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Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Proteomics-Based Approach Recognize Unique Expression Profiles in Adult Acute Monocytic/Monoblastic Leukemia: Implications for Prognostication and Drug Repurposing

Eduardo Sabino De Camargo Magalhaes, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2024) 144 (Supplement 1): 2942.
https://doi.org/10.1182/blood-2024-208114
Published: 2024
Journal Articles

Identification of Prognostic Signatures and Potential New Therapies in NPM1 Mutant Adult Acute Myeloid Leukemia Patients Using Proteomics

Eduardo Sabino De Camargo Magalhaes, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2024) 144 (Supplement 1): 1534.
https://doi.org/10.1182/blood-2024-204068
Published: 2024
Journal Articles

Optimizing FLT3 Inhibitor Use in Adult Acute Myeloid Leukemia with FLT3 Mutations Using Proteomics

Eduardo Sabino Magalhaes, Stefan Hubner, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2023) 142 (Supplement 1): 165.
https://doi.org/10.1182/blood-2023-186508
Published: 2023
Journal Articles

Proteomic Profiling Identifies Unique IDH Mutant Signatures and Novel Therapeutic Opportunities in Adult Acute Myeloid Leukemia Patients

Eduardo Sabino de Camargo Magalhaes, Stefan Hubner, Brandon D. Brown, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2023) 142 (Supplement 1): 1581.
https://doi.org/10.1182/blood-2023-186723
Published: 2023
Journal Articles

A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

Samarpana Chakraborty, Claudia Morganti, Joyoti Dey, Hui Zhang, Srinivas Aluri, Nadege Gitego, Kith Pradhan, Bianca Rivera, Yogesh Chutake, Anna Skwarska, Ioannis Mantzaris, Mendel Goldfinger, Eric J Feldman, Gaurav S Choudhary, Stefan Hubner, Yihua Qiu, Brandon D. Brown, Amit Verma, Evripidis Gavathiotis, Marina Y. Konopleva, Steven M. Kornblau, Jared Gollob, Keisuke Ito, Aditi Shastri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2787.
https://doi.org/10.1182/blood-2023-186947
Published: 2023
Journal Articles

RPPA-Profiling in Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia Identifies Protein Patterns Associated with Outcome

Fieke W Hoff, Lourdes Sriraja, Yihua Qiu, Gaye Jenkins, Andrew Ligeralde, David T. Teachey, Brent L. Wood, Meenakshi Devidas, Mignon L. Loh, Todd A. Alonzo, Amina A Qutub, Evangelia Petsalaki, Steven M. Kornblau, Terzah M. Horton
Journal: Blood
Blood (2022) 140 (Supplement 1): 6352–6353.
https://doi.org/10.1182/blood-2022-163881
Published: 2022
Journal Articles

Proteomics-Based Strategy for the Recommendation of Conventional Chemotherapy Vs Venetoclax Plus Hypomethylating Agents in Adult Acute Myeloid Leukemia (AML)

Eduardo Sabino de Camargo Magalhaes, Brandon D Brown, Stefan Hubner, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2022) 140 (Supplement 1): 6312–6313.
https://doi.org/10.1182/blood-2022-165158
Published: 2022
Journal Articles

Targeting Vimentin (VIM) in Acute Myelogenous Leukemia (AML)

Stefan Hubner, Marina Konopleva, Zhihong Zeng, Fieke W Hoff, Yihua Qiu, Vivian Ruvolo, Terzah M. Horton, Steven M. Kornblau
Journal: Blood
Blood (2022) 140 (Supplement 1): 6260–6261.
https://doi.org/10.1182/blood-2022-163664
Published: 2022
Journal Articles

Epigenetic Landscape Predicts Overall Survival and Remission Duration in Adult Acute Myeloid Leukemia

Eduardo Sabino de Camargo Magalhaes, Yihua Qiu, Steven M. Kornblau
Journal: Blood
Blood (2022) 140 (Supplement 1): 6331–6332.
https://doi.org/10.1182/blood-2022-169962
Published: 2022
Journal Articles

Valosin-Containing Protein (VCP/p97) Is Prognostically Unfavorable in Subtypes of Acute Leukemia, and Negatively Correlates with UPR-Proteins IRE1 and GRP78

Fieke W Hoff, Yihua Qiu, Brandon Brown, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye Jenkins, Terzah M. Horton, Steven M. Kornblau
Journal: Blood
Blood (2021) 138 (Supplement 1): 3447.
https://doi.org/10.1182/blood-2021-147066
Published: 2021
Journal Articles

Proteomic Profiling Based Classification of CLL Provides Prognostication for Modern Therapy and Identifies Novel Therapeutic Targets

Ti'ara L. Griffen, Fieke W Hoff, Yihua Qiu, James W Lillard, Alessandra Ferrajoli, Philip A. Thompson, Endurance Toro, Kevin Ruiz, Jan A. Burger, William G. Wierda, Steven M. Kornblau
Journal: Blood
Blood (2021) 138 (Supplement 1): 1538.
https://doi.org/10.1182/blood-2021-151513
Published: 2021
Journal Articles

Protein Expression Signatures Predict Response, Relapse, and Survival after Venetoclax Containing Therapy in Adults with Acute Myeloid Leukemia

Brandon Brown, Yihua Qiu, Fieke W Hoff, Steven M. Kornblau
Journal: Blood
Blood (2021) 138 (Supplement 1): 227.
https://doi.org/10.1182/blood-2021-153906
Published: 2021
Journal Articles

Heat shock factor 1 (HSF1-pSer 326 ) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report

Clinical Trials & Observations
Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Peter P. Ruvolo, Robert B. Gerbing, Amanda R. Leonti, Gaye N. Jenkins, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman, Steven M. Kornblau, Terzah M. Horton
Journal: Blood
Blood (2021) 137 (8): 1050–1060.
https://doi.org/10.1182/blood.2020005208
Published: 2021
Includes: Supplemental data
Journal Articles

Proteomics in Pediatric Acute Myeloid and T-Cell Lymphoblastic Leukemia: Shared Individual Protein Expression Patterns Co-Cluster into Overall Distinct Combinations

Fieke W Hoff, BSc, Anneke D. van Dijk, MD, Yihua Qiu, Eveline S. de Bont, MD PhD, Steven M. Kornblau, MD, Terzah M Horton, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-138522
Published: 2020
Journal Articles

Loss of H3K27 Methylation Identifies Poor Outcome in Adult-Onset Acute Myeloid Leukemia

Anneke D. van Dijk, MD, Fieke W Hoff, BSc, Yihua Qiu, Eveline S. de Bont, MD PhD, Sophia W.M. Bruggeman, PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
https://doi.org/10.1182/blood-2020-139387
Published: 2020
Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Sara Mirali, BSc, Botham Aaron, Veronique Voisin, PhD, Changjiang Xu, Jonathan St-Germain, David Sharon, PhD, Fieke W Hoff, BSc, Yihua Qiu, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G Wei Xu, Boaz Nachmias, MD PhD, Neil MacLean, Xiaoming Wang, Andrea Arruda, Mark D. Minden, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Brian Raught, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 729.
https://doi.org/10.1182/blood-2019-122784
Published: 2019
Journal Articles

Prognostic Significance of FOXO3 in Pediatric Acute Myeloid Leukemia (AML) Patients Treated with Bortezomib Addition to Standard Therapy: Results from a Children's Oncology Group Phase 3 Clinical Trial

Anneke D. van Dijk, BS, Peter P. Ruvolo, PhD, Fieke W Hoff, BSc, Yihua Qiu, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, Anders E. Kolb, MD, Todd A. Alonzo, PhD, Robert B. Gerbing, Eveline S. de Bont, MD PhD, Sophia W.M. Bruggeman, PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2676.
https://doi.org/10.1182/blood-2019-128579
Published: 2019
Journal Articles

Trimethylated H3K27, and Di- and Trimethylated H3K4 Proteomic Profiling Distinguishes Acute Lymphoid Leukemia (ALL) from Acute Myeloid Leukemia (AML) and Associates with Overall Survival and Tyrosine Kinase Inhibitor Sensitivity in Adult ALL

Anneke D. van Dijk, BS, Fieke W Hoff, BSc, Yihua Qiu, Mary Figueroa, BS, Joya Chandra, PhD, Elias Jabbour, MD, Eveline S. de Bont, MD PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1460.
https://doi.org/10.1182/blood-2019-124960
Published: 2019
Journal Articles

Proteomic Landscape of Acute Leukemia: A Comparison between ALL and AML in Adults

Fieke W Hoff, BSc, Yihua Qiu, Wendy Hu, PhD, Amina A Qutub, PhD, Eveline S. de Bont, MD PhD, Terzah M Horton, MD PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1461.
https://doi.org/10.1182/blood-2019-123470
Published: 2019