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Issue Archive

Volume 131, Issue 8
February 22 2018
Issue Cover

Table of Contents

BLOOD COMMENTARIES

Lymphoid Neoplasia
Dual PI3K blockade: PTCL’s Achilles heel?
Jonathan E. Brammer
View Articletitled, Dual PI3K blockade: PTCL’s Achilles heel?
Red Cells, Iron, and Erythropoiesis
How does hepcidin hinder ferroportin activity?
De-Liang Zhang,Tracey A. Rouault
View Articletitled, How does hepcidin hinder ferroportin activity?
THROMBOSIS AND HEMOSTASIS
VWF clearance: it’s glycomplicated
Cécile V. Denis,Peter J. Lenting
View Articletitled, VWF clearance: it’s glycomplicated
TRANSPLANTATION
HSCT for PID: not just for children
Blachy J. Dávila Saldaña
View Articletitled, HSCT for PID: not just for children

HOW I TREAT

How I treat disseminated intravascular coagulation
Marcel Levi,Marie Scully
View Articletitled, How I treat disseminated intravascular coagulation

CLINICAL TRIALS AND OBSERVATIONS

Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia
Clinical Trials & Observations
Christine Chen,David Siegel,Martin Gutierrez,Meagan Jacoby,Craig C. Hofmeister,Nashat Gabrail,Rachid Baz,Morten Mau-Sorensen,Jesus G. Berdeja,Michael Savona,Lynn Savoie,Suzanne Trudel,Nuchanan Areethamsirikul,T. J. Unger,Tami Rashal,Tim Hanke,Michael Kauffman,Sharon Shacham,Donna Reece
View Articletitled, Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria
Theodora A. M. Claushuis,Alex F. de Vos,Bernard Nieswandt,Louis Boon,Joris J. T. H. Roelofs,Onno J. de Boer,Cornelis van ’t Veer,Tom van der Poll
View Articletitled, Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria
Supplemental data

LYMPHOID NEOPLASIA

Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies
Clinical Trials & Observations
Ian W. Flinn,Susan O’Brien,Brad Kahl,Manish Patel,Yasuhiro Oki,Francine F. Foss,Pierluigi Porcu,Jeffrey Jones,Jan A. Burger,Nitin Jain,Virginia M. Kelly,Kerstin Allen,Mark Douglas,Jennifer Sweeney,Patrick Kelly,Steven Horwitz
View Articletitled, Duvelisib, a novel oral dual inhibitor of PI3K-δ,γ, is clinically active in advanced hematologic malignancies
Supplemental data
Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma
Clinical Trials & Observations
Steven M. Horwitz,Raphael Koch,Pierluigi Porcu,Yasuhiro Oki,Alison Moskowitz,Megan Perez,Patricia Myskowski,Adam Officer,Jacob D. Jaffe,Sara N. Morrow,Kerstin Allen,Mark Douglas,Howard Stern,Jennifer Sweeney,Patrick Kelly,Virginia Kelly,Jon C. Aster,David Weaver,Francine M. Foss,David M. Weinstock
View Articletitled, Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin
Sharraya Aschemeyer,Bo Qiao,Deborah Stefanova,Erika V. Valore,Albert C. Sek,T. Alex Ruwe,Kyle R. Vieth,Grace Jung,Carla Casu,Stefano Rivella,Mika Jormakka,Bryan Mackenzie,Tomas Ganz,Elizabeta Nemeth
View Articletitled, Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin
Supplemental data

THROMBOSIS AND HEMOSTASIS

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance
Brief Report
Soracha E. Ward,Jamie M. O’Sullivan,Clive Drakeford,Sonia Aguila,Christopher N. Jondle,Jyotika Sharma,Padraic G. Fallon,Teresa M. Brophy,Roger J. S. Preston,Paul Smyth,Orla Sheils,Alain Chion,James S. O’Donnell
View Articletitled, A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance
Supplemental data

TRANSPLANTATION

Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency
Clinical Trials & Observations
Thomas A. Fox,Ronjon Chakraverty,Siobhan Burns,Benjamin Carpenter,Kirsty Thomson,David Lowe,Adele Fielding,Karl Peggs,Panagiotis Kottaridis,Benjamin Uttenthal,Venetia Bigley,Matthew Buckland,Victoria Grandage,Shari Denovan,Sarah Grace,Julia Dahlstrom,Sarita Workman,Andrew Symes,Stephen Mackinnon,Rachael Hough,Emma Morris
View Articletitled, Successful outcome following allogeneic hematopoietic stem cell transplantation in adults with primary immunodeficiency

LETTERS TO BLOOD

Intraocular involvement of mycosis fungoides associated with immunophenotypic switch from CD4+ to CD8+
Jonathan A. Braue,Anthony B. Daniels,Jeffrey P. Zwerner,Stephen J. Kim,John A. Zic
View Articletitled, Intraocular involvement of mycosis fungoides associated with immunophenotypic switch from CD4<sup>+</sup> to CD8<sup>+</sup>
Identification of novel recurrent STAT3-RARA fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/PML-RARA
Li Yao,Lijun Wen,Nana Wang,Tianhui Liu,Yang Xu,Changgeng Ruan,Depei Wu,Suning Chen
View Articletitled, Identification of novel recurrent <em>STAT3</em>-<em>RARA</em> fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/<em>PML</em>-<em>RARA</em>
Supplemental data

BLOOD WORK

Chewing the bone: bone marrow with adult T-cell leukemia/lymphoma
Andrew Siref,Qin Huang
View Articletitled, Chewing the bone: bone marrow with adult T-cell leukemia/lymphoma
B-cell acute lymphoblastic leukemia in JAK2 V617F–positive polycythemia vera
Vanya Jaitly,Wei Wang
View Articletitled, B-cell acute lymphoblastic leukemia in JAK2 V617F–positive polycythemia vera
  • Cover Image

    Cover Image

    issue cover

    A paraffin-embedded murine left lung lobe was cut into 4-μm sections, and immunohistochemistry staining on podoplanin was performed with anti–mouse podoplanin antibody (1:1000; eBioscience). The image shows type 1 alveolar cells that stain positive for podoplanin, whereas the blood vessel (including erythrocytes in the lumen) does not. See the article by Claushuis et al on page 864.

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