Issue Archive

In this issue of Blood, McLaughlin et al demonstrate the safety and efficacy of donor-derived Epstein-Barr virus (EBV) latent membrane protein (LMP)-specific T cells to prevent relapse of aggressive EBV-positive B- or T/NK-cell lymphomas following allogeneic hematopoietic stem cell transplantation (HSCT).¹ 

In this issue of Blood, Brigida et al¹  demonstrate that null mutations in ARPC1B result in combined immunodeficiency because of defects in T-cell migration, lymphoproliferation, and formation of the immune synapse, and further show that these abnormalities may be rescued by transduction of wild-type ARPC1B.

In this issue of Blood, Bretones et al expand knowledge of the functional consequences of recurrent mutations in RPS15, a gene that encodes a ribosomal protein of the 40S subunit and is enriched in patients with clinically aggressive chronic lymphocytic leukemia (CLL).¹  By transfecting RPS15 mutants and applying different technologies to assess ribosome activity and efficiency in combination with high-throughput proteome profiling, they were able to demonstrate reduced half-life of RPS15, impaired translational fidelity, and changes in the expressed proteome in mutant vs wild-type RPS15.

In this issue of Blood, Mottok et al¹  demonstrate the utility of a molecular assay that assesses the expression of 58 genes to distinguish primary mediastinal B-cell lymphoma (PMBCL) from diffuse large B-cell lymphoma (DLBCL) by using routinely available formalin-fixed paraffin-embedded tissue (FFPET) biopsies. The results could improve diagnostic accuracy for patients with PMBCL and may have important implications for clinical trial selection and interpretation of clinical outcomes for patients with this rare form of lymphoma.

Studies by Qu et al¹  in this issue of Blood provide new mechanistic insight into the ineffective erythropoiesis of TET2 deficiency including selective colony-forming unit–erythroid (CFU-E) hyperproliferation, heightened expression of KIT and AXL, and the rescue by KIT and AXL inhibitors of faltered late stage erythropoiesis.

There is a Blood Commentary on this article in this issue.

There is a Blood Commentary on this article in this issue.