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        Highs and lows of minimal residual disease in CLL
        
        
            
        
    
        
    
            
                
            
    
    
    
        
        
     
    
                     
    
                    
        
                    
        
        Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
        
                    
                
            
    
    
    
        
        
     
    
                    
        
        
        
     
    
                    
        
                    
                
            
    
    
    
        
        
     
    
                    
                    
        
        Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab
        
        
            
        
    
        
                
            
    
    
    
                    
        
        Tenofovir vs lamivudine for the prevention of hepatitis B virus reactivation in advanced-stage DLBCL
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                     
    
 
    
            
    
        
    
         
 
    
    
        
    
            
    
        
    
    
    
        
    
    
    
            
    
                    
 
    
    
 
    
    
        
    
    
    
            
        
 
    
    
 
    
    
        
    
    
    
            
        
            
    
        
        
    
             
            
             
            
             
        
    
 
    
    
 
    
    
        
    
    
    
            
    
                    
 
    
    
 
    
    
 
    
    
    
    
        
    Issue Archive
Table of Contents
EDITORIAL
BLOOD COMMENTARIES
CLINICAL TRIALS AND OBSERVATIONS
                    
        
        Highs and lows of minimal residual disease in CLL
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
    
            REVIEW SERIES
LYMPHOID NEOPLASIA
        
        Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Christian Grommes,Sarah S. Tang,Julia Wolfe,Thomas J. Kaley,Mariza Daras,Elena I. Pentsova,Anna F. Piotrowski,Jacqueline Stone,Andrew Lin,Craig P. Nolan,Malbora Manne,Paolo Codega,Carl Campos,Agnes Viale,Alissa A. Thomas,Michael F. Berger,Vaios Hatzoglou,Anne S. Reiner,Katherine S. Panageas,Lisa M. DeAngelis,Ingo K. Mellinghoff
            
        
    
            MYELOID NEOPLASIA
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
            Amina M. Abdul-Aziz,Yu Sun,Charlotte Hellmich,Christopher R. Marlein,Jayna Mistry,Eoghan Forde,Rachel E. Piddock,Manar S. Shafat,Adam Morfakis,Tarang Mehta,Federica Di Palma,Iain Macaulay,Christopher J. Ingham,Anna Haestier,Angela Collins,Judith Campisi,Kristian M. Bowles,Stuart A. Rushworth
            
        
    
            RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability
            Rami Abu-Fanne,Victoria Stepanova,Rustem I. Litvinov,Suhair Abdeen,Khalil Bdeir,Mohamed Higazi,Emad Maraga,Chandrasekaran Nagaswami,Alexander R. Mukhitov,John W. Weisel,Douglas B. Cines,Abd Al-Roof Higazi
            
        
    
            LETTERS TO BLOOD
        
        Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Anton W. Langerak,Matthias Ritgen,Valentin Goede,Sandra Robrecht,Jasmin Bahlo,Kirsten Fischer,Michael Steurer,Marek Trněný,Stephen P. Mulligan,Ulrich J. M. Mey,Kerstin Trunzer,Günter Fingerle-Rowson,Kathryn Humphrey,Stephan Stilgenbauer,Sebastian Böttcher,Monika Brüggemann,Michael Hallek,Michael Kneba,Jacques J. M. van Dongen
            
        
    
            
        
        Tenofovir vs lamivudine for the prevention of hepatitis B virus reactivation in advanced-stage DLBCL
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Marco Picardi,Roberta Della Pepa,Claudia Giordano,Irene Zacheo,Novella Pugliese,Chiara Mortaruolo,Fabio Trastulli,Antonio Giordano,Mariano Lucignano,Maria Di Perna,Marta Raimondo,Claudia Salvatore,Fabrizio Pane
            
        
    
            BLOOD WORK
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            Cover Image
        
        
Cover Image
            Superoxide derived from acute myeloid leukemia (AML) drives bone marrow stromal cell senescence through upregulation of p16INK4a. The image shows stromal cell senescence associated β-galactosidase staining (blue) after culture with AML blasts. See the article by Abdul-Aziz et al on page 446.
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