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Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W. Smith, Preethi Jayanth, Mark D. Minden, Aaron D. Schimmer, David A. Hess, Kristin Hope, Kevin A. Rea, Tariq A. Akhtar, Eric Bohrnsen, Angelo D’Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo

Blood (2021) 137 (25): 3518–3532.

https://doi.org/10.1182/blood.2020008551

Published: 2021

Includes: Supplemental data

Journal Articles

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Blood (2021) 137 (24): 3403–3415.

https://doi.org/10.1182/blood.2020009023

Published: 2021

Includes: Supplemental data

Journal Articles

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Blood (2019) 134 (Supplement_1): 564.

https://doi.org/10.1182/blood-2019-129189

Published: 2019

Journal Articles

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Konstantinos Tzelepis, Etienne De Braekeleer, PhD MSc, Eliza Yankova, PhD, Justyna Rak, PhD, Demetrios Aspris, MSc, Ana Filipa Domingues, PhD, Richard Fosbeary, Alan Hendrick, PhD, Dan Leggate, PhD, Yaara Ofir-Rosenfeld, PhD, Alexandra Sapetschnig, PhD, Cristina Pina, MDDPhil, Mark Albertella, PhD, Wesley Blackaby, PhD, Oliver Rausch, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Tony Kouzarides, PhD

Blood (2019) 134 (Supplement_1): 403.

https://doi.org/10.1182/blood-2019-127962

Published: 2019

Journal Articles

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Mark C Wilkes, PhD, Jacqueline D Mercado, Mallika Saxena, Jun Chen, MD PhD, Kavitha Siva, PhD, Hee-Don Chae, PhD, Minyoung Youn, PhD, Ethan Patrick Wentworth, Kevin Jung, Ryan Sathianathen, Hiral Patel, Bertil Glader, MD PhD, Anupama Narla, MD, Claire E Repellin, PhD, Hanna T Gazda, MD PhD, Manuel Serrano, PhD, Johan Flygare, MD PhD, Kathleen M. Sakamoto, MD PhD

Blood (2019) 134 (Supplement_1): 455.

https://doi.org/10.1182/blood-2019-129570

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 3557.

https://doi.org/10.1182/blood-2019-125664

Published: 2019

Journal Articles

Venous Thromboembolism Prophylaxis in Acute Medically Ill Patients: A Retrospective Cohort Study

Anat Gafter-Gvili, MD, Genady Drozdinsky, Oren Zusman, MD, Shiri Kushnir, Leonard Leibovici, MD

Blood (2019) 134 (Supplement_1): 3678.

https://doi.org/10.1182/blood-2019-124495

Published: 2019

Journal Articles

Pharmacological Increase of Hb-O 2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO 2 or Limit O 2 Extraction in Brain Tissues of Sickle Cell Mice

Kobina Dufu, PhD, Alfredo Lucas, MS, Cynthia Rodrigues Muller, PhD, Alexander T Williams, MS, Xinchun Zhang, MS, Peter Rademacher, PhD, Carsten Alt, MSc, PhD, Donna Oksenberg, PhD, Pedro Cabrales, PhD

Blood (2019) 134 (Supplement_1): 3564.

https://doi.org/10.1182/blood-2019-129282

Published: 2019

Journal Articles

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

Carsten Dan Ley, PhD, Thomas Lindebo Holm, PhD, Daniel Elenius, PhD, Heidi Lindgreen Holmberg, PhD, Jais Rose Bjelke, PhD, Mette Loftager, PhD, Mette B Hermit, PhD, Ida Hilden, Stine L Kjellev, PhDDVM

Blood (2019) 134 (Supplement_1): 3631.

https://doi.org/10.1182/blood-2019-128159

Published: 2019

Journal Articles

Potency Equated Porcine and Bovine Mucosal Heparin Are Bioequivalent in Terms of Biochemical and Pharmacological Effects

Nausheen Baig, Ahmed Kouta, Fakiha Siddiqui, Ambar Farooqui, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Cassie Bacher, Sharan Krishnappan, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 3665.

https://doi.org/10.1182/blood-2019-126075

Published: 2019

Journal Articles

CRISPR Dropout Screens Identify DHODH, PIK3C3 , and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia

Gregory Takacs, BS, Yujia Zhou, BS,BA, David J. King, BS, Amy Meacham, MS, Loguinov Alex, PhD, Abderrahmane Tagmount, PhD, Amin Sobh, PhD, Max Russo, BS, Chris D Vulpe, MD PhD, Christopher R. Cogle, MD

Blood (2019) 134 (Supplement_1): 1452.

https://doi.org/10.1182/blood-2019-128180

Published: 2019

Journal Articles

Pharmacologic Inhibition of SUMO-Activating Enzyme (SAE) with TAK-981 Augments Interferon Signaling and Regulates T Cell Differentiation in Ex Vivo studies of Chronic Lymphocytic Leukemia (CLL)

Vi Lam, Scott R Best, BS, Nur Bruss, BS, Tingting Liu, Taylor Hashiguchi Rowland, BS, Dennis Huszar, PhD, Alexey Danilov, MD PhD

Blood (2019) 134 (Supplement_1): 1760.

https://doi.org/10.1182/blood-2019-127539

Published: 2019

Journal Articles

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Blood (2019) 134 (Supplement_1): 2472.

https://doi.org/10.1182/blood-2019-129056

Published: 2019

Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD

Blood (2019) 134 (Supplement_1): 2552.

https://doi.org/10.1182/blood-2019-123364

Published: 2019

Journal Articles

Mitochondrial Activity Identifies a Transcriptionally and Functionally Distinct Subset of Aged HSCs with Lineage-Balanced Output

Els Mansell, PhD, Valgardur Sigurdsson, PhD, Elitza Deltcheva, PhD, John Brown, PhD, Chela James, PhD, Kenichi Miharada, PhD, Shamit Soneji, PhD, Jonas Larsson, MD PhD, Tariq Enver, PhD

Blood (2019) 134 (Supplement_1): 2480.

https://doi.org/10.1182/blood-2019-124001

Published: 2019

Journal Articles

Pharmacological Perturbation of the Immunoproteasome in Hematologic Neoplasias: Therapeutic Implications

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Megan Bariteau, BSc, Minasri L. Borah, Sam Bender, Janaka Foneska, Jennifer Roth, Richard Groen, Gina Walter, Manja Friese-Hamim, Samantha M. Goodstal, Michael Sanderson, Constantine S. Mitsiades, MD PhD

Blood (2019) 134 (Supplement_1): 1291.

https://doi.org/10.1182/blood-2019-130356

Published: 2019

Journal Articles

Desialylation and Apoptosis Crosstalk to Modulate Platelet Clearance

Renata Grozovsky, PhD, Cameron Fraser, BS, Karin M. Hoffmeister, MD, Kristopher Sarosiek, PhD, Silvia Giannini, PhD

Blood (2019) 134 (Supplement_1): 1055.

https://doi.org/10.1182/blood-2019-122184

Published: 2019

Journal Articles

M6PR-Specific Targeting of Lysosomal Heparanase Regulates Platelet Hemostatic Function in Mice

Nathan Eaton, BS, Caleb Drew, BS, Theresa A. Dlugi, PhD, Karin M. Hoffmeister, MD, Hervé Falet, PhD

Blood (2019) 134 (Supplement_1): 1059.

https://doi.org/10.1182/blood-2019-129075

Published: 2019

Journal Articles

A Quantitative Systems Pharmacology (QSP) Model to Predict Receptor Occupancy of Bruton's Tyrosine Kinase (BTK) Inhibitors in Peripheral Blood Mononuclear Cells, Bone Marrow and Lymph Nodes of Patients with B-Cell Malignancies

Srikumar Sahasranaman, PhD, Oleg Demin, Jr., Dmitry Shchelokov, Veronika Musatova, Nageshwar Budha, PhD, Ying Ou, PhD

Blood (2019) 134 (Supplement_1): 1289.

https://doi.org/10.1182/blood-2019-129133

Published: 2019

Journal Articles

Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

Yonghan He, MD, Jianhui Chang, Dongwen Lv, Ha-neui Kim, Maria Almeida, Xin Zhang, Xinjian Mao, PhD, Xinghui Zhao, PhD, Linheng Li, PhD, Judith Campisi, Ying Liang, MD PhD, Daohong Zhou

Blood (2019) 134 (Supplement_1): 1204.

https://doi.org/10.1182/blood-2019-123159

Published: 2019

NARROW

Very long chain fatty acid metabolism is required in acute myeloid leukemia

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Pharmacologic Normalization of Altered Transcriptome of SF3B1 Mutant Myeloid Neoplasia

Pharmacological Inhibition of the RNA m 6 a Writer METTL3 As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Pharmacological Inhibition of Nemo-like Kinase Rescues mTOR-Mediated Translation and Primes Progenitors for Leucine-Stimulated Erythroid Expansion in Pre-Clinical Models of Diamond Blackfan Anemia

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Venous Thromboembolism Prophylaxis in Acute Medically Ill Patients: A Retrospective Cohort Study

Pharmacological Increase of Hb-O 2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO 2 or Limit O 2 Extraction in Brain Tissues of Sickle Cell Mice

Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo

Potency Equated Porcine and Bovine Mucosal Heparin Are Bioequivalent in Terms of Biochemical and Pharmacological Effects

CRISPR Dropout Screens Identify DHODH, PIK3C3 , and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia

Pharmacologic Inhibition of SUMO-Activating Enzyme (SAE) with TAK-981 Augments Interferon Signaling and Regulates T Cell Differentiation in Ex Vivo studies of Chronic Lymphocytic Leukemia (CLL)

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Mitochondrial Activity Identifies a Transcriptionally and Functionally Distinct Subset of Aged HSCs with Lineage-Balanced Output

Pharmacological Perturbation of the Immunoproteasome in Hematologic Neoplasias: Therapeutic Implications

Desialylation and Apoptosis Crosstalk to Modulate Platelet Clearance

M6PR-Specific Targeting of Lysosomal Heparanase Regulates Platelet Hemostatic Function in Mice

A Quantitative Systems Pharmacology (QSP) Model to Predict Receptor Occupancy of Bruton's Tyrosine Kinase (BTK) Inhibitors in Peripheral Blood Mononuclear Cells, Bone Marrow and Lymph Nodes of Patients with B-Cell Malignancies

Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice

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American Society of Hematology

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American Society of Hematology

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