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Five hematologic tests and treatments to question
Rituximab plus liposomal doxorubicin in HIV-infected patients with KSHV-associated multicentric Castleman disease
A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL
Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13
Issue Archive
December 4 2014
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent
Yelena V. Lerman,Kihong Lim,Young-Min Hyun,Kathleen L. Falkner,Hongmei Yang,Anthony P. Pietropaoli,Arnoud Sonnenberg,Pranita P. Sarangi,Minsoo Kim
PERSPECTIVES
Five hematologic tests and treatments to question
Clinical Trials & Observations
Lisa K. Hicks,Harriet Bering,Kenneth R. Carson,Adam E. Haynes,Judith Kleinerman,Vishal Kukreti,Alice Ma,Brigitta U. Mueller,Sarah H. O'Brien,Julie A. Panepinto,Marcelo C. Pasquini,Anita Rajasekhar,Ravi Sarode,William A. Wood
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
Rituximab plus liposomal doxorubicin in HIV-infected patients with KSHV-associated multicentric Castleman disease
Clinical Trials & Observations
Thomas S. Uldrick,Mark N. Polizzotto,Karen Aleman,Kathleen M. Wyvill,Vickie Marshall,Denise Whitby,Victoria Wang,Stefania Pittaluga,Deirdre O’Mahony,Seth M. Steinberg,Richard F. Little,Robert Yarchoan
A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL
Clinical Trials & Observations
Jennifer A. Woyach,Farrukh Awan,Ian W. Flinn,Jesus G. Berdeja,Elizabeth Wiley,Sharmeen Mansoor,Ying Huang,Gerard Lozanski,Paul A. Foster,John C. Byrd
IMMUNOBIOLOGY
IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens
Paul J. Maglione,Noa Simchoni,Samuel Black,Lin Radigan,Jessica R. Overbey,Emilia Bagiella,James B. Bussel,Xavier Bossuyt,Jean-Laurent Casanova,Isabelle Meyts,Andrea Cerutti,Capucine Picard,Charlotte Cunningham-Rundles
LYMPHOID NEOPLASIA
Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations
Brief Report
Roberta La Starza,Chiara Borga,Gianluca Barba,Valentina Pierini,Claire Schwab,Caterina Matteucci,Anair G. Lema Fernandez,Anna Leszl,Gianni Cazzaniga,Sabina Chiaretti,Giuseppe Basso,Christine J. Harrison,Geertruy te Kronnie,Cristina Mecucci
MYELOID NEOPLASIA
Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13
Brief Report
Suzan Imren,Michael Heuser,Maura Gasparetto,Philip A. Beer,Gudmundur L. Norddahl,Ping Xiang,Ling Chen,Tobias Berg,Garrett W. Rhyasen,Patricia Rosten,Gyeongsin Park,Yeonsook Moon,Andrew P. Weng,Connie J. Eaves,R. Keith Humphries
PLATELETS AND THROMBOPOIESIS
Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice
Jose A. Guerrero,Cavan Bennett,Louise van der Weyden,Harriet McKinney,Melody Chin,Paquita Nurden,Zoe McIntyre,Emma L. Cambridge,Jeanne Estabel,Hannah Wardle-Jones,Anneliese O. Speak,Wendy N. Erber,Augusto Rendon,Willem H. Ouwehand,Cedric Ghevaert
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression
M. Bilal Iqbal,Michael Johns,Jun Cao,Yu Liu,Sheng-Chun Yu,Gareth D. Hyde,Michael A. Laffan,Francesco P. Marchese,Sung Hoon Cho,Andrew R. Clark,Felicity N. Gavins,Kevin J. Woollard,Perry J. Blackshear,Nigel Mackman,Jonathan L. Dean,Mark Boothby,Dorian O. Haskard
VASCULAR BIOLOGY
Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets
Yanfang Pan,Tadayuki Yago,Jianxin Fu,Brett Herzog,J. Michael McDaniel,Padmaja Mehta-D’Souza,Xiaofeng Cai,Changgeng Ruan,Rodger P. McEver,Christopher West,Kesheng Dai,Hong Chen,Lijun Xia
BLOOD WORK
ERRATA
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Cover Image
Cover Image
![issue cover]()
Unresolved replicative stress and common fragile site expression are the main reasons for thrombocytopenia in FANCA-deficient mice. This image shows fluorescently labeled DNA (red) and lamin A/C (green) of polylobulated mouse megakaryocytes demonstrating the accumulation of characteristic nucleoplasmic bridges, a consequence of under-replicated DNA regions in FANCA-deficient cells. The presence of the DNA bridges restrains the endomitotic cycling of the megakaryocytes, affecting their differentiation and normal platelet production in Fanca−/− mice. See the article by Pawlikowska et al on page 3613.
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