja Sigurdardottir,Yvonne Merki,Kathrin Neuenschwander,Yannik Busch,Peter Trojok,Marco Schäfer,Jochen Gottschalk,Andre Franke,Christoph Gassner,Wolfgang Peter,Beat M. Frey,Maja P. Mattle-Greminger
View Articletitled, Haplotype sequence collection of <em>ABO</em> blood group alleles by long-read sequencing reveals putative <em>A1</em>-diagnostic variants
Supplemental data

RESEARCH LETTERS

Megakaryocyte buds are distinct from microvesicles and likely to represent platelet precursors
Marc L. Ellis,Imala Alwis,Rhyll Smythe,Yuping Yuan,Shaun P. Jackson
View Articletitled, Megakaryocyte buds are distinct from microvesicles and likely to represent platelet precursors
Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model
Helena C. Brown,Sarah Beck,Stefano Navarro,Ying Di,Eva M. Soriano Jerez,Jana Kaczmarzyk,Steven G. Thomas,Valbona Mirakaj,Steve P. Watson,Bernhard Nieswandt,David Stegner
View Articletitled, Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model
Supplemental data
Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML
Clinical Trials & Observations
Aarif M. N. Batcha,Nele Buckup,Stefanos A. Bamopoulos,Vindi Jurinovic,Maja Rothenberg-Thurley,Hanna Gittinger,Bianka Ksienzyk,Annika Dufour,Stephanie Schneider,Mika Kontro,Joseph Saad,Caroline A. Heckmann,Cristina Sauerland,Dennis Görlich,Wolfgang E. Berdel,Bernhard J. Wörmann,Utz Krug,Jan Braess,Ulrich Mansmann,Wolfgang Hiddemann,Karsten Spiekermann,Klaus H. Metzeler,Tobias Herold
View Articletitled, Germline SNPs previously implicated as prognostic biomarkers do not associate with outcomes in intensively treated AML
Supplemental data
Genetic landscapes and curative effect of CAR T-cell immunotherapy in patients with relapsed or refractory DLBCL
Hui Shi,Peihao Zheng,Rui Liu,Teng Xu,Fan Yang,Shaomei Feng,Yuelu Guo,Lixia Ma,Haidi Liu,Yang Lei,Ruiting Li,Biping Deng,Shuling Hou,Yang Li,Qinlong Zheng,Kai Hu,Xiaoyan Ke
View Articletitled, Genetic landscapes and curative effect of CAR T-cell immunotherapy in patients with relapsed or refractory DLBCL
Supplemental data

ERRATA

Palma-Barqueros V, Bury L, Kunishima S, et al. Expanding the genetic spectrum of TUBB1-related thrombocytopenia. Blood Adv. 2021;5(24):5453–5467.
View Articletitled, Palma-Barqueros V, Bury L, Kunishima S, et al. Expanding the genetic spectrum of <em>TUBB1</em>-related thrombocytopenia. <em>Blood Adv.</em> 2021;5(24):5453–5467.
Visco C, Marcheselli L, Mina R, et al. A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. Blood Adv. (2022);6(1):327-338.
View Articletitled, Visco C, Marcheselli L, Mina R, et al. A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. <em>Blood Adv.</em> (2022);6(1):327-338.
  • Cover Image

    Cover Image

    issue cover

    Phylogenetic network showing the evolutionary relationships among ABO blood group alleles. Each circle represents a unique ABO allele with the size being proportional to its frequency in the data set. Mutational steps between ABO alleles are displayed as hatch marks along the connection lines. The length of the connection lines is not scaled by phylogenetic distance. See the article by Gueuning et al.

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