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Issue Archive

Volume 128, Issue 12
September 22 2016
Issue Cover

Table of Contents

BLOOD FLASHBACK

Thomas ED, Buckner CD, Rudolph RH, et al. Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs. Blood. 1971;38(3):267-287.
View Articletitled, Thomas ED, Buckner CD, Rudolph RH, et al. Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs. <em>Blood</em>. 1971;38(3):<span class="related-article">267-287</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Blind men and the refractory ITP elephant
Shruti Chaturvedi,Keith R. McCrae
View Articletitled, Blind men and the refractory ITP elephant
INSIDE BLOOD COMMENTARY
Unchanneling cardiac iron in humans
Clinical Trials & Observations
Thomas D. Coates
View Articletitled, Unchanneling cardiac iron in humans
INSIDE BLOOD COMMENTARY
BV for HL: can the responses last?
Clinical Trials & Observations
Brad S. Kahl
View Articletitled, BV for HL: can the responses last?
INSIDE BLOOD COMMENTARY
Turning it down a Notch
Marella de Bruijn
View Articletitled, Turning it down a Notch
INSIDE BLOOD COMMENTARY
EBV, an inhibited receptor kinase, and lymphoma
Richard F. Ambinder
View Articletitled, EBV, an inhibited receptor kinase, and lymphoma
INSIDE BLOOD COMMENTARY
When is a thrombogenic matrix not thrombogenic?
Jack Lawler
View Articletitled, When is a thrombogenic matrix not thrombogenic?
INSIDE BLOOD COMMENTARY
RBC storage lesions
John R. Hess
View Articletitled, RBC storage lesions

HOW I TREAT

How I treat refractory immune thrombocytopenia
Clinical Trials & Observations
Adam Cuker,Cindy E. Neunert
View Articletitled, How I treat refractory immune thrombocytopenia

CLINICAL TRIALS AND OBSERVATIONS

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major
Clinical Trials & Observations
Juliano L. Fernandes,Sandra R. Loggetto,Monica P. A. Veríssimo,Kleber Y. Fertrin,Giorgio R. Baldanzi,Luciana A. B. Fioravante,Doralice M. Tan,Tatiana Higa,Denise A. Mashima,Antonio Piga,Otavio R. Coelho,Fernando F. Costa,Sara T. Saad
View Articletitled, A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major
Supplemental data
Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma
Clinical Trials & Observations Brief Report
Robert Chen,Ajay K. Gopal,Scott E. Smith,Stephen M. Ansell,Joseph D. Rosenblatt,Kerry J. Savage,Joseph M. Connors,Andreas Engert,Emily K. Larsen,Dirk Huebner,Abraham Fong,Anas Younes
View Articletitled, Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Developing HSCs become Notch independent by the end of maturation in the AGM region
Céline Souilhol,Javier G. Lendinez,Stanislav Rybtsov,Fiona Murphy,Heather Wilson,David Hills,Antoniana Batsivari,Anahí Binagui-Casas,Alison C. McGarvey,H. Robson MacDonald,Ryoichiro Kageyama,Christian Siebel,Suling Zhao,Alexander Medvinsky
View Articletitled, Developing HSCs become Notch independent by the end of maturation in the AGM region
Supplemental data

LYMPHOID NEOPLASIA

Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival
Ya-Chi Huang,Sue-Jane Lin,Kai-Min Lin,Ya-Ching Chou,Chung-Wu Lin,Shan-Chi Yu,Chi-Long Chen,Tang-Long Shen,Chi-Kuan Chen,Jean Lu,Mei-Ru Chen,Ching-Hwa Tsai
View Articletitled, Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival
Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication
Gang An,Chirag Acharya,Xiaoyan Feng,Kenneth Wen,Mike Zhong,Li Zhang,Nikhil C. Munshi,Lugui Qiu,Yu-Tzu Tai,Kenneth C. Anderson
View Articletitled, Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication
Supplemental data
Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo
Brief Report
James Q. Wang,Bruce Beutler,Christopher C. Goodnow,Keisuke Horikawa
View Articletitled, Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of <em>MYD88</em><sup><em>L265P</em></sup> plasmablasts in vivo
Supplemental data
Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis
Brief Report
Gabriela Pavlasova,Marek Borsky,Vaclav Seda,Katerina Cerna,Jitka Osickova,Michael Doubek,Jiri Mayer,Raffaele Calogero,Martin Trbusek,Sarka Pospisilova,Matthew S. Davids,Thomas J. Kipps,Jennifer R. Brown,Marek Mraz
View Articletitled, Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis
Supplemental data

MYELOID NEOPLASIA

Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia
Yoshiki Sumitomo,Junji Koya,Kumi Nakazaki,Keisuke Kataoka,Takako Tsuruta-Kishino,Ken Morita,Tomohiko Sato,Mineo Kurokawa
View Articletitled, Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia
Matthieu Mahévas,Mathieu Gerfaud-Valentin,Guillaume Moulis,Louis Terriou,Sylvain Audia,Sophie Guenin,Guillaume Le Guenno,Gilles Salles,Olivier Lambotte,Nicolas Limal,Jean-François Viallard,Stephane Cheze,Cecile Tomowiak,Bruno Royer,Antoine Neel,Odile Debouverie,Arnaud Hot,Isabelle Durieu,Antoinette Perlat,Manuel Cliquennois,Clémence Deteix,Marc Michel,Bertrand Godeau
View Articletitled, Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation
Merlin Nithya Gnanapragasam,Kathleen E. McGrath,Seana Catherman,Li Xue,James Palis,James J. Bieker
View Articletitled, EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice
Nina Kristofik,Nicole E. Calabro,Weiming Tian,Aaron Meng,Susan MacLauchlan,Yinong Wang,Christopher K. Breuer,George Tellides,Laura E. Niklason,Themis R. Kyriakides
View Articletitled, Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice
Supplemental data

TRANSFUSION MEDICINE

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells
e-blood
Julie A. Reisz,Matthew J. Wither,Monika Dzieciatkowska,Travis Nemkov,Aaron Issaian,Tatsuro Yoshida,Andrew J. Dunham,Ryan C. Hill,Kirk C. Hansen,Angelo D’Alessandro
View Articletitled, Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells
Supplemental data

TRANSPLANTATION

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells
Mathieu Leclerc,Sina Naserian,Caroline Pilon,Allan Thiolat,Gaëlle H. Martin,Charlotte Pouchy,Claude Dominique,Yazid Belkacemi,Frédéric Charlotte,Sébastien Maury,Benoit L. Salomon,José L. Cohen
View Articletitled, Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells
Supplemental data

LETTERS TO BLOOD

Reduced frequency of circulating CD4+CD25brightCD127lowFOXP3+ regulatory T cells in primary myelofibrosis
Margherita Massa,Rita Campanelli,Gabriela Fois,Laura Villani,Elisa Bonetti,Paolo Catarsi,Valentina Poletto,Gianluca Viarengo,Mara De Amici,Vittorio Rosti,Robert Peter Gale,Giovanni Barosi
View Articletitled, Reduced frequency of circulating CD4<sup>+</sup>CD25<sup>bright</sup>CD127<sup>low</sup>FOXP3<sup>+</sup> regulatory T cells in primary myelofibrosis
Supplemental data

BLOOD WORK

Acute myeloid leukemia with myelodysplasia-related changes demonstrating mixed-lineage phenotype
Babita Kajal,Hong Chang
View Articletitled, Acute myeloid leukemia with myelodysplasia-related changes demonstrating mixed-lineage phenotype
Blastic plasmacytoid dendritic cell neoplasm associated with chronic myelomonocytic leukemia
Zhihong Hu,Tsieh Sun
View Articletitled, Blastic plasmacytoid dendritic cell neoplasm associated with chronic myelomonocytic leukemia
  • Cover Image

    Cover Image

    issue cover

    Cell-derived thrombospondin-2 (TSP2) knockout (KO) mouse extracellular matrix (ECM) does not support platelet aggregation. Dermal fibroblast–derived ECM was prepared in vitro following decellularization of long-term (7 days) cultures. Mouse platelets were exposed to either wild-type or TSP2 ECM for 30 minutes at room temperature. A representative image of platelets stained by rhodamine-phalloidin (red) on TSP2 KO ECM is shown. Detection of fibronectin (green) confirms the retention of ECM during the duration of the experiment. See the article by Kristofik et al on page 1642.

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