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Journal Articles

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Hu, Saira Khan, Jeffrey Kurkewich, Tanner C. Martinez, Donald Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron, Megan E. McNerney
Journal: Blood
Blood (2021) 138 (9): 790–805.
https://doi.org/10.1182/blood.2020009195
Published: 2021
Includes: Supplemental data
Journal Articles

piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL

Huiying Han, Gao Fan, Sha Song, Yunxin Jiang, Chen'ao Qian, Weimin Zhang, Qi Su, Xiaofeng Xue, Wenzhuo Zhuang, Bingzong Li
Journal: Blood
Blood (2021) 137 (12): 1603–1614.
https://doi.org/10.1182/blood.2019003764
Published: 2021
Includes: Supplemental data
Journal Articles

Modeling and targeting of erythroleukemia by hematopoietic genome editing

Ilaria Iacobucci, Chunxu Qu, Elena Varotto, Laura J. Janke, Xu Yang, Aman Seth, Anang Shelat, Jake D. Friske, Reiji Fukano, Jiyang Yu, Burgess B. Freeman, III, James A. Kennedy, Adam S. Sperling, Rena Zheng, Yingzhe Wang, Harini Jogiraju, Kirsten M. Dickerson, Debbie Payne-Turner, Sarah M. Morris, Emily S. Hollis, Nina Ghosn, Georgia E. Haggard, R. Coleman Lindsley, Benjamin L. Ebert, Charles G. Mullighan
Journal: Blood
Blood (2021) 137 (12): 1628–1640.
https://doi.org/10.1182/blood.2020009103
Published: 2021
Includes: Supplemental data
Journal Articles

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation

Cornelius Pauli, Yi Liu, Christian Rohde, Chunhong Cui, Daria Fijalkowska, Dennis Gerloff, Carolin Walter, Jeroen Krijgsveld, Martin Dugas, Bayram Edemir, Caroline Pabst, Lutz P. Müller, Fengbiao Zhou, Carsten Müller-Tidow
Journal: Blood
Blood (2020) 135 (23): 2059–2070.
https://doi.org/10.1182/blood.2019004121
Published: 2020
Includes: Supplemental data
Journal Articles

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis

Xiaotian Zhang, Xinyu Wang, Xue Qing David Wang, Jianzhong Su, Nagireddy Putluri, Ting Zhou, Ying Qu, Mira Jeong, Anna Guzman, Carina Rosas, Yun Huang, Arun Sreekumar, Wei Li, Margaret A. Goodell
Journal: Blood
Blood (2020) 135 (11): 845–856.
https://doi.org/10.1182/blood.2019003330
Published: 2020
Includes: Supplemental data
Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3755.
https://doi.org/10.1182/blood-2019-122340
Published: 2019
Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)

Satoko Morishima, MD PhD, Kenji Ishitsuka, MD PhD, Koji Izutsu, MD PhD, Shigeru Kusumoto, MD PhD, Junya Makiyama, MD PhD, Atae Utsunomiya, MD, Kisato Nosaka, MD PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD PhD, Nobuhiko Yamauchi, MD, Kazushi Araki, DVM, PhD, Nobuaki Adachi, PhD, Tomonari Yamashita, Ryo Atsumi, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4025.
https://doi.org/10.1182/blood-2019-125507
Published: 2019
Journal Articles

The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies

Joseph L. Wiemels, PhD, Ivo S Muskens, Shaobo Li, Priyatama Pandey, Ritu Roy, PhD, Helen M Hansen, BSc, Kimberly D Siegmund, PhD, Beth A Mueller, PhD, Xiaomei Ma, PhD, Catherine Metayer, MD PhD, Adam J de Smith, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2510.
https://doi.org/10.1182/blood-2019-131455
Published: 2019
Journal Articles

Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia

Gretchen Johnston, Haley E. Ramsey, PhDMSc, Kristy Stengel, PhD, Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Maria Arrate, MSc, Matthew C. Stubbs, PhD, Timothy Burn, PhD, Scott Hiebert, PhD, Michael R. Savona, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2509.
https://doi.org/10.1182/blood-2019-130458
Published: 2019
Journal Articles

PRDM1 Binds an Extensive Network of Genes to Regulate Human Natural Killer Cell Homeostasis

Xuxiang Liu, PhD, Yunfei Shi, MD PhD, Yuping Li, PhD, Ru Chen, PhD, Sheng Pan, PhD, Gehong Dong, MD PhD, Qiang Gong, PhD, Javeed Iqbal, PhD, Haiqing Li, PhD, Jinhui Wang, PhD, Shuhua Yi, MD, Timothy McKeithan, MD PhD, Wing C. Chan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2536.
https://doi.org/10.1182/blood-2019-129270
Published: 2019
Journal Articles

DNA Methylation Profiling of AML Reveals Epigenetic Subgroups with Distinct Clinical Outcome

Sebastian Vosberg, Paul Kerbs, MSc, Vindi Jurinovic, MSc, Klaus H. Metzeler, MD, Susanne Amler, PhD, Cristina Sauerland, Dennis Görlich, PhD, Wolfgang E. Berdel, MD, Jan Braess, MD, Wolfgang Hiddemann, MD PhD, Karsten Spiekermann, MD, Tobias Herold, MD, Philipp A. Greif, MD PD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2715.
https://doi.org/10.1182/blood-2019-130047
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Genome-Wide Methylation Analysis Using the Digital Restriction Enzyme Analysis of Methylation for Stratification of Patients with Juvenile Myelomonocytic Leukemia

Hironobu Kitazawa, Hideki Muramatsu, MD PhD, Norihiro Murakami, MD PhD, Yusuke Okuno, MD PhD, Manabu Wakamatsu, MD, Taro Yoshida, MD, Masayuki Imaya, MD, Ayako Yamamori, MD, Shunsuke Miwata, MD, Kotaro Narita, MD, Motoharu Hamada, MD PhD, Daisuke Ichikawa, MD, Rieko Taniguchi, MD, Nozomu Kawashima, MD PhD, Eri Nishikawa, MD PhD, Atsushi Narita, Nobuhiro Nishio, MD PhD, Seiji Kojima, MD PhD, Yoshiyuki Takahashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2973.
https://doi.org/10.1182/blood-2019-127792
Published: 2019
Journal Articles

Fto Promotes Extramedullary Progression of Multiple Myeloma By Regulation of HSF1 through m 6 a RNA Methylation

Aoshuang Xu, MD, Jiasi Zhang, MD, Liping Zuo, MD, Jian Xu, PhD, Xuejiao Yin, MD, Qianwen Cheng, MD, Yuyang Zhang, MD, Lei Chen, PhD, Fei Zhao, PhD, Fengjuan Fan, PhD, Yu Hu, Chunyan Sun, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3063.
https://doi.org/10.1182/blood-2019-125635
Published: 2019
Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Pulsation Activates Mechanosensitive Piezo1 to Form Long-Term Hematopoietic Stem Cells

Giorgia Scapin, PhD, Dhvanit I Shah, PhDPharmD
Journal: Blood
Blood (2019) 134 (Supplement_1): 445.
https://doi.org/10.1182/blood-2019-121948
Published: 2019
Journal Articles

Distinct Evolutionary Patterns in Chronic Lymphocytic Leukemia (CLL) during Resistance to Graft-Versus-Leukemia (GvL)

Pavan Bachireddy, MD, Christina Ennis, BA, Vinhkhang N Nguyen, BSc, Nikolas Barkas, PhD, Sachet Shukla, PhD, Kendell Clement, PhD, Samuel Freeman, BSc, Satyen H Gohil, PhD, M.B.,B.S., Natalie Bavli, MD, Liudmila Elagina, PhD, Ignaty Leshchiner, PhD, Jennifer R. Brown, MD PhD, Gad Getz, PhD, Vincent T. Ho, MD, Donna S Neuberg, ScD, Robert J. Soiffer, MD, Jerome Ritz, MD, Edwin P. Alyea, III, MD, Peter Kharchenko, PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 516.
https://doi.org/10.1182/blood-2019-129520
Published: 2019
Journal Articles

Synthetic Lethality-Based Approach Identified EED and BRD4 As Critical Survival Factorsin Acte Myeloid Leukemia with Monosomy 7

Kensuke Matsuda, MD, Yuki Kagoya, MD PhD, Sho Yamazaki, MD PhD, Masashi Miyauchi, MD PhD, Mineo Kurokawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1233.
https://doi.org/10.1182/blood-2019-123595
Published: 2019
Journal Articles

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Sina Staeble, MSc, Stephen Kraemer, MSc, Jens Langstein, MSc, Ruzhica Bogeska, PhD, Mark Hartmann, PhD, Maximilian Schoenung, MSc, Melinda Czeh, PhD, Julia Knoch, Natasha Anstee, PhD, Simon Haas, PhD, Abdelrahman Mahmoud, MSc, Julius Graesel, MSc, Daniel Huebschmann, MD PhD, Lars Feuerbach, PhD, Weichenhan Dieter, PhD, Benedikt Brors, PhD, Karsten Rippe, PhD, Jan-Philipp Mallm, PhD, Frank Rosenbauer, PhD, Christoph Plass, PhD, Matthias Schlesner, PhD, Michael D. Milsom, PhD, Daniel B. Lipka, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1179.
https://doi.org/10.1182/blood-2019-124429
Published: 2019