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Volume 2, Issue 20

October 23 2018

In this Issue

POINT-COUNTERPOINT
REVIEW ARTICLE
HEMATOPOIESIS AND STEM CELLS
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
ERRATUM

POINT-COUNTERPOINT

Implementing emicizumab in hemophilia inhibitor management: emicizumab should be prescribed after tolerance

Guy Young

This article has a companion Counterpoint by Le Quellec and Negrier.

View Articletitled, Implementing emicizumab in hemophilia inhibitor management: emicizumab should be prescribed after tolerance

Emicizumab should be prescribed independent of immune tolerance induction

Sandra Le Quellec,Claude Negrier

This article has a companion Point by Young.

View Articletitled, Emicizumab should be prescribed independent of immune tolerance induction

REVIEW ARTICLE

Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy
Clinical Trials & Observations

Alex Aleshin,Peter L. Greenberg

View Articletitled, Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy

HEMATOPOIESIS AND STEM CELLS

Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo

Chris Moore,Joanna L. Richens,Yasmin Hough,Deniz Ucanok,Sunir Malla,Fei Sang,Yan Chen,Stone Elworthy,Robert N. Wilkinson,Martin Gering

View Articletitled, Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo

Supplemental data

Visualizing hematopoiesis as a stochastic process

Jason Xu,Yiwen Wang,Peter Guttorp,Janis L. Abkowitz

View Articletitled, Visualizing hematopoiesis as a stochastic process

Supplemental data

MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis

Nur-Taz Rahman,Vincent P. Schulz,Lin Wang,Patrick G. Gallagher,Oleg Denisenko,Francesco Gualdrini,Cyril Esnault,Diane S. Krause

View Articletitled, MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis

Supplemental data

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Luena Papa,Eran Zimran,Mansour Djedaini,Yongchao Ge,Umut Ozbek,Robert Sebra,Stuart C. Sealfon,Ronald Hoffman

View Articletitled, Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

Supplemental data

LYMPHOID NEOPLASIA

Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma

Tilmann Bochtler,Maximilian Merz,Thomas Hielscher,Martin Granzow,Korbinian Hoffmann,Alwin Krämer,Marc-Steffen Raab,Jens Hillengass,Anja Seckinger,Christoph Kimmich,Tobias Dittrich,Carsten Müller-Tidow,Dirk Hose,Hartmut Goldschmidt,Ute Hegenbart,Anna Jauch,Stefan O. Schönland

View Articletitled, Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma

Supplemental data

High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology

Lauren C. Chong,Susana Ben-Neriah,Graham W. Slack,Ciara Freeman,Daisuke Ennishi,Anja Mottok,Brett Collinge,Pau Abrisqueta,Pedro Farinha,Merrill Boyle,Barbara Meissner,Robert Kridel,Alina S. Gerrie,Diego Villa,Kerry J. Savage,Laurie H. Sehn,Reiner Siebert,Ryan D. Morin,Randy D. Gascoyne,Marco A. Marra,Joseph M. Connors,Andrew J. Mungall,Christian Steidl,David W. Scott

View Articletitled, High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology

Supplemental data

MYELOID NEOPLASIA

The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes
Clinical Trials & Observations

Caroline J. McNamara,Tony Panzarella,James A. Kennedy,Andrea Arruda,Jaime O. Claudio,Georgina Daher-Reyes,Jenny Ho,Nancy Siddiq,Rebecca Devlin,Hubert Tsui,Jie Su,Tracy Stockley,Mahadeo Sukhai,Nisha Kanwar,Steven Chan,Dawn Maze,Aaron Schimmer,Andre Schuh,Hassan Sibai,Auro Viswabandya,Karen Yee,Mark D. Minden,Suzanne Kamel-Reid,Vikas Gupta

View Articletitled, The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes

Supplemental data

The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera
Clinical Trials & Observations

Nikolai A. Podoltsev,Mengxin Zhu,Amer M. Zeidan,Rong Wang,Xiaoyi Wang,Amy J. Davidoff,Scott F. Huntington,Smith Giri,Steven D. Gore,Xiaomei Ma

View Articletitled, The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera

Supplemental data

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA

Nikola P. Konstandin,Friederike Pastore,Tobias Herold,Annika Dufour,Maja Rothenberg-Thurley,Tanja Hinrichsen,Bianka Ksienzyk,Sebastian Tschuri,Stephanie Schneider,Eva Hoster,Wolfgang E. Berdel,Bernhard J. Woermann,Maria C. Sauerland,Jan Braess,Stefan K. Bohlander,Hanns-Georg Klein,Wolfgang Hiddemann,Klaus H. Metzeler,Karsten Spiekermann

View Articletitled, Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA

Supplemental data

Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia
Clinical Trials & Observations

Masahiro Sakaguchi,Hiroki Yamaguchi,Yuho Najima,Kensuke Usuki,Toshimitsu Ueki,Iekuni Oh,Sinichiro Mori,Eri Kawata,Nobuhiko Uoshima,Yutaka Kobayashi,Shinichi Kako,Kenji Tajika,Seiji Gomi,Katsuhiro Shono,Kensuke Kayamori,Masao Hagihara,Junya Kanda,Hitoji Uchiyama,Junya Kuroda,Naoyuki Uchida,Yasushi Kubota,Shinya Kimura,Saiko Kurosawa,Nana Nakajima,Atsushi Marumo,Ikuko Omori,Yusuke Fujiwara,Shunsuke Yui,Satoshi Wakita,Kunihito Arai,Tomoaki Kitano,Kazuhiko Kakihana,Yoshinobu Kanda,Kazuteru Ohashi,Takahiro Fukuda,Koiti Inokuchi

View Articletitled, Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia

Supplemental data

PLATELETS AND THROMBOPOIESIS

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase
Clinical Trials & Observations

Sebastian Vogel,Taruna Arora,Xunde Wang,Laurel Mendelsohn,James Nichols,Darlene Allen,Arun S. Shet,Christian A. Combs,Zenaide M. N. Quezado,Swee Lay Thein

View Articletitled, The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Sensing of red blood cells with decreased membrane deformability by the human spleen

Innocent Safeukui,Pierre A. Buffet,Guillaume Deplaine,Sylvie Perrot,Valentine Brousse,Alain Sauvanet,Beatrice Aussilhou,Safi Dokmak,Anne Couvelard,Dominique Cazals-Hatem,Odile Mercereau-Puijalon,Geneviève Milon,Peter H. David,Narla Mohandas

View Articletitled, Sensing of red blood cells with decreased membrane deformability by the human spleen

Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes

Emilie-Fleur Gautier,Marjorie Leduc,Sylvie Cochet,Karine Bailly,Catherine Lacombe,Narla Mohandas,François Guillonneau,Wassim El Nemer,Patrick Mayeux

View Articletitled, Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes

Supplemental data

Frequent STAT3 mutations in CD8⁺ T cells from patients with pure red cell aplasia
Clinical Trials & Observations

Toru Kawakami,Nodoka Sekiguchi,Jun Kobayashi,Tatsuya Imi,Kazuyuki Matsuda,Taku Yamane,Sayaka Nishina,Yasushi Senoo,Hitoshi Sakai,Toshiro Ito,Tomonobu Koizumi,Makoto Hirokawa,Shinji Nakao,Hideyuki Nakazawa,Fumihiro Ishida

View Articletitled, Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia

Supplemental data

Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice

Ki Soon Kim,De-Liang Zhang,Gennadiy Kovtunovych,Manik C. Ghosh,Hayden Ollivierre,Michael A. Eckhaus,Tracey A. Rouault

View Articletitled, Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice

Supplemental data

THROMBOSIS AND HEMOSTASIS

A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding
Clinical Trials & Observations

Victoria Candy,Hilary Whitworth,Julie Grabell,Lisa Thibeault,Lori Harpell,Mackenzie Bowman,David Good,Wilma M. Hopman,Robert F. Sidonio, Jr,Paula D. James

View Articletitled, A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding

TRANSFUSION MEDICINE

Complete RHD next-generation sequencing: establishment of reference RHD alleles

Wajnat A. Tounsi,Tracey E. Madgett,Neil D. Avent

View Articletitled, Complete RHD next-generation sequencing: establishment of reference RHD alleles

TRANSPLANTATION

Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD
Clinical Trials & Observations

Sarah A. Wall,Qiuhong Zhao,Martha Yearsley,Luke Blower,Akwasi Agyeman,Parvathi Ranganathan,Shangbin Yang,Haiwa Wu,Matthew Bostic,Samantha Jaglowski,Jonathan E. Brammer,Basem William,Hannah Choe,Alice S. Mims,Sam Penza,Yvonne Efebera,Steven Devine,Spero Cataland,Stella M. Davies,Sumithira Vasu

View Articletitled, Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD

Supplemental data

ERRATUM

Lee J, Zhang LL, Wu W, et al. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood Adv. 2018;2(16):2039-2051.

View Articletitled, Lee J, Zhang LL, Wu W, et al. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood Adv. 2018;2(16):2039-2051.

Cover Image

Cover Image

COVER FIGURE
Zebrafish embryos homozygous for the mutant gfi1b allele sh339 display normal expression of gfi1aa messenger RNA in hemogenic endothelial cells in the ventral wall of the dorsal aorta at 28 hours postfertilization. The embryo shown was stained by RNA in situ hybridization. See the article by Moore et al.
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A multicenter phase 2 clinical trial of low-dose subcutaneous decitabine in myelofibrosis

In vivo silencing of intestinal DMT1 mitigates iron loading in β-thalassemia intermedia (Hbb^th3/+) mice

Antithrombotic efficacy and bleeding risks of vaccine-induced immune thrombotic thrombocytopenia treatments

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Table of Contents

POINT-COUNTERPOINT

Implementing emicizumab in hemophilia inhibitor management: emicizumab should be prescribed after tolerance

Emicizumab should be prescribed independent of immune tolerance induction

REVIEW ARTICLE

Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy
Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo

Visualizing hematopoiesis as a stochastic process

MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis

Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

LYMPHOID NEOPLASIA

Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma

High-resolution architecture and partner genes of MYC rearrangements in lymphoma with DLBCL morphology

MYELOID NEOPLASIA

The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes
Clinical Trials & Observations

The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera
Clinical Trials & Observations

Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA

Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia
Clinical Trials & Observations

PLATELETS AND THROMBOPOIESIS

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase
Clinical Trials & Observations

RED CELLS, IRON, AND ERYTHROPOIESIS

Sensing of red blood cells with decreased membrane deformability by the human spleen

Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes

Frequent STAT3 mutations in CD8⁺ T cells from patients with pure red cell aplasia
Clinical Trials & Observations

Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice

THROMBOSIS AND HEMOSTASIS

A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding
Clinical Trials & Observations

TRANSFUSION MEDICINE

Complete RHD next-generation sequencing: establishment of reference RHD alleles

TRANSPLANTATION

Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD
Clinical Trials & Observations

ERRATUM

Lee J, Zhang LL, Wu W, et al. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood Adv. 2018;2(16):2039-2051.

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ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

POINT-COUNTERPOINT

REVIEW ARTICLE

Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes Clinical Trials & Observations

The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera Clinical Trials & Observations

Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia Clinical Trials & Observations

PLATELETS AND THROMBOPOIESIS

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase Clinical Trials & Observations

RED CELLS, IRON, AND ERYTHROPOIESIS

Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia Clinical Trials & Observations

THROMBOSIS AND HEMOSTASIS

A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding Clinical Trials & Observations

TRANSFUSION MEDICINE

TRANSPLANTATION

Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD Clinical Trials & Observations

ERRATUM

Cover Image

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

Molecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy
Clinical Trials & Observations

The mutational landscape of accelerated- and blast-phase myeloproliferative neoplasms impacts patient outcomes
Clinical Trials & Observations

The impact of phlebotomy and hydroxyurea on survival and risk of thrombosis among older patients with polycythemia vera
Clinical Trials & Observations

Prognostic impact of low allelic ratio FLT3-ITD and NPM1 mutation in acute myeloid leukemia
Clinical Trials & Observations

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase
Clinical Trials & Observations

Frequent STAT3 mutations in CD8⁺ T cells from patients with pure red cell aplasia
Clinical Trials & Observations

A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding
Clinical Trials & Observations

Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD
Clinical Trials & Observations