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Journal Articles

Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2, and PRN473 reduces venous thrombosis formation in mice

Christopher W. Smith, Joana Campos, Helena C. Brown, Natalie J. Jooss, Vanesa-Sindi Ivanova, Maan Harbi, Lourdes Garcia-Quintanilla, Sian Jossi, Marisol Perez-Toledo, Kieran Rookes, Alexander Brill, Lindsay N. Theodore, Tim Owens, Jacob LaStant, Matthew C. Foulke, Shin Mukai, Michelle Francesco, Michael Storek, Alexandra Hicks, Claire Langrish, Philip A. Nunn, Adam F. Cunningham, Abhi Chauhan, Mark R. Thomas, Steve P. Watson, Phillip L. R. Nicolson
Journal: Blood Advances
Blood Adv (2024) 8 (21): 5557–5570.
https://doi.org/10.1182/bloodadvances.2024012713
Published: 2024
Includes: Supplemental data
Journal Articles

Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer

Rui-Gang Xu, Christian Tiede, Antonio N. Calabrese, Lih T. Cheah, Thomas L. Adams, Julia S. Gauer, Matthew S. Hindle, Beth A. Webb, Daisie M. Yates, Alexandre Slater, Cédric Duval, Khalid M. Naseem, Andrew B. Herr, Darren C. Tomlinson, Steve P. Watson, Robert A. S. Ariëns
Journal: Blood Advances
Blood Adv (2024) 8 (15): 3917–3928.
https://doi.org/10.1182/bloodadvances.2024012689
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition

Philippe Billiald, Alexandre Slater, Martin Welin, Joanne C. Clark, Stéphane Loyau, Martine Pugnière, Isabella G. Jiacomini, Nadia Rose, Kristell Lebozec, Elie Toledano, Déborah François, Steve P. Watson, Martine Jandrot-Perrus
Journal: Blood Advances
Blood Adv (2023) 7 (7): 1258–1268.
https://doi.org/10.1182/bloodadvances.2022007863
Published: 2023
Includes: Multimedia, Supplemental data
Journal Articles

Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

Helena C. Brown, Sarah Beck, Stefano Navarro, Ying Di, Eva M. Soriano Jerez, Jana Kaczmarzyk, Steven G. Thomas, Valbona Mirakaj, Steve P. Watson, Bernhard Nieswandt, David Stegner
Journal: Blood Advances
Blood Adv (2023) 7 (6): 997–1000.
https://doi.org/10.1182/bloodadvances.2021006463
Published: 2023
Includes: Supplemental data
Journal Articles

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

Alexandra Mazharian, Blandine Maître, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Journal: Blood Advances
Blood Adv (2023) 7 (1): 46–59.
https://doi.org/10.1182/bloodadvances.2022008873
Published: 2023
Includes: Supplemental data
Journal Articles

Introduction of an ancient founder glycoprotein VI mutation into the Chilean population

Amanda Dalby, Diego Mezzano, José Rivera, Steve P. Watson, Neil V. Morgan
Journal: Blood Advances
Blood Adv (2022) 6 (22): 5866–5869.
https://doi.org/10.1182/bloodadvances.2022008531
Published: 2022
Journal Articles

Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry

Samuel Kemble, Amanda Dalby, Gillian C. Lowe, Phillip L. R. Nicolson, Steve P. Watson, Yotis Senis, Steven G. Thomas, Paul Harrison
Journal: Blood Advances
Blood Adv (2022) 6 (9): 2932–2946.
https://doi.org/10.1182/bloodadvances.2021006073
Published: 2022
Includes: Supplemental data
Journal Articles

AVEXIS technology identifies novel platelet-leukocyte binding partners including CD148-CD300a

Ruben Barroso, Roy Bicknell, George Ed Rainger, Steve P. Watson, Yi Sun
Journal: Blood Advances
Blood Adv (2021) 5 (23): 5016–5019.
https://doi.org/10.1182/bloodadvances.2021004546
Published: 2021
Includes: Supplemental data
Journal Articles

Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment

Rachel J. Stapley, Christopher W. Smith, Elizabeth J. Haining, Andrea Bacon, Sian Lax, Vera P. Pisareva, Andrey V. Pisarev, Steve P. Watson, Abdullah O. Khan, Neil V. Morgan
Journal: Blood Advances
Blood Adv (2021) 5 (2): 377–390.
https://doi.org/10.1182/bloodadvances.2020002404
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions

Magdolna Nagy, Gina Perrella, Amanda Dalby, M. Francisca Becerra, Lourdes Garcia Quintanilla, Jeremy A. Pike, Neil V. Morgan, Elizabeth E. Gardiner, Johan W. M. Heemskerk, Lorena Azócar, Juan Francisco Miquel, Diego Mezzano, Steve P. Watson
Journal: Blood Advances
Blood Adv (2020) 4 (13): 2953–2961.
https://doi.org/10.1182/bloodadvances.2020001761
Published: 2020
Includes: Supplemental data
Journal Articles

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα

Caroline Kardeby, Knut Fälker, Elizabeth J. Haining, Maarten Criel, Madelene Lindkvist, Ruben Barroso, Peter Påhlsson, Liza U. Ljungberg, Mattias Tengdelius, G. Ed Rainger, Stephanie Watson, Johannes A. Eble, Marc F. Hoylaerts, Jonas Emsley, Peter Konradsson, Steve P. Watson, Yi Sun, Magnus Grenegård
Journal: Blood Advances
Blood Adv (2019) 3 (3): 275–287.
https://doi.org/10.1182/bloodadvances.2018024950
Published: 2019
Includes: Supplemental data
Journal Articles

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

Samantha J. Montague, Céline Delierneux, Christelle Lecut, Nathalie Layios, Robert J. Dinsdale, Christine S.-M. Lee, Natalie S. Poulter, Robert K. Andrews, Peter Hampson, Christopher M. Wearn, Nathalie Maes, Jonathan Bishop, Amy Bamford, Chris Gardiner, Woei Ming Lee, Tariq Iqbal, Naiem Moiemen, Steve P. Watson, Cécile Oury, Paul Harrison, Elizabeth E. Gardiner
Journal: Blood Advances
Blood Adv (2018) 2 (3): 240–251.
https://doi.org/10.1182/bloodadvances.2017011171
Published: 2018
Includes: Supplemental data
Journal Articles

Fibrin and D-dimer bind to monomeric GPVI

Marie-Blanche Onselaer, Alexander T. Hardy, Clare Wilson, Ximena Sanchez, Amir K. Babar, Jeanette L. C. Miller, Callum N. Watson, Stephanie K. Watson, Arkadiusz Bonna, Helen Philippou, Andrew B. Herr, Diego Mezzano, Robert A. S. Ariëns, Steve P. Watson
Journal: Blood Advances
Blood Adv (2017) 1 (19): 1495–1504.
https://doi.org/10.1182/bloodadvances.2017007732
Published: 2017
Includes: Supplemental data