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Volume 133, Issue 25

June 20 2019

In this Issue

BLOOD COMMENTARIES
CLINICAL TRIALS AND OBSERVATIONS
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
VASCULAR BIOLOGY
LETTERS TO BLOOD
BLOOD WORK
CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Table of Contents

BLOOD COMMENTARIES

CLINICAL TRIALS AND OBSERVATIONS

Red blood cells: beyond the transfusion
Clinical Trials & Observations

Beth H. Shaz

View Articletitled, Red blood cells: beyond the transfusion

Lymphoid Neoplasia

Hedgehog activation in CLL

Giorgia Chiodin,Francesco Forconi

View Articletitled, Hedgehog activation in CLL

MYELOID NEOPLASIA

Mutated CALR: tails from the crypt

Jerry L. Spivak

View Articletitled, Mutated <em>CALR</em>: tails from the crypt

MYELOID NEOPLASIA

Message from the void: MRD analysis from ctDNA

Michael Heuser,Courteney K. Lai

View Articletitled, Message from the void: MRD analysis from ctDNA

PLATELETS AND THROMBOPOIESIS

GPVI inhibitor as antitumor gateway drug

Lawrence E. Goldfinger

View Articletitled, GPVI inhibitor as antitumor gateway drug

VASCULAR BIOLOGY

WPBs and α-granules: more and more look-alike?

Harry F. G. Heijnen

View Articletitled, WPBs and α-granules: more and more look-alike?

MYELOID NEOPLASIA

FouNdER mutations confer risk for leukemias

Lucy A. Godley

View Articletitled, FouNdER mutations confer risk for leukemias

CLINICAL TRIALS AND OBSERVATIONS

Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial
Clinical Trials & Observations

Anders Møller,Henning B. Nielsen,Jørn Wetterslev,Ole B. Pedersen,Dorthe Hellemann,Per Winkel,Klaus V. Marcussen,Benedicte G. U. Ramsing,Anette Mortensen,Janus C. Jakobsen,Saeid Shahidi

View Articletitled, Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial

Supplemental data

LYMPHOID NEOPLASIA

Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia

Emanuela M. Ghia,Laura Z. Rassenti,Donna S. Neuberg,Alejandro Blanco,Fouad Yousif,Erin N. Smith,John D. McPherson,Thomas J. Hudson,the HALT Pan-Leukemia Gene Panel Consortium,Olivier Harismendy,Kelly A. Frazer,Thomas J. Kipps

View Articletitled, Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia

Supplemental data

Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease
CME Clinical Trials & Observations Brief Report

Juan-José Lahuerta,Ana Jiménez-Ubieto,Bruno Paiva,Joaquín Martínez-López,José González-Medina,Lucía López-Anglada,María-Teresa Cedena,Noemi Puig,Albert Oriol,María-Jesús Blanchard,Rafael Ríos,Jesús Martin,Rafael Martínez,Anna Sureda,Miguel Teodoro Hernández,Javier de la Rubia,Isabel Krsnik,Valentín Cabañas,Luis Palomera,Joan Bargay,María-Victoria Mateos,Laura Rosiñol,Jesús F. San Miguel,Joan Blade

View Articletitled, Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease

MYELOID NEOPLASIA

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Christian Pecquet,Ilyas Chachoua,Anita Roy,Thomas Balligand,Gaëlle Vertenoeil,Emilie Leroy,Roxana-Irina Albu,Jean-Philippe Defour,Harini Nivarthi,Eva Hug,Erica Xu,Yasmine Ould-Amer,Céline Mouton,Didier Colau,Didier Vertommen,Myat Marlar Shwe,Caroline Marty,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu

There is a Blood Commentary on this article in this issue.

View Articletitled, Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Supplemental data

Prognostic impact of circulating tumor DNA status post–allogeneic hematopoietic stem cell transplantation in AML and MDS
Clinical Trials & Observations

Sousuke Nakamura,Kazuaki Yokoyama,Eigo Shimizu,Nozomi Yusa,Kanya Kondoh,Miho Ogawa,Tomomi Takei,Asako Kobayashi,Mika Ito,Masamichi Isobe,Takaaki Konuma,Seiko Kato,Rika Kasajima,Yuka Wada,Tokiko Nagamura-Inoue,Rui Yamaguchi,Satoshi Takahashi,Seiya Imoto,Satoru Miyano,Arinobu Tojo

View Articletitled, Prognostic impact of circulating tumor DNA status post–allogeneic hematopoietic stem cell transplantation in AML and MDS

Supplemental data

PLATELETS AND THROMBOPOIESIS

Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice

Julia Volz,Elmina Mammadova-Bach,Jesus Gil-Pulido,Rajender Nandigama,Katharina Remer,Lydia Sorokin,Alma Zernecke,Scott I. Abrams,Süleyman Ergün,Erik Henke,Bernhard Nieswandt

There is a Blood Commentary on this article in this issue.

View Articletitled, Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice

Supplemental data

VASCULAR BIOLOGY

Stimulated release of intraluminal vesicles from Weibel-Palade bodies

James Streetley,Ana-Violeta Fonseca,Jack Turner,Nikolai I. Kiskin,Laura Knipe,Peter B. Rosenthal,Tom Carter

There is a Blood Commentary on this article in this issue.

View Articletitled, Stimulated release of intraluminal vesicles from Weibel-Palade bodies

Supplemental data

LETTERS TO BLOOD

Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum

Alain Sarasin,Samuel Quentin,Nathalie Droin,Mourad Sahbatou,Véronique Saada,Nathalie Auger,Yannick Boursin,Philippe Dessen,Anna Raimbault,Vahid Asnafi,Jean-Luc Schmutz,Alain Taïeb,Carlos F. M. Menck,Filippo Rosselli,Laurianne Drieu La Rochelle,Caroline Robert,Flore Sicre de Fontbrune,Marie Sébert,Thierry Leblanc,Patricia Kannouche,Stéphane De Botton,Eric Solary,Jean Soulier

There is a Blood Commentary on this article in this issue.

View Articletitled, Familial predisposition to TP53/complex karyotype MDS and leukemia in DNA repair-deficient xeroderma pigmentosum

Supplemental data

ERCC6L2 defines a novel entity within inherited acute myeloid leukemia

Suvi P. M. Douglas,Pihla Siipola,Panu E. Kovanen,Marja Pyörälä,Sakari Kakko,Eeva-Riitta Savolainen,Urpu Salmenniemi,Katri Orte,Soili Kytölä,Esa Pitkänen,Kimmo Porkka,Outi Kilpivaara,Ulla Wartiovaara-Kautto

There is a Blood Commentary on this article in this issue.

View Articletitled, <em>ERCC6L2</em> defines a novel entity within inherited acute myeloid leukemia

Supplemental data

BLOOD WORK

Mantle cell lymphoma with unusual Burkitt-like morphologic features

Alison Christie Chan,Elham Vali Betts

View Articletitled, Mantle cell lymphoma with unusual Burkitt-like morphologic features

Ring-shaped granulomas on bone marrow found in a returning traveler with fever of unknown origin

Teng Fong Ng,Hun Sheng Chuah

View Articletitled, Ring-shaped granulomas on bone marrow found in a returning traveler with fever of unknown origin

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Role of urine immunofixation in defining CR in MM
CME

View Articletitled, Role of urine immunofixation in defining CR in MM

Cover Image

Cover Image

Hematoxylin and eosin staining of AT-3 mammary tumor resected 18 hours after platelet depletion. Note the drastic increase in intratumoral hemorrhage, which was absent in control immunoglobulin G–treated mice. A similar increase in intratumoral bleeding can also be induced by blocking the platelet receptor glycoprotein VI. See the article by Volz et al on page 2696.
Front Matter
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Silva A, Almeida ARM, Cachucho A, et al. Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood. 2021;138(12):1040-1052.

MRD and EFS in pediatric T-lymphoblastic lymphoma

Outcomes of younger patients with mantle-cell lymphoma experiencing late relapse (>24 months): the LATE-POD study

Mutational profile of previously treated chronic lymphocytic leukemia patients progressing on acalabrutinib or ibrutinib

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