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Journal Articles

Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2 & PRN473 reduces venous thrombosis formation in mice.

Christopher W Smith, Joana Campos, Helena C Brown, Natalie J Jooss, Vanesa-Sindi Ivanova, Maan Harbi, Lourdes Garcia Quintanilla, Sian Jossi, Marisol Perez-Toledo, Kieran Rookes, Alexander Brill, Lindsay N Theodore, Tim Owens, Jacob J. La Stant, Matthew C Foulke, Shin Mukai, Michelle Francesco, Michael J Storek, Alexandra Hicks, Claire Langrish, Philip A Nunn, Adam F Cunningham, Abhishek Chauhan, Mark R Thomas, Steve P Watson, Phillip Lindsay Ross Nicolson
Journal: Blood Advances
Blood Adv bloodadvances.2024012713.
https://doi.org/10.1182/bloodadvances.2024012713
Published: 2024
Includes: Supplemental data
Journal Articles

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells

Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R. Light
Journal: Blood Advances
Blood Adv (2023) 7 (11): 2317–2323.
https://doi.org/10.1182/bloodadvances.2022008710
Published: 2023
Includes: Supplemental data
Journal Articles

MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease

Melanie Demers, Sarah Sturtevant, Kevin R. Guertin, Dipti Gupta, Kunal Desai, Benjamin F. Vieira, Wenjing Li, Alexandra Hicks, Ayman Ismail, Bronner P. Gonçalves, Giuseppe Di Caprio, Ethan Schonbrun, Scott Hansen, Faik N. Musayev, Martin K. Safo, David K. Wood, John M. Higgins, David R. Light
Journal: Blood Advances
Blood Adv (2021) 5 (5): 1388–1402.
https://doi.org/10.1182/bloodadvances.2020003670
Published: 2021
Includes: Supplemental data