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Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Valentina Palermo, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey S. Revenko, A. Robert Macleod, Brandon Willis, Hongbo Cai, Joana Hauser, Claire Rooney, Sophie E. Willis, Philip Lloyd Martin, Anna Staniszewska, Helen Ambrose, Lyndsey Hanson, Chiara Cattaneo, Alessandra Tucci, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood
Blood (2021) 138 (18): 1705–1720.
https://doi.org/10.1182/blood.2020010572
Published: 2021
Includes: Supplemental data
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Antonio Sacco, RN, Cinzia Federico, PhD, Katia Todoerti, PhD, Bachisio Ziccheddu, PhD, Arianna Giacomini, PhD, Cosetta Ravelli, PhD, Federica Maccarinelli, PhD, Giada Bianchi, MD, Angelo Belotti, Rossella Ribolla, MD, Vanessa Favasuli, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brandon Willis, PhD, Hongoo Cai, PhD, Joana Hauser, RN, Claire Rooney, PhD, Helen Ambrose, PhD, Anna Staniszewska, PhD, Lyndsey Hanson, PhD, Giuseppe Rossi, Roberto Ronca, PhD, Antonino Neri, MD, Stefania Mitola, PhD, Niccolò Bolli, MD PhD, Marco Presta, PhD, Michele Moschetta, MD PhD, Sarah Ross, PhD, Aldo M. Roccaro, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3104.
https://doi.org/10.1182/blood-2019-124391
Published: 2019
Journal Articles

Therapeutic Targeting of Interferon Regulatory Factor 4 with Next Generation Antisense Oligonucleotides Produces Robust In Vivo Antitumor Activity in Preclinical Models of Multiple Myeloma

Tianyuan Zhou, PhD, Joanna Schmidt, Youngsoo Kim, PhD, A. Robert MacLeod, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3078.
https://doi.org/10.1182/blood.V130.Suppl_1.3078.3078
Published: 2017
Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 364.
https://doi.org/10.1182/blood.V130.Suppl_1.364.364
Published: 2017
Journal Articles

Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland
Journal: Blood
Blood (2017) 129 (18): 2547–2556.
https://doi.org/10.1182/blood-2016-11-753202
Published: 2017
Includes: Supplemental data
Journal Articles

Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12

Clinical Trials & Observations
John Kuruvilla, David A. MacDonald, C. Tom Kouroukis, Matthew Cheung, Harold J. Olney, A. Robert Turner, Peter Anglin, Matthew Seftel, Walid Sabry Ismail, Stefano Luminari, Stephen Couban, Tara Baetz, Ralph M. Meyer, Annette E. Hay, Lois Shepherd, Marina S. Djurfeldt, Sameer Alamoudi, Bingshu E. Chen, Michael Crump
Journal: Blood
Blood (2015) 126 (6): 733–738.
https://doi.org/10.1182/blood-2015-01-622084
Published: 2015
Journal Articles

Novel Evidence That Pituitary Gonadotropins Directly Stimulate Human Leukemic cells—studies on Myeloid Cell Lines and Primary Patient AML and CML Cells

Ahmed Ismail, PhD, Katarzyna Anna Mierzejewska, PhD, Anna Janowska-Wieczorek, MD PhD, A. Robert Turner, MD FRCPC, Mariusz Z Ratajczak, MD PhD, Magdalena Kucia, PhD
Journal: Blood
Blood (2014) 124 (21): 2204.
https://doi.org/10.1182/blood.V124.21.2204.2204
Published: 2014
Journal Articles

Aggressive Non-Hodgkin Lymphoma: Predictive Value Of Sarcopenia and Skeletal Muscle Density On Prognosis With Rituximab Containing Therapy

Michael P Chu, MD, Jessica Lieffers, Andrew R Belch, MD, Neil Chua, MD, FRCPC, Amelie Fontaine, MD, Randeep Sangha, A. Robert Turner, MD, FRCPC, Sunita Ghosh, PhD, Michael Sawyer, MD
Journal: Blood
Blood (2013) 122 (21): 3023.
https://doi.org/10.1182/blood.V122.21.3023.3023
Published: 2013
Journal Articles

Indolent Non-Hodgkin Lymphoma: Skeletal Muscle Density Predicts Overall Survival With Rituximab Based Chemotherapy

Michael P Chu, MD, Jessica Lieffers, Andrew R Belch, MD, Neil Chua, MD, FRCPC, Amelie Fontaine, MD, Randeep Sangha, A. Robert Turner, MD, Sunita Ghosh, PhD, Michael Sawyer, MD
Journal: Blood
Blood (2013) 122 (21): 5078.
https://doi.org/10.1182/blood.V122.21.5078.5078
Published: 2013
Journal Articles

A Randomized Trial Of Rituximab Vs Observation Following Autologous Stem Cell Transplantation (ASCT) For Relapsed Or Refractory CD20-Positive B Cell Lymphoma: Final Results Of NCIC CTG LY.12

Michael Crump, MD FRCPC, John Kuruvilla, MD, C. Tom Kouroukis, MD, MSc, FRCP(C), Ann Benger, MD, FRCP(C), Matthew C. Cheung, MD, FRCPC, Neil L Berinstein, MD, Stephen Couban, MD, FRCPC, Matthew D. Seftel, MBChB, FRCP(C), MRCP, Kang Howson-Jan, MD, Armand Keating, MD, Massimo Federico, MD, David A Macdonald, MD, FRCPC, Harold J. Olney, MD, Morel Rubinger, MD, Michael Voralia, A. Robert Turner, MD, FRCPC, Tara Baetz, MD, Annette E Hay, MBChB, Marina Djurfeldt, MSc, Ralph M. Meyer, MD, Bingshu Chen, PhD, Lois Shepherd, M.D.
Journal: Blood
Blood (2013) 122 (21): 155.
https://doi.org/10.1182/blood.V122.21.155.155
Published: 2013
Journal Articles

Gemcitabine, Dexamethasone, Cisplatin (GDP) Compared to Dexamethasone, Cytarabine, Cisplatin (DHAP) Chemotherapy Prior to Autologous Stem Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: Final Results of the Randomized Phase III NCIC CTG Study LY12

Michael Crump, MD, FRCPC, John Kuruvilla, MD, FRCPC, Stephen Couban, MD, FRCPC, David Macdonald, MD, FRCPC, Vishal Kukreti, MD, C. Tom Kouroukis, MD, MSc, FRCPC, Ralph M. Meyer, MD, Morel Rubinger, MD, Rena Buckstein, MD, Kevin R Imrie, MD, Massimo Federico, MD, Nicola Di Renzo, MD, Kang Howson-Jan, MD, Tara Baetz, MD, Leonard Kaizer, MD FRCPC, Michael Voralia, MD, FRCPC, Harold J. Olney, MD, A. Robert Turner, MD, FRCPC, Jonathan Sussman, MD, Annette E Hay, MBChB, Marina Djurfeldt, MSc, Bingshu E Chen, PhD, Lois Shepherd, MD
Journal: Blood
Blood (2012) 120 (21): 745.
https://doi.org/10.1182/blood.V120.21.745.745
Published: 2012
Journal Articles

A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia

Clinical Trials & Observations
Jerald P. Radich, Kenneth J. Kopecky, Frederick R. Appelbaum, Suzanne Kamel-Reid, Wendy Stock, Greg Malnassy, Elisabeth Paietta, Martha Wadleigh, Richard A. Larson, Peter Emanuel, Martin Tallman, Jeff Lipton, A. Robert Turner, Michael Deininger, Brian J. Druker
Journal: Blood
Blood (2012) 120 (19): 3898–3905.
https://doi.org/10.1182/blood-2012-02-410688
Published: 2012
Journal Articles

A Canadian Expanded Access Trial of Oral Nilotinb in Adult Patients with Imatinib-Resistant or -Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase

Robert Delage, MD, MSc, FRCP, A. Robert Turner, MD, FRCPC, Brian Leber, MD, Wanda S. Hasegawa, MD, Denis-Claude Roy, MD, Mary Lynn Savoie, MD, Heather A Leitch, MD, PhD, Isabelle Bence-Bruckler, MD, FRCPC, Donna L. Forrest, MD, Sindu Kanjeekal, MD, Sehdev Sandeep, MD, Pierre Laneuville, MD, Sarit Assouline, MD, Kuljit Grewal, MD, Michael J. Kovacs, MD, FRCPC, Wendy Lam, MD, Annie Woo, M.Sc., Pierre Beauparlant, Ph.D., Jeffrey H. Lipton, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4437.
https://doi.org/10.1182/blood.V118.21.4437.4437
Published: 2011
Journal Articles

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod
Journal: Blood
Blood (2011) 118 (19): 5302–5311.
https://doi.org/10.1182/blood-2011-05-355248
Published: 2011
Includes: Supplemental data
Journal Articles

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C. M. Meijers, Erik S. Stroes, Marcel Levi, Brett P. Monia
Journal: Blood
Blood (2010) 116 (22): 4684–4692.
https://doi.org/10.1182/blood-2010-04-277798
Published: 2010
Includes: Multimedia, Supplemental data
Journal Articles

Nilotinib Responses and Tolerability Confirmed in North American Patients with Chronic Myeloid Leukemia (CML) From ENACT (Expanding Nilotinib Access in Clinical Trials).

Bayard L. Powell, MD, Hanna Jean Khoury, MD, Jeffrey H. Lipton, David A. Rizzieri, Denise Williams, MD, A. Robert Turner, MD, FRCPC
Journal: Blood
Blood (2009) 114 (22): 3295.
https://doi.org/10.1182/blood.V114.22.3295.3295
Published: 2009
Journal Articles

MT1-MMP Associates with Membrane Lipid Rafts and Is Required for G-CSF-Induced Hematopoietic Stem/Progenitor Cell Mobilization.

Neeta Shirvaikar, MSc, Leah A. Marquez-Curtis, PhD, BSc, Andrew Shaw, PhD, A. Robert Turner, MD, FRCPC, Anna Janowska-Wieczorek, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3536.
https://doi.org/10.1182/blood.V114.22.3536.3536
Published: 2009
Journal Articles

MMP-14 Mediates Migration of Acute Myelogenous Leukemia Cells

Neeta Shirvaikar, MSc, Ali Jalili, MSc, PhD, Imran Mirza, FRCPC, Sara Ilnitsky, BSc, Chris Korol, Loree M. Larratt, MD, A. Robert Turner, MD, FRCPC, Anna Janowska-Wieczorek, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2943.
https://doi.org/10.1182/blood.V112.11.2943.2943
Published: 2008
Journal Articles

The Potent Deacetylase Inhibitor Trichostatin a (TSA) Increases CXCR4 Expression in Hematopoietic Stem/Progenitor Cells by Chromatin Remodelling

Hilal Gul, PhD, MSc, Leah A. Marquez-Curtis, PhD, BSc, Jennifer Lo, Nadia Jahroudi, PhD, A. Robert Turner, MD, FRCPC, Loree M. Larratt, MD, Anna Janowska-Wieczorek, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3487.
https://doi.org/10.1182/blood.V112.11.3487.3487
Published: 2008