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Issue Archive

Volume 5, Issue 7
April 13 2021
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

ETV6-FLT3–positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML
Clinical Trials & Observations
Barbara Spitzer,Filemon S. Dela Cruz,Glorymar D. Ibanez Sanchez,Yanming Zhang,Wenbin Xiao,Ryma Benayed,Alina Markova,M. Irene Rodriguez-Sanchez,Nancy Bouvier,Mikhail Roshal,Andrew L. Kung,Neerav Shukla
View Articletitled, <em>ETV6-FLT3–</em>positive myeloid/lymphoid neoplasm with eosinophilia presenting in an infant: an entity distinct from JMML

STIMULUS REPORTS

Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
Clinical Trials & Observations
L. Alexander Liggett,Matthew D. Galbraith,Keith P. Smith,Kelly D. Sullivan,Ross E. Granrath,Belinda Enriquez-Estrada,Kohl T. Kinning,Jessica R. Shaw,Angela L. Rachubinski,Joaquin M. Espinosa,James DeGregori
View Articletitled, Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation
Supplemental data
Autoimmune hypoglycemia expands the biological spectrum of HHV8+ multicentric Castleman disease
Clinical Trials & Observations
Pierre Arnautou,Martine Auclair,Soraya Fellahi,Clara Bouché,Claire Fieschi,Elias Barrak,Viviane Queyrel-Moranne,Lucy Chaillous,Nicolas Blin,Marion Malphettes,Jehane Fadlallah,Remi Bertinchamp,Laurence Gérard,Djaouida Bengoufa,Lionel Galicier,Eric Oksenhendler,Corinne Vigouroux,David Boutboul
View Articletitled, Autoimmune hypoglycemia expands the biological spectrum of HHV8<sup>+</sup> multicentric Castleman disease
Supplemental data
CDX2 regulates ACE expression in blood development and leukemia cells
Reine El Omar,Emmanuelle Julien,Katia Biasch,Blandine Guffroy,Bruno Lioure,Laurent Vallat,Isabelle Gross,Claire Domon-Dell,François Lanza,Christian Gachet,Matteo Negroni,Jean-Noël Freund,Manuela Tavian
View Articletitled, CDX2 regulates ACE expression in blood development and leukemia cells
Supplemental data

REVIEW ARTICLE

The potential of proliferative and apoptotic parameters in clinical flow cytometry of myeloid malignancies
Stefan G. C. Mestrum,Anton H. N. Hopman,Frans C. S. Ramaekers,Math P. G. Leers
View Articletitled, The potential of proliferative and apoptotic parameters in clinical flow cytometry of myeloid malignancies

CLINICAL TRIALS AND OBSERVATIONS

Minimally myelosuppressive regimen for remission induction in pediatric AML: long-term results of an observational study
Clinical Trials & Observations
Yixin Hu,Aili Chen,Li Gao,Hailong He,Shuting Jiang,Xinchang Zheng,Peifang Xiao,Jun Lu,Yi Wang,Jie Li,Jianqin Li,Junjie Fan,Yanhua Yao,Jing Ling,Liyan Fan,Shengqin Cheng,Cheng Cheng,Fang Fang,Jian Pan,Qian-fei Wang,Raul C. Ribeiro,Shaoyan Hu
View Articletitled, Minimally myelosuppressive regimen for remission induction in pediatric AML: long-term results of an observational study
Supplemental data
Prognostic value of measurable residual disease after venetoclax and decitabine in acute myeloid leukemia
Clinical Trials & Observations
Abhishek Maiti,Courtney D. DiNardo,Sa A. Wang,Jeffrey Jorgensen,Tapan M. Kadia,Naval G. Daver,Nicholas J. Short,Musa Yilmaz,Naveen Pemmaraju,Gautam Borthakur,Prithviraj Bose,Ghayas C. Issa,Alessandra Ferrajoli,Elias J. Jabbour,Nitin Jain,Guillermo Garcia-Manero,Maro Ohanian,Koichi Takahashi,Guillermo Montalban-Bravo,Lucia Masarova,Jan A. Burger,Philip A. Thompson,Srdan Verstovsek,Koji Sasaki,Michael Andreeff,Caitlin R. Rausch,Kathryn S. Montalbano,Sherry Pierce,Wei Qiao,Jing Ning,Hagop M. Kantarjian,Marina Y. Konopleva,Farhad Ravandi
View Articletitled, Prognostic value of measurable residual disease after venetoclax and decitabine in acute myeloid leukemia
Supplemental data

HEALTH SERVICES AND OUTCOMES

COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals
Clinical Trials & Observations
Ashima Singh,Amanda M. Brandow,Julie A. Panepinto
View Articletitled, COVID-19 in individuals with sickle cell disease/trait compared with other Black individuals
Health care resource utilization and cost burden of hemophilia B in the United States
Tyler W. Buckner,Iryna Bocharova,Kaitlin Hagan,Arielle G. Bensimon,Hongbo Yang,Eric Q. Wu,Eileen K. Sawyer,Nanxin Li
View Articletitled, Health care resource utilization and cost burden of hemophilia B in the United States
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors
Amanda L. Evans,Amanda Dalby,Holly R. Foster,Daniel Howard,Amie K. Waller,Momal Taimoor,Moyra Lawrence,Souradip Mookerjee,Marcus Lehmann,Annie Burton,Jorge Valdez,Jonathan Thon,Joseph Italiano,Thomas Moreau,Cedric Ghevaert
View Articletitled, Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors
Supplemental data

LYMPHOID NEOPLASIA

Microenvironment immune reconstitution patterns correlate with outcomes after autologous transplant in multiple myeloma
Harsh Parmar,Morie Gertz,Emilie Ingrid Anderson,Shaji Kumar,Taxiarchis V. Kourelis
View Articletitled, Microenvironment immune reconstitution patterns correlate with outcomes after autologous transplant in multiple myeloma
Supplemental data
Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection
Mayumi Yoshimori,Haruna Shibayama,Ken-Ichi Imadome,Fuyuko Kawano,Ayaka Ohashi,Miwako Nishio,Norio Shimizu,Morito Kurata,Shigeyoshi Fujiwara,Ayako Arai
View Articletitled, Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection
Supplemental data
Functional characterization of PD1+TIM3+ tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade
Mikaël Roussel,Kieu-Suong Le,Clémence Granier,Francisco Llamas Gutierrez,Etienne Foucher,Simon Le Gallou,Céline Pangault,Luc Xerri,Vincent Launay,Thierry Lamy,Eric Tartour,Daniel Olive,Thierry Fest
View Articletitled, Functional characterization of PD1<sup>+</sup>TIM3<sup>+</sup> tumor-infiltrating T cells in DLBCL and effects of PD1 or TIM3 blockade
Supplemental data
Involved-site radiotherapy for Helicobacter pylori–independent gastric MALT lymphoma: 26 years of experience with 178 patients
Clinical Trials & Observations
Joachim Yahalom,Amy J. Xu,Ariela Noy,Stephanie Lobaugh,Monica Chelius,Karen Chau,Carol Portlock,Carla Hajj,Brandon S. Imber,David J. Straus,Craig H. Moskowitz,Morton Coleman,Andrew D. Zelenetz,Zhigang Zhang,Ahmet Dogan
View Articletitled, Involved-site radiotherapy for <em>Helicobacter pylori</em>–independent gastric MALT lymphoma: 26 years of experience with 178 patients
Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial
Clinical Trials & Observations
Etan Orgel,Celia Framson,Rubi Buxton,Jiyoon Kim,Gang Li,Jonathan Tucci,David R. Freyer,Weili Sun,Matthew J. Oberley,Christina Dieli-Conwright,Steven D. Mittelman
View Articletitled, Caloric and nutrient restriction to augment chemotherapy efficacy for acute lymphoblastic leukemia: the IDEAL trial
Supplemental data
Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells
Elina Parri,Heikki Kuusanmäki,Daria Bulanova,Satu Mustjoki,Krister Wennerberg
View Articletitled, Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells
Supplemental data
The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma
Brittany C. Lipchick,Adam Utley,Zhannan Han,Sudha Moparthy,Dong Hyun Yun,Anna Bianchi-Smiraglia,David W. Wolff,Emily Fink,Liang Liu,Cristina M. Furdui,Jingyun Lee,Kelvin P. Lee,Mikhail A. Nikiforov
View Articletitled, The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma
Supplemental data
The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL
Clinical Trials & Observations
Alessandra Di Grande,Sofie Peirs,Paul D. Donovan,Maaike Van Trimpont,Julie Morscio,Beatrice Lintermans,Lindy Reunes,Niels Vandamme,Steven Goossens,Hien Anh Nguyen,Arnon Lavie,Richard B. Lock,Jochen H. M. Prehn,Pieter Van Vlierberghe,Triona Ní Chonghaile
View Articletitled, The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL
Supplemental data
The landscape of copy number variations in classical Hodgkin lymphoma: a joint KU Leuven and LYSA study on cell-free DNA
Lieselot Buedts,Iwona Wlodarska,Julio Finalet-Ferreiro,Olivier Gheysens,Luc Dehaspe,Thomas Tousseyn,Luc-Matthieu Fornecker,Julien Lazarovici,René-Olivier Casasnovas,Anne-Claire Gac,Christophe Bonnet,Kamal Bouabdallah,Christiane Copie-Bergman,Bettina Fabiani,Daan Dierickx,Lukas Marcelis,Joris Vermeesch,Marc André,Peter Vandenberghe
View Articletitled, The landscape of copy number variations in classical Hodgkin lymphoma: a joint KU Leuven and LYSA study on cell-free DNA
Supplemental data
Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen
Zhongying Mo,Scott Wood,Shawn Namiranian,Reina Mizukoshi,Stephanie Weng,In Sock Jang,Celia Fontanillo,Joshua M. Baughman,Arianna Silva-Torres,Michelle Slade,Marwa Khater,Kai Wang,Mark Rolfe,Gang Lu
View Articletitled, Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen
Supplemental data

MYELOID NEOPLASIA

Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis
Jeanne F. Rivera,April J. Baral,Fatima Nadat,Grace Boyd,Rachael Smyth,Hershna Patel,Emma L. Burman,Ghadah Alameer,Sally A. Boxall,Brian R. Jackson,E. Joanna Baxter,Peter Laslo,Anthony R. Green,David G. Kent,Ann Mullally,Edwin Chen
View Articletitled, Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis
Supplemental data

PLATELETS AND THROMBOPOIESIS

Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding
Dragana Nešić,Martin Bush,Aleksandar Spasic,Jihong Li,Tetsuji Kamata,Makoto Handa,Marta Filizola,Thomas Walz,Barry S. Coller
View Articletitled, Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding
Supplemental data
Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling
Xiaojuan Zhao,Dominic Alibhai,Ting Sun,Jawad Khalil,James L. Hutchinson,Kaya Olzak,Christopher M. Williams,Yong Li,Richard Sessions,Stephen Cross,Richard Seager,Riyaad Aungraheeta,Alan Leard,Caroline M. McKinnon,David Phillips,Lei Zhang,Alastair W. Poole,George Banting,Stuart J. Mundell
View Articletitled, Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling
Supplemental data
Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ
Clinical Trials & Observations
Saori Oishi,Nagaharu Tsukiji,Shimon Otake,Naoki Oishi,Tomoyuki Sasaki,Toshiaki Shirai,Yuri Yoshikawa,Katsuhiro Takano,Hideyuki Shinmori,Takeshi Inukai,Tetsuo Kondo,Katsue Suzuki-Inoue
View Articletitled, Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ
Supplemental data

THROMBOSIS AND HEMOSTASIS

The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer
Min Soon Cho,Jiasong Li,Ricardo Gonzalez-Delgado,Hani Lee,Matthew Vasquez,Tiancheng He,Yunjie He,Kai Liu,Tomoyuki Sasano,Bernd Nürnberg,Anil K. Sood,Stephen T. C. Wong,Vahid Afshar-Kharghan
View Articletitled, The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer
Supplemental data

TRANSPLANTATION

Risk factors for seasonal human coronavirus lower respiratory tract infection after hematopoietic cell transplantation
Chikara Ogimi,Hu Xie,Alpana Waghmare,Masumi Ueda Oshima,Kanwaldeep K. Mallhi,Keith R. Jerome,Wendy M. Leisenring,Janet A. Englund,Michael Boeckh
View Articletitled, Risk factors for seasonal human coronavirus lower respiratory tract infection after hematopoietic cell transplantation
Supplemental data
Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML
Brian C. Shaffer,Jean-Benoit Le Luduec,Soo Park,Sean Devlin,Anne Archer,Eric Davis,Candice Cooper,Melissa Nhaissi,Beth Suri,Deborah Wells,Roni Tamari,Esperanza Papadopoulos,Ann A. Jakubowski,Sergio Giralt,Katharine C. Hsu
View Articletitled, Prospective KIR genotype evaluation of hematopoietic cell donors is feasible with potential to benefit patients with AML
Supplemental data

ERRATA

Srivaths L, Minard CG, O’Brien SH, et al. The spectrum and severity of bleeding in adolescents with low von Willebrand factor–associated heavy menstrual bleeding. Blood Adv. 2020;4(13):3209-3216.
View Articletitled, Srivaths L, Minard CG, O’Brien SH, et al. The spectrum and severity of bleeding in adolescents with low von Willebrand factor–associated heavy menstrual bleeding. <em>Blood Adv.</em> 2020;4(13):3209-3216.
Lyman GH, Carrier M, Ay C, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv. 2021;5(4):927-974.
View Articletitled, Lyman GH, Carrier M, Ay C, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. <em>Blood Adv.</em> 2021;5(4):927-974.
Khurana A, Novo M, Nowakowski GS, et al. Clinical manifestations of, diagnostic approach to, and treatment of neurolymphomatosis in the rituximab era. Blood Adv. 2021;5(5):1379-1387.
View Articletitled, Khurana A, Novo M, Nowakowski GS, et al. Clinical manifestations of, diagnostic approach to, and treatment of neurolymphomatosis in the rituximab era. <em>Blood Adv.</em> 2021;5(5):1379-1387.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Cryo-electron microscopy density map of the αIIbβ3 headpiece in complex with the Fab fragment of activating monoclonal antibody PT25-2 (only the variable domains are shown) at a resolution of 3.3 Å. The map is segmented and colored according to the individual polypeptide chains. The asterisk indicates the ligand-binding site. See the article by Nešić et al.

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