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Issue Archive

Volume 7, Issue 5
March 14 2023
Issue Cover

Table of Contents

STIMULUS REPORT

Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression
Jihyun Song,Soo Jin Kim,Jahnavi Gollamudi,Perumal Thiagarajan,Josef T. Prchal
View Articletitled, Downregulated <em>KLF2</em> in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Phase 1 study of CART-ddBCMA for the treatment of subjects with relapsed and refractory multiple myeloma
Clinical Trials & Observations
Matthew J. Frigault,Michael R. Bishop,Jacalyn Rosenblatt,Elizabeth K. O’Donnell,Noopur Raje,Daniella Cook,Andrew J. Yee,Emma Logan,David E. Avigan,Andrzej Jakubowiak,Kit Shaw,Heather Daley,Sarah Nikiforow,Faith Griffin,Christine Cornwell,Angela Shen,Christopher Heery,Marcela V. Maus
View Articletitled, Phase 1 study of CART-ddBCMA for the treatment of subjects with relapsed and refractory multiple myeloma
Supplemental data
Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing
Clinical Trials & Observations
W. Huisman,M. C. J. Roex,L. Hageman,E. A. S. Koster,S. A. J. Veld,C. Hoogstraten,P. van Balen,H. M. van Egmond,C. A. M. van Bergen,H. Einsele,L. Germeroth,D. Amsen,J. H. F. Falkenburg,I. Jedema
View Articletitled, Tracking the progeny of adoptively transferred virus-specific T cells in patients posttransplant using TCR sequencing
Supplemental data
sCD25 as an independent adverse prognostic factor in adult patients with HLH: results of a multicenter retrospective study
Clinical Trials & Observations
Thomas Wimmer,Raphael Mattes,Hans-Joachim Stemmler,Fabian Hauck,Hendrik Schulze-Koops,Stephanie-Susanne Stecher,Michael Starck,Clemens-Martin Wendtner,Peter Bojko,Marcus Hentrich,Katharina E. Nickel,Katharina S. Götze,Florian Bassermann,Michael von Bergwelt-Baildon,Karsten Spiekermann
View Articletitled, sCD25 as an independent adverse prognostic factor in adult patients with HLH: results of a multicenter retrospective study
Supplemental data
Late effects in patients with mantle cell lymphoma treated with or without autologous stem cell transplantation
Clinical Trials & Observations
Sara Ekberg,Karin E. Smedby,Alexandra Albertsson-Lindblad,Mats Jerkeman,Caroline E. Weibull,Ingrid Glimelius
View Articletitled, Late effects in patients with mantle cell lymphoma treated with or without autologous stem cell transplantation
Supplemental data

GENE THERAPY

CD14+/CD31+ monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII
Muhammad Elnaggar,Anjud Al-Mohannadi,Waseem Hasan,Doua Abdelrahman,Mohammed J. Al-Kubaisi,Igor Pavlovski,Giusy Gentilcore,Abbirami Sathappan,Dhanya Kizhakayil,Aesha I. Ali,Suruchi Mohan,Damilola Olagunju,Chiara Cugno,Jean-Charles Grivel,Chiara Borsotti,Antonia Follenzi,Sahar I. Da’as,Sara Deola
View Articletitled, CD14<sup>+</sup>/CD31<sup>+</sup> monocytes expanded by UM171 correct hemophilia A in zebrafish upon lentiviral gene transfer of factor VIII
Supplemental data

HEALTH SERVICES AND OUTCOMES

Second malignancies among older patients with classical myeloproliferative neoplasms treated with hydroxyurea
Rong Wang,Rory M. Shallis,Jessica M. Stempel,Scott F. Huntington,Amer M. Zeidan,Steven D. Gore,Xiaomei Ma,Nikolai A. Podoltsev
View Articletitled, Second malignancies among older patients with classical myeloproliferative neoplasms treated with hydroxyurea

IMMUNOBIOLOGY AND IMMUNOTHERAPY

HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma
Estelle Bourbon,Pierre Sesques,Morgane Gossez,Jérémie Tordo,Emmanuelle Ferrant,Violaine Safar,Florent Wallet,Guillaume Aussedat,Alizée Maarek,Fadhela Bouafia,Lionel Karlin,Dana Ghergus,Camille Golfier,Hélène Lequeu,Anne Lazareth,Vérane Schwiertz,Sébastien Viel,Maryam Idlhaj,Hervé Ghesquières,Guillaume Monneret,Emmanuel Bachy,Fabienne Venet
View Articletitled, HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma
Supplemental data

LYMPHOID NEOPLASIA

Efficacy, safety, and molecular response predictors of oral ixazomib and short-course rituximab in untreated iNHL
Clinical Trials & Observations
Solomon A. Graf,Ryan C. Lynch,Chaitra S. Ujjani,Ted A. Gooley,Heather Rasmussen,David G. Coffey,Andrew J. Cowan,Stephen D. Smith,Mazyar Shadman,Edus H. Warren,Edward N. Libby, III,Alexander L. Greninger,Jonathan R. Fromm,Ajay K. Gopal
View Articletitled, Efficacy, safety, and molecular response predictors of oral ixazomib and short-course rituximab in untreated iNHL
Supplemental data
Spatiotemporal assessment of immunogenomic heterogeneity in multiple myeloma
Maximilian Merz,Qiang Hu,Almuth Maria Anni Merz,Jie Wang,Nicholas Hutson,Cherie Rondeau,Kimberly Celotto,Ahmed Belal,Ronald Alberico,AnneMarie W. Block,Hemn Mohammadpour,Paul K. Wallace,Joseph Tario,Jesse Luce,Sean T. Glenn,Prashant Singh,Mehmet Samur,Nikhil Munshi,Song Liu,Philip L. McCarthy,Lei Wei,Jens Hillengass
View Articletitled, Spatiotemporal assessment of immunogenomic heterogeneity in multiple myeloma
Supplemental data
Cost-effectiveness of chimeric antigen receptor T-cell therapy in adults with relapsed or refractory follicular lymphoma
Kunal C. Potnis,Mengyang Di,Iris Isufi,Lohith Gowda,Stuart E. Seropian,Francine M. Foss,Howard P. Forman,Scott F. Huntington
View Articletitled, Cost-effectiveness of chimeric antigen receptor T-cell therapy in adults with relapsed or refractory follicular lymphoma
Supplemental data
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
Findlay Bewicke-Copley,Koorosh Korfi,Shamzah Araf,Brendan Hodkinson,Emil Kumar,Thomas Cummin,Margaret Ashton-Key,Sharon Barrans,Suzan van Hoppe,Cathy Burton,Mohamed Elshiekh,Simon Rule,Nicola Crosbie,Andrew Clear,Maria Calaminici,Hendrik Runge,Robert K. Hills,David W. Scott,Lisa M. Rimsza,Geetha Menon,Chulin Sha,John R. Davies,Ai Nagano,Andrew Davies,Daniel Painter,Alexandra Smith,John Gribben,Kikkeri N. Naresh,David R. Westhead,Jessica Okosun,Andrew Steele,Daniel J. Hodson,Sriram Balasubramanian,Peter Johnson,Jun Wang,Jude Fitzgibbon
View Articletitled, Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma
Supplemental data

MYELOID NEOPLASIA

Patient-specific comorbidities as prognostic variables for survival in myelofibrosis
Andrew L. Sochacki,Cosmin Adrian Bejan,Shilin Zhao,Ameet Patel,Ashwin Kishtagari,Travis P. Spaulding,Alexander J. Silver,Shannon S. Stockton,Kelly Pugh,R. Dixon Dorand,Manasa Bhatta,Nicholas Strayer,Siwei Zhang,Christina A. Snider,Thomas Stricker,Aziz Nazha,Alexander G. Bick,Yaomin Xu,Michael R. Savona
View Articletitled, Patient-specific comorbidities as prognostic variables for survival in myelofibrosis
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load
Devon J. Eddins,Junkai Yang,Astrid Kosters,Vincent D. Giacalone,Ximo Pechuan-Jorge,Joshua D. Chandler,Jinyoung Eum,Benjamin R. Babcock,Brian S. Dobosh,Mindy R. Hernández,Fathma Abdulkhader,Genoah L. Collins,Darya Y. Orlova,Richard P. Ramonell,Ignacio Sanz,Christine Moussion,F. Eun-Hyung Lee,Rabindra M. Tirouvanziam,Eliver E. B. Ghosn
View Articletitled, Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load
Supplemental data

TRANSPLANTATION

The promising efficacy of a risk-based letermovir use strategy in CMV-positive allogeneic hematopoietic cell recipients
Mathilde Sourisseau,Emmanuel Faure,Hélène Béhal,Paul Chauvet,Micha Srour,Antoine Capes,Valérie Coiteux,Léonardo Magro,Serge Alfandari,Enagnon Kazali Alidjinou,Nicolas Simon,Fanny Vuotto,Micheline Karam,Karine Faure,Ibrahim Yakoub-Agha,David Beauvais
View Articletitled, The promising efficacy of a risk-based letermovir use strategy in CMV-positive allogeneic hematopoietic cell recipients

RESEARCH LETTERS

Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3mut AML
Clinical Trials & Observations
Toshiki Terao,Ken-ichi Matsuoka,Hiroko Ueda,Akifumi Matsumura,Chisato Matsubara,Kaho Kondo,Takumi Kondo,Hideaki Fujiwara,Noboru Asada,Daisuke Ennishi,Hisakazu Nishimori,Keiko Fujii,Nobuharu Fujii,Yoshinobu Maeda
View Articletitled, Early initiation of low-dose gilteritinib maintenance improves posttransplant outcomes in patients with R/R FLT3<sup>mut</sup> AML
Supplemental data
Validation of the ALFA-1200 model in older patients with AML treated with intensive chemotherapy
Clinical Trials & Observations
Hussein A. Abbas,Hanxiao Sun,Sherry Pierce,Rashmi Kanagal-Shamanna,Ziyi Li,Musa Yilmaz,Gautam Borthakur,Adam J. DiPippo,Elias Jabbour,Marina Konopleva,Nicholas J. Short,Courtney DiNardo,Naval Daver,Farhad Ravandi,Tapan M. Kadia
View Articletitled, Validation of the ALFA-1200 model in older patients with AML treated with intensive chemotherapy
Supplemental data

ERRATA

Lévy R, Fusaro M, Guerin F, et al. Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. Blood Adv. 2020;4(7):1383-1387.
View Articletitled, Lévy R, Fusaro M, Guerin F, et al. Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. <em>Blood Adv</em>. 2020;4(7):1383-1387.
Cuker A, Tseng EK, Nieuwlaat R, et al. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients. Blood Adv. 2021;5(20):3951-3959.
View Articletitled, Cuker A, Tseng EK, Nieuwlaat R, et al. American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients. <em>Blood Adv.</em> 2021;5(20):3951-3959.
Oñate G, Bataller A, Garrido A, et al; CETLAM (Spanish Cooperative Group for the Diagnosis and Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes). Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1. Blood Adv. 2022;6(3):882-890.
View Articletitled, Oñate G, Bataller A, Garrido A, et al; CETLAM (Spanish Cooperative Group for the Diagnosis and Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes). Prognostic impact of <em>DNMT3A</em> mutation in acute myeloid leukemia with mutated <em>NPM1</em>. <em>Blood Adv.</em> 2022;6(3):882-890.
  • Cover Image

    Cover Image

    issue cover

    Engraftment of human CD34+ cells (red) in the hematopoietic niche of a zebrafish larvae, transgenic for green vasculature. CD34+ cells are transduced in vitro with rLV.EF1.tdTomato-9, expanded with UM171 compound, and injected in 2-day-old zebrafish larvae. The engraftment is captured 24 hours after cell injection. Small bulks of CD34+ cells grow in tight proximity of the hematopoietic-niche vasculature in the Tg(fli1:EGFP) zebrafish model. See the article by Elnaggar et al.

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