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Issue Archive

Volume 6, Issue 3
February 8 2022
Blood Advances Cover Image for Volume 6, Issue 3

Table of Contents

BLOOD ADVANCES TALK

GRNDaD: big data and sickle cell disease
Sophie Lanzkron,Deepa Manwani,Payal Desai,Julie Kanter,Jane Little
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EXCEPTIONAL CASE REPORT

Daratumumab for immune thrombotic thrombocytopenic purpura
Clinical Trials & Observations
Jana van den Berg,Johanna A. Kremer Hovinga,Claudia Pfleger,Inga Hegemann,Gregor Stehle,Andreas Holbro,Jan-Dirk Studt
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Successful allogeneic hematopoietic stem cell transplantation in patients with VEXAS syndrome: a 2-center experience
Ava Diarra,Nicolas Duployez,Elise Fournier,Claude Preudhomme,Valérie Coiteux,Leonardo Magro,Bruno Quesnel,Maël Heiblig,Pierre Sujobert,Fiorenza Barraco,Marie Balsat,Quentin Scanvion,Eric Hachulla,David Launay,Ibrahim Yakoub-Agha,Louis Terriou,,on behalf of the French VEXAS study group
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STIMULUS REPORT

Vemurafenib acts as a molecular on-off switch governing systemic inflammation in Langerhans cell histiocytosis
Clinical Trials & Observations
Sebastian K. Eder,Raphaela Schwentner,Philipp Ben Soussia,Giulio Abagnale,Andishe Attarbaschi,Milen Minkov,Florian Halbritter,Caroline Hutter
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CLINICAL TRIALS AND OBSERVATIONS

Sequential different B-cell antigen–targeted CAR T-cell therapy for pediatric refractory/relapsed Burkitt lymphoma
Clinical Trials & Observations
Ying Liu,Biping Deng,Bo Hu,Wenqun Zhang,Qing Zhu,Yang Liu,Shan Wang,Pei Zhang,Ying Yang,Junhan Yang,Qinlong Zheng,Xinjian Yu,Zifen Gao,Chunju Zhou,Wei Han,Jing Yang,Ling Jin,Chunrong Tong,Alex H. Chang,Yonghong Zhang
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Reduced cardiovascular morbidity in patients with hemophilia: results of a 5-year multinational prospective study
Clinical Trials & Observations
Paul Van Der Valk,Michael Makris,Kathelijn Fischer,Robert C. Tait,Pratima Chowdary,Peter W. Collins,Karina Meijer,Lize F. D. van Vulpen,Eveline Mauser-Bunschoten,Roger E. G. Schutgens
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Blinatumomab in pediatric relapsed/refractory B-cell acute lymphoblastic leukemia: RIALTO expanded access study final analysis
Clinical Trials & Observations
Franco Locatelli,Gerhard Zugmaier,Noemi Mergen,Peter Bader,Sima Jeha,Paul-Gerhardt Schlegel,Jean-Pierre Bourquin,Rupert Handgretinger,Benoit Brethon,Claudia Rössig,William N. Kormany,Puneeth Viswagnachar,Christiane Chen-Santel
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Response and survival predictors in a cohort of 319 patients with Waldenström macroglobulinemia treated with ibrutinib monotherapy
Clinical Trials & Observations
Jorge J. Castillo,Shayna R. Sarosiek,Joshua N. Gustine,Catherine A. Flynn,Carly R. Leventoff,Timothy P. White,Kirsten Meid,Maria L. Guerrera,Amanda Kofides,Xia Liu,Manit Munshi,Nicholas Tsakmaklis,Zachary R. Hunter,Christopher J. Patterson,Andrew R. Branagan,Steven P. Treon
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Pharmacodynamics and molecular correlates of response to glofitamab in relapsed/refractory non-Hodgkin lymphoma
Clinical Trials & Observations
Ann-Marie E. Bröske,Koorosh Korfi,Anton Belousov,Sabine Wilson,Chia-Huey Ooi,Christopher R. Bolen,Marta Canamero,Enrique Gomez Alcaide,Ian James,Emily C. Piccione,David J. Carlile,Natalie Dimier,Pablo Umaña,Marina Bacac,Martin Weisser,Michael Dickinson
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HEMATOPOIESIS AND STEM CELLS

LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells
Nicholas Holdreith,Grace Lee,Vemika Chandra,Carlo Salas Salinas,Peter Nicholas,Timothy S. Olson,Wei Tong
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IMMUNOBIOLOGY AND IMMUNOTHERAPY

Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies
Clinical Trials & Observations
Moraima Jiménez,Elisa Roldán,Candela Fernández-Naval,Guillermo Villacampa,Mónica Martinez-Gallo,Daniel Medina-Gil,Soraya Peralta-Garzón,Gemma Pujadas,Cristina Hernández,Carlota Pagès,Mercedes Gironella,Laura Fox,Guillermo Orti,Pere Barba,Tomás Pumarola,Alba Cabirta,Eva Catalá,Mercedes Valentín,Ana Marín-Niebla,Alberto Orfao,Marcos González,Magda Campins,Isabel Ruiz-Camps,David Valcárcel,Francesc Bosch,Manuel Hernández,Marta Crespo,Juliana Esperalba,Pau Abrisqueta
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LYMPHOID NEOPLASIA

Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia
Briana A. Fitch,Mi Zhou,Jamilla Situ,Sangeetha Surianarayanan,Melissa Q. Reeves,Michelle L. Hermiston,Joseph L. Wiemels,Scott C. Kogan
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Epstein Barr virus–positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo
Xiaoshan Zhang,Ran Zhang,Chenghui Ren,Yi Xu,Shuhong Wu,Carrie Meng,Apar Pataer,Xingzhi Song,Jianhua Zhang,Yixin Yao,Hua He,Huiqin Chen,Wencai Ma,Jing Wang,Funda Meric-Bernstam,Richard E. Champlin,John V. Heymach,Cliona M. Rooney,Stephen G. Swisher,Ara A. Vaporciyan,Jack A. Roth,M. James You,Michael Wang,Bingliang Fang
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Informing radiotherapy decisions in stage I/IIa Hodgkin lymphoma: modeling life expectancy using radiation dosimetry
Clinical Trials & Observations
David A. Jones,Paolo Candio,Rebecca Shakir,Georgios Ntentas,Johanna Ramroth,Alastair M. Gray,David J. Cutter
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Outcome of allogeneic transplantation for mature T-cell lymphomas: impact of donor source and disease characteristics
Clinical Trials & Observations
Mehdi Hamadani,Maud Ngoya,Anna Sureda,Qaiser Bashir,Carlos Alejandro Litovich,Hervé Finel,Yue Chen,Ariane Boumendil,Jasmine Zain,Luca Castagna,Amanda F. Cashen,Didier Blaise,Mazyar Shadman,Rocco Pastano,Farhad Khimani,Mutlu Arat,Sascha Dietrich,Norbert Schmitz,Bertram Glass,Mohamed A. Kharfan-Dabaja,Paolo Corradini,Craig S. Sauter,Silvia Montoto,Mi Kwon,Alex F. Herrera,Peter Dreger
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Expert-independent classification of mature B-cell neoplasms using standardized flow cytometry: a multicentric study
Sebastian Böttcher,Robby Engelmann,Georgiana Grigore,Paula Fernandez,Joana Caetano,Juan Flores-Montero,Vincent H. J. van der Velden,Michaela Novakova,Jan Philippé,Matthias Ritgen,Leire Burgos,Quentin Lecrevisse,Sandra Lange,Tomas Kalina,Javier Verde Velasco,Rafael Fluxa Rodriguez,Jacques J. M. van Dongen,Carlos E. Pedreira,Alberto Orfao,,on behalf of the EuroFlow Consortium
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MYELOID NEOPLASIA

ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome
Clinical Trials & Observations
Robert R. West,Katherine R. Calvo,Lisa J. Embree,Weixin Wang,Laura M. Tuschong,Thomas R. Bauer, Jr,Desiree Tillo,Justin Lack,Stephenie Droll,Amy P. Hsu,Steven M. Holland,Dennis D. Hickstein
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Clinical implications of loss of bone marrow minimal residual disease negativity in multiple myeloma
Clinical Trials & Observations
Meera Mohan,Samantha Kendrick,Aniko Szabo,Naveen Yarlagadda,Dinesh Atwal,Yadav Pandey,Arya Roy,Richa Parikh,James Lopez,Sharmilan Thanendrarajan,Carolina Schinke,Daisy Alapat,Jeffrey Sawyer,Erming Tian,Guido Tricot,Frits van Rhee,Maurizio Zangari
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t(4;12)(q12;p13) ETV6-rearranged AML without eosinophilia does not involve PDGFRA: relevance for imatinib insensitivity
Sarah B. Mueller,Paola Dal Cin,Long P. Le,Dora Dias-Santagata,Jochen K. Lennerz,A. John Iafrate,Hetal Desai Marble,Andrew M. Brunner,Matthew J. Weinstock,Marlise R. Luskin,Daniel J. De Angelo,Richard M. Stone,Valentina Nardi
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Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1
Clinical Trials & Observations
Guadalupe Oñate,Alex Bataller,Ana Garrido,Montserrat Hoyos,Montserrat Arnan,Susana Vives,Rosa Coll,Mar Tormo,Antònia Sampol,Lourdes Escoda,Olga Salamero,Antoni Garcia,Joan Bargay,Alba Aljarilla,Josep F. Nomdedeu,Jordi Esteve,Jorge Sierra,Marta Pratcorona,for the CETLAM (Spanish Cooperative Group for the Diagnosis and Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes)
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A clinical laboratory–developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia
Stanley W. K. Ng,Tracy Murphy,Ian King,Tong Zhang,Michelle Mah,Zhibin Lu,Natalie Stickle,Narmin Ibrahimova,Andrea Arruda,Amanda Mitchell,Ming Mai,Rong He,Bindu Swapna Madala,David S. Viswanatha,John E. Dick,Steven Chan,Carl Virtanen,Mark D. Minden,Timothy Mercer,Tracy Stockley,Jean C. Y. Wang
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PLATELETS AND THROMBOPOIESIS

Cost-effectiveness of eltrombopag vs intravenous immunoglobulin for the perioperative management of immune thrombocytopenia
Manraj N. Kaur,Donald M. Arnold,Nancy M. Heddle,Richard J. Cook,Cyrus Hsia,Mark Blostein,Erin Jamula,Michelle Sholzberg,Yulia Lin,Jeannine Kassis,Loree Larratt,Alan Tinmouth,Julie Carruthers,Na Li,Yang Liu,Feng Xie
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RED CELLS, IRON, AND ERYTHROPOIESIS

ABCB6 polymorphisms are not overly represented in patients with porphyria
Colin P. Farrell,Gäel Nicolas,Robert J. Desnick,Charles J. Parker,Jerome Lamoril,Laurent Gouya,Zoubida Karim,Dimitri Tchernitchko,Brenden Chan,Herve Puy,John D. Phillips
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THROMBOSIS AND HEMOSTASIS

Morbidities and mortality in patients with hereditary thrombotic thrombocytopenic purpura
Clinical Trials & Observations
Azra Borogovac,Jessica A. Reese,Samiksha Gupta,James N. George
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C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19
Sistiana Aiello,Sara Gastoldi,Miriam Galbusera,Piero Ruggenenti,Valentina Portalupi,Stefano Rota,Nadia Rubis,Lucia Liguori,Sara Conti,Matteo Tironi,Sara Gamba,Donata Santarsiero,Ariela Benigni,Giuseppe Remuzzi,Marina Noris
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Nonneutralizing FVIII-specific antibody signatures in patients with hemophilia A and in healthy donors
Clinical Trials & Observations
Helmut Schweiger,Judit Rejtő,Christoph J. Hofbauer,Verena Berg,Peter Allacher,Karl Zwiauer,Clemens Feistritzer,Gerhard Schuster,Cihan Ay,Birgit M. Reipert,Ingrid Pabinger
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An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice
Bilgimol Chumappumkal Joseph,Byron Y. Miyazawa,Charles T. Esmon,Mitchell J. Cohen,Annette von Drygalski,Laurent O. Mosnier
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Multifaceted pathomolecular mechanism of a VWF large deletion involved in the pathogenesis of severe VWD
Hamideh Yadegari,Muhammad Ahmer Jamil,Jens Müller,Natascha Marquardt,Orla Rawley,Ulrich Budde,Osman El-Maarri,David Lillicrap,Johannes Oldenburg
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Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Malgorzata Wygrecka,Anna Birnhuber,Benjamin Seeliger,Laura Michalick,Oleg Pak,Astrid-Solveig Schultz,Fabian Schramm,Martin Zacharias,Gregor Gorkiewicz,Sascha David,Tobias Welte,Julius J. Schmidt,Norbert Weissmann,Ralph T. Schermuly,Guillermo Barreto,Liliana Schaefer,Philipp Markart,Markus C. Brack,Stefan Hippenstiel,Florian Kurth,Leif E. Sander,Martin Witzenrath,Wolfgang M. Kuebler,Grazyna Kwapiszewska,Klaus T. Preissner
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TRANSPLANTATION

Cumulative incidence of subsequent malignancy after allo-HCT conditioned with or without low-dose total body irradiation
Clinical Trials & Observations
Lina Nunez,Tasnima Abedin,Syed Naqvi,Hua Shen,Ahsan Chaudhry,Scott Bellerby,Lynn Savoie,Andrew Daly,Mona Shafey,Peter Duggan,Jan Storek,Kareem Jamani
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Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML
Kamal Menghrajani,Alexandra Gomez-Arteaga,Rafael Madero-Marroquin,Mei-Jie Zhang,Khalid Bo-Subait,Jonathan Sanchez,Hai-Lin Wang,Mahmoud Aljurf,Amer Assal,Vera Ulrike Bacher,Sherif M. Badawy,Nelli Bejanyan,Vijaya Raj Bhatt,Christopher Bredeson,Michael Byrne,Paul Castillo,Jan Cerny,Saurabh Chhabra,Stefan Octavian Ciurea,Zachariah DeFilipp,Nosha Farhadfar,Shahinaz Gadalla,Robert Peter Gale,Siddhartha Ganguly,Lohith Gowda,Michael R. Grunwald,Shahrukh Hashmi,Gerhard Hildebrandt,Christopher G. Kanakry,Ankit Kansagra,Farhad Khimani,Maxwell Krem,Hillard Lazarus,Hongtao Liu,Rodrigo Martino,Fotios V. Michelis,Sunita Nathan,Taiga Nishihori,Richard Olsson,Ran Reshef,David Rizzieri,Jacob M. Rowe,Bipin N. Savani,Sachiko Seo,Akshay Sharma,Melhem Solh,Celalettin Ustun,Leo F. Verdonck,Christopher Hourigan,Brenda Sandmaier,Mark Litzow,Partow Kebriaei,Daniel Weisdorf,Yanming Zhang,Martin S. Tallman,Wael Saber
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Antithymocyte globulin exposure in CD34+ T-cell–depleted allogeneic hematopoietic cell transplantation
Madhavi Lakkaraja,Michael Scordo,Audrey Mauguen,Christina Cho,Sean Devlin,Josel D. Ruiz,Elizabeth Klein,Scott T. Avecilla,Farid Boulad,Maria I. Cancio,Kevin J. Curran,Ann A. Jakubowski,Nancy A. Kernan,Andrew L. Kung,Richard J. O’Reilly,Esperanza B. Papadopoulos,Susan Prockop,Ichelle van Roessel,Andromachi Scaradavou,Brian C. Shaffer,Gunjan Shah,Barbara Spitzer,Roni Tamari,Sergio A. Giralt,Miguel-Angel Perales,Jaap Jan Boelens
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VASCULAR BIOLOGY

Antithrombin protects against Plasmodium falciparum histidine-rich protein II-mediated inflammation and coagulation
Indranil Biswas,Sumith R. Panicker,Hemant Giri,Xiaofeng S. Cai,Alireza R. Rezaie
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RESEARCH LETTER

Booster effect after SARS-CoV-2 vaccination in immunocompromised hematology patients with prior COVID-19
Clinical Trials & Observations
José Luis Piñana,Ramon Garcia-Sanz,Rodrigo Martino,María Garcia-Roa,Gabriel Andrés Martin-Martin,Irene Risco-Gálvez,Mar Tormo,Pilar Martinez-Barranco,Sara Marcos-Corrales,Marisa Calabuig,Venancio Conesa,Anabel Teruel,Sara Ruiz-Pérez,Carlos Solano,David Navarro,Ángel Cedillo,Anna Sureda,,on behalf of Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell TransplantationCell Therapy Group
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Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation
Clinical Trials & Observations
Muna Qayed,Benjamin Watkins,Scott Gillespie,Brandi Bratrude,Kayla Betz,Sung W. Choi,Jeffrey Davis,Christine Duncan,Roger Giller,Michael Grimley,Andrew C. Harris,David Jacobsohn,Nahal Lalefar,Maxim Norkin,Nosha Farhadfar,Michael A. Pulsipher,Shalini Shenoy,Aleksandra Petrovic,Kirk R. Schultz,Gregory A. Yanik,Edmund K. Waller,Amelia Langston,Leslie S. Kean,John T. Horan
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All Issues

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DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions

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