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Journal Articles

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Alyssa C. Parker, Joseph Van Amburg, J Brett Heimlich, Yash Pershad, Nicole Angelina Mickels, Taralynn Mack, Paul Brent Ferrell, Jr., Michael R. Savona, Angela Jones, Alexander G. Bick

Blood blood.2024026555.

https://doi.org/10.1182/blood.2024026555

Published: 2024

Includes: Supplemental data

Journal Articles

Distinct Transcriptomic Cell States Differentiate Low-Risk MDS from Healthy Marrow

Pawan Bhat, Joseph C. Van Amburg, Thomas J. Gracie, Justin A Cartailler, Chad R Potts, Alexander G. Bick, Robert Welner, P. Brent Ferrell, Jr.

Blood (2024) 144 (Supplement 1): 1814.

https://doi.org/10.1182/blood-2024-211672

Published: 2024

Journal Articles

Combined Natural Language Processing and Gpt-4 Pathology Report Interpretation Efficiently Identify a Myelodysplastic Syndrome Cohort for Large Scale Clinical Research Applications

Thomas J. Gracie, Yash Pershad, Cosmin Bejan, Alexander G. Bick, Brent Ferrell, Ashwin Kishtagari

Blood (2024) 144 (Supplement 1): 3607.

https://doi.org/10.1182/blood-2024-201083

Published: 2024

Journal Articles

Time to Response and Overall Survival in Patients with m IDH1 Relapsed/Refractory Acute Myeloid Leukemia Treated with Olutasidenib

Eunice S. Wang, Jorge E. Cortes, Justin M. Watts, Brian A. Jonas, Andrew H Wei, Jay Yang, Joseph G Jurcic, Gail J. Roboz, Karen Seiter, Alice Mims, Karen Yee, Brent Ferrell, Shira N. Dinner, William B. Donnellan, William Blum, Francois Di Trapani, Hua Tian, Stephane De Botton

Blood (2024) 144 (Supplement 1): 1514.

https://doi.org/10.1182/blood-2024-198504

Published: 2024

Journal Articles

Combination of Olutasidenib and Azacitidine Induces Durable Complete Remissions in m IDH1 Acute Myeloid Leukemia: A Multicohort Open-Label Phase 1/2 Trial

Jorge E. Cortes, Gail J. Roboz, Justin M. Watts, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, Brent Ferrell, Jay Yang, Eunice S. Wang, William Blum, Alice Mims

Blood (2024) 144 (Supplement 1): 2886.

https://doi.org/10.1182/blood-2024-201710

Published: 2024

Journal Articles

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Y. Emily Chu, Matthew A Cottam, Chad R Potts, Kirsten M Dickerson, Matthew T Jenkins, Justin A Cartailler, Rui Lu, Stanley C. Lee, Ross L Levine, Robert L. Bowman, Robert Welner, P. Brent Ferrell, Jr.

Blood (2024) 144 (Supplement 1): 2939.

https://doi.org/10.1182/blood-2024-205733

Published: 2024

Journal Articles

Synchronous Dual Hematologic Neoplasms of Myeloid and Lymphoid Lineage Are of Common Clonal Origin

Blood (2024) 144 (Supplement 1): 4578.

https://doi.org/10.1182/blood-2024-210599

Published: 2024

Journal Articles

Bone Marrow Spatial Multi-Omics Identifies Reduced Interactions between Hematopoietic Stem Cells and Myeloid Cells in Myelodysplastic Syndrome

Alyssa C. Parker, Joseph C. Van Amburg, Tianzi Zhang, Diane C. Saunders, Thomas J. Gracie, Pawan Bhat, J. Brett Heimlich, John W. Hickey, Emily F. Mason, Ashwin Kishtagari, P. Brent Ferrell, Jr., Alexander G. Bick

Blood (2024) 144 (Supplement 1): 4577.

https://doi.org/10.1182/blood-2024-210307

Published: 2024

Journal Articles

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Matthew Jenkins, Yunli Chu, Sajesan Aryal, Xinyue Zhou, Kirsten Dickerson, Rebecca Dubin, Chad R Potts, Valeriya Kuznetsova, Alana Franceski, Paran Goel, Stanley C Lee, Rui Lu, Robert Welner, P. Brent Ferrell, Jr.

Blood (2023) 142 (Supplement 1): 4061.

https://doi.org/10.1182/blood-2023-182278

Published: 2023

Journal Articles

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Eunice S. Wang, Brian A. Jonas, Justin M. Watts, Joseph Jurcic, P. Brent Ferrell, Jr., Shira N. Dinner, Jay Yang, Karen Seiter, Alice Mims, William B. Donnellan, William Blum, Jorge Cortes

Blood (2023) 142 (Supplement 1): 6047.

https://doi.org/10.1182/blood-2023-187584

Published: 2023

Journal Articles

Olutasidenib for the Treatment of mIDH1 Acute Myeloid Leukemia in Patients Relapsed or Refractory to Hematopoietic Stem Cell Transplant, Prior mIDH1 Inhibitor, or Venetoclax

Jorge Cortes, Joseph Jurcic, Maria R. Baer, William Blum, P. Brent Ferrell, Jr., Brian A. Jonas, Sangmin Lee, Alice Mims, Shyam Ajay Patel, Gary J. Schiller, Jay Yang, Justin M. Watts

Blood (2023) 142 (Supplement 1): 2888.

https://doi.org/10.1182/blood-2023-187861

Published: 2023

Journal Articles

DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data

Blood (2023) 142 (Supplement 1): 815.

https://doi.org/10.1182/blood-2023-187244

Published: 2023

Journal Articles

Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE), a Prospective, Longitudinal Clonal Hematopoiesis Cohort and Biorepository

Blood (2023) 142 (Supplement 1): 5594.

https://doi.org/10.1182/blood-2023-189808

Published: 2023

Journal Articles

Combined Single-Cell Transcriptomics and Mitochondrial Lineage Tracing Identify IL-6 Signaling Responses in TET2 Clonal Hematopoiesis of Indeterminate Potential

Pawan Bhat, J. Brett Heimlich, Alyssa Parker, Matthew T. Jenkins, Chad R. Potts, Jessica Ulloa, Alexander J. Silver, Donovan J. Brown, Peter Van Galen, Michael R. Savona, Alexander G. Bick, Brent Ferrell

Blood (2022) 140 (Supplement 1): 2891–2892.

https://doi.org/10.1182/blood-2022-167850

Published: 2022

Journal Articles

Primary HSPC-Derived Monocytes with DNMT3A p.R882H Exhibit Activated Myeloid Cell Gene Signatures

Alexander J. Silver, Donovan J. Brown, Maria P. Arrate, Yu Wang, Melissa A. Fischer, Pawan Bhat, J. Brett Heimlich, Alexander G. Bick, P. Brent Ferrell, Yaomin Xu, Michael R. Savona

Blood (2022) 140 (Supplement 1): 2885–2886.

https://doi.org/10.1182/blood-2022-170803

Published: 2022

Journal Articles

Epigenetic Dysregulation Leads to Enhanced IL-1β Signaling and Transcriptional Responses in TET2 Deficient HSPCs

Matthew T. Jenkins, Timothy J Scott, Lindsey N Guerin, Alana M Franceski, Yunli E Chu, Pawan Bhat, Chad R. Potts, Robert S. Welner, Emily Hodges, Brent Ferrell

Blood (2022) 140 (Supplement 1): 2883–2884.

https://doi.org/10.1182/blood-2022-169568

Published: 2022

Journal Articles

Integrating Mosaic Chromosomal Alterations and Single-Nucleotide Variants to Predict Evolution of Clonal Hematopoiesis

Ashwin Kishtagari, MA Wasay Khan, Yajing Li, Cosmin Bejan, Naimisha Marneni, Alexander J. Silver, Kelly von Beck, Travis Spaulding, Shannon Stockton, Christina A. Snider, Kelly Pugh, Andrew Sochacki, Dixon Dorand, Taralynn Mack, Caitlyn Vlasschaert, Brent Ferrell, Yaomin Xu, Michael R. Savona, Alexander G. Bick

Blood (2022) 140 (Supplement 1): 2868–2870.

https://doi.org/10.1182/blood-2022-170957

Published: 2022

Journal Articles

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Robert L. Bowman, Tanmay Mishra, Shira E. Eisman, Louise Cai, Wenbin Xiao, Michael R. Waarts, Pablo Sanchez Vela, Inés Fernández-Maestre, Isabelle S. Csete, Chad R. Potts, Matthew T. Jenkins, Linde A. Miles, Jennifer J. Trowbridge, Paul Brent Ferrell, Jr., Ross L. Levine

Blood (2021) 138 (Supplement 1): 2220.

https://doi.org/10.1182/blood-2021-149846

Published: 2021

Journal Articles

Olutasidenib (FT-2102), an IDH1m Inhibitor As a Single Agent or in Combination with Azacitidine, Induces Deep Clinical Responses with Mutation Clearance in Patients with Acute Myeloid Leukemia Treated in a Phase 1 Dose Escalation and Expansion Study

Blood (2019) 134 (Supplement_1): 231.

https://doi.org/10.1182/blood-2019-123920

Published: 2019

Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD

Blood (2019) 134 (Supplement_1): 2680.

https://doi.org/10.1182/blood-2019-129602

Published: 2019

NARROW

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics

Distinct Transcriptomic Cell States Differentiate Low-Risk MDS from Healthy Marrow

Combined Natural Language Processing and Gpt-4 Pathology Report Interpretation Efficiently Identify a Myelodysplastic Syndrome Cohort for Large Scale Clinical Research Applications

Time to Response and Overall Survival in Patients with m IDH1 Relapsed/Refractory Acute Myeloid Leukemia Treated with Olutasidenib

Combination of Olutasidenib and Azacitidine Induces Durable Complete Remissions in m IDH1 Acute Myeloid Leukemia: A Multicohort Open-Label Phase 1/2 Trial

Combined Human and In Vivo Analyses Implicate the Critical Importance of Acute Myeloid Leukemia Associated CD8 T Cells and Identifies Their Molecular Dysfunction

Synchronous Dual Hematologic Neoplasms of Myeloid and Lymphoid Lineage Are of Common Clonal Origin

Bone Marrow Spatial Multi-Omics Identifies Reduced Interactions between Hematopoietic Stem Cells and Myeloid Cells in Myelodysplastic Syndrome

Multi-Omics Analysis Reveals That TET2 Loss Epigenetically Primes Monocytes for Inflammatory Responses Via AP-1 Signaling

Factors Impacting Response to Olutasidenib in Patients with mIDH1 Acute Myeloid Leukemia

Olutasidenib for the Treatment of mIDH1 Acute Myeloid Leukemia in Patients Relapsed or Refractory to Hematopoietic Stem Cell Transplant, Prior mIDH1 Inhibitor, or Venetoclax

DNMT3A R882H Exhibits Greater Inflammatory Potential Than R882C in Primary Hematopoietic Stem and Progenitor Cell Knock-in Model and Population Data

Clonal Hematopoiesis and Inflammation in the Vasculature (CHIVE), a Prospective, Longitudinal Clonal Hematopoiesis Cohort and Biorepository

Combined Single-Cell Transcriptomics and Mitochondrial Lineage Tracing Identify IL-6 Signaling Responses in TET2 Clonal Hematopoiesis of Indeterminate Potential

Primary HSPC-Derived Monocytes with DNMT3A p.R882H Exhibit Activated Myeloid Cell Gene Signatures

Epigenetic Dysregulation Leads to Enhanced IL-1β Signaling and Transcriptional Responses in TET2 Deficient HSPCs

Integrating Mosaic Chromosomal Alterations and Single-Nucleotide Variants to Predict Evolution of Clonal Hematopoiesis

Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Olutasidenib (FT-2102), an IDH1m Inhibitor As a Single Agent or in Combination with Azacitidine, Induces Deep Clinical Responses with Mutation Clearance in Patients with Acute Myeloid Leukemia Treated in a Phase 1 Dose Escalation and Expansion Study

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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