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Volume 128, Issue 12

September 22 2016

In this Issue

BLOOD FLASHBACK
INSIDE BLOOD COMMENTARIES
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS AND STEM CELLS
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSFUSION MEDICINE
TRANSPLANTATION
LETTERS TO BLOOD
BLOOD WORK

Table of Contents

BLOOD FLASHBACK

Thomas ED, Buckner CD, Rudolph RH, et al. Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs. Blood. 1971;38(3):267-287.

View Articletitled, Thomas ED, Buckner CD, Rudolph RH, et al. Allogeneic marrow grafting for hematologic malignancy using HL-A matched donor-recipient sibling pairs. <em>Blood</em>. 1971;38(3):<span class="related-article">267-287</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY

Blind men and the refractory ITP elephant

Shruti Chaturvedi,Keith R. McCrae

View Articletitled, Blind men and the refractory ITP elephant

INSIDE BLOOD COMMENTARY

Unchanneling cardiac iron in humans
Clinical Trials & Observations

Thomas D. Coates

View Articletitled, Unchanneling cardiac iron in humans

INSIDE BLOOD COMMENTARY

BV for HL: can the responses last?
Clinical Trials & Observations

Brad S. Kahl

View Articletitled, BV for HL: can the responses last?

INSIDE BLOOD COMMENTARY

Turning it down a Notch

Marella de Bruijn

View Articletitled, Turning it down a Notch

INSIDE BLOOD COMMENTARY

EBV, an inhibited receptor kinase, and lymphoma

Richard F. Ambinder

View Articletitled, EBV, an inhibited receptor kinase, and lymphoma

INSIDE BLOOD COMMENTARY

When is a thrombogenic matrix not thrombogenic?

Jack Lawler

View Articletitled, When is a thrombogenic matrix not thrombogenic?

INSIDE BLOOD COMMENTARY

RBC storage lesions

John R. Hess

View Articletitled, RBC storage lesions

HOW I TREAT

How I treat refractory immune thrombocytopenia
Clinical Trials & Observations

Adam Cuker,Cindy E. Neunert

View Articletitled, How I treat refractory immune thrombocytopenia

CLINICAL TRIALS AND OBSERVATIONS

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major
Clinical Trials & Observations

Juliano L. Fernandes,Sandra R. Loggetto,Monica P. A. Veríssimo,Kleber Y. Fertrin,Giorgio R. Baldanzi,Luciana A. B. Fioravante,Doralice M. Tan,Tatiana Higa,Denise A. Mashima,Antonio Piga,Otavio R. Coelho,Fernando F. Costa,Sara T. Saad

View Articletitled, A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major

Supplemental data

Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma
Clinical Trials & Observations Brief Report

Robert Chen,Ajay K. Gopal,Scott E. Smith,Stephen M. Ansell,Joseph D. Rosenblatt,Kerry J. Savage,Joseph M. Connors,Andreas Engert,Emily K. Larsen,Dirk Huebner,Abraham Fong,Anas Younes

View Articletitled, Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Developing HSCs become Notch independent by the end of maturation in the AGM region

Céline Souilhol,Javier G. Lendinez,Stanislav Rybtsov,Fiona Murphy,Heather Wilson,David Hills,Antoniana Batsivari,Anahí Binagui-Casas,Alison C. McGarvey,H. Robson MacDonald,Ryoichiro Kageyama,Christian Siebel,Suling Zhao,Alexander Medvinsky

View Articletitled, Developing HSCs become Notch independent by the end of maturation in the AGM region

Supplemental data

LYMPHOID NEOPLASIA

Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival

Ya-Chi Huang,Sue-Jane Lin,Kai-Min Lin,Ya-Ching Chou,Chung-Wu Lin,Shan-Chi Yu,Chi-Long Chen,Tang-Long Shen,Chi-Kuan Chen,Jean Lu,Mei-Ru Chen,Ching-Hwa Tsai

View Articletitled, Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival

Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

Gang An,Chirag Acharya,Xiaoyan Feng,Kenneth Wen,Mike Zhong,Li Zhang,Nikhil C. Munshi,Lugui Qiu,Yu-Tzu Tai,Kenneth C. Anderson

View Articletitled, Osteoclasts promote immune suppressive microenvironment in multiple myeloma: therapeutic implication

Supplemental data

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88^L265P plasmablasts in vivo
Brief Report

James Q. Wang,Bruce Beutler,Christopher C. Goodnow,Keisuke Horikawa

View Articletitled, Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of <em>MYD88</em><sup><em>L265P</em></sup> plasmablasts in vivo

Supplemental data

Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis
Brief Report

Gabriela Pavlasova,Marek Borsky,Vaclav Seda,Katerina Cerna,Jitka Osickova,Michael Doubek,Jiri Mayer,Raffaele Calogero,Martin Trbusek,Sarka Pospisilova,Matthew S. Davids,Thomas J. Kipps,Jennifer R. Brown,Marek Mraz

View Articletitled, Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis

Supplemental data

MYELOID NEOPLASIA

Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia

Yoshiki Sumitomo,Junji Koya,Kumi Nakazaki,Keisuke Kataoka,Takako Tsuruta-Kishino,Ken Morita,Tomohiko Sato,Mineo Kurokawa

View Articletitled, Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia

Supplemental data

PLATELETS AND THROMBOPOIESIS

Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia

Matthieu Mahévas,Mathieu Gerfaud-Valentin,Guillaume Moulis,Louis Terriou,Sylvain Audia,Sophie Guenin,Guillaume Le Guenno,Gilles Salles,Olivier Lambotte,Nicolas Limal,Jean-François Viallard,Stephane Cheze,Cecile Tomowiak,Bruno Royer,Antoine Neel,Odile Debouverie,Arnaud Hot,Isabelle Durieu,Antoinette Perlat,Manuel Cliquennois,Clémence Deteix,Marc Michel,Bertrand Godeau

View Articletitled, Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation

Merlin Nithya Gnanapragasam,Kathleen E. McGrath,Seana Catherman,Li Xue,James Palis,James J. Bieker

View Articletitled, EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation

Supplemental data

THROMBOSIS AND HEMOSTASIS

Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice

Nina Kristofik,Nicole E. Calabro,Weiming Tian,Aaron Meng,Susan MacLauchlan,Yinong Wang,Christopher K. Breuer,George Tellides,Laura E. Niklason,Themis R. Kyriakides

View Articletitled, Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice

Supplemental data

TRANSFUSION MEDICINE

Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells
e-blood

Julie A. Reisz,Matthew J. Wither,Monika Dzieciatkowska,Travis Nemkov,Aaron Issaian,Tatsuro Yoshida,Andrew J. Dunham,Ryan C. Hill,Kirk C. Hansen,Angelo D’Alessandro

View Articletitled, Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells

Supplemental data

TRANSPLANTATION

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

Mathieu Leclerc,Sina Naserian,Caroline Pilon,Allan Thiolat,Gaëlle H. Martin,Charlotte Pouchy,Claude Dominique,Yazid Belkacemi,Frédéric Charlotte,Sébastien Maury,Benoit L. Salomon,José L. Cohen

View Articletitled, Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

Supplemental data

LETTERS TO BLOOD

Reduced frequency of circulating CD4⁺CD25^brightCD127^lowFOXP3⁺ regulatory T cells in primary myelofibrosis

Margherita Massa,Rita Campanelli,Gabriela Fois,Laura Villani,Elisa Bonetti,Paolo Catarsi,Valentina Poletto,Gianluca Viarengo,Mara De Amici,Vittorio Rosti,Robert Peter Gale,Giovanni Barosi

View Articletitled, Reduced frequency of circulating CD4<sup>+</sup>CD25<sup>bright</sup>CD127<sup>low</sup>FOXP3<sup>+</sup> regulatory T cells in primary myelofibrosis

Supplemental data

BLOOD WORK

Acute myeloid leukemia with myelodysplasia-related changes demonstrating mixed-lineage phenotype

Babita Kajal,Hong Chang

View Articletitled, Acute myeloid leukemia with myelodysplasia-related changes demonstrating mixed-lineage phenotype

Blastic plasmacytoid dendritic cell neoplasm associated with chronic myelomonocytic leukemia

Zhihong Hu,Tsieh Sun

View Articletitled, Blastic plasmacytoid dendritic cell neoplasm associated with chronic myelomonocytic leukemia

Cover Image

Cover Image

Cell-derived thrombospondin-2 (TSP2) knockout (KO) mouse extracellular matrix (ECM) does not support platelet aggregation. Dermal fibroblast–derived ECM was prepared in vitro following decellularization of long-term (7 days) cultures. Mouse platelets were exposed to either wild-type or TSP2 ECM for 30 minutes at room temperature. A representative image of platelets stained by rhodamine-phalloidin (red) on TSP2 KO ECM is shown. Detection of fibronectin (green) confirms the retention of ECM during the duration of the experiment. See the article by Kristofik et al on page 1642.
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