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Journal Articles

First-in-Class JAK/Rock Inhibitor Rovadicitinib in Myeloproliferative Neoplasms: A Single Arm, Multicenter, Open-Label, Phase I/Ib Study

Zefeng Xu, Ling Pan, Zhenya Hong, Qingsong Yin, Xuelan Zuo, Qin Wen, Fan Yu, Chunkang Chang, Wei Ling, Dong Wang, Dawei Ding, Zhijian Xiao
Journal: Blood
Blood (2023) 142 (Supplement 1): 1829.
https://doi.org/10.1182/blood-2023-178956
Published: 2023
Journal Articles

Preliminary Results of a Phase 2 Study of IMM01 Combined with Azacitidine (AZA) As the First-Line Treatment in Adult Patients with Higher Risk Myelodysplastic Syndromes (MDS)

Wei Yang, Sujun Gao, Xiaojing Yan, Rong Guo, Lijie Han, Fei Li, Yafei Wang, Junmin Li, Chunkang Chang, Haiping Yang, Ronghua Hu, Hongyan Tong, Xingli Zhao, Qiubai Li, Jingdong Zhang, Xin Du, Sanfang Tu, Cheng Zhang, Congmeng Lin, Xin Du, Zhenling Li, Ligen Liu, Zhenyu Li, Zheng Dong, Yixuan Yang, Qiying Lu, Wenzhi Tian, Zhijian Xiao
Journal: Blood
Blood (2023) 142 (Supplement 1): 320.
https://doi.org/10.1182/blood-2023-174420
Published: 2023
Journal Articles

The Mechanism of Setd2 in Mesenchymal Stromal Cell in MDS-Associated Ineffective Hematopoiety

Roujia Wang, Lan Wang, Chunkang Chang
Journal: Blood
Blood (2023) 142 (Supplement 1): 6460.
https://doi.org/10.1182/blood-2023-184439
Published: 2023
Journal Articles

EX103, a Novel CD20xCD3 Bispecific Antibody, Showed a Favorable Safety and Potent Single-Agent Antitumor Activity in Heavily Pretreated Relapsed/Refractory Patients with B-Cell Non-Hodgkin Lymphoma

Junyuan Qi, Mingyuan Sun, Keshu Zhou, Chunyan Ji, Fei Lu, Chunkang Chang, Wenjun Zhang, Daniel Yang, Jiali Lu, Jisen Li, Ying Cheng, Yanfei Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 6230.
https://doi.org/10.1182/blood-2023-173486
Published: 2023
Journal Articles

MDS-MSC Derived Exosomes Promote MDS Cells Malignant Proliferation through RIG-1/Isgs Pathway Via RN7SL1

Juan Guo, Jianxiang Wang, Chunkang Chang
Journal: Blood
Blood (2023) 142 (Supplement 1): 6461.
https://doi.org/10.1182/blood-2023-185531
Published: 2023
Journal Articles

Combination Therapy of Eltrombopag and Cyclosporine a Improves Hematopoiesis in Patients with Lower-Risk Myelodysplastic Syndrome

Luxi Song, Chunkang Chang, Jianxiang Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 4084–4085.
https://doi.org/10.1182/blood-2022-168147
Published: 2022
Journal Articles

Incorporation of Mutations and Bone Marrow Fibrosis into the Revised International Prognostic Scoring System in Patients with Myelodysplastic Syndromes

Youshan Zhao, ChunKang Chang
Journal: Blood
Blood (2022) 140 (Supplement 1): 4063–4064.
https://doi.org/10.1182/blood-2022-165202
Published: 2022
Journal Articles

A Phase 1b Study to Evaluate Safety and Efficacy of IBI188 in Combination with Azacitidine (AZA) As a First-Line Treatment in Subjects with Newly Diagnosed Higher Risk Myelodysplastic Syndrome

Miao Miao, Depei WU, Shuangfeng Xie, Mei Hong, ChunKang Chang, Li Yu, Sujun Gao, Yan Li, Yuhua Li, Zunmin Zhu, Baolin Tang, Bingzong Li, Haiping Yang, Jishi Wang, Ling Qin, Rong Fu, Fei Li, Liangming Ma, Qifa Liu, Xin Du, Zhongxing Jiang, Zhenyu Li, Aijun Liu, Hongyan Tong, Jun Ma, Li Liu, Qingchi Liu, Yajing Xu, Hui Zhou, Yan Wang, Jianlin Chen, Ziru Niu, Mingxia Chen, Zhijian Xiao
Journal: Blood
Blood (2022) 140 (Supplement 1): 4045–4046.
https://doi.org/10.1182/blood-2022-155901
Published: 2022
Journal Articles

Phase I Study of TQB3455, a Selective Inhibitor of IDH2 with Favorable Safety and More Potent Efficacy to IDH2-R172K Mutation, for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Hao Jiang, Xudong Wei, Chunkang Chang, Hongbing Ma, Xuejun Zhang, Xiao-Jun Huang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9082–9083.
https://doi.org/10.1182/blood-2022-164984
Published: 2022
Journal Articles

Molecular Biomarker Analyses for Exploring the Therapeutic Mechanism of Lemzoparlimab and Azacitidine (AZA) in Newly Diagnosed Higher Risk Myelodysplastic Syndrome (HR-MDS)

Zhijian Xiao, Chunkang Chang, Qiubai Li, Xiaojing Yan, Tiejun Qin, Hongyan Tong, Yu Zhang, Min Dai, Yanjie He, Jianyu Weng, Jian Li, Sujun Gao, Rong Fu, Xudong Wei, Aili He, Jinhai Ren, Tong Wu, Xin Du, Yanni Zhang, Ke Xu, Zhengyi Wang, Michelle Yang, Andrew Zhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8821–8822.
https://doi.org/10.1182/blood-2022-163880
Published: 2022
Journal Articles

Phase 2 March Study: ATG-010 Plus Low Dose Dexamethasone in Chinese Relapsed/Refractory Multiple Myeloma (RRMM) Patients Previously Treated with an Immunomodulatory Agent (IMiD) and a Proteasome Inhibitor (PI)

Lugui Qiu, Weijun Fu, Zhongjun Xia, Zhengzheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Li Fei, Zhuogang Liu, Xiequn Chen, Jing Liu, Yang Yu, Aihua Wang, Yijun Yang, Zhinuan Yu, Kevin Lynch
Journal: Blood
Blood (2021) 138 (Supplement 1): 4770.
https://doi.org/10.1182/blood-2021-145282
Published: 2021
Journal Articles

ATG-010 Plus Low-Dose Dexamethasone (Sd) in Chinese Relapsed/Refractory Multiple Myeloma (RRMM) Patients Previously Received Chimeric Antigen Receptor T-Cell (CAR-T)

Weijun Fu, Lugui Qiu, Zhongjun Xia, Zhengzheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Li Fei, Zhuogang Liu, Xiequn Chen, Jing Liu, Yang Yu, Aihua Wang, Zhinuan Yu, Yijun Yang, Kevin Lynch
Journal: Blood
Blood (2021) 138 (Supplement 1): 4778.
https://doi.org/10.1182/blood-2021-146784
Published: 2021
Journal Articles

Efficacy and Safety of Recombinant Human-Mouse Chimeric Anti-CD20 Monoclonal Antibody (SCT400) Combined with CHOP in Patients with Treatment-Naïve Diffuse Large B-Cell Lymphoma: A Multicenter, Randomized, Single-Blind, Parallel Active-Controlled, Phase III Study

Yuankai Shi, QingYuan Zhang, Xiaonan Hong, Zhen Wang, Yuhuan Gao, Liqun Zou, Hong Cen, Lin Gui, Yufu Li, Jifeng Feng, Zhao Wang, Mingzhi Zhang, Chuan Jin, Weihua Zhang, Jianda Hu, Chengyun Zheng, Zhendong Zheng, Liling Zhang, Shaoshui Chen, Yunhong Huang, Yun Tang, Yajie Gao, Miaowang Hao, Xiaoling Li, Chunkang Chang, Haiyan Yang, Hui Wu, Lida Shen, Xiaoyan Ke, Liangming Zhang, Yaming Xi, Linhua Yang, Liangzhi Xie
Journal: Blood
Blood (2021) 138 (Supplement 1): 2480.
https://doi.org/10.1182/blood-2021-149861
Published: 2021
Journal Articles

DNMT3A wt NPM1-Mutation Defines a Subgroup of MDS with Special Favorable Outcomes Towards Decitabine Therapy

Lingyun Wu, MD PhD, Xiao Li, MD, Feng Xu, He Qi, Zheng Zhang, Dong Wu, Luxi Song, MD, Liyu Zhou, Chao Xiao, Jiying Su, Juan Guo, Chunkang Chang
Journal: Blood
Blood (2019) 134 (Supplement_1): 1724.
https://doi.org/10.1182/blood-2019-124008
Published: 2019
Journal Articles

Reduction of Dicer1 By Multiple Myeloma Cells in Mesenchymal Stem Cells Promotes Cellular Senescence and Tumor-Supporting Effect and Decreases the Differentiation

Juan Guo, Xiao Li, MD, Youshan Zhao, Chengming Fei, Chunkang Chang, PhD, Sida Zhao, Qingqing Zheng
Journal: Blood
Blood (2017) 130 (Supplement 1): 4399.
https://doi.org/10.1182/blood.V130.Suppl_1.4399.4399
Published: 2017
Journal Articles

Iron Overload Injures the Function of MDS-Derived Mesenchymal Stromal Cells through Activating the Ampkα/Mff/Drp1 Signaling Pathway

Qingqing Zheng, Xiao Li, MD, Chunkang Chang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5268.
https://doi.org/10.1182/blood.V130.Suppl_1.5268.5268
Published: 2017
Journal Articles

Dysregulation of ANKRD11 Influenced Hematopoisis By Histone Acetylation-Mediated Gene Expression in Myelodysplastic Syndrome

Youshan Zhao, MD, Feng Xu, Juan Guo, MD, Sida Zhao, MD, Chunkang Chang, MD PhD, Xiao Li, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4292.
https://doi.org/10.1182/blood.V128.22.4292.4292
Published: 2016
Journal Articles

Ribosomal Protein L23 Negatively Regulates Cell Apoptosis Via Its Suppression of Miz1 and Activation c-Myc in Higher-Risk Myelodysplastic Syndromes

Yuekun Qi, Lingyun Wu, Chunkang Chang, MD PhD, Feng Xu, Qi He, Xiao Li, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5508.
https://doi.org/10.1182/blood.V128.22.5508.5508
Published: 2016
Journal Articles

Activation of Notch-Hes Signaling Pathway Impairs Osteogenic Differentiation and Hematopoietic Stem Cell-Supporting Capacitiy of Mesenchymal Stromal Cells Derived from Myelodysplastic Syndromes Patients

Chunkang Chang, MDPhD, Chengming Fei, MD, Juan Guo, MD, Youshan Zhao, MD, Shucheng Gu, MD, Xiao Li, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2857.
https://doi.org/10.1182/blood.V126.23.2857.2857
Published: 2015
Journal Articles

A Primary Study of the Gene Mutations in Predicting Treatment Response to Decitabine in Patients with MDS

Chunkang Chang, MDPhD, Youshan Zhao, MD, Feng Xu, Xiao Li, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1689.
https://doi.org/10.1182/blood.V126.23.1689.1689
Published: 2015