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Journal Articles

Blinatumomab Added to Chemotherapy Improves Disease-Free Survival in Newly Diagnosed NCI Standard Risk Pediatric B-Acute Lymphoblastic Leukemia: Results from the Randomized Children's Oncology Group Study AALL1731

Rachel E. Rau, Sumit Gupta, John A. Kairalla, Karen R Rabin, Anne Angiolillo, Cindy Wang, Andrew J. Carroll, Susan Conway, Meenakshi Devidas, Lia Gore, Ilan R. Kirsch, Holly R. Kubaney, Amanda M Li, Jennifer L. McNeer, Olga Militano, Yvonne Moyer, Maureen M. O'Brien, Maki Okada, Shalini C. Reshmi, Mary Shago, Elizabeth R. Wagner, Naomi J. Winick, Brent L. Wood, Faraz Zaman, Gerhard Zugmaier, Sue Zupanec, Stephen P. Hunger, David T. Teachey, Elizabeth A. Raetz, Mignon L. Loh
Journal: Blood
Blood (2024) 144 (Supplement 1): 1.
https://doi.org/10.1182/blood-2024-207450
Published: 2024
Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Andrew Hughes, Rawan Shraim, Lahari Uppuluri, Haley Newman, Gongping Shi, Julie Asare, Theresa Ryan, Elizabeth A. Raetz, James A. Whitlock, Maureen M. O'Brien, Deepa Bhojwani, Rachel E. Rau, Kara L. Davis, Stacy Cooper, Patrick Brown, Stephen P. Hunger, Mignon L. Loh, Laura E. Hogan, Stephan A. Grupp, Jun J. Yang, David T. Teachey, Caroline Diorio
Journal: Blood
Blood (2024) 144 (Supplement 1): 634.
https://doi.org/10.1182/blood-2024-203756
Published: 2024
Journal Articles

Feasibility of Discontinuation of Bruton's Tyrosine Kinase Inhibitors in Patients with Chronic Lymphocytic Leukemia: A Patient Survey

Deborah M. Stephens, Chris Stewart, Liza Avruch, Catherine C Coombs, Alexey Danilov, Brian T. Hill, Mazyar Shadman, Alina S. Gerrie, Christopher E. Jensen, Marc Hoffmann, Allison M. Winter, Daniel A. Ermann, Paul M Barr, Susan M. O'Brien, Brian Koffman, John C. Byrd
Journal: Blood
Blood (2024) 144 (Supplement 1): 7743.
https://doi.org/10.1182/blood-2024-193298
Published: 2024
Journal Articles

Efficacy and Safety of Odronextamab Monotherapy in Patients (Pts) with Diffuse Large B-Cell Lymphoma (DLBCL) Progressing after CAR T-Cell Therapy: Primary Analysis from the ELM-1 Study

Matthew Matasar, Max S. Topp, John N. Allan, Stephen M. Ansell, Jeffrey A. Barnes, Jon E. Arnason, Jean-Marie Michot, Neta Goldschmidt, Susan M. O'Brien, Uri Abadi, Irit Avivi Mazza, Jingxian Cai, Julia Zecchini, Min Zhu, Jurriaan Brouwer-Visser, Aafia Chaudhry, Hesham Mohamed, Srikanth Ambati, Jennifer L. Crombie
Journal: Blood
Blood (2024) 144 (Supplement 1): 866.
https://doi.org/10.1182/blood-2024-199155
Published: 2024
Journal Articles

Consistently High 5.5-Year Progression-Free Survival (PFS) Rates in Patients with and without Bulky Baseline Lymphadenopathy ≥5 Cm Are Associated with High Undetectable Minimal Residual Disease (uMRD4) Rates after First-Line Treatment with Fixed-Duration Ibrutinib + Venetoclax for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) in the Phase 2 CAPTIVATE Study

William G. Wierda, Ryan Jacobs, Paul M Barr, John N. Allan, Tanya Siddiqi, Alessandra Tedeschi, Thomas J. Kipps, Susan M. O'Brien, Xavier C. Badoux, Andrea Visentin, Masa Lasica, Dennis A. Carney, Anna Elinder Cambrun, Javier De la Serna, Edith Szafer Glusman, Cathy Zhou, Jutta K. Neuenburg, Lynne Neumayr, Anita Szoke, James P. Dean, Paolo Ghia, Constantine S. Tam
Journal: Blood
Blood (2024) 144 (Supplement 1): 1869.
https://doi.org/10.1182/blood-2024-200936
Published: 2024
Journal Articles

PEPN2312: A Pediatric Early Phase Clinical Trials Network (PEP-CTN) Phase 1 Trial of Imetelstat with Fludarabine/Cytarabine in Pediatric Patients with Relapsed/Refractory AML, MDS, or JMML

Alexandra McLean Stevens, Maureen M. O'Brien, Xiaowei Liu, Charles G Minard, Olga Militano, Joel M Reid, Shyamala Navada, Todd M Cooper, Sarah K. Tasian, Elizabeth Fox, Brenda J. Weigel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.4.
https://doi.org/10.1182/blood-2024-207907
Published: 2024
Journal Articles

A Children's Oncology Group Clinical Trial of Long-Term Outcomes in Survivors of Down Syndrome-Associated Acute Leukemia (ALTE22C1): Clinical Trial in Progress

Maria Monica Gramatges, Lauren N Sanclemente, Lacey Hall, Danielle L Mitchell, Olga A Taylor, Tanya Shannon, Tyler Brown, Michelle M Nuño, Smita Bhatia, Eric J. Chow, Kelly D. Getz, Johann K. Hitzler, Amanda M Li, Kaitlin McCloskey, Paul C Nathan, Maureen M. O'Brien, Serina Patel, Anupam Verma, Angela R Yarbrough, Geraldine Aubert, Tracie C Rosser, Lisa M Jacola, Philip J Lupo, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 2808.1.
https://doi.org/10.1182/blood-2024-203724
Published: 2024
Journal Articles

First-Line Treatment Choice and Risk of Other Malignancies in US Veterans Diagnosed with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

Helen Ma, Sameer A. Parikh, Roberta Santos Azevedo, Susan M. O'Brien, Pankaj Gupta, Alessandra Ferrajoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 5038.
https://doi.org/10.1182/blood-2024-207780
Published: 2024
Journal Articles

A Retrospective Study of Inotuzumab Ozogamicin in Individuals with Down Syndrome and B-Cell Acute Lymphoblastic Leukemia

Amanda M Li, Catherine Aftandilian, Susan Colace, Sarah Fanizzi, Kelly Elizabeth Faulk, Erin M. Guest, Ammar Hayani, Richard Ho, Anjali Khanna, Kasey Leger, David McCall, Tamara P. Miller, Holly Pacenta, Troy Quigg, Jeremy D. Rubinstein, Deepa Bhojwani, Susan R Rheingold, Maureen M. O'Brien, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4204.
https://doi.org/10.1182/blood-2024-209455
Published: 2024
Journal Articles

Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

Kate D. Westmoreland, Zachary L Taylor, Tamara P. Miller, Ashley Chavana, Karen R Rabin, Austin L Brown, Melanie Brooke Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1438.
https://doi.org/10.1182/blood-2024-211870
Published: 2024
Journal Articles

Sustained Benefit of Zanubrutinib vs Ibrutinib in Patients With R/R CLL/SLL: Final Comparative Analysis of ALPINE

Clinical Trials & Observations
Jennifer R. Brown, Barbara Eichhorst, Nicole Lamanna, Susan M O'Brien, M.D., Constantine S. Tam, Lugui Qiu, Wojciech Jurczak, Keshu Zhou, Martin Šimkovič, Jiří Mayer, Amanda Gillespie-Twardy, Alessandra Ferrajoli, Peter Stephen Ganly, Robert Weinkove, Sebastian Grosicki, Andrzej Mital, Tadeusz Robak, Prof., Anders Osterborg, Habte A. Yimer, Megan (Der Yu) Wang, Tommi Salmi, Liping Wang, Jessica Li, Kenneth Wu, Aileen Cleary Cohen, Mazyar Shadman
Journal: Blood
Blood blood.2024024667.
https://doi.org/10.1182/blood.2024024667
Published: 2024
Includes: Supplemental data
Journal Articles

Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up

Clinical Trials & Observations Brief Report
Philip A. Thompson, Alexandre Bazinet, William G. Wierda, Constantine S. Tam, Susan M. O’Brien, Satabdi Saha, Christine B. Peterson, William Plunkett, Michael J. Keating
Journal: Blood
Blood (2023) 142 (21): 1784–1788.
https://doi.org/10.1182/blood.2023020158
Published: 2023
Includes: Supplemental data
Journal Articles

Efficacy and Safety of a Third Generation CD20 CAR-T (MB-106) for Treatment of Relapsed/Refractory Indolent B-Cell Non-Hodgkin Lymphoma: Phase-1 Results from a Multicenter Trial

Mazyar Shadman, Paolo F. Caimi, Susan M. O'Brien, Patrick M. Reagan, Bruce Dezube, Punya Navaratnarajah, Tripti Gaur, Suzanne Petrossian, Anthony Germani, Brian G Till, Jeremy S. Abramson
Journal: Blood
Blood (2023) 142 (Supplement 1): 2102.
https://doi.org/10.1182/blood-2023-175007
Published: 2023
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

Impact of Treatment with Inotuzumab Ozogamicin before or after Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Lymphoblastic Leukemia

Susan R Rheingold, Lingyun Ji, Lia Gore, Xinxin Xu, Deepa Bhojwani, Nirali N. Shah, Elizabeth A. Raetz, Mignon L. Loh, Maureen M. O'Brien
Journal: Blood
Blood (2023) 142 (Supplement 1): 2876.
https://doi.org/10.1182/blood-2023-183103
Published: 2023
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Overall Survival Outcomes in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Patients with High-Risk Molecular-Cytogenetic Features Treated with 1L Ibrutinib: A Comparative Effectiveness Study Using the Flatiron Health Data

John N. Allan, Tao Ran, Zhijie Ding, Jinghua He, Alex Bokun, Zaina P Qureshi, Susan M. O'Brien
Journal: Blood
Blood (2023) 142 (Supplement 1): 3278.
https://doi.org/10.1182/blood-2023-184318
Published: 2023
Journal Articles

Long-Term Follow up for SWOG 1318: Combination of Dasatinib, Prednisone, and Blinatumomab for Older Patients with Philadelphia-Chromosome (Ph) Positive Acute Lymphoblastic Leukemia (ALL)

Anjali S. Advani, Anna B Moseley, Kristen M. O'Dwyer, Brent L. Wood, Jae H. Park, Matthew J. Wieduwilt, Deepa Jeyakumar, George Yaghmour, Ehab L. Atallah, Aaron T. Gerds, Susan M. O'Brien, Jane L. Liesveld, Megan Othus, Mark R. Litzow, Richard M Stone, Elad Sharon, Cecilia C.S. Yeung, Jerald P. Radich, Harry P. Erba
Journal: Blood
Blood (2023) 142 (Supplement 1): 1499.
https://doi.org/10.1182/blood-2023-180204
Published: 2023
Journal Articles

Incidence and Management of COVID-19 Infections in Vaccinated Patients with CLL

Chaitra S Ujjani, Ted Gooley, Tanya Siddiqi, Deborah M. Stephens, Catherine Broome, Stephen E Spurgeon, Catherine Lai, Allison Winter, Georgios Pongas, Alex Greninger, Joshua A. Hill, Susan M. O'Brien, Matthew S Davids, Kerry A Rogers, Alexey Danilov, Genesis Quezada, Haiying Zhu, Amy Sperling, Tyler Sorensen, Kelsey Launchbury, William G. Wierda, Mazyar Shadman, Philip A. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 5149.
https://doi.org/10.1182/blood-2023-173992
Published: 2023
Journal Articles

Odronextamab Demonstrates Durable Complete Responses in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Progressing after CAR-T Therapy: Outcomes from the ELM-1 Study

Jennifer L. Crombie, Matthew Matasar, Max S. Topp, John N. Allan, Jeffrey A. Barnes, Jon E. Arnason, Jean-Marie Michot, Neta Goldschmidt, Susan M. O'Brien, Uri Abadi, Irit Avivi Mazza, Jessica Cai, Dina M. Flink, Min Zhu, Jurriaan Brouwer-Visser, Hesham Mohamed, Aafia Chaudhry, Srikanth Ambati, Steve M Ansell
Journal: Blood
Blood (2023) 142 (Supplement 1): 4461.
https://doi.org/10.1182/blood-2023-181602
Published: 2023